Beyond the increasing complexity of the immunomodulatory HLA-G molecule

The biology of human natural killer-cell subsets

Cooper, M. A., Fehniger, T. A., & Caligiuri, M. A. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(01)02060-9 · Cited by 2,975

A Class I Antigen, HLA-G, Expressed in Human Trophoblasts

Kovats, S., Main, E. K., Librach, C. L., Stubblebine, M., Fisher, S. J., & DeMars, R. (1990) · Science · doi:10.1126/science.2326636 · Cited by 1,406

A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells

Colonna, M., Navarro, F., Bellón, T., Llano, M., Garcı́a, P., Samaridis, J., Ångman, L., Cella, M., & López‐Botet, M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.11.1809 · Cited by 948

A Human Histocompatibility Leukocyte Antigen (HLA)-G–specific Receptor Expressed on All Natural Killer Cells

Rajagopalan, S., & Long, E. O. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.7.1093 · Cited by 721

Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis

Rouas‐Freiss, N., Bras‐Gonçalves, R., Menier, C., Dausset, J. B., & Carosella, E. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11520 · Cited by 699

Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G

Shiroishi, M., Tsumoto, K., Amano, K., Shirakihara, Y., Colonna, M., Braud, V. M., Allan, D., Makadzange, T., Rowland‐Jones, S., Willcox, B. E., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1431057100 · Cited by 559

Tregs and rethinking cancer immunotherapy

Curiel, T. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31202 · Cited by 558

What is trogocytosis and what is its purpose?

Joly, E., & Hudrisier, D. (2003) · Nature Immunology · doi:10.1038/ni0903-815 · Cited by 543

Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens.

Ishitani, A., & Geraghty, D. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.3947 · Cited by 516

A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.

Geraghty, D. E., Koller, B. H., & Orr, H. T. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9145 · Cited by 514

Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation

Bernardo, M. E., & Fibbe, W. E. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.09.006 · Cited by 1,423

The Role of the Immune System in Autism Spectrum Disorder

Meltzer, A., & Van de Water, J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.158 · Cited by 533

Immunoregulation by Mesenchymal Stem Cells: Biological Aspects and Clinical Applications

Castro-Manrreza, M. E., & Montesinos, J. J. (2015) · Journal of Immunology Research · doi:10.1155/2015/394917 · Cited by 400

The Role of Tumor-Infiltrating Immune Cells and Chronic Inflammation at the Tumor Site on Cancer Development, Progression, and Prognosis: Emphasis on Non-small Cell Lung Cancer

Bremnes, R. M., Al-Shibli, K. I., Dønnem, T., Sirera, R., Al‐Saad, S., Andersen, S., Stenvold, H., Camps, C., & Busund, L. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3182037b76 · Cited by 373

Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association

Donadi, E. A., Castelli, E. C., Arnaiz‐Villena, A., Roger, M., Rey, D., & Moreau, P. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0580-7 · Cited by 371

Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

Riera-Domingo, C., Audigé, A., Granja, S., Cheng, W.-C., Ho, P.-C., Baltazar, F., Stockmann, C., & Mazzone, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00018.2019 · Cited by 310

A Systematic Review of Immunotherapy in Urologic Cancer: Evolving Roles for Targeting of CTLA-4, PD-1/PD-L1, and HLA-G

Carosella, E. D., Ploussard, G., LeMaoult, J., & Desgrandchamps, F. (2015) · European Urology · doi:10.1016/j.eururo.2015.02.032 · Cited by 231

The genetic structure of 3′untranslated region of the HLA-G gene: polymorphisms and haplotypes

Castelli, E. C., Mendes‐Junior, C. T., Deghaide, N. H. S., de Albuquerque, R. S., Muniz, Y. C. N., Simões, R. T., Carosella, E. D., Moreau, P., & Donadi, E. A. (2009) · Genes and Immunity · doi:10.1038/gene.2009.74 · Cited by 212

Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges

Noman, M. Z., Hasmim, M., Lequeux, A., Xiao, M., Duhem, C., Chouaı̈b, S., Berchem, G., & Janji, B. (2019) · Cells · doi:10.3390/cells8091083 · Cited by 220

