Beyond the increasing complexity of the immunomodulatory HLA-G molecule

The biology of human natural killer-cell subsets

Cooper, M. A., Fehniger, T. A., & Caligiuri, M. A. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(01)02060-9 · Cited by 2,975

A Class I Antigen, HLA-G, Expressed in Human Trophoblasts

Kovats, S., Main, E. K., Librach, C. L., Stubblebine, M., Fisher, S. J., & DeMars, R. (1990) · Science · doi:10.1126/science.2326636 · Cited by 1,406

A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells

Colonna, M., Navarro, F., Bellón, T., Llano, M., Garcı́a, P., Samaridis, J., Ångman, L., Cella, M., & López‐Botet, M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.11.1809 · Cited by 948

A Human Histocompatibility Leukocyte Antigen (HLA)-G–specific Receptor Expressed on All Natural Killer Cells

Rajagopalan, S., & Long, E. O. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.7.1093 · Cited by 721

Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis

Rouas‐Freiss, N., Bras‐Gonçalves, R., Menier, C., Dausset, J. B., & Carosella, E. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11520 · Cited by 699

Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G

Shiroishi, M., Tsumoto, K., Amano, K., Shirakihara, Y., Colonna, M., Braud, V. M., Allan, D., Makadzange, T., Rowland‐Jones, S., Willcox, B. E., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1431057100 · Cited by 559

Tregs and rethinking cancer immunotherapy

Curiel, T. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31202 · Cited by 558

What is trogocytosis and what is its purpose?

Joly, E., & Hudrisier, D. (2003) · Nature Immunology · doi:10.1038/ni0903-815 · Cited by 543

Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens.

Ishitani, A., & Geraghty, D. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.3947 · Cited by 516

A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.

Geraghty, D. E., Koller, B. H., & Orr, H. T. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9145 · Cited by 514

HLA-E Surface Expression Depends on Binding of TAP-Dependent Peptides Derived from Certain HLA Class I Signal Sequences

Lee, N., Goodlett, D. R., Ishitani, A., Marquardt, H., & Geraghty, D. E. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.10.4951 · Cited by 505

Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules.

Colonna, M., Samaridis, J., Cella, M., Ångman, L., Allen, R. L., O’Callaghan, C. A., Dunbar, P. R., Ogg, G. S., Cerundolo, V., & Rolink, A. G. (1998) · PubMed · Cited by 499

Cutting Edge: Soluble HLA-G1 Triggers CD95/CD95 Ligand-Mediated Apoptosis in Activated CD8+ Cells by Interacting with CD8

Fournel, S., Aguerre‐Girr, M., Huc, X., Lenfant, F., Alam, A., Toubert, A., Bensussan, A., & Bouteiller, P. P. L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6100 · Cited by 462

Cutting Edge: Human Myelomonocytic Cells Express an Inhibitory Receptor for Classical and Nonclassical MHC Class I Molecules

Colonna, M., Samaridis, J., Cella, M., Ångman, L., Allen, R. L., O’Callaghan, C. A., Dunbar, R., Ogg, G. S., Cerundolo, V., & Rolink, A. G. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.7.3096 · Cited by 457

HLA-G expression in melanoma: A way for tumor cells to escape from immunosurveillance

Paul, P., Rouas‐Freiss, N., Khalil, I., Moreau, P., Riteau, B., Gal, F. A. L., Avril, M.-F., Dausset, J. B., Guillet, J. G., & Carosella, E. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4510 · Cited by 432

Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA Class I molecule.

