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Leukemia stem cells in a genetically defined murine model of blast-crisis CML.

Neering, Sarah J., Bushnell, Timothy, Sozer, Selcuk, Ashton, John, Rossi, Randall M., Wang, Pin-Yi, Bell, Deborah R., Heinrich, David, Bottaro, Andrea, Jordan, Craig T.·2007·Blood
DOI 10.1182/blood-2007-02-073031
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Abstract

Myeloid leukemia arises from leukemia stem cells (LSCs), which are resistant to standard chemotherapy agents and likely to be a major cause of drug-resistant disease and relapse. To investigate the in vivo properties of LSCs, we developed a mouse model in which the biologic features of human LSCs are closely mimicked. Primitive normal hematopoietic cells were modified to express the BCR/ABL and Nup98/HoxA9 translocation products, and a distinct LSC population, with the aberrant immunophenotype of lineage−, Kit+/−, Flt3+, Sca+, CD34+, and CD150−, was identified. In vivo studies were then performed to assess the response of LSCs to therapeutic insult. Treatment of animals with the ABL kinase inhibitor imatinib mesylate induced specific modulation of blasts and progenitor cells but not stem- cell populations, thereby recapitulating events inferred to occur in human chronic myelogenous leukemia (CML) patients. In addition, challenge of leukemic mice with total body irradiation was selectively toxic to normal hematopoietic stem cells (HSCs), suggesting that LSCs are resistant to apoptosis and/or senescence in vivo. Taken together, the system provides a powerful means by which the in vivo behavior of LSCs versus HSCs can be characterized and candidate treatment regimens can be optimized for maximal specificity toward primitive leukemia cells.

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  1. Bonnet, 1997, Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell., Nat Med, 3, 730, 10.1038/nm0797-730 · DOI · Paper page
  2. Guan, 2003, Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML)., Blood, 101, 3142, 10.1182/blood-2002-10-3062 · DOI
  3. Jordan, 2002, Unique molecular and cellular features of acute myelogenous leukemia stem cells., Leukemia, 16, 559, 10.1038/sj.leu.2402446 · DOI
  4. Holyoake, 2002, Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia., Leukemia, 16, 549, 10.1038/sj.leu.2402444 · DOI
  5. Reya, 2001, Stem cells, cancer, and cancer stem cells., Nature, 414, 105, 10.1038/35102167 · DOI · Paper page
  6. Passegue, 2003, Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?, Proc Natl Acad Sci U S A, 100, 11842, 10.1073/pnas.2034201100 · DOI
  7. Pardal, 2003, Applying the principles of stem-cell biology to cancer., Nat Rev Cancer, 3, 895, 10.1038/nrc1232 · DOI
  8. Hope, 2003, Human acute myeloid leukemia stem cells., Arch Med Res, 34, 507, 10.1016/j.arcmed.2003.08.007 · DOI
  9. Jordan, 2005, Targeting the most critical cells: approaching leukemia therapy as a problem in stem cell biology., Nat Clin Pract Oncol, 2, 224, 10.1038/ncponc0164 · DOI
  10. Guzman, 2004, Considerations for targeting malignant stem cells in leukemia., Cancer Control, 11, 97, 10.1177/107327480401100216 · DOI
  11. Al-Hajj, 2004, Therapeutic implications of cancer stem cells., Curr Opin Genet Dev, 14, 43, 10.1016/j.gde.2003.11.007 · DOI
  12. Cozzio, 2003, Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors., Genes Dev, 17, 3029, 10.1101/gad.1143403 · DOI
  13. Huntly, 2004, MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors., Cancer Cell, 6, 587, 10.1016/j.ccr.2004.10.015 · DOI · Paper page
  14. Huntly, 2005, Leukaemia stem cells and the evolution of cancer-stem-cell research., Nat Rev Cancer, 5, 311, 10.1038/nrc1592 · DOI · Paper page
  15. Somervaille, 2006, Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia., Cancer Cell, 10, 257, 10.1016/j.ccr.2006.08.020 · DOI · Paper page
  16. Deshpande, 2006, Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia., Cancer Cell, 10, 363, 10.1016/j.ccr.2006.08.023 · DOI
  17. Hu, 2006, Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice., Proc Natl Acad Sci U S A, 103, 16870, 10.1073/pnas.0606509103 · DOI
  18. Peng, 2007, Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells., Blood, 110, 678, 10.1182/blood-2006-10-054098 · DOI
  19. Daley, 1990, Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome., Science, 247, 824, 10.1126/science.2406902 · DOI · Paper page
  20. Van Etten, 2001, Models of chronic myeloid leukemia., Curr Oncol Rep, 3, 228, 10.1007/s11912-001-0055-y · DOI
  21. Cuenco, 2001, Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia., Oncogene, 20, 8236, 10.1038/sj.onc.1205095 · DOI
  22. Dash, 2002, A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9., Proc Natl Acad Sci U S A, 99, 7622, 10.1073/pnas.102583199 · DOI
  23. Mayotte, 2002, Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system., Blood, 100, 4177, 10.1182/blood-2002-04-1244 · DOI
  24. Yamamoto, 2000, Expression of the NUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia with t(7;11)(p15;p15)., Br J Haematol, 109, 423, 10.1046/j.1365-2141.2000.02003.x · DOI
  25. Ahuja, 2001, NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia., Genes Chromosomes Cancer, 30, 410, 10.1002/1098-2264(2001)9999:9999<::AID-GCC1108>3.0.CO;2-9 · DOI
  26. Dash, 2001, Molecular genetics of acute myeloid leukaemia., Best Pract Res Clin Haematol, 14, 49, 10.1053/beha.2000.0115 · DOI
  27. Mardiney, 1996, Enhanced engraftment of hematopoietic progenitor cells in mice treated with granulocyte colony-stimulating factor before low-dose irradiation: implications for gene therapy., Blood, 87, 4049
  28. Li, 1999, The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity., J Exp Med, 189, 1399, 10.1084/jem.189.9.1399 · DOI
  29. Kiel, 2005, SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells., Cell, 121, 1109, 10.1016/j.cell.2005.05.026 · DOI · Paper page
  30. van Pelt, 2005, Administration of low-dose cytarabine results in immediate S-phase arrest and subsequent activation of cell cycling in murine stem cells., Exp Hematol, 33, 226, 10.1016/j.exphem.2004.10.013 · DOI
  31. Graham, 2002, Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro., Blood, 99, 319, 10.1182/blood.V99.1.319 · DOI
  32. Meng, 2003, Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms., Exp Hematol, 31, 1348, 10.1016/j.exphem.2003.08.014 · DOI
  33. Wang, 2006, Total body irradiation selectively induces murine hematopoietic stem cell senescence., Blood, 107, 358, 10.1182/blood-2005-04-1418 · DOI · Paper page
  34. Koschmieder, 2005, Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis., Blood, 105, 324, 10.1182/blood-2003-12-4369 · DOI · Paper page
  35. Blair, 2000, Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD117)., Exp Hematol, 28, 660, 10.1016/S0301-472X(00)00155-7 · DOI · Paper page
  36. Skorski, 2002, BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability., Oncogene, 21, 8591, 10.1038/sj.onc.1206087 · DOI
  37. Bao, 2006, Glioma stem cells promote radioresistance by preferential activation of the DNA damage response., Nature, 444, 756, 10.1038/nature05236 · DOI
  38. Krause, 2006, Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells., Nat Med, 12, 1175, 10.1038/nm1489 · DOI · Paper page
  39. Jin, 2006, Targeting of CD44 eradicates human acute myeloid leukemic stem cells., Nat Med, 12, 1167, 10.1038/nm1483 · DOI

Cited by

Metadata

Authors
Neering, S. J., Bushnell, T., Sozer, S., Ashton, J., Rossi, R. M., Wang, P.-Y., Bell, D. R., Heinrich, D., Bottaro, A., & Jordan, C. T.
Affiliations
  • James P. Wilmot Cancer Center, and
  • Department of Microbiology and Immunology, University of Kentucky, Lexington;
  • Department of Biomedical Genetics, and
  • Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, NY;
  • Markey Cancer Center, University of Kentucky, Lexington;
  • Department of Medicine, and
Venue
Blood
Publisher
American Society of Hematology
Published
2007-10-01
Volume
110
Issue
7
Pages
2578-2585
ISSN
  • 0006-4971
  • 1528-0020
DOI
10.1182/blood-2007-02-073031
Cited by
129
References
4
Language
en

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