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Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon‐alpha and ‐gamma signal transduction pathways.

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Transcriptional cross-talk, the second mode of steroid hormone receptor action

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STAT3β, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription

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TAFs mediate transcriptional activation and promoter selectivity

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Activation of STAT4 by IL-12 and IFN-α: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation

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Stat Protein Transactivation Domains Recruit p300/CBP through Widely Divergent Sequences

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p300/CREB-Binding Protein Enhances the Prolactin-Mediated Transcriptional Induction through Direct Interaction with the Transactivation Domain of Stat5, but Does Not Participate in the Stat5-Mediated Suppression of the Glucocorticoid Response

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Interacting Regions in Stat3 and c-Jun That Participate in Cooperative Transcriptional Activation

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Ser727‐dependent recruitment of MCM5 by Stat1α in IFN‐γ‐induced transcriptional activation

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Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6.

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Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes

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Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components

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Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

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Interleukin-6: Biology, signaling and strategies of blockade

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Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map

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Interleukin-22 (IL-22) Activates the JAK/STAT, ERK, JNK, and p38 MAP Kinase Pathways in a Rat Hepatoma Cell Line

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HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas

Gray, M. J., Zhang, J., Ellis, L. M., Semenza, G. L., Evans, D. B., Watowich, S. S., & Gallick, G. E. (2005) · Oncogene · doi:10.1038/sj.onc.1208513 · Cited by 372 · see citing works

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works

Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention

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Hypoxia-inducible factor-1 in human breast and prostate cancer

Kimbro, K. S., & Simons, J. W. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.00728 · Cited by 246 · see citing works

Activation of Stat3 Sequence-specific DNA Binding and Transcription by p300/CREB-binding Protein-mediated Acetylation

Wang, R., Cherukuri, P., & Luo, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413930200 · Cited by 275 · see citing works

STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells

Pawlus, M. R., Wang, L., & Hu, C. (2013) · Oncogene · doi:10.1038/onc.2013.115 · Cited by 224 · see citing works

STAT3 in the systemic inflammation of cancer cachexia

Zimmers, T. A., Fishel, M. L., & Bonetto, A. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.02.009 · Cited by 223 · see citing works

STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells

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Multiple transcription factor families regulate axon growth and regeneration

Moore, D. L., & Goldberg, J. L. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20934 · Cited by 192 · see citing works

STAT3 the oncogene – still eluding therapy?

Wake, M. S., & Watson, C. (2015) · The FEBS Journal · doi:10.1111/febs.13285 · Cited by 190 · see citing works

Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains

Wojciak, J. M., Martinez‐Yamout, M. A., Dyson, H. J., & Wright, P. E. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.30 · Cited by 172 · see citing works

Interleukin-6 signalling: More than Jaks and STATs

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IL-6-STAT3 signaling and premature senescence

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Essential role of STAT3 in cytokine‐driven NF‐κB‐mediated serum amyloid A gene expression

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The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communicationPreprint

Karr, J. P., Ferrie, J. J., Tjian, R., & Darzacq, X. (2021) · Genes & Development · doi:10.1101/gad.349160.121 · Cited by 147 · see citing works

Interleukin-6 Inhibits Receptor Activator of Nuclear Factor κB Ligand-Induced Osteoclastogenesis by Diverting Cells into the Macrophage Lineage: Key Role of Serine727 Phosphorylation of Signal Transducer and Activator of Transcription 3

Duplomb, L., Baud’huin, M., Charrier, C., Berreur, M., Trichet, V., Blanchard, F., & Heymann, D. (2008) · Endocrinology · doi:10.1210/en.2007-1719 · Cited by 140 · see citing works

Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells.