Ellis, S. A., Palmer, M. S., & McMichael, A. J. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.2.731 · Cited by 390

HLA-G Molecules: from Maternal–Fetal Tolerance to Tissue Acceptance

Carosella, E. D., Moreau, P., LeMaoult, J., Discorde, M. L., Dausset, J. B., & Rouas‐Freiss, N. (2003) · Advances in immunology · doi:10.1016/s0065-2776(03)81006-4 · Cited by 377

Activation of NK Cells by an Endocytosed Receptor for Soluble HLA-G

Rajagopalan, S., Bryceson, Y. T., Kuppusamy, S. P., Geraghty, D. E., van der Meer, A., Joosten, I., & Long, E. O. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0040009 · Cited by 362

Soluble HLA‐A,‐B,‐C and ‐G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation

Contini, P., Ghio, M., Poggi, A. D., Filaci, G., Indiveri, F., Ferrone, S., & Puppo, F. (2002) · European Journal of Immunology · doi:10.1002/immu.200390015 · Cited by 359

The α 1 domain of HLA-G1 and HLA-G2 inhibits cytotoxicity induced by natural killer cells: Is HLA-G the public ligand for natural killer cell inhibitory receptors?

Rouas‐Freiss, N., Bras‐Gonçalves, R., Kirszenbaum, M., Dausset, J. B., & Carosella, E. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5249 · Cited by 352

HLA-G in human reproduction: aspects of genetics, function and pregnancy complications

Hviid, T. V. F. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi048 · Cited by 333

A Functional Role of HLA-G Expression in Human Gliomas: An Alternative Strategy of Immune Escape

Wiendl, H., Mitsdoerffer, M., Hofmeister, V., Wischhusen, J., Bornemann, A., Meyermann, R., Weiss, E. H., Melms, A., & Weller, M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.9.4772 · Cited by 325

HLA-G2, -G3, and -G4 Isoforms Expressed as Nonmature Cell Surface Glycoproteins Inhibit NK and Antigen-Specific CTL Cytolysis

Riteau, B., Rouas‐Freiss, N., Menier, C., Paul, P., Dausset, J. B., & Carosella, E. D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.5018 · Cited by 324

HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes

Gal, F. L., Riteau, B., Sedlik, C., Khalil, I., Menier, C., Dausset, J. B., Guillet, J., Carosella, E. D., & Rouas‐Freiss, N. (1999) · International Immunology · doi:10.1093/intimm/11.8.1351 · Cited by 316

Tolerization of dendritic cells by HLA‐G

Ristich, V., Liang, S., Zhang, W., Wu, J., & Horuzsko, A. (2005) · European Journal of Immunology · doi:10.1002/eji.200425741 · Cited by 315

HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4 + T cells

LeMaoult, J., Krawice-Radanne, I., Dausset, J. B., & Carosella, E. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401922101 · Cited by 314

HLA‐G up‐regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells

LeMaoult, J., Zafaranloo, K., Danff, C. L., & Carosella, E. D. (2005) · The FASEB Journal · doi:10.1096/fj.04-1617fje · Cited by 303

Evidence for a novel HLA antigen found on human extravillous trophoblast and a choriocarcinoma cell line.

Ellis, S. A., Sargent, I. L., Redman, C., & McMichael, A. J. (1986) · PubMed Central · Cited by 289

Intercellular transfer of cell-surface proteins is common and can affect many stages of an immune response

Davis, D. M. (2007) · Nature reviews. Immunology · doi:10.1038/nri2020 · Cited by 286

Cutting Edge: Induction of IFN-γ Production but Not Cytotoxicity by the Killer Cell Ig-Like Receptor KIR2DL4 (CD158d) in Resting NK Cells

Rajagopalan, S., Fu, J., & Long, E. O. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1877 · Cited by 274

Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells

LeMaoult, J., Caumartin, J., Daouya, M., Favier, B., Rond, S. L., González, Á., & Carosella, E. D. (2006) · Blood · doi:10.1182/blood-2006-05-024547 · Cited by 274

Expression of HLA-G in human cornea, an immune-privileged tissue

Discorde, M. L., Moreau, P., Sabatier, P., Legeais, J., & Carosella, E. D. (2003) · Human Immunology · doi:10.1016/j.humimm.2003.08.346 · Cited by 270

Trogocytosis‐based generation of suppressive NK cells

Caumartin, J., Favier, B., Daouya, M., Guillard, C., Moreau, P., Carosella, E. D., & LeMaoult, J. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601570 · Cited by 249

HLA-G Proteins in Cancer: Do They Provide Tumor Cells with an Escape Mechanism?