The immunosuppressive molecule HLA-G and its clinical implications

González, Á., Rebmann, V., LeMaoult, J., Horn, P. A., Carosella, E. D., & Alegre, E. (2012) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2012.677947 · Cited by 197

Hypoxia-Driven Immunosuppressive Metabolites in the Tumor Microenvironment: New Approaches for Combinational Immunotherapy

Li, Y., Patel, S. P., Roszik, J., & Qin, Y. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01591 · Cited by 203

KIR2DL4 (CD158d): An activation receptor for HLA-G

Rajagopalan, S., & Long, E. O. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00258 · Cited by 214

Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells

Chen, P., Yen, M., Liu, K., Sytwu, H., & Yen, B. L. (2011) · Journal of Biomedical Science · doi:10.1186/1423-0127-18-49 · Cited by 182

The role of classical and non-classical HLA class I antigens in human tumors

Bukur, J., Jasinski‐Bergner, S., & Seliger, B. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.03.003 · Cited by 174

In silico analysis of microRNAS targeting the HLA-G 3′ untranslated region alleles and haplotypes

Castelli, E. C., Moreau, P., Chiromatzo, A. O. E., Mendes‐Junior, C. T., Veiga-Castelli, L. C., Yaghi, L., Giuliatti, S., Carosella, E. D., & Donadi, E. A. (2009) · Human Immunology · doi:10.1016/j.humimm.2009.07.028 · Cited by 164

Unraveling the Mesenchymal Stromal Cells' Paracrine Immunomodulatory Effects

Fontaine, M. J., Shih, H., Schäfer, R., & Pittenger, M. F. (2016) · Transfusion Medicine Reviews · doi:10.1016/j.tmrv.2015.11.004 · Cited by 162

A Comprehensive Study of Polymorphic Sites along the HLA-G Gene: Implication for Gene Regulation and Evolution

Castelli, E. C., Mendes‐Junior, C. T., Veiga-Castelli, L. C., Roger, M., Moreau, P., & Donadi, E. A. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr138 · Cited by 168

Role of non-classical MHC class I molecules in cancer immunosuppression

Kochan, G. T., Escors, D., Breckpot, K., & Guerrero‐Setas, D. (2013) · OncoImmunology · doi:10.4161/onci.26491 · Cited by 160

Transplantation of Human Amnion Epithelial Cells Reduces Hepatic Fibrosis in Immunocompetent CCl 4 -Treated Mice

Manuelpillai, U., Tchongue, J., Lourensz, D., Vaghjiani, V., Samuel, C. S., Liu, A., Williams, E. D., & Sievert, W. (2010) · Cell Transplantation · doi:10.3727/096368910x504496 · Cited by 152

Role of HLA-G in tumor escape through expansion of myeloid-derived suppressor cells and cytokinic balance in favor of Th2 versus Th1/Th17

Agaugué, S., Carosella, E. D., & Rouas‐Freiss, N. (2011) · Blood · doi:10.1182/blood-2010-07-294389 · Cited by 142

Tumor Microenvironment: A New Treatment Target for Cancer

Tsai, M., Chang, W., Huang, M., & Kuo, P. (2014) · ISRN Biochemistry · doi:10.1155/2014/351959 · Cited by 147

Human Leukocyte Antigen-G (HLA-G) Expression in Cancers: Roles in Immune Evasion, Metastasis and Target for Therapy

Lin, A., & Yan, W. (2015) · Molecular Medicine · doi:10.2119/molmed.2015.00083 · Cited by 137

Biology of HLA-G in cancer: a candidate molecule for therapeutic intervention?

