The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin
Open accessAbstract
Regulatory T cells (Tregs) are crucial for the induction and maintenance of self-tolerance and are present in peripheral tissues such as skin and gut under normal, noninflamed conditions. We report isolation and expansion of the Treg population resident in normal human skin. Cutaneous Tregs expressed high levels of CD25, L-selectin, GITR, FOXP3, and intracellular CTLA-4, low levels of CD69, and high levels of the skin-homing addressins CLA, CCR4, and CCR6. Skin Tregs suppressed the proliferation of CD25lo T cells from the same skin sample in response to CD3 and CD28 antibodies. Suppression was dependent on cell contact and not affected by neutralizing antibodies to interleukin-10 (IL-10) and transforming growth factor-β (TGF-β). Surprisingly, cutaneous Tregs proliferated in an antigen-independent manner when cultured in contact with dermal fibroblasts and IL-15, conditions similar to those found in chronically inflamed skin. We hypothesize that local proliferation of Tregs may occur within inflamed skin and could serve as a brake for cutaneous inflammation as well as a mechanism for the homeostatic proliferation of natural Tregs that has been observed within intact organisms.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608
Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669
Bromley, S. K., Thomas, S. Y., & Luster, A. D. (2005) · Nature Immunology · doi:10.1038/ni1240 · Cited by 509
Cited by
Human T cell development, localization, and function throughout life
Kumar, B. V., Connors, T. J., & Farber, D. L. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.007 · Cited by 1,257
Treg cell-based therapies: challenges and perspectives
Raffin, C., Vo, L. T., & Bluestone, J. A. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0232-6 · Cited by 720
The emerging role of resident memory T cells in protective immunity and inflammatory disease
Park, C. O., & Kupper, T. S. (2015) · Nature Medicine · doi:10.1038/nm.3883 · Cited by 517
Self-citationSeneschal, J., Clark, R. A., Gehad, A., Baecher-Allan, C. M., & Kupper, T. S. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.018 · Cited by 455
Self-citationMemory regulatory T cells reside in human skin
Sanchez Rodriguez, R., Pauli, M. L., Neuhaus, I. M., Yu, S. S., Arron, S. T., Harris, H. W., Yang, S. H.-Y., Anthony, B. A., Sverdrup, F. M., Krow-Lucal, E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72932 · Cited by 354
Metadata
- Authors
- Clark, R. A., & Kupper, T. S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-09-12
- Volume
- 109
- Issue
- 1
- Pages
- 194-202
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2035972887
- Cited by
- 179
- References
- 5
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- green
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