Rouas‐Freiss, N., Moreau, P., Ferrone, S., & Carosella, E. D. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0097 · Cited by 247

HLA-G suppresses proliferation of CD4+ T-lymphocytes

Bainbridge, D. R. J., Ellis, S. A., & Sargent, I. L. (2000) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(00)00070-x · Cited by 244

Human Leukocyte Antigen-G Expression After Heart Transplantation Is Associated With a Reduced Incidence of Rejection

Lila, N., Amrein, C., Guillemain, R., Chevalier, P. G., Latrémouille, C., Fabiani, J., Dausset, J. B., Carosella, E. D., & Carpentier, A. (2002) · Circulation · doi:10.1161/01.cir.0000015075.89984.46 · Cited by 244

Efficient Leukocyte Ig-like Receptor Signaling and Crystal Structure of Disulfide-linked HLA-G Dimer

Shiroishi, M., Kuroki, K., Ose, T., Rasubala, L., Shiratori, I., Arase, H., Tsumoto, K., Kumagai, I., Kohda, D., & Maenaka, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512305200 · Cited by 230

Implication of HLA-G molecule in heart-graft acceptance

Lila, N., Carpentier, A., Amrein, C., Khalil, I., Dausset, J. B., & Carosella, E. D. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02386-2 · Cited by 224

2-(8-Hydroxy-6-Methoxy-1-Oxo-1H-2-Benzopyran-3-yl) Propionic Acid, an Inhibitor of Angiogenesis, Ameliorates Renal Alterations in Obese Type 2 Diabetic Mice

Ichinose, K., Maeshima, Y., Yamamoto, Y., Kinomura, M., Hirokoshi, K., Kitayama, H., Takazawa, Y., Sugiyama, H., Yamasaki, Y., Agata, N., et al. (2006) · Diabetes · doi:10.2337/diabetes · Cited by 217

A homodimeric complex of HLA‐G on normal trophoblast cells modulates antigen‐presenting cells via LILRB1

Apps, R., Gardner, L., Sharkey, A., Holmes, N., & Moffett, A. (2007) · European Journal of Immunology · doi:10.1002/eji.200737089 · Cited by 210

Disulfide bond-mediated dimerization of HLA-G on the cell surface

Boyson, J. E., Erskine, R. A., Whitman, M. C., Chiu, M. T.-K., Lau, J. M., Koopman, L. A., Valter, M. M., Angelisová, P., Hořejšı́, V., & Strominger, J. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212643199 · Cited by 210

HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation

Feger, U., Tolosa, E., Huang, Y., Waschbisch, A., Biedermann, T., Melms, A., & Wiendl, H. (2007) · Blood · doi:10.1182/blood-2006-11-057125 · Cited by 208

Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells

Fons, P., Chabot, S., Cartwright, J. E., Lenfant, F., L'Faqihi‐Olive, F., Giustiniani, J., Herault, J.-P., Guéguen, G., Bono, F., Savi, P., et al. (2006) · Blood · doi:10.1182/blood-2005-12-019919 · Cited by 208

HLA-G is a potential tumor marker in malignant ascites.

Singer, G., Rebmann, V., Chen, Y., Liu, H. T., Ali, S. Z., REINSBERG, J., McMaster, M., Pfeiffer, K. A., Chan, D. W., Wardelmann, E., et al. (2003) · PubMed · Cited by 194

HLA-G: a shield against inflammatory aggression

Carosella, E. D., Moreau, P., Aractingi, S., & Rouas‐Freiss, N. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(01)02007-5 · Cited by 186

KIR2DL4 Is an IL-2-Regulated NK Cell Receptor That Exhibits Limited Expression in Humans but Triggers Strong IFN-γ Production

Kikuchi-Maki, A., Yusa, S.-I., Catina, T. L., & Campbell, K. S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3415 · Cited by 183

The Class I HLA Repertoire of Pancreatic Islets Comprises the Nonclassical Class Ib Antigen HLA-G

Cirulli, V., Zalatan, J., McMaster, M., Prinsen, R. C., Salomon, D. R., Ricordi, C., Torbett, B. E., Meda, P., & Crisá, L. (2006) · Diabetes · doi:10.2337/db05-0731 · Cited by 182

Monocytes and T lymphocytes in HIV-1-positive patients express HLA-G molecule

Lozano, J. M., González, R., Kindelán, J. M., Rouas‐Freiss, N., Caballos, R., Dausset, J. B., Carosella, E. D., & Peña, J. (2002) · AIDS · doi:10.1097/00002030-200202150-00005 · Cited by 182

Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity

Wiendl, H., Feger, U., Mittelbronn, M. G. A., Jack, C. S., Schreiner, B., Stadelmann, C., Antel, J. P., Brück, W., Meyermann, R., Bar‐Or, A., et al. (2005) · Brain · doi:10.1093/brain/awh609 · Cited by 181

HLA-G inhibits the allogeneic proliferative response

Riteau, B., Menier, C., Khalil, I., Sedlik, C., Dausset, J. B., Rouas‐Freiss, N., & Carosella, E. D. (1999) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(99)00034-0 · Cited by 177

Evidence to Support the Role of HLA-G5 in Allograft Acceptance through Induction of Immunosuppressive/ Regulatory T Cells

Rond, S. L., Azéma, C., Krawice-Radanne, I., Dürrbach, A., Guettier, C., Carosella, E. D., & Rouas‐Freiss, N. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.5.3266 · Cited by 173

Soluble HLA-G circulates in maternal blood during pregnancy

Hunt, J. S., Jadhav, L., Chu, W., Geraghty, D. E., & Ober, C. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2000.106762 · Cited by 173

HLA-G expression is associated with an unfavorable outcome and immunodeficiency in chronic lymphocytic leukemia

Nückel, H., Rebmann, V., Dürig, J., Dührsen, U., & Grosse‐Wilde, H. (2004) · Blood · doi:10.1182/blood-2004-08-3335 · Cited by 165

Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis

Menier, C., Rabreau, M., Challier, J.-C., Discorde, M. L., Carosella, E. D., & Rouas‐Freiss, N. (2004) · Blood · doi:10.1182/blood-2004-03-0809 · Cited by 162

Crystal structure of HLA-G: A nonclassical MHC class I molecule expressed at the fetal–maternal interface

Clements, C. S., Kjer‐Nielsen, L., Kostenko, L., Hoare, H. L., Dunstone, M. A., Moses, E. K., Freed, K. A., Brööks, A. G., Rossjohn, J., & McCluskey, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409676102 · Cited by 160

Human leukocyte antigen G expression: as a significant prognostic indicator for patients with colorectal cancer

Ye, S.-R., Yang, H., Li, K., Dong, D., Lin, X., & Yie, S.-M. (2007) · Modern Pathology · doi:10.1038/modpathol.3800751 · Cited by 159

Human leukocyte antigen-G (HLA-G) expression in biliary epithelial cells is associated with allograft acceptance in liver-kidney transplantation

Créput, C., Dürrbach, A., Menier, C., Guettier, C., Samuel, D., Dausset, J. B., Charpentier, B., Carosella, E. D., & Rouas‐Freiss, N. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00354-4 · Cited by 155

HLA-G and NK Receptor Are Expressed in Psoriatic Skin

Aractingi, S., Briand, N., Danff, C. L., Viguier, M. A., Bachelez, H., Michel, L., Dubertret, L., & Carosella, E. D. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61675-6 · Cited by 154

Soluble HLA-G Inhibits Cell Cycle Progression in Human Alloreactive T Lymphocytes

Bahri, R., Hirsch, F., Josse, A., Rouas‐Freiss, N., Bidère, N., Vasquez, A. C., Carosella, E. D., Charpentier, B., & Dürrbach, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1331 · Cited by 143

Complexes of HLA-G Protein on the Cell Surface Are Important for Leukocyte Ig-Like Receptor-1 Function

Gonen‐Gross, T., Achdout, H., Gazit, R., Hanna, J. H., Mizrahi, S., Markel, G., Goldman‐Wohl, D., Yagel, S., Hořejšı́, V., Levy, O., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.3.1343 · Cited by 142

Soluble HLA-G influences the release of cytokines from allogeneic peripheral blood mononuclear cells in culture

Kanai, T. (2001) · Molecular Human Reproduction · doi:10.1093/molehr/7.2.195 · Cited by 142

Functional role of human leukocyte antigen-G up-regulation in renal cell carcinoma.

Bukur, J., Rebmann, V., Grosse‐Wilde, H., Luboldt, H., Ruebben, H., Drexler, I., Sutter, G., Huber, C., & Seliger, B. (2003) · PubMed · Cited by 137

CD3+CD4low and CD3+CD8low are induced by HLA-G: novel human peripheral blood suppressor T-cell subsets involved in transplant acceptance

Naji, A., Rond, S. L., Dürrbach, A., Krawice-Radanne, I., Créput, C., Daouya, M., Caumartin, J., LeMaoult, J., Carosella, E. D., & Rouas‐Freiss, N. (2007) · Blood · doi:10.1182/blood-2007-04-083139 · Cited by 136

SHP-1- and Phosphotyrosine-Independent Inhibitory Signaling by a Killer Cell Ig-Like Receptor Cytoplasmic Domain in Human NK Cells

Yusa, S.-I., Catina, T. L., & Campbell, K. S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.5047 · Cited by 132

KIR2DL4 (CD158d) Genotype Influences Expression and Function in NK Cells

Goodridge, J. P., Witt, C. S., Christiansen, F., & Warren, H. S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.4.1768 · Cited by 132

HLA-G in the human thymus: a subpopulation of medullary epithelial but not CD83+ dendritic cells expresses HLA-G as a membrane-bound and soluble protein

Mallet, V., Blaschitz, A., Crisá, L., Schmitt, C., Fournel, S., King, A., Loke, Y. W., Dohr, G., & Bouteiller, P. P. L. (1999) · International Immunology · doi:10.1093/intimm/11.6.889 · Cited by 129

Modulation of HLA-G Expression in Human Neural Cells after Neurotropic Viral Infections

Lafon, M., Prehaud, C. J. N., Mégret, F., Lafage, M., Mouillot, G., Roa, M., Moreau, P., Rouas‐Freiss, N., & Carosella, E. D. (2005) · Journal of Virology · doi:10.1128/jvi.79.24.15226-15237.2005 · Cited by 126

Unaltered phenotype, tissue distribution and function of Vα14+ NKT cells in germ-free mice

Park, S.-H., Benlagha, K., Lee, D., Balish, E., & Bendelac, A. S. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(200002)30:2 · Cited by 122

Alloreactive CD4+ and CD8+ T cells express the immunotolerant HLA‐G molecule in mixed lymphocyte reactions: in vivo implications in transplanted patients

Rond, S. L., LeMaoult, J., Créput, C., Menier, C., Deschamps, M., Friec, G. L., Amiot, L., Dürrbach, A., Dausset, J. B., Carosella, E. D., et al. (2004) · European Journal of Immunology · doi:10.1002/eji.200324266 · Cited by 121

CTLA-4 regulates cell cycle progression during a primary immune response

Greenwald, R. J., Oosterwegel, M. A., van der Woude, D., Kubal, A., Mandelbrot, D. A., Boussiotis, V. A., & Sharpe, A. H. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200202)32:2 · Cited by 120

Membrane-bound HLA-G activates proliferation and interferon- production by uterine natural killer cells

van der Meer, A. (2004) · Molecular Human Reproduction · doi:10.1093/molehr/gah032 · Cited by 117

Placental Cell Expression of HLA-G2 Isoforms Is Limited to the Invasive Trophoblast Phenotype

Morales, P. J., Pace, J. L., Platt, J. S., Phillips, T. A., Morgan, K., Fazleabas, A. T., & Hunt, J. S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6215 · Cited by 116

Soluble HLA-G Expression and Renal Graft Acceptance

Qiu, J., Terasaki, P. I., Miller, J. S., Mizutani, K., Cai, J., & Carosella, E. D. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01417.x · Cited by 116

The CD85J/Leukocyte Inhibitory Receptor-1 Distinguishes between Conformed and β2-Microglobulin-Free HLA-G Molecules

Gonen‐Gross, T., Achdout, H., Arnon, T. I., Gazit, R., Stern‐Ginossar, N., Hořejšı́, V., Goldman‐Wohl, D., Yagel, S., & Mandelboim, O. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.4866 · Cited by 114

Human Neuroblastoma Cells Trigger an Immunosuppressive Program in Monocytes by Stimulating Soluble HLA-G Release

Morandi, F., Levreri, I., Bocca, P., Galleni, B., Raffaghello, L., Ferrone, S., Prigione, I., & Pistoia, V. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4588 · Cited by 113

HLA-G revisited

Carosella, E. D., Dausset, J. B., & Kirszenbaum, M. (1996) · Immunology Today · doi:10.1016/0167-5699(96)30055-8 · Cited by 109

NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains

Selvakumar, A., Steffens, U., & Dupont, B. (1996) · Tissue Antigens · doi:10.1111/j.1399-0039.1996.tb02647.x · Cited by 103

Regulatory T cells and tumour immunity – observations in mice and men

Gallimore, A., & Godkin, A. J. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02748.x · Cited by 101

NK resistance of tumor cells from multiple myeloma and chronic lymphocytic leukemia patients: implication of HLA-G

Maki, G., Hayes, G. M., Naji, A., Tyler, T., Carosella, E. D., Rouas‐Freiss, N., & Gregory, S. A. (2008) · Leukemia · doi:10.1038/leu.2008.15 · Cited by 98

Analysis of HLA antigen expression in benign and malignant melanocytic lesions reveals that upregulation of HLA‐G expression correlates with malignant transformation, high inflammatory infiltration and HLA‐A1 genotype

Ibrahim, E. C., Aractingi, S., Allory, Y., Borrini, F., Dupuy, A., Duvillard, P., Carosella, E. D., Avril, M.-F., & Paul, P. (2003) · International Journal of Cancer · doi:10.1002/ijc.11456 · Cited by 94

Soluble HLA‐G molecules impair natural killer/dendritic cell crosstalk via inhibition of dendritic cells

Gros, F., Cabillic, F., Toutirais, O., Maux, A. L., Sebti, Y., & Amiot, L. (2008) · European Journal of Immunology · doi:10.1002/eji.200736918 · Cited by 89

Soluble HLA-G Molecules Are Increased during Acute Leukemia, Especially in Subtypes Affecting Monocytic and Lymphoid Lineages'

Gros, F., Sebti, Y., de Guiber, S., Branger, B., Bernard, M., Fauchet, R., & Amiot, L. (2006) · Neoplasia · doi:10.1593/neo.05703 · Cited by 84

HLA-G Expression in Atopic Dermatitis

Khosrotehrani, K., Danff, C. L., Reynaud-Mendel, B., Dubertret, L., Carosella, E. D., & Aractingi, S. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01487.x · Cited by 76

Synthesis of β2‐microglobulin‐free, disulphide‐linked HLA‐G5 homodimers in human placental villous cytotrophoblast cells

Morales, P. J., Pace, J. L., Platt, J. S., Langat, D. K., & Hunt, J. S. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02623.x · Cited by 75

Homozygous HLA‐G*0105N healthy individuals indicate that membrane‐anchored HLA‐G1 molecule is not necessary for survival

Castro, M. J., Morales, P., Rojo‐Amigo, R., Martı́nez-Laso, J., Allende, L. M., Varela, P., García-Berciano, M., Guillén‐perales, J., & Arnaiz‐Villena, A. (2000) · Tissue Antigens · doi:10.1034/j.1399-0039.2000.560305.x · Cited by 71

Expression of functional soluble human leucocyte antigen‐G molecules in lymphoproliferative disorders

Sebti, Y., Maux, A. L., Gros, F., de Guibert, S., Pangault, C., Rouas‐Freiss, N., Bernard, M., & Amiot, L. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06647.x · Cited by 68

Switch ofHLA-G alternative splicing in a melanoma cell line causes loss of HLA-G1 expression and sensitivity to NK lysis

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HLA-G Expression is a Fundamental Prerequisite to Pregnancy

Rizzo, R., Melchiorri, L., Stignani, M., & Baricordi, O. R. (2006) · Human Immunology · doi:10.1016/j.humimm.2006.10.012 · Cited by 61

HLA-G*0105N Null Allele Encodes Functional HLA-G Isoforms1

Discorde, M. L., Danff, C. L., Moreau, P., Rouas‐Freiss, N., & Carosella, E. D. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.104.037986 · Cited by 55

Analysis of HLA-G expression in malignant hematopoetic cells from leukemia patients

Poláková, K. X. N., Kŕcová, M., Kuba, D. M., & Russ, G. (2003) · Leukemia Research · doi:10.1016/s0145-2126(02)00228-x · Cited by 40

Soluble Human Leukocyte Antigen-G: A New Strategy for Monitoring Acute and Chronic Rejections After Heart Transplantation

Lila, N., Amrein, C., Guillemain, R., Chevalier, P. G., Fabiani, J., & Carpentier, A. (2007) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2007.01.001 · Cited by 36

Aberrant expression of HLA-G antigen in interferon gamma-stimulated acute myelogenous leukaemia

Mizuno, S., Emi, N., Kasai, M., Ishitani, A., & Saito, H. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02345.x · Cited by 35

sHLA-G levels in the monitoring of immunosuppressive therapy and rejection following heart transplantation

Luque, J., Torres, M. I., Aumente, M. D., Lozano, J. M., García-Jurado, G., González, R., Álvarez-López, M. R., Arizón, J. M., & Peña, J. (2006) · Transplant Immunology · doi:10.1016/j.trim.2006.09.009 · Cited by 29

A novel sandwich ELISA for α1 domain based detection of soluble HLA-G heavy chains

Juch, H., Blaschitz, A., Daxböck, C., Rueckert, C., Kofler, K., & Dohr, G. (2005) · Journal of Immunological Methods · doi:10.1016/j.jim.2005.09.016 · Cited by 23

Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation

Bernardo, M. E., & Fibbe, W. E. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.09.006 · Cited by 1,423

The Role of the Immune System in Autism Spectrum Disorder

Meltzer, A., & Van de Water, J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.158 · Cited by 533

Immunoregulation by Mesenchymal Stem Cells: Biological Aspects and Clinical Applications

Castro-Manrreza, M. E., & Montesinos, J. J. (2015) · Journal of Immunology Research · doi:10.1155/2015/394917 · Cited by 400

The Role of Tumor-Infiltrating Immune Cells and Chronic Inflammation at the Tumor Site on Cancer Development, Progression, and Prognosis: Emphasis on Non-small Cell Lung Cancer

Bremnes, R. M., Al-Shibli, K. I., Dønnem, T., Sirera, R., Al‐Saad, S., Andersen, S., Stenvold, H., Camps, C., & Busund, L. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3182037b76 · Cited by 373

Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association

Donadi, E. A., Castelli, E. C., Arnaiz‐Villena, A., Roger, M., Rey, D., & Moreau, P. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0580-7 · Cited by 371

Review in translational hematology Beyond the increasing complexity of the immunomodulatory HLA-G molecule

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Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases

Morandi, F., Rizzo, R., Fainardi, E., Rouas‐Freiss, N., & Pistoia, V. (2016) · Journal of Immunology Research · doi:10.1155/2016/4326495 · Cited by 126

Harnessing the immunomodulatory properties of HLA-G for advanced immunotherapies

Beli, X., Savvopoulos, N., Kefala, D., Lysandrou, M., Liga, M., & Spyridonidis, A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1716778 · Cited by 9

Impact of HLA-G analysis in prevention, diagnosis and treatment of pathological conditions

Bortolotti, D. (2014) · World Journal of Methodology · doi:10.5662/wjm.v4.i1.11 · Cited by 18

HLA-G

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