Ghosh, A., Shanafelt, T., Cimmino, A., Taccioli, C., Volinia, S., Liu, C.-G., Calin, G., Croce, C., Chan, D., Giaccia, A., et al. (2009) · Blood · doi:10.1182/blood-2008-10-185686 · Cited by 141 · see citing works

Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy

Gupta, M., Han, J. J., Stenson, M. J., Wellik, L. E., & Witzig, T. E. (2011) · Leukemia · doi:10.1038/leu.2011.340 · Cited by 134 · see citing works

Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

Fu, A. K. Y., Fu, W., Ng, A. K. Y., Chien, W. W. Y., Ng, Y.-P., Wang, J. H.-C., & Ip, N. Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307606100 · Cited by 135 · see citing works

S-glutathionylation impairs signal transducer and activator of transcription 3 activation and signaling

Xie, Y., Kole, S., Precht, P., Pazin, M. J., & Bernier, M. (2009) · Endocrinology · doi:10.1210/en.2008-1241 · Cited by 126 · see citing works

STAT3 and cardiac remodeling

Haghikia, A., Stapel, B., Hoch, M., & Hilfiker-Kleiner, D. (2010) · Heart Failure Reviews · doi:10.1007/s10741-010-9170-x · Cited by 117 · see citing works

NF-κB/STAT3/PI3K signaling crosstalk in iMycEμ B lymphoma

Han, S., Yun, H., Son, D.-J., Tompkins, V. S., Peng, L., Chung, S.-T., Kim, J., Park, E.-S., & Janz, S. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-97 · Cited by 114 · see citing works

STAT3 as a Downstream Mediator of Trk Signaling and Functions

Ng, Y. P., Cheung, Z. H., & Ip, N. Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601863200 · Cited by 111 · see citing works

Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration

Chung, Y.-J., Park, B.-B., Kang, Y.-J., Kim, T.-M., Eaves, C. J., & Oh, I.-H. (2006) · Blood · doi:10.1182/blood-2006-01-010199 · Cited by 107 · see citing works

Rosmanol Potently Inhibits Lipopolysaccharide-Induced iNOS and COX-2 Expression through Downregulating MAPK, NF-κB, STAT3 and C/EBP Signaling Pathways

Lai, C., Lee, J. H., Ho, C., Liu, C. B., Wang, J., Wang, Y., & Pan, M. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9025713 · Cited by 104 · see citing works

Role and Regulation of STAT3 Phosphorylation at Ser727 in Melanocytes and Melanoma Cells

Sakaguchi, M., Oka, M., Iwasaki, T., Fukami, Y., & Nishigori, C. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.45 · Cited by 100 · see citing works

Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45

Wakahara, R., Kunimoto, H., Tanino, K., Kojima, H., Inoue, A., Shintaku, H., & Nakajima, K. (2012) · Genes to Cells · doi:10.1111/j.1365-2443.2011.01575.x · Cited by 95 · see citing works

Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin signaling through serine 727 phosphorylation

Kim, J.-H., Yoon, M.-S., & Chen, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.051516 · Cited by 92 · see citing works

STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling

Wang, Z., Luo, F., Li, L., Yang, L., Hu, D., Ma, X., Lu, Z., Sun, L., & Cao, Y. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.07.008 · Cited by 86 · see citing works

Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response

Pawlus, M. R., & Hu, C. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.05.018 · Cited by 83 · see citing works

Pivotal importance of STAT3 in protecting the heart from acute and chronic stress: new advancement and unresolved issues

Zouein, F. A., Altara, R., Chen, Q., Lesnefsky, E. J., Kurdi, M., & Booz, G. W. (2015) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2015.00036 · Cited by 82 · see citing works

Gadd45a Suppresses Tumor Angiogenesis via Inhibition of the mTOR/STAT3 Protein Pathway*

Yang, F., Zhang, W., Li, D., & Zhan, Q. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.418335 · Cited by 79 · see citing works

Recent Developments on the Crosstalk Between STAT3 and Inflammation in Heart Function and Disease

Kurdi, M., Zgheib, C., & Booz, G. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03029 · Cited by 76 · see citing works