Amiot, L., Ferrone, S., Grosse‐Wilde, H., & Seliger, B. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0583-4 · Cited by 135

ILT2/HLA‐G interaction impairs NK‐cell functions through the inhibition of the late but not the early events of the NK‐cell activating synapse

Favier, B., LeMaoult, J., Lesport, E., & Carosella, E. D. (2009) · The FASEB Journal · doi:10.1096/fj.09-135194 · Cited by 131

Molecular Pathways: Human Leukocyte Antigen G (HLA-G)

Curigliano, G., Criscitiello, C., Gelao, L., & Goldhirsch, A. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3697 · Cited by 127

Tolerance versus immune response — MicroRNAs as important elements in the regulation of the HLA-G gene expression

Veit, T. D., & Chies, J. A. B. (2008) · Transplant Immunology · doi:10.1016/j.trim.2008.11.001 · Cited by 124

HLA-G Molecules in Autoimmune Diseases and Infections

Rizzo, R., Bortolotti, D., Bolzani, S., & Fainardi, E. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00592 · Cited by 124

Mesenchymal stem cells and cardiac repair

Neßelmann, C., Ma, N., Bieback, K., Wagner, W., Ho, A. D., Konttinen, Y. T., Zhang, H., Hinescu, M. E., & Steinhoff, G. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00457.x · Cited by 121

microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer

Goh, J. N., Loo, S. Y., Datta, A., Siveen, K. S., Yap, W. N., Cai, W., Shin, E. M., Wang, C., Kim, J. E., Chan, M., et al. (2015) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12176 · Cited by 121

The Dual Role of HLA-G in Cancer

Rouas‐Freiss, N., Moreau, P., LeMaoult, J., & Carosella, E. D. (2014) · Journal of Immunology Research · doi:10.1155/2014/359748 · Cited by 116

Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors

Avanzini, M. A., Bernardo, M. E., Cometa, A. M., Perotti, C. G., Zaffaroni, N., Novara, F., Visai, L., Moretta, A., Fante, C. D., Villa, R., et al. (2009) · Haematologica · doi:10.3324/haematol.2009.006171 · Cited by 114

Melanoma cells become resistant to NK ‐cell‐mediated killing when exposed to NK ‐cell numbers compatible with NK ‐cell infiltration in the tumor

Balsamo, M., Vermi, W., Parodi, M., Pietra, G., Manzini, C., Queirolo, P., Lonardi, S., Augugliaro, R., Moretta, A., Facchetti, F., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201142179 · Cited by 110

Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices

Marco, M. D., Schuster, H., Backert, L., Ghosh, M., Rammensee, H., & Stevanović, S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700938 · Cited by 102

HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction

Rajagopalan, S. (2014) · Cellular and Molecular Immunology · doi:10.1038/cmi.2014.53 · Cited by 106

Non‐classical transcriptional regulation of HLA‐G: an update

Moreau, P., Flajollet, S., & Carosella, E. D. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00800.x · Cited by 111

CD86+ or HLA-G+ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis

Brown, R. D., Kabani, K., Favaloro, J., Yang, S., Ho, P. J., Gibson, J., Fromm, P. D., Suen, H., Woodland, N., Nassif, N. T., et al. (2012) · Blood · doi:10.1182/blood-2012-03-416792 · Cited by 108

The importance of HLA-G expression in embryos, trophoblast cells, and embryonic stem cells

Rizzo, R., Vercammen, M. J., de Velde, H. V., Horn, P. A., & Rebmann, V. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0578-1 · Cited by 104

Immunomodulatory Properties of HLA-G in Infectious Diseases

Amiot, L., Vu, N., & Samson, M. (2014) · Journal of Immunology Research · doi:10.1155/2014/298569 · Cited by 98

HLA-G–dependent suppressor cells: Diverse by nature, function, and significance

Carosella, E. D., HoWangYin, K.-Y., Favier, B., & LeMaoult, J. (2008) · Human Immunology · doi:10.1016/j.humimm.2008.08.280 · Cited by 97

The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells

Carosella, E. D., Gregori, S., & LeMaoult, J. (2011) · Blood · doi:10.1182/blood-2011-07-370742 · Cited by 95

Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors

HoWangYin, K.-Y., Loustau, M., Wu, J., Alegre, E., Daouya, M., Caumartin, J., Sousa, S., Horuzsko, A., Carosella, E. D., & LeMaoult, J. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1069-3 · Cited by 91

