The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
Open accessAbstract
The use of antiretroviral therapy in HIV type 1 (HIV-1)–infected patients does not lead to virus eradication. This is due, to a significant degree, to the fact that HIV-1 can establish a highly stable reservoir of latently infected cells. In this work, we describe an ex vivo experimental system that generates high levels of HIV-1 latently infected memory cells using primary CD4+ T cells. Using this model, we were able to dissect the T cell–signaling pathways and to characterize the long terminal repeat (LTR) cis-acting elements involved in reactivation of HIV-1 in memory CD4+ T cells. We conclude that Lck and nuclear factor of activated T cells (NFAT), but not NF-κB, are required for optimal latent virus reactivation in memory T cells. We also found that the cis-acting elements which are critical toward HIV-1 reactivation are the Sp1 and κB/NFAT transcription factor binding sites.
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Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
Finzi, D., Hermankova, M., Pierson, T., Carruth, L. M., Buck, C., Chaisson, R. E., Quinn, T. C., Chadwick, K., Margolick, J., Brookmeyer, R., et al. (1997) · Science · doi:10.1126/science.278.5341.1295 · Cited by 3,098
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
Chun, T.-W., Carruth, L., Finzi, D., Shen, X., DiGiuseppe, J. A., Taylor, H., Hermankova, M., Chadwick, K., Margolick, J., Quinn, T. C., et al. (1997) · Nature · doi:10.1038/387183a0 · Cited by 2,050
Franke, T. F., Yang, S.-I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., & Tsichlis, P. N. (1995) · Cell · doi:10.1016/0092-8674(95)90534-0 · Cited by 2,006
Osborn, L., Kunkel, S., & Nabel, G. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2336 · Cited by 1,621
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
Jordan, A., Bisgrove, D., & Verdin, E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg188 · Cited by 914
Cytokine-Induced Expression of HIV-1 in a Chronically Infected Promonocyte Cell Line
Folks, T. M., Justement, J., Kinter, A., Dinarello, C. A., & Fauci, A. S. (1987) · Science · doi:10.1126/science.3313729 · Cited by 905
Duh, E. J., Maury, W. J., Folks, T. M., Fauci, A. S., & Rabson, A. B. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.15.5974 · Cited by 767
Folks, T. M., Clouse, K. A., Justement, J., Rabson, A., Duh, E., Kehrl, J. H., & Fauci, A. S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2365 · Cited by 712
Activation of the AIDS Retrovirus Promoter by the Cellular Transcription Factor, Sp1
Jones, K. A., Kadonaga, J. T., Luciw, P. A., & Tjian, R. (1986) · Science · doi:10.1126/science.3008338 · Cited by 701
A quantitative assay for HIV DNA integration in vivo
Butler, S. L., Hansen, M. S. T., & Bushman, F. D. (2001) · Nature Medicine · doi:10.1038/87979 · Cited by 687
Cited by
Towards an HIV cure: a global scientific strategy
The International AIDS Society Scientific Working Group on HIV Cure (2012) · Nature Reviews Immunology · doi:10.1038/nri3262 · Cited by 554
IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV
Monroe, K. M., Yang, Z., Johnson, J. R., Geng, X., Doitsh, G., Krogan, N. J., & Greene, W. C. (2014) · Science · doi:10.1126/science.1243640 · Cited by 511
Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression
Karn, J., & Stoltzfus, C. M. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006916 · Cited by 437
The Molecular Basis for Human Immunodeficiency Virus Latency
Mbonye, U., & Karn, J. (2017) · Annual Review of Virology · doi:10.1146/annurev-virology-101416-041646 · Cited by 182
Pace, M. J., Graf, E. H., Agosto, L. M., Mexas, A. M., Male, F., Brady, T., Bushman, F. D., & O'Doherty, U. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002818 · Cited by 144
Metadata
- Authors
- Bosque, A., & Planelles, V.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2009-01-01
- Volume
- 113
- Issue
- 1
- Pages
- 58-65
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1980668957
- Cited by
- 340
- References
- 46
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