Physical and functional interactions between STAT3 and KAP1

Tsuruma, R., Ohbayashi, N., Kamitani, S., Ikeda, O., Sato, N., Muromoto, R., Sekine, Y., Oritani, K., & Matsuda, T. (2007) · Oncogene · doi:10.1038/sj.onc.1210952 · Cited by 76 · see citing works

Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3

Aziz, M. H., Manoharan, H. T., & Verma, A. K. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3350 · Cited by 76 · see citing works

Development of Diabesity in Mice with Neuronal Deletion of Shp2 Tyrosine Phosphatase

Krajewska, M., Banares, S., Zhang, E. E., Huang, X., Scadeng, M., Jhala, U. S., Feng, G.-S., & Krajewski, S. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070594 · Cited by 72 · see citing works

Physical and functional interactions between STAT3 and ZIP kinase

Sato, N., Kawai, T., Sugiyama, K., Muromoto, R., Imoto, S., Sekine, Y., Ishida, M., Akira, S., & Matsuda, T. (2005) · International Immunology · doi:10.1093/intimm/dxh331 · Cited by 65 · see citing works

Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes

Ng, I. H. W., Ng, D. C. H., Jans, D. A., & Bogoyevitch, M. A. (2012) · Biochemical Journal · doi:10.1042/bj20120941 · Cited by 63 · see citing works

Selective activation of STAT3 in human monocytes stimulated by G-CSF: implication in inhibition of LPS-induced TNF-α production

Nishiki, S., Hato, F., Kamata, N., Sakamoto, E., Hasegawa, T., Eto-Kimura, A., Hino, M., & Kitagawa, S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00387.2003 · Cited by 63 · see citing works

The HAT/HDAC interplay: Multilevel control of STAT signaling

Icardi, L., Bosscher, K. D., & Tavernier, J. H. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.08.002 · Cited by 61 · see citing works

S897 phosphorylation of EphA2 is indispensable for EphA2-dependent nasopharyngeal carcinoma cell invasion, metastasis and stem properties

Li, J.-Y., Xiao, T., Yi, H.-M., Yi, H. L., Feng, J., Zhu, J.-F., Huang, W., Lu, S., Zhou, Y., Li, X., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.12.011 · Cited by 61 · see citing works

Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma

Liu, Y., Tan, Y.-N., Wang, Z.-L., Zeng, L., Lu, Z., Li, L., Luo, W., Tang, M., & Cao, Y. (2008) · International Journal of Molecular Medicine · doi:10.3892/ijmm.21.2.153 · Cited by 59 · see citing works

STAT3 ser727 phosphorylation and its association with negative estrogen receptor status in breast infiltrating ductal carcinoma

Yeh, Y., Ou‐Yang, F., Chen, I., Yang, S., Wang, Y. Y., Chuang, H., Su, J., Hou, M., & Yuan, S. F. (2006) · International Journal of Cancer · doi:10.1002/ijc.21771 · Cited by 58 · see citing works

Signal transducers and activators of transcription—from cytokine signalling to cancer biology

Santos, C. I., & Costa‐Pereira, A. P. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.03.003 · Cited by 56 · see citing works

Oncostatin M causes VEGF release from human airway smooth muscle: synergy with IL-1β

Faffe, D. S., Flynt, L., Mellema, M. S., Whitehead, T. R., Bourgeois, K., Panettieri, R. A., Silverman, E. S., & Shore, S. A. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00333.2004 · Cited by 55 · see citing works

Reciprocal Inhibition between MyoD and STAT3 in the Regulation of Growth and Differentiation of Myoblasts

Kataoka, Y., Matsumura, I., Ezoe, S., Nakata, S., Takigawa, E., Sato, Y., Kawasaki, A., Yokota, T., Nakajima, K., Felsani, A., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304884200 · Cited by 55 · see citing works