Regulation of T‐cell immunity by leucocyte immunoglobulin‐like receptors: innate immune receptors for self on antigen‐presenting cells

Anderson, K. J., & Allen, R. L. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03097.x · Cited by 87

Distinct effects of human glioblastoma immunoregulatory molecules programmed cell death ligand-1 (PDL-1) and indoleamine 2,3-dioxygenase (IDO) on tumour-specific T cell functions

Avril, T., Saïkali, S., Vauléon, É., Jary, A., Hamlat, A., de Tayrac, M., Mosser, J., & Quillien, V. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.04.003 · Cited by 87

T cell suppression by naturally occurring HLA-G-expressing regulatory CD4+ T cells is IL-10-dependent and reversible

Huang, Y., Zozulya, A. L., Weidenfeller, C., Schwab, N., & Wiendl, H. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008649 · Cited by 86

The prognostic impact of soluble and vesicular HLA-G and its relationship to circulating tumor cells in neoadjuvant treated breast cancer patients

König, L., Kasimir‐Bauer, S., Hoffmann, O., Bittner, A., Wagner, B., Manvailer, L. F. S., Schramm, S., Bánkfalvi, Á., Giebel, B., Kimmig, R., et al. (2016) · Human Immunology · doi:10.1016/j.humimm.2016.01.002 · Cited by 82

Targeting human leukocyte antigen G with chimeric antigen receptors of natural killer cells convert immunosuppression to ablate solid tumors

Jan, C., Huang, S., Canoll, P., Bruce, J. N., Lin, Y., Pan, C., Lu, H.-M., Chiu, S., & Cho, D. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003050 · Cited by 83

Human leukocyte antigen-G in the male reproductive system and in seminal plasma

Larsen, M. H., Bzorek, M., Pass, M. B., Larsen, L. G., Nielsen, M. W., Svendsen, S. G., Lindhard, A., & Hviid, T. V. F. (2011) · Molecular Human Reproduction · doi:10.1093/molehr/gar052 · Cited by 81

Expression of HLA-G by mast cells is associated with hepatitis C virus-induced liver fibrosis

Amiot, L., Vu, N., Rauch, M., L’Helgoualc’h, A., Chalmel, F., Gascan, H., Turlin, B., Guyader, D., & Samson, M. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.09.006 · Cited by 80

CD8+PD-1–ILT2+ T Cells Are an Intratumoral Cytotoxic Population Selectively Inhibited by the Immune-Checkpoint HLA-G

Dumont, C., Jacquier, A., Verine, J., Noël, F., Goujon, A., Wu, C., Hung, T., Desgrandchamps, F., Culine, S., Carosella, E. D., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0764 · Cited by 78

microRNAs targeting the immunomodulatory HLA-G gene: A new survey searching for microRNAs with potential to regulate HLA-G

Porto, I. D. O. P., Mendes‐Junior, C. T., Felício, L. P., Georg, R. D. C., Moreau, P., Donadi, E. A., Chies, J. A. B., & Castelli, E. C. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.01.030 · Cited by 78

Emerging topics and new perspectives on HLA-G

Fainardi, E., Castellazzi, M., Stignani, M., Morandi, F., Sana, G., Gonzalez, R., Pistoia, V., Baricordi, O. R., Sokal, E. M., & Peña, J. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0584-3 · Cited by 76

Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1 and HLA-G

Fernando, M. M. A., Freudenberg, J., Lee, A., Morris, D. L., Boteva, L., Rhodes, B., González‐Escribano, M. F., López‐Nevot, M. Á., Navarra, S., Gregersen, P. K., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200808 · Cited by 76

New insights into HLA ‐G mediated tolerance

Amodio, G., de Albuquerque, R. S., & Gregori, S. (2014) · Tissue Antigens · doi:10.1111/tan.12427 · Cited by 73

Non-classical HLA-class I expression in serous ovarian carcinoma: Correlation with the HLA-genotype, tumor infiltrating immune cells and prognosis

Andersson, E. K., Poschke, I. C., Villabona, L. E. E., Carlson, J. W., Lundqvist, A., Kiessling, R. W., Seliger, B., & Masucci, G. V. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1052213 · Cited by 73

