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Timing of neutrophil tissue repopulation predicts restoration of innate immune protection in a murine bone marrow transplantation model
Open accessAbstract
It has been suggested that neutrophil tissue repopulation following bone marrow transplantation (BMT) serves as an earlier and more relevant marker of susceptibility to infection than circulating neutrophil counts. In a previous study using an oral rinse protocol, we found that oral neutrophil recovery always preceded blood neutrophil engraftment and that the day of oral neutrophil detection served as a predictor of patient susceptibility to infection after BMT. Consequently, we have developed and validated a mouse BMT model which uses bone marrow transplants containing enhanced green fluorescent protein-expressing neutrophils to follow neutrophil tissue repopulation after BMT. Using this in vivo cell migration model, we assessed the significance of neutrophil tissue recruitment kinetics with neutrophil functionality and in vivo bacterial killing after BMT. Using the animal model, we have demonstrated that protection against bacterial infection is conferred at the time of neutrophil tissue delivery, which always occurs before neutrophils are detected in the blood. We therefore conclude that neutrophil tissue recovery is an early measure of the restoration of cellular innate immune function after BMT. This model will help us better understand the factors regulating neutrophil recruitment to the tissues.
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In a murine model, the kinetics of neutrophil delivery to tissues during the engraftment phase was a better predictor of reconstitution of the immune system than reappearance of circulating neutrophils in the blood.
“Further, in a murine model the kinetics of neutrophil delivery to tissues during the engraftment phase was a better predictor of reconstitution of the immune system than reappearance of circulating neutrophils in the blood [35].”
From Oral neutrophils are an independent marker of the systemic inflammatory response after cardiac bypass (2014) · cites this paper as [35]
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Metadata
- Authors
- Cheretakis, C., Leung, R., Sun, C. X., Dror, Y., & Glogauer, M.
- Affiliations
- University of Toronto (CA)
- From the Canadian Institutes of Health Research (CIHR) Group in Matrix Dynamics, University of Toronto; and the Department of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-10-15
- Volume
- 108
- Issue
- 8
- Pages
- 2821-2826
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1978906002
- Cited by
- 50
- References
- 21
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 1
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Toronto
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- bone marrow transplantation, neutrophil engraftment, infection susceptibility, bacterial killing, post-transplant infection
- MeSH terms
- Animals, Cell Movement, Chemotaxis, Leukocyte, Humans, Immunity, Cellular, Immunity, Innate, Leukocyte Count, Mice, Transgenic, Neutrophils, Organ Specificity, Pseudomonas aeruginosa, Pseudomonas Infections, Recombinant Proteins, Time Factors, Bone Marrow Transplantation, Granulocyte Colony-Stimulating Factor, Pneumonia, Bacterial, Models, Animal, Green Fluorescent Proteins, Mice
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