The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
β2-Glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome
Abstract
The antiphospholipid syndrome is defined by the presence of antiphospholipid antibodies in blood of patients with thrombosis or fetal loss. There is ample evidence that β2-glycoprotein I (β2GPI) is the major antigen for antiphospholipid antibodies. The autoantibodies recognize β2GPI when bound to anionic surfaces and not in solution. We showed that β2GPI can exist in at least 2 different conformations: a circular plasma conformation and an “activated” open conformation. We also showed that the closed, circular conformation is maintained by interaction between the first and fifth domain of β2GPI. By changing pH and salt concentration, we were able to convert the conformation of β2GPI from the closed to the open conformation and back. In the activated open conformation, a cryptic epitope in the first domain becomes exposed that enables patient antibodies to bind and form an antibody-β2GPI complex. We also demonstrate that the open conformation of β2GPI prolonged the activated partial thromboplastin time when added to normal plasma, whereas the activated partial thromboplastin time is further prolonged by addition of anti-β2GPI antibodies. The conformational change of β2GPI, and the influence of the autoantibodies may have important consequences for our understanding of the antiphospholipid syndrome.
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Cites
MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., et al. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01753.x · Cited by 7,203
Self-citationMcNeil, H. P., Simpson, R. J., Chesterman, C. N., & Krilis, S. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4120 · Cited by 1,595
Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor
Galli, M., Barbui, T., Comfurius, P., Maassen, C., Hemker, H. C., Zwaal, R. F. A., Bevers, E. M., de Baets, M. H., & van Breda-Vriesman, P. J. C. (1990) · The Lancet · doi:10.1016/0140-6736(90)91374-j · Cited by 1,270
Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease
Matsuura, E., Igarashi, Y., Fujimoto, M., Ichikawa, K., & Koike, T. (1990) · The Lancet · doi:10.1016/0140-6736(90)91697-9 · Cited by 720
Blank, M., Cohen, J., Toder, V, & Shoenfeld, Y. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3069 · Cited by 455
Urbanus, R. T., Siegerink, B., Roest, M., Rosendaal, F. R., de Groot, P. G., & Algra, A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70239-x · Cited by 429
Self-citationAdhesion mechanism of human beta 2-glycoprotein I to phospholipids based on its crystal structure
Bouma, B. (1999) · The EMBO Journal · doi:10.1093/emboj/18.19.5166 · Cited by 333
Pierangeli, S. S., Colden-Stanfield, M., Liu, X., Barker, J. H., Anderson, G. L., & Harris, E. N. (1999) · Circulation · doi:10.1161/01.cir.99.15.1997 · Cited by 325
Complete amino acid sequence of human plasma beta 2-glycoprotein I.
Lozier, J., Takahashi, N., & Putnam, F. W. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.12.3640 · Cited by 323
Schwarzenbacher, R., Zeth, K., Diederichs, K., Gries, A., Kostner, G. M., Laggner, P., & Prassl, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.22.6228 · Cited by 311
Cited by
Guidelines on the investigation and management of antiphospholipid syndrome
Keeling, D., Mackie, I., Moore, G. W., Greer, I. A., Greaves, M., & British Committee for Standards in Haematology (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09037.x · Cited by 740
The Pathogenesis of the Antiphospholipid Syndrome
Giannakopoulos, B., & Krilis, S. A. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1112830 · Cited by 688
Pathogenesis of antiphospholipid syndrome: understanding the antibodies
Meroni, P. L., Borghi, M. O., Raschi, E., & Tedesco, F. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.52 · Cited by 620
The antiphospholipid syndrome: still an enigma
Chaturvedi, S., & McCrae, K. R. (2015) · Hematology · doi:10.1182/asheducation-2015.1.53 · Cited by 51
Antiphospholipid autoantibodies as blood biomarkers for detection of early stage Alzheimer’s disease
McIntyre, J. A., Ramsey, C. J., Gitter, B. D., Saykin, A. J., Wagenknecht, D. R., Hyslop, P. A., & Initiative, F. T. A. D. N. (2015) · Autoimmunity · doi:10.3109/08916934.2015.1008464 · Cited by 22
Metadata
- Authors
- Ağar, Ç., van Os, G. M. A., Mörgelin, M., Sprenger, R. R., Marquart, J. A., Urbanus, R. T., Derksen, R. H. W. M., Meijers, J. C. M., & de Groot, P. G.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2010-08-26
- Volume
- 116
- Issue
- 8
- Pages
- 1336-1343
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2096428341
- Cited by
- 263
- References
- 33
- FWCI
- 15.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ağar, Ç., van Os, G. M. A., Mörgelin, M., Sprenger, R. R., Marquart, J. A., Urbanus, R. T., Derksen, R. H. W. M., Meijers, J. C. M., & de Groot, P. G. (2010). β2-Glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome. Blood. https://doi.org/10.1182/blood-2009-12-260976
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
