The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
The role of B cells in the pathogenesis of graft-versus-host disease
Abstract
Allogeneic hematopoietic stem cell transplantation is an established treatment modality for malignant and nonmalignant hematologic diseases. Acute and chronic graft-versus-host diseases (GVHDs) are a major cause of morbidity and mortality after allogeneic stem cell transplantation. T cells have been identified as key players in the graft-versus-host reaction and, therefore, most established drugs used against GVHD target T cells. Despite our knowledge on the pathogenesis of the GVH reaction, success of established therapies for prevention and treatment of GHVD is unsatisfactory. Recently, animal and human studies demonstrated that B cells are involved in the immunopathophysiology of acute and chronic GVHD. Early phase clinical trials of B-cell depletion with rituximab have shown beneficial effects on both acute and chronic GVHD. This review summarizes the current experimental and clinical evidence for the involvement of B cells in the pathogenesis of acute and chronic GVHD and discusses the clinical implications for the management of patients undergoing allogeneic stem cell transplantation.
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B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
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Predominant Autoantibody Production by Early Human B Cell Precursors
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B cells regulate autoimmunity by provision of IL-10
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Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells
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Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression
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Reciprocal regulation of polarized cytokine production by effector B and T cells
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Cited by
Regulatory T cells in multiple sclerosis and myasthenia gravis
Danikowski, K. M., Jayaraman, S., & Prabhakar, B. S. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0892-8 · Cited by 323
Chronic graft-versus-host disease. Part I: Epidemiology, pathogenesis, and clinical manifestations
Baumrin, E., Loren, A. W., Falk, S. J., Mays, J. W., & Cowen, E. W. (2024) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2022.12.024 · Cited by 59
RetractedAutoimmunity in lipodystrophy syndromes
Ceccarini, G., Magno, S., Gilio, D., Pelosini, C., & Santini, F. (2021) · La Presse Médicale · doi:10.1016/j.lpm.2021.104073 · Cited by 34
Metadata
- Authors
- Shimabukuro-Vornhagen, A., Hallek, M. J., Storb, R. F., & von Bergwelt-Baildon, M. S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2009-12-03
- Volume
- 114
- Issue
- 24
- Pages
- 4919-4927
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2006493080
- Cited by
- 271
- References
- 64
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shimabukuro-Vornhagen, A., Hallek, M. J., Storb, R. F., & von Bergwelt-Baildon, M. S. (2009). The role of B cells in the pathogenesis of graft-versus-host disease. Blood. https://doi.org/10.1182/blood-2008-10-161638
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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