Targeting the STAT3 oncogenic pathway: Cancer immunotherapy and drug repurposing

Dong, Y., Chen, J., Chen, Y., & Liu, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115513 · Cited by 54 · see citing works

Understanding STAT3 signaling in cardiac ischemia

O’Sullivan, K. E., Breen, E. P., Gallagher, H. C., Buggy, D. J., & Hurley, J. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0543-8 · Cited by 53 · see citing works

Of alphas and betas: distinct and overlapping functions of STAT3 isoforms

Dewilde, S. (2008) · Frontiers in Bioscience · doi:10.2741/3170 · Cited by 53 · see citing works

HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A

Togi, S., Kamitani, S., Kawakami, S., Ikeda, O., Muromoto, R., Nanbo, A., & Matsuda, T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.132 · Cited by 51 · see citing works

Extracellular UDP-Glucose Activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 Phosphorylation and Binding to Hyaluronan Synthase 2 (HAS2) Promoter, Stimulating Hyaluronan Synthesis of Keratinocytes

Jokela, T. A., Kärnä, R., Makkonen, K. M., Laitinen, J. T., Tammi, R., & Tammi, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.551804 · Cited by 51 · see citing works

LIF- and IL-6-Induced Acetylation of STAT3 at Lys-685 through PI3K/Akt Activation

Ohbayashi, N., Ikeda, O., Taira, N., Yamamoto, Y., Muromoto, R., Sekine, Y., Sugiyama, K., Honjoh, T., & Matsuda, T. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.1860 · Cited by 51 · see citing works

Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking

Yu, W., Li, C., Zhang, W., Xia, Y., Li, S., Lin, J., Yu, K., Liu, M., Yang, L. F., Luo, J., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01489 · Cited by 48 · see citing works

Diallyl disulfide alleviates inflammatory osteolysis by suppressing osteoclastogenesis via NF‐κB–NFATc1 signal pathway

Yang, J., Tang, R., Jin, Y., Chen, Y., Li, X., Yu, T., & Fei, J. (2019) · The FASEB Journal · doi:10.1096/fj.201802172r · Cited by 48 · see citing works

The Physiological and Pathophysiological Role of IL-6/STAT3-Mediated Signal Transduction and STAT3 Binding Partners in Therapeutic Applications

Matsuda, T. (2023) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b22-00887 · Cited by 46 · see citing works

STAT3 signal transduction through interleukin-22 in oral squamous cell carcinoma

Naher, L., Kiyoshima, T., Kobayashi, I., WADA, H., Nagata, K., Fujiwara, H., Ookuma, Y., Ozeki, S., Nakamura, S., & Sakai, H. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1594 · Cited by 45 · see citing works

Signal integration and gene induction by a functionally distinct STAT3 phosphoform

Waitkus, M. S., Chandrasekharan, U. M., Willard, B., Tee, T. L., Hsieh, J. K., Przybycin, C. G., Rini, B. I., & DiCorleto, P. E. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00034-14 · Cited by 45 · see citing works

STAT3beta, a distinct isoform from STAT3

Zhang, H., Yang, P.-L., Li, E., & Xu, L. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.02.006 · Cited by 45 · see citing works

Krüppel-Associated Box-Associated Protein 1 Negatively Regulates TNF-α–Induced NF-κB Transcriptional Activity by Influencing the Interactions among STAT3, p300, and NF-κB/p65

Kamitani, S., Togi, S., Ikeda, O., Nakasuji, M., Sakauchi, A., Sekine, Y., Muromoto, R., Oritani, K., & Matsuda, T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003243 · Cited by 44 · see citing works

SH2B1β enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway

Lin, W., Chen, C.-J., Chang, Y., Chen, S.-L., Chiu, I., & Chen, L. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.02.009 · Cited by 44 · see citing works

Capric Acid Inhibits NO Production and STAT3 Activation during LPS-Induced Osteoclastogenesis