Immunohistochemical Study of HLA-G Expression in Lung Transplant Recipients

Brugière, O., Thabut, G., Pretolani, M., Krawice-Radanne, I., Dill, C., Herbreteau, A., Poras, I., Moreau, P., Colombat, M., Danel, C. J., et al. (2009) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02650.x · Cited by 72

HLA-G Expression in Human Embryonic Stem Cells and Preimplantation Embryos

Verloes, A., de Velde, H. V., LeMaoult, J., Mateizel, I., Cauffman, G., Horn, P. A., Carosella, E. D., Devroey, P., Waele, M. D., Rebmann, V., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001081 · Cited by 71

Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2

Yaghi, L., Poras, I., Simões, R. T., Donadi, E. A., Tost, J., Daunay, A., de Almeida, B. S., Carosella, E. D., & Moreau, P. (2016) · Oncotarget · doi:10.18632/oncotarget.11628 · Cited by 71

Role of HLA-G as a Predictive Marker of Low Risk of Chronic Rejection in Lung Transplant Recipients: A Clinical Prospective Study

Brugière, O., Thabut, G., Krawice-Radanne, I., Rizzo, R., Dauriat, G., Danel, C. J., Suberbielle, C., Mal, H., Stern, M., Schilte, C., et al. (2014) · American Journal of Transplantation · doi:10.1111/ajt.12977 · Cited by 70

HLA‐G: Function, polymorphisms and pathology

Arnaiz‐Villena, A., Juárez, I., Suárez‐Trujillo, F., López‐Nares, A., Vaquero‐Yuste, C., Palacio-Grüber, J., & Martín‐Villa, J. M. (2020) · International Journal of Immunogenetics · doi:10.1111/iji.12513 · Cited by 69

Specific central nervous system recruitment of HLA‐G+ regulatory T cells in multiple sclerosis

Huang, Y., Zozulya, A. L., Weidenfeller, C., Metz, I., Buck, D., Toyka, K. V., Brück, W., & Wiendl, H. (2009) · Annals of Neurology · doi:10.1002/ana.21705 · Cited by 69

Prognostic relevance of soluble human leukocyte antigen–G and total human leukocyte antigen class I molecules in lung cancer patients

Schütt, P., Schütt, B., Switala, M., Bauer, S., Stamatis, G., Opalka, B., Eberhardt, W., Schüler, M., Horn, P. A., & Rebmann, V. (2010) · Human Immunology · doi:10.1016/j.humimm.2010.02.015 · Cited by 69

The Potential of HLA-G-Bearing Extracellular Vesicles as a Future Element in HLA-G Immune Biology

Rebmann, V., König, L., Nardi, F. D. S., Wagner, B., Manvailer, L. F. S., & Horn, P. A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00173 · Cited by 69

Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells

Pezzolo, A., Parodi, F., Marimpietri, D., Raffaghello, L., Cocco, C., Pistorio, A., Mosconi, M., Gambini, C., Cilli, M., Deaglio, S., et al. (2011) · Cell Research · doi:10.1038/cr.2011.38 · Cited by 68

Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complexPreprint

Vandiedonck, C., Taylor, M. S., Lockstone, H. E., Plant, K., Taylor, J. M., Durrant, C., Broxholme, J., Fairfax, B. P., & Knight, J. C. (2011) · Genome Research · doi:10.1101/gr.116681.110 · Cited by 70

The tolerogenic molecule HLA-G

Carosella, E. D. (2011) · Immunology Letters · doi:10.1016/j.imlet.2011.02.011 · Cited by 67

RREB-1 Is a Transcriptional Repressor of HLA-G

Flajollet, S., Poras, I., Carosella, E. D., & Moreau, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902053 · Cited by 67

Inhibition of human Vγ9Vδ2 T-cell antitumoral activity through HLA-G: implications for immunotherapy of cancer

Lesport, E., Baudhuin, J., Sousa, S., LeMaoult, J., Zamborlini, A., Rouas‐Freiss, N., Carosella, E. D., & Favier, B. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0632-7 · Cited by 64

