The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
Beyond the increasing complexity of the immunomodulatory HLA-G molecule
Abstract
Human leukocyte antigen G (HLA-G) is a nonclassic major histocompatibility complex (MHC) class I molecule that functions as an immunomodulatory molecule capable of protecting fetal tissues from the maternal immune system. The relevance of HLA-G in other contexts was investigated soon afterward. Numerous studies have sought (and some have shown) the relevance of HLA-G in pathologic conditions, such as transplantation, autoimmunity, and cancer and hematologic malignancies. One of the main goals of the current research on HLA-G is now to use it in the clinic, either for diagnosis or as a therapeutic tool/target. For this, precise knowledge on the nature and functions of HLA-G is critical. We highlight here what we consider are recent key basic findings on the immunomodulatory function of HLA-G. These strengthen the case for considering HLA-G as clinically relevant.
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“HLA-G interacts with natural killer cells as part of the innate immune system and is primarily expressed in placental tissues as part of immune tolerance during pregnancy (Carosella et al, 2008).”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Carosella et al, 2008
Citations
Cites
The biology of human natural killer-cell subsets
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A Class I Antigen, HLA-G, Expressed in Human Trophoblasts
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Rouas‐Freiss, N., Bras‐Gonçalves, R., Menier, C., Dausset, J. B., & Carosella, E. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11520 · Cited by 699
Self-citationShiroishi, M., Tsumoto, K., Amano, K., Shirakihara, Y., Colonna, M., Braud, V. M., Allan, D., Makadzange, T., Rowland‐Jones, S., Willcox, B. E., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1431057100 · Cited by 559
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Research works printed but not linked: 2
- Yan, 2007, Unfavorable clinical implications for HLA-G expression in acute myeloid leukemia., J Cell Mol Med
- Naji, 2007, CD3+CD4low and CD3+CD8low are induced by HLA-G: novel human peripheral blood suppressor T-cell subsets involved in transplant acceptance., Blood, 110, 3936, 10.1182/blood-2007-04-083139 · DOI
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Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation
Bernardo, M. E., & Fibbe, W. E. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.09.006 · Cited by 1,423
The Role of the Immune System in Autism Spectrum Disorder
Meltzer, A., & Van de Water, J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.158 · Cited by 533
Immunoregulation by Mesenchymal Stem Cells: Biological Aspects and Clinical Applications
Castro-Manrreza, M. E., & Montesinos, J. J. (2015) · Journal of Immunology Research · doi:10.1155/2015/394917 · Cited by 400
Bremnes, R. M., Al-Shibli, K. I., Dønnem, T., Sirera, R., Al‐Saad, S., Andersen, S., Stenvold, H., Camps, C., & Busund, L. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3182037b76 · Cited by 373
Donadi, E. A., Castelli, E. C., Arnaiz‐Villena, A., Roger, M., Rey, D., & Moreau, P. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0580-7 · Cited by 371
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Metadata
- Authors
- Carosella, E. D., Favier, B., Rouas-Freiss, N., Moreau, P., & LeMaoult, J.
- Affiliations
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- CEA, I2BM, Service de Recherches en Hemato-Immunologie, Paris, France
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-05-15
- Volume
- 111
- Issue
- 10
- Pages
- 4862-4870
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1979253523
- Cited by
- 348
- References
- 94
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 10 · 2023: 15 · 2022: 16 · 2021: 12 · 2020: 17 · 2019: 17 · 2018: 13 · 2017: 10 · 2016: 25 · 2015: 31 · 2014: 27 · 2013: 21 · 2012: 32
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- HLA-G, immunomodulation, non-classical MHC class I, maternal-fetal immune tolerance, transplantation, autoimmunity, tumor immunology, hematologic malignancies
- MeSH terms
- Female, HLA Antigens, Humans, Immune System, Immunologic Factors, Killer Cells, Natural, Male, Pregnancy, Receptors, Immunologic, Histocompatibility Antigens Class I, Hematologic Neoplasms, HLA-G Antigens
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