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Cited by 397

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Control of coronavirus infection through plasmacytoid dendritic-cell–derived type I interferon

Open access
Cervantes-Barragan, Luisa, Züst, Roland, Weber, Friedemann, Spiegel, Martin, Lang, Karl S., Akira, Shizuo, Thiel, Volker, Ludewig, Burkhard·2007·Blood

Abstract

This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-α production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections.

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Crossref · 10.1182/blood-2006-05-023770

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Metadata

Authors
Cervantes-Barragan, L., Züst, R., Weber, F., Spiegel, M., Lang, K. S., Akira, S., Thiel, V., & Ludewig, B.
Venue
Blood
Published
2006-09-19
Volume
109
Issue
3
Pages
1131-1137
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W1977728069
Cited by
397
References
4
FWCI
7.00
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Control of coronavirus infection through plasmacytoid dendritic-cell–derived type I interferon. https://app.cochat.ai/papers/10.1182/blood-2006-05-023770
The paper
Cervantes-Barragan, L., Züst, R., Weber, F., Spiegel, M., Lang, K. S., Akira, S., Thiel, V., & Ludewig, B. (2007). Control of coronavirus infection through plasmacytoid dendritic-cell–derived type I interferon. Blood. https://doi.org/10.1182/blood-2006-05-023770

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.