The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
IL-7 administration drives T cell–cycle entry and expansion in HIV-1 infection
Open accessAbstract
Interleukin 7 (IL-7) is a common gamma chain receptor cytokine implicated in thymopoiesis and in peripheral expansion and survival of T lymphocytes. The safety and activity of recombinant human IL-7 (rhIL-7) administration were therefore examined in HIV-infected persons. In this prospective randomized placebo-controlled study, a single subcutaneous dose of rhIL-7 was well tolerated with biologic activity demonstrable at 3 μg/kg and a maximum tolerated dose of 30 μg/kg. Injection site reactions and transient elevations of liver function tests were the most notable side effects. Transient increases in plasma HIV-RNA levels were observed in 6 of 11 IL-7–treated patients. Recombinant hIL-7 induced CD4 and CD8 T cells to enter cell cycle; cell-cycle entry was also confirmed in antigen-specific CD8 T cells. Administration of rhIL-7 led to transient down-regulation of the IL-7 receptor alpha chain (CD127) in both CD4+ and CD8+ T cells. Single-dose rhIL-7 increased the numbers of circulating CD4+ and CD8+ T cells, predominantly of central memory phenotype. The frequency of CD4+ T cells with a regulatory T-cell phenotype (CD25high CD127low) did not change after rhIL-7 administration. Thus, rhIL-7 has a biologic and toxicity profile suggesting a potential for therapeutic trials in HIV infection and other settings of lymphopenia. This clinical trial has been registered at http://www.clinicaltrials.gov under NCT0099671.
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HIV infection: epidemiology, pathogenesis, treatment, and prevention
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Metadata
- Authors
- Sereti, I., Dunham, R. M., Spritzler, J., Aga, E., Proschan, M. A., Medvik, K., Battaglia, C. A., Landay, A. L., Pahwa, S., Fischl, M. A., Asmuth, D. M., Tenorio, A. R., Altman, J. D., Fox, L., Moir, S., Malaspina, A., Morre, M., Buffet, R., Silvestri, G., & Lederman, M. M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2009-06-18
- Volume
- 113
- Issue
- 25
- Pages
- 6304-6314
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2002051431
- Cited by
- 342
- References
- 30
- FWCI
- 13.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Sereti, I., Dunham, R. M., Spritzler, J., Aga, E., Proschan, M. A., Medvik, K., Battaglia, C. A., Landay, A. L., Pahwa, S., Fischl, M. A., Asmuth, D. M., Tenorio, A. R., Altman, J. D., Fox, L., Moir, S., Malaspina, A., Morre, M., Buffet, R., Silvestri, G., & Lederman, M. M. (2009). IL-7 administration drives T cell–cycle entry and expansion in HIV-1 infection. Blood. https://doi.org/10.1182/blood-2008-10-186601
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
