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Cited by 41T-cell and Retrovirus StudiesMicroRNA in disease regulationViral-associated cancers and disorders

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Role of microRNAs in HTLV-1 infection and transformation

Ruggero, Katia, Corradin, Alberto, Zanovello, Paola, Amadori, Alberto, Bronte, Vincenzo, Ciminale, Vincenzo, D’Agostino, Donna M.·2010·Molecular Aspects of Medicine
DOI 10.1016/j.mam.2010.05.001
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Abstract

Human T-cell leukemia virus type 1 (HTLV-1), a retrovirus that infects more than 20 million people worldwide, is the etiological agent of ATLL (adult T-cell leukemia/lymphoma), an aggressive leukemia of CD4+ T lymphocytes which arises in a small percentage of infected individuals after a long clinical latency. Tumor emergence is attributed primarily to the oncogenic activity of the viral protein Tax, which drives the expression of viral transcripts and controls the expression and function of a broad variety of host-cell genes involved in proliferation, genetic stability and apoptosis. Nevertheless, many aspects of HTLV-1 replication, persistence and pathogenesis remain to be understood. The emerging role of microRNAs in tumor development and viral infection has prompted investigations on the interactions between HTLV-1 and the microRNA regulatory network. In the present review we discuss recent data demonstrating changes in cellular microRNA expression in HTLV-1-infected cell lines and ATLL cells, and the functional impact of a subset microRNAs deregulated by HTLV-1 on cellular gene expression and signal transduction pathways. Mechanisms through which the viral proteins may influence microRNA expression are discussed. Results of searches for potential cellular microRNAs that target viral transcripts and for microRNAs produced by HTLV-1 are described. Observations along with regarding the expression of tRNA-derived small regulatory RNAs in HTLV-1-infected cells are presented.

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  • Nonprimer-derived tRFs, such as a tRNA Ser-derived 19-nt tRF-3, are highly expressed in transformed cell lines, including those chronically infected with HTLV-1.

    “For example, nonprimerderived tRFs, such as a tRNA Ser -derived 19-nt tRF-3, is highly expressed in transformed cell lines, including those chronically infected with HTLV-1 (97).”

    From Role of host tRNAs and aminoacyl-tRNA synthetases in retroviral replication (2019) · cites this paper as [97]

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Authors
Ruggero, K., Corradin, A., Zanovello, P., Amadori, A., Bronte, V., Ciminale, V., & D’Agostino, D. M.
Affiliations
  • University of Padua (IT)
  • Istituto Oncologico Veneto (IT)
Corresponding author
  • Ciminale, Vincenzo
  • D’Agostino, Donna M.
ORCID
Venue
Molecular Aspects of Medicine
Publisher
Elsevier BV
Published
2010-10
Volume
31
Issue
5
Pages
367-382
ISSN
0098-2997 (ISSN-L)
DOI
10.1016/j.mam.2010.05.001
OpenAlex
W2041531155
Cited by
41
References
8
Citations by year
2025: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 1 · 2016: 1 · 2014: 3 · 2013: 4 · 2012: 6
FWCI
0.38
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Molecular Aspects of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Funders
Associazione Italiana per la Ricerca sul Cancro
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords
HTLV-1, microRNA, adult T-cell leukemia/lymphoma, Tax protein, viral oncogenesis, viral microRNAs, host-virus interaction, signaling pathways
MeSH terms
Cell Transformation, Neoplastic, Humans, Human T-lymphotropic virus 1, Leukemia-Lymphoma, Adult T-Cell, HTLV-I Infections, Gene Expression Regulation, Leukemic, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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