Clinical relevance and functional implications for human leucocyte antigen‐g expression in non‐small‐cell lung cancer

Lin, A., Zhu, C., Chen, H. ‐., Chen, B. ‐., Zhang, X., Zhang, J. ‐., Wang, Q., Zhou, W., Hu, W., Yang, H., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00858.x · Cited by 65

The role of HLA-G in immunity and hematopoiesis

Carosella, E. D., Gregori, S., Rouas‐Freiss, N., LeMaoult, J., Menier, C., & Favier, B. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0579-0 · Cited by 65

Comparison of Mesenchymal Stem Cells Isolated From Pulp and Periodontal Ligament

Hakki, S. S., Kayış, S. A., Hakki, E. E., Bozkurt, Ş. B., Duruksu, G., HALBUTOĞULLARI, Z. S., Turaç, G., & Karaöz, E. (2014) · Journal of Periodontology · doi:10.1902/jop.2014.140257 · Cited by 64

Generation of hypoimmunogenic human pluripotent stem cells via expression of membrane-bound and secreted β2m-HLA-G fusion proteins

Shi, L., Li, W., Liu, Y., Chen, Z., Hui, Y., Hao, P., Xu, X., Zhang, S., Feng, H., Zhang, B., et al. (2020) · Stem Cells · doi:10.1002/stem.3269 · Cited by 63

Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege

Wang, X., Marr, A. K., Breitkopf, T., Leung, G., Hao, J., Wang, E., Kwong, N., Akhoundsadegh, N., Chen, L., Mui, A., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.368 · Cited by 62

Endosomal Signaling and a Novel Pathway Defined by the Natural Killer Receptor KIR2DL4 (CD158d)

Rajagopalan, S. (2010) · Traffic · doi:10.1111/j.1600-0854.2010.01112.x · Cited by 67

Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells

Garziera, M., Scarabel, L., & Toffoli, G. (2017) · Journal of Immunology Research · doi:10.1155/2017/4587520 · Cited by 62

HLA-G polymorphisms in women with squamous intraepithelial lesions harboring human papillomavirus

Simões, R. T., Gonçalves, M. A. G., Castelli, E. C., Mendes‐Junior, C. T., Bettini, J. S. R., Discorde, M. L., Duarte, G. G., Quintana, S. M., Simões, A. L., Moreau, P., et al. (2009) · Modern Pathology · doi:10.1038/modpathol.2009.67 · Cited by 59

What the HLA-I!—Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes

Wyatt, R. C., Lanzoni, G., Russell, M. A., Gerling, I., & Richardson, S. J. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1245-z · Cited by 63

Concise review: Combining human leukocyte antigen G and mesenchymal stem cells for immunosuppressant biotherapy

Naji, A., Rouas‐Freiss, N., Dürrbach, A., Carosella, E. D., Sensebé, L., & Deschaseaux, F. (2013) · Stem Cells · doi:10.1002/stem.1494 · Cited by 58

Altered HLA Class I and HLA-G Expression Is Associated with IL-10 Expression in Patients with Cervical Cancer

Rodrı́guez, J. A., Galeano, L., Palacios, D. M., Gómez, C., Serrano, M. L., Bravo, M. M., & Cómbita, A. L. (2011) · Pathobiology · doi:10.1159/000334089 · Cited by 58

Neutrophil Gelatinase-Associated Lipocalin Increases HLA-G+/FoxP3+ T-Regulatory Cell Population in an In Vitro Model of PBMC

Manna, G. L., Ghinatti, G., Tazzari, P. L., Alviano, F., Ricci, F., Capelli, I., Cuna, V., Todeschini, P., Brunocilla, E., Pagliaro, P., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089497 · Cited by 55

Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations

Yücesoy, B., Talzhanov, Y. A., Johnson, V. J., Wilson, N. W., Biagini, R. E., Wang, W., Frye, B. L., Weissman, D. N., Germolec, D. R., Luster, M. I., et al. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.09.026 · Cited by 57