Park, E., Kim, S. A., Choi, Y.-M., Kwon, H., Shim, W., Lee, G., & Choi, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027739 · Cited by 44 · see citing works

STAT3 plays an important role in DNA replication by turning on WDHD1

Zhou, Y., & Chen, J. J. (2021) · Cell & Bioscience · doi:10.1186/s13578-020-00524-x · Cited by 38 · see citing works

The STAT3 beacon: IL-6 recurrently activates STAT 3 from endosomal structures

German, C. L., Sauer, B. M., & Howe, C. L. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.05.009 · Cited by 38 · see citing works

The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3

Gambi, G., Simone, E. D., Basso, V., Ricci, L., Wang, R., Verma, A., Elemento, O., Ponzoni, M., Inghirami, G., Icardi, L., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-0359 · Cited by 38 · see citing works

Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT

Shravah, J., Wang, B., Pavlović, M., Kumar, U., Chen, D. D., Luo, H., & Ansley, D. M. (2014) · JAK-STAT · doi:10.4161/jkst.29554 · Cited by 35 · see citing works

Dancing rhinos in stilettos

Zouein, F. A., Kurdi, M., & Booz, G. W. (2013) · JAK-STAT · doi:10.4161/jkst.24352 · Cited by 34 · see citing works

Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes

Nerstedt, A., Cansby, E., Amrutkar, M., Smith, U., & Mahlapuu, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.05.013 · Cited by 34 · see citing works

The role of understudied post‐translational modifications for the behavior and function of Signal Transducer and Activator of Transcription 3

Diallo, M., & Herrera, F. (2021) · FEBS Journal · doi:10.1111/febs.16116 · Cited by 35 · see citing works

Detrimental Effects of Leptin on Intracerebral Hemorrhage via the STAT3 Signal Pathway

Kim, C. K., Ryu, W., Choi, I.-Y., Kim, Y. J., Rim, D., Kim, B. J., Jang, H., Yoon, B., & Lee, S. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.35 · Cited by 34 · see citing works

β‐Naphthoflavone disturbs astrocytic differentiation of C6 glioma cells by inhibiting autocrine interleukin‐6

Takanaga, H., Yoshitake, T., Yatabe, E., Hara, S., & Kunimoto, M. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02681.x · Cited by 29 · see citing works

The role of p-STAT3 (ser727) revealed by its association with Ki-67 in cervical intraepithelial neoplasia

Yang, S., Yuan, S. F., Yeh, Y., Wu, M., Su, J., Hung, S., & Chai, C. (2005) · Gynecologic Oncology · doi:10.1016/j.ygyno.2005.05.032 · Cited by 28 · see citing works

Cytokine-induced tumor suppressors: A GRIM story

Kalvakolanu, D. V., Nallar, S. C., & Kalakonda, S. (2010) · Cytokine · doi:10.1016/j.cyto.2010.03.009 · Cited by 25 · see citing works

Bilateral activation of STAT3 by phosphorylation at the tyrosine-705 (Y705) and serine-727 (S727) positions and its nuclear translocation in primary sensory neurons following unilateral sciatic nerve injury

Dubový, P., Hradilová‐Svíženská, I., Klusáková, I., Kokošová, V., Brázda, V., & Joukal, M. (2018) · Histochemistry and Cell Biology · doi:10.1007/s00418-018-1656-y · Cited by 24 · see citing works

Lymphoma and Myeloma Cell Resistance to Cytotoxic Agents and Ionizing Radiations Is Not Affected by Exposure to Anti–IL-6 Antibody

Gougèlet, A., Mansuy, A., Blay, J., Alberti, L., & Vermot‐Desroches, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008026 · Cited by 24 · see citing works

Hypothesis of Opposite Interplay Between the Canonical WNT/beta-catenin Pathway and PPAR Gamma in Primary Central Nervous System Lymphomas

Vallée, A., Lecarpentier, Y., & Vallée, J.-N. (2019) · Current Issues in Molecular Biology · doi:10.21775/cimb.031.001 · Cited by 23 · see citing works

