The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis
Open accessAbstract
Although several transcription factors have been shown to be critical for the induction and maintenance of IL-17 expression by CD4 Th cells, less is known about the role of nontranscriptional mechanisms. Here we show that the p38 MAPK signaling pathway is essential for in vitro and in vivo IL-17 production by regulating IL-17 synthesis in CD4 T cells through the activation of the eukaryotic translation initiation factor 4E/MAPK-interacting kinase (eIF-4E/MNK) pathway. We also show that p38 MAPK activation is required for the development and progression of both chronic and relapsing-remitting forms of experimental allergic encephalomyelitis (EAE), the principal autoimmune model of multiple sclerosis. Furthermore, we show that regulation of p38 MAPK activity specifically in T cells is sufficient to modulate EAE severity. Thus, mechanisms other than the regulation of gene expression also contribute to Th17 cell effector functions and, potentially, to the pathogenesis of other Th17 cell–mediated diseases.
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Cites
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Immunology of multiple sclerosis
Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149
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TH17 cells in development: an updated view of their molecular identity and genetic programming
Dong, C. (2008) · Nature reviews. Immunology · doi:10.1038/nri2295 · Cited by 1,064
Multiple sclerosis: a complicated picture of autoimmunity
McFarland, H. F., & Martin, R. (2007) · Nature Immunology · doi:10.1038/ni1507 · Cited by 985
Th17 cells: from precursors to players in inflammation and infection
Awasthi, A., & Kuchroo, V. K. (2009) · International Immunology · doi:10.1093/intimm/dxp021 · Cited by 241
MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells
Zhang, Y., Liu, G., & Dong, Z. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106044200 · Cited by 81
Cited by
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
Kleinewietfeld, M., Manzel, A., Titze, J., Kvakan, H., Yosef, N., Linker, R. A., Muller, D. N., & Hafler, D. A. (2013) · Nature · doi:10.1038/nature11868 · Cited by 1,394
Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine
Haghikia, A., Jörg, S., Duscha, A., Berg, J., Manzel, A., Waschbisch, A., Hammer, A., Lee, D.-H., May, C., Wilck, N., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.007 · Cited by 927
Stress-Activated Protein Kinases in Spinal Cord Injury: Focus on Roles of p38
Kasuya, Y., Umezawa, H., & Hatano, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030867 · Cited by 54
Venkatesha, S. H., & Moudgil, K. D. (2019) · Inflammation Research · doi:10.1007/s00011-019-01219-x · Cited by 36
Identification and functional analysis of specific MS risk miRNAs and their target genes
Luo, D., Wang, J., Zhang, X., Rang, X., Xu, C., & Fu, J. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102044 · Cited by 12
Metadata
- Authors
- Noubade, R., Krementsov, D. N., del Rio, R., Thornton, T., Nagaleekar, V., Saligrama, N., Spitzack, A., Spach, K., Sabio, G., Davis, R. J., Rincon, M., & Teuscher, C.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-09-22
- Volume
- 118
- Issue
- 12
- Pages
- 3290-3300
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2044571863
- Cited by
- 162
- References
- 7
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Noubade, R., Krementsov, D. N., del Rio, R., Thornton, T., Nagaleekar, V., Saligrama, N., Spitzack, A., Spach, K., Sabio, G., Davis, R. J., Rincon, M., & Teuscher, C. (2011). Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis. Blood. https://doi.org/10.1182/blood-2011-02-336552
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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