Efficient Derivation and Concise Gene Expression Profiling of Human Embryonic Stem Cell-Derived Mesenchymal Progenitors (EMPs)

Yen, M., Hou, C., Peng, K., Tseng, P., Jiang, S. S., Shun, C., Chen, Y., & Kuo, M. (2011) · Cell Transplantation · doi:10.3727/096368910x564067 · Cited by 56

HLA-G Expression Is an Independent Predictor for Improved Survival in High Grade Ovarian Carcinomas

Rutten, M. J., Dijk, F., Savci-Heijink, C. D., Buist, M. R., Kenter, G. G., van de Vijver, M. J., & Jordanova, E. S. (2014) · Journal of Immunology Research · doi:10.1155/2014/274584 · Cited by 55

Soluble HLA-G Inhibits Myeloid Dendritic Cell Function in HIV-1 Infection by Interacting with Leukocyte Immunoglobulin-Like Receptor B2

Huang, J., Burke, P. S., Yang, Y., Seiss, K., Beamon, J., Cung, T. D. H., Tóth, I., Pereyra, F., Lichterfeld, M. D., & Yu, X. G. (2010) · Journal of Virology · doi:10.1128/jvi.01292-10 · Cited by 55

Liver HLA-G expression is associated with multiple clinical and histopathological forms of chronic hepatitis B virus infection

Souto, F. J. D., Crispim, J. C. O., Ferreira, S. D. C., da Silva, A. S. M., Bassi, C. L., Soares, C. P., Zucoloto, S., Rouas‐Freiss, N., Moreau, P., Martinelli, A. L. C., et al. (2010) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2010.01286.x · Cited by 54

First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G

Anna, F., Bôle‐Richard, E., LeMaoult, J., Escande, M. C., Lecomte, M., Certoux, J.-M., Souque, P., Garnache‐Ottou, F., Adotévi, O., Langlade‐Demoyen, P., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001998 · Cited by 56

Expression of the nonclassical HLA-G and HLA-E molecules in laryngeal lesions as biomarkers of tumor invasiveness.

Silva, T. G., Crispim, J. C. O., Miranda, F. A., Hassumi, M. K., de Mello, J. M. Y., Simões, R. T., Souto, F. J. D., Soares, E. G., Donadi, E. A., & Soares, C. P. (2011) · PubMed · doi:10.14670/hh-26.1487 · Cited by 53

The Role of HLA-G in Tumor Escape: Manipulating the Phenotype and Function of Immune Cells

Liu, L., Wang, L., Zhao, L., He, C., & Wang, G. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.597468 · Cited by 53

Expansion of CD 4+ HLA ‐G+ T Cell in Human Pregnancy is Impaired in Pre‐eclampsia

Hsu, P. S., Santner‐Nanan, B., Joung, S. J. S., Peek, M. J., & Nanan, R. K. H. (2014) · American Journal of Reproductive Immunology · doi:10.1111/aji.12195 · Cited by 52

Surface Expression of HLA-G is Involved in Mediating Immunomodulatory Effects of Placenta-Derived Multipotent Cells (PDMCs) towards Natural Killer Lymphocytes

Liu, K.-J., Wang, C.-J., Chang, C.-J., Hu, H.-I., Hsu, P., Wu, Y.-C., Bai, C., Sytwu, H., & Yen, B. L. (2011) · Cell Transplantation · doi:10.3727/096368911x580590 · Cited by 53

Association between HLA-G 3'UTR 14-bp ins/del polymorphism and susceptibility to breast cancer

Eskandari‐Nasab, E., Hashemi, M. M., Hasani, S., Omrani, M., Taheri, M., & Mashhadi, M. A. (2013) · Cancer Biomarkers · doi:10.3233/cbm-130364 · Cited by 51

Trogocytosis-mediated immune evasion in the tumor microenvironment

Kim, J., Park, S. Y., Kim, J., Kim, Y. W., Yoon, H. M., Rayhan, B. R., Jeong, J., Bothwell, A. L. M., & Shin, J. H. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01364-2 · Cited by 55

HLA-G polymorphisms and soluble HLA-G protein levels in women with recurrent pregnancy loss from Basrah province in Iraq

Jassem, R. M., Shani, W. S., Loisel, D. A., Sharief, M., Billstrand, C., & Ober, C. (2012) · Human Immunology · doi:10.1016/j.humimm.2012.05.009 · Cited by 55

HLA-G5 Induces IL-4 Secretion Critical for Successful Pregnancy through Differential Expression of ILT2 Receptor on Decidual CD4+ T Cells and Macrophages

Lombardelli, L., Aguerre‐Girr, M., Logiodice, F., Kullolli, O., Casart, Y. C., Polgár, B., Berrebi, A., Romagnani, S., Maggi, E., Bouteiller, P. P. L., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300567 · Cited by 47

The role of immune checkpoints in antitumor response: a potential antitumor immunotherapy

Mejía-Guarnizo, L. V., Monroy-Camacho, P. S., Turizo-Smith, A. D., & Rodríguez-García, J. A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1298571 · Cited by 48

Breast cancer circulating biomarkers: advantages, drawbacks, and new insights

on behalf of the Solid Tumor Working Party of European Blood and Marrow Transplantation Society (EBMT), Ravelli, A., Reuben, J. M., Lanza, F., Anfossi, S., Cappelletti, M. R., Zanotti, L., Gobbi, A., Senti, C., Brambilla, P., et al. (2015) · Tumor Biology · doi:10.1007/s13277-015-3944-7 · Cited by 49

Characterization of HLA‐G expression in renal cell carcinoma

Li, B., Lin, A., Zhang, X. ‐., Zhang, X., Zhang, J. ‐., Wang, Q., Zhou, W., Chen, H. ‐., Wang, T., & Yan, W. (2009) · Tissue Antigens · doi:10.1111/j.1399-0039.2009.01302.x · Cited by 47

Human leucocyte antigen-G polymorphisms are associated with cervical squamous cell carcinoma risk in Taiwanese women

Yang, Y., Chang, T., Chen, T.-C., Lin, W., Chang, S.-C., & Lee, Y. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2013.10.018 · Cited by 45

HLA-G expression in gastric carcinoma: clinicopathological correlations and prognostic impact

Murdaca, G., Calamaro, P., Lantieri, F., Pigozzi, S., Mastracci, L., Grillo, F., Magnani, O., Ceppa, P., Puppo, F., & Fiocca, R. (2018) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-018-2379-0 · Cited by 43

Human Leukocyte Antigen G Expression in Breast Cancer: Role in Immunosuppression

Elliott, R. L., Jiang, X. P., Phillips, J. T., Barnett, B. G., & Head, J. F. (2011) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2010.0924 · Cited by 42

Synthetic HLA‐G proteins for therapeutic use in transplantation

LeMaoult, J., Daouya, M., Wu, J., Loustau, M., Horuzsko, A., & Carosella, E. D. (2013) · The FASEB Journal · doi:10.1096/fj.13-228247 · Cited by 42

Review in translational hematology Beyond the increasing complexity of the immunomodulatory HLA-G molecule

Carosella, E. D., Favier, B., Rouas‐Freiss, N., & LeMaoult, J. (2016)

Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases

Morandi, F., Rizzo, R., Fainardi, E., Rouas‐Freiss, N., & Pistoia, V. (2016) · Journal of Immunology Research · doi:10.1155/2016/4326495 · Cited by 126

Harnessing the immunomodulatory properties of HLA-G for advanced immunotherapies

Beli, X., Savvopoulos, N., Kefala, D., Lysandrou, M., Liga, M., & Spyridonidis, A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1716778 · Cited by 9

Impact of HLA-G analysis in prevention, diagnosis and treatment of pathological conditions

Bortolotti, D. (2014) · World Journal of Methodology · doi:10.5662/wjm.v4.i1.11 · Cited by 18

HLA-G

Carosella, E. D., Rouas‐Freiss, N., Roux, D. T., Moreau, P., & LeMaoult, J. (2015) · Advances in immunology · doi:10.1016/bs.ai.2015.04.001 · Cited by 414