STAT3β Enhances Sensitivity to Concurrent Chemoradiotherapy by Inducing Cellular Necroptosis in Esophageal Squamous Cell Carcinoma

Zheng, Z.-Y., Yang, P.-L., Luo, W., Yu, S.-X., Xu, H.-Y., Huang, Y., Li, R.-Y., Chen, Y., Xu, X., Liao, L., et al. (2021) · Cancers · doi:10.3390/cancers13040901 · Cited by 23 · see citing works

Endothelin-1 stimulates expression of cyclin D1 and S-phase kinase–associated protein 2 by activating the transcription factor STAT3 in cultured rat astrocytes

Kōyama, Y., Sumie, S., Nakano, Y., Nagao, T., Tokumaru, S., & Michinaga, S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005614 · Cited by 22 · see citing works

Posttranslational modifications as therapeutic targets for intestinal disorders

Choo, J., Heo, G., Pothoulakis, C., & Im, E. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105412 · Cited by 21 · see citing works

Signal transducer and activator of transcription 3 regulation by novel binding partners

Matsuda, T. (2015) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v6.i4.324 · Cited by 19 · see citing works

Intranuclear Crosstalk between Extracellular Regulated Kinase1/2 and Signal Transducer and Activator of Transcription 3 Regulates JEG‐3 Choriocarcinoma Cell Invasion and Proliferation

Prieto, D. M. M., Ospina‐Prieto, S., Chaiwangyen, W., Weber, M., Hölters, S., Schleußner, E., Fitzgerald, J. S., & Markert, U. R. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/259845 · Cited by 18 · see citing works

Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis

Jokela, T. A., Kärnä, R., Rauhala, L., Bart, G., Pasonen‐Seppänen, S., Oikari, S., Tammi, M., & Tammi, R. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.760322 · Cited by 18 · see citing works

N-Myc-Interacting Protein Negatively Regulates TNF-α-Induced NF-κB Transcriptional Activity by Sequestering NF-κB/p65 in the Cytoplasm

Hou, J.-J., Jiang, S., Zhao, J.-B., Zhu, D., Zhao, X., Cai, J.-C., & Zhang, S.-Q. (2017) · Scientific Reports · doi:10.1038/s41598-017-15074-5 · Cited by 19 · see citing works

Oncogenic Ras blocks transforming growth factor-β–induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway

Schepers, H., Wierenga, A. T. J., Eggen, B. J. L., & Vellenga, E. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.04.006 · Cited by 18 · see citing works

Histone acetyltransferase activity of p300 enhances the activation of IL-12 p40 promoter

Sun, H., Lü, J., Wei, L., Wang, X., Xu, X., Dong, M., & Huang, B. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.05.013 · Cited by 17 · see citing works

Cytokine‐Induced Slowing of STAT3 Nuclear Import; Faster Basal Trafficking of the STAT3β Isoform

Ng, I. H. W., Bogoyevitch, M., & Jans, D. A. (2014) · Traffic : the International Journal of Intracellular Transport · doi:10.1111/tra.12181 · Cited by 16 · see citing works

Screening approaches to generating STAT inhibitors

Walker, S. R., & Frank, D. A. (2012) · JAK-STAT · doi:10.4161/jkst.22662 · Cited by 15 · see citing works

Pigment epithelium-derived factor (PEDF) blocks the interleukin-6 signaling to C-reactive protein expression in Hep3B cells by suppressing Rac-1 activation

Yoshida, T., Yamagishi, S., Nakamura, K., Matsui, T., Imaizumi, T., Inoue, H., Ueno, T., & Sata, M. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.06.034 · Cited by 15 · see citing works

Calyculin A Reveals Serine/Threonine Phosphatase Protein Phosphatase 1 as a Regulatory Nodal Point in Canonical Signal Transducer and Activator of Transcription 3 Signaling of Human Microvascular Endothelial Cells

