Cited by 877Cytokine Signaling Pathways and InteractionsNF-κB Signaling PathwaysCell death mechanisms and regulation

The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

Open access

Aggarwal, Bharat B., Gupta, Subash C., Kim, Ji Hye·2012·Blood

DOI 10.1182/blood-2011-04-325225PMC PMC3265196

Open this paper in CoChat — free account Open PDF

Abstract

Although activity that induced tumor regression was observed and termed tumor necrosis factor (TNF) as early as the 1960s, the true identity of TNF was not clear until 1984, when Aggarwal and coworkers reported, for the first time, the isolation of 2 cytotoxic factors: one, derived from macrophages (molecular mass 17 kDa), was named TNF, and the second, derived from lymphocytes (20 kDa), was named lymphotoxin. Because the 2 cytotoxic factors exhibited 50% amino acid sequence homology and bound to the same receptor, they came to be called TNF-α and TNF-β. Identification of the protein sequences led to cloning of their cDNA. Based on sequence homology to TNF-α, now a total of 19 members of the TNF superfamily have been identified, along with 29 interacting receptors, and several molecules that interact with the cytoplasmic domain of these receptors. The roles of the TNF superfamily in inflammation, apoptosis, proliferation, invasion, angiogenesis, metastasis, and morphogenesis have been documented. Their roles in immunologic, cardiovascular, neurologic, pulmonary, and metabolic diseases are becoming apparent. TNF superfamily members are active targets for drug development, as indicated by the recent approval and expanding market of TNF blockers used to treat rheumatoid arthritis, psoriasis, Crohns disease, and osteoporosis, with a total market of more than US $20 billion. As we learn more about this family, more therapeutics will probably emerge. In this review, we summarize the initial discovery of TNF-α, and the insights gained regarding the roles of this molecule and its related family members in normal physiology and disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1182/blood-2011-04-325225

Cites

144 of 144 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED ARTICLE: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
Nikolaev, A., McLaughlin, T., O’Leary, D. D. M., & Tessier-Lavigne, M. (2009) · Nature · doi:10.1038/nature07767 · Cited by 992
Retracted
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650
Identification and characterization of a new member of the TNF family that induces apoptosis
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900
Signalling pathways of the TNF superfamily: a double-edged sword
Aggarwal, B. B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1184 · Cited by 2,793
Self-citation
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
Levine, B., Kalman, J., Mayer, L., Fillit, H. M., & Packer, M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007263230405 · Cited by 2,582
Inflammation: the link between insulin resistance, obesity and diabetes
Dandona, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.10.013 · Cited by 2,170

Show all 144 references

Research works printed but not linked: 1

Wua, 2010, Docking prediction for tumor necrosis factor-α and five herbal inhibitors., Intl J Eng Sci Technol, 2, 4263

Sorted by citations

Items 301–400 of 876

Correlation of inducible nitric oxide synthase (iNOS) inhibition with TNF-α, caspase-1, FasL and TLR-3 in pathogenesis of rabies in mouse model
Madhu, B. P., Singh, K. P., Saminathan, M., Singh, R. P., Tiwari, A. K., Manjunatha, V., Harish, C. C., & Manjunathareddy, G. B. (2015) · Virus Genes · doi:10.1007/s11262-015-1265-y · Cited by 21
Is There a Risk of Lymphoma Associated With Anti-tumor Necrosis Factor Drugs in Patients With Inflammatory Bowel Disease? A Systematic Review of Observational Studies
Ferraro, S., Leonardi, L., Convertino, I., Blandizzi, C., & Tuccori, M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00247 · Cited by 20
Partners in crime: TNFα-based networks promoting cancer progression
Ben‐Baruch, A. (2019) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-019-02435-4 · Cited by 20
Role of Apoptosis in HIV Pathogenesis
Ekabe, C. J., Asaba, C. N., Agyei, E. K., & Kehbila, J. (2022) · Advances in Virology · doi:10.1155/2022/8148119 · Cited by 20
Identification and immunological characterization of cuproptosis-related molecular clusters in idiopathic pulmonary fibrosis disease
Shi, X., Pan, Z., Cai, W., Zhang, Y., Duo, J., Liu, R., & Cai, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1171445 · Cited by 20
Elevated CRP and TNF-α levels are associated with blunted neural oscillations serving fluid intelligence
Dietz, S. M., Schantell, M. D., Spooner, R. K., Sandal, M. E., Mansouri, A., Arif, Y., Okelberry, H. