The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis
Open accessAbstract
CD40 ligand (CD40L), identified as a costimulatory molecule expressed on T cells, is also expressed and functional on platelets. We investigated the thrombotic and inflammatory contributions of platelet CD40L in atherosclerosis. Although CD40L-deficient (Cd40l−/−) platelets exhibited impaired platelet aggregation and thrombus stability, the effects of platelet CD40L on inflammatory processes in atherosclerosis were more remarkable. Repeated injections of activated Cd40l−/− platelets into Apoe−/− mice strongly decreased both platelet and leukocyte adhesion to the endothelium and decreased plasma CCL2 levels compared with wild-type platelets. Moreover, Cd40l−/− platelets failed to form proinflammatory platelet-leukocyte aggregates. Expression of CD40L on platelets was required for platelet-induced atherosclerosis as injection of Cd40l−/− platelets in contrast to Cd40l+/+ platelets did not promote lesion formation. Remarkably, injection of Cd40l+/+, but not Cd40l−/−, platelets transiently decreased the amount of regulatory T cells (Tregs) in blood and spleen. Depletion of Tregs in mice injected with activated Cd40l−/− platelets abrogated the athero-protective effect, indicating that CD40L on platelets mediates the reduction of Tregs leading to accelerated atherosclerosis. We conclude that platelet CD40L plays a pivotal role in atherosclerosis, not only by affecting platelet-platelet interactions but especially by activating leukocytes, thereby increasing platelet-leukocyte and leukocyte-endothelium interactions.
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CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
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Platelets in inflammation and atherogenesis
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Immune and Inflammatory Mechanisms of Atherosclerosis
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Self-citationPlatelet Activation in Unstable Coronary Disease
Fitzgerald, D. J., Roy, L., Catella, F., & FitzGerald, G. A. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610163151602 · Cited by 1,141
Natural regulatory T cells control the development of atherosclerosis in mice
Ait-Oufella, H., Salomon, B. L., Potteaux, S., Robertson, A.-K. L., Gourdy, P., Zoll, J., Merval, R., Esposito, B., Cohen, J. L., Fisson, S., et al. (2006) · Nature Medicine · doi:10.1038/nm1343 · Cited by 1,100
Self-citationCirculating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E
Huo, Y., Schober, A., Forlow, S. B., Smith, D. F., Hyman, M. C., Jung, S., Littman, D. R., Weber, C., & Ley, K. (2003) · Nature Medicine · doi:10.1038/nm810 · Cited by 1,005
Self-citationReduction of atherosclerosis in mice by inhibition of CD40 signalling
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Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues
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Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation
Mandel, J., Casari, M., Stepanyan, M., Martyanov, A., & Deppermann, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073868 · Cited by 253
Foer, D., Amin, T., Nagai, J., Tani, Y., Feng, C., Liu, T., Newcomb, D. C., Lai, J., Hayashi, H., Snyder, W. E., et al. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2300102 · Cited by 17
Metadata
- Authors
- Lievens, D., Zernecke, A., Seijkens, T., Soehnlein, O., Beckers, L., Munnix, I. C. A., Wijnands, E., Goossens, P., van Kruchten, R., Thevissen, L., Boon, L., Flavell, R. A., Noelle, R. J., Gerdes, N., Biessen, E. A., Daemen, M. J. A. P., Heemskerk, J. W. M., Weber, C., & Lutgens, E.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2010-11-18
- Volume
- 116
- Issue
- 20
- Pages
- 4317-4327
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2034551997
- Cited by
- 301
- References
- 51
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Lievens, D., Zernecke, A., Seijkens, T., Soehnlein, O., Beckers, L., Munnix, I. C. A., Wijnands, E., Goossens, P., van Kruchten, R., Thevissen, L., Boon, L., Flavell, R. A., Noelle, R. J., Gerdes, N., Biessen, E. A., Daemen, M. J. A. P., Heemskerk, J. W. M., Weber, C., & Lutgens, E. (2010). Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood. https://doi.org/10.1182/blood-2010-01-261206
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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