Zgheib, C., Zouein, F. A., Chidiac, R., Kurdi, M., & Booz, G. W. (2011) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0059 · Cited by 15 · see citing works

STAT3-mediated Coincidence Detection Regulates Noncanonical Immediate Early Gene Induction

Waitkus, M. S., Chandrasekharan, U. M., Willard, B. B., Haque, S. J., & DiCorleto, P. E. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.428516 · Cited by 13 · see citing works

Defective activations of STAT3 Ser727 and PKC isoforms lead to oncostatin M resistance in metastatic melanoma cells

Lacreusette, A., Barbieux, I., Nguyen, J., Pandolfino, M., Dréno, B., Jacques, Y., Godard, A., & Blanchard, F. (2008) · The Journal of Pathology · doi:10.1002/path.2490 · Cited by 12 · see citing works

Pro-angiogenic effects of MDM2 through HIF-1α and NF-κB mediated mechanisms in LNCaP prostate cancer cells

Muthumani, P., Karthikeyan, A., Dhandayuthapani, S., Venkatesan, T., & Rathinavelu, A. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3430-0 · Cited by 12 · see citing works

A strategic review of STAT3 signaling inhibition by phytochemicals for cancer prevention and treatment: Advances and insights

Manoharan, S., & Perumal, E. (2024) · Fitoterapia · doi:10.1016/j.fitote.2024.106265 · Cited by 11 · see citing works

High Content Imaging Assays for IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines

Johnston, P. A., Sen, M., Hua, Y., Camarco, D. P., Shun, T. Y., Lazo, J. S., & Grandis, J. R. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7357-6_14 · Cited by 11 · see citing works

Region 752–761 of STAT3 is critical for SRC-1 recruitment and Ser727 phosphorylation

Zhao, H., Nakajima, R., Kunimoto, H., Sasaki, T., Kojima, H., & Nakajima, K. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.075 · Cited by 11 · see citing works

Histone acetyltransferase activity of p300 enhances the activation of IL‐18 promoter

Sun, H., Lü, J., Xu, X., Jin, S., Wang, X., Wei, L., Dong, M., & Huang, B. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20194 · Cited by 10 · see citing works

β-Adrenergic Receptors Cooperate With Transcription Factors

Balligand, J. (2015) · Circulation · doi:10.1161/circulationaha.115.019860 · Cited by 9 · see citing works

STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFβ-activated kinase 1 for STAT3 Ser-727 phosphorylation

Kojima, H., Sasaki, T., Ishitani, T., Iemura, S.-I., Zhao, H., Kaneko, S., Kunimoto, H., Natsume, T., Matsumoto, K., & Nakajima, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500679102 · Cited by 81 · see citing works

Regulation of Stat3 transcriptional activity by the conserved LPMSP motif for OSM and IL‐6 signaling

Sun, W. Y., Snyder, M., Levy, D. E., & Zhang, J. J. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.09.054 · Cited by 25 · see citing works

Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45

Wakahara, R., Kunimoto, H., Tanino, K., Kojima, H., Inoue, A., Shintaku, H., & Nakajima, K. (2012) · Genes to Cells · doi:10.1111/j.1365-2443.2011.01575.x · Cited by 95 · see citing works

The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway

Abe, K., Hirai, M., Mizuno, K., Higashi, N., Sekimoto, T., Miki, T., Hirano, T., & Nakajima, K. (2001) · Oncogene · doi:10.1038/sj.onc.1204461 · Cited by 65 · see citing works

Sequential Activation of Rac-1, SEK-1/MKK-4, and Protein Kinase Cδ Is Required for Interleukin-6-induced STAT3 Ser-727 Phosphorylation and Transactivation

Schuringa, J. J., Dekker, L. V., Vellenga, E., & Kruijer, W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009821200 · Cited by 81 · see citing works