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microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification
Open accessAbstract
Aberrant expression of microRNAs has been recently associated with chronic lymphocytic leukemia (CLL) outcome. Although disease evolution can be predicted by several prognostic factors, a better outcome individualization in a given patient is still of utmost interest. Here, we showed that miR-29c and miR-223 expression levels decreased significantly with progression from Binet stage A to C were significantly lower in poor prognostic subgroups (defined by several prognostic factors) and could significantly predict treatment-free survival (TFS) and overall survival (OS). Furthermore, we developed a quantitative real-time polymerase chain reaction (qPCR) score combining miR-29c, miR-223, ZAP70, and LPL (from 0 to 4 poor prognostic markers) to stratify treatment and death risk in a cohort of 110 patients with a median follow-up of 72 months (range, 2-312). Patients with a score of 0/4, 1/4, 2/4, 3/4, and 4/4 had a median TFS of greater than 312, of 129, 80, 36, and 19 months, respectively (hazard ratio, HR0/4 < 1/4 < 2/4 < 3/4 < 4/4 = 17.00, P < .001). Patients with a score of 0-1/4, 2-3/4, and 4/4 had a median OS of greater than 312, of 183 and 106 months, respectively (HR0/4 < 1/4 < 2/4 < 3/4 < 4/4 = 13.69, P = .001). This score will help to identify, among the good and poor prognosis subgroups, patients who will need early therapy and thus will require a closer follow-up.
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Cites
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
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miR-29c regulates BACE1 protein expression
Zong, Y., Wang, H., Dong, W., Quan, X., Zhu, H., Xu, Y., Huang, L., Ma, C., & Qin, C. (2011) · Brain Research · doi:10.1016/j.brainres.2011.04.035 · Cited by 117
Role of microRNAs in HTLV-1 infection and transformation
Ruggero, K., Corradin, A., Zanovello, P., Amadori, A., Bronte, V., Ciminale, V., & D’Agostino, D. M. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.05.001 · Cited by 41
SnoU6 and 5S RNAs are not reliable miRNA reference genes in neuronal differentiation
Lim, Q. E., Zhou, L., Ho, Y. K., Wan, G., & Too, H. P. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.024 · Cited by 30
Li, F., Hao, M., Feng, X., Zang, M., Qin, Y., Yi, S., Li, Z., Xu, Y., Zhou, L., Sui, W., et al. (2015) · Leukemia Research · doi:10.1016/j.leukres.2015.04.010 · Cited by 25
Metadata
- Authors
- Stamatopoulos, B., Meuleman, N., Haibe-Kains, B., Saussoy, P., Van Den Neste, E., Michaux, L., Heimann, P., Martiat, P., Bron, D., & Lagneaux, L.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2009-05-21
- Volume
- 113
- Issue
- 21
- Pages
- 5237-5245
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2074277423
- Cited by
- 240
- References
- 1
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification. https://app.cochat.ai/papers/10.1182/blood-2008-11-189407
- The paper
- Stamatopoulos, B., Meuleman, N., Haibe-Kains, B., Saussoy, P., Van Den Neste, E., Michaux, L., Heimann, P., Martiat, P., Bron, D., & Lagneaux, L. (2009). microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification. Blood. https://doi.org/10.1182/blood-2008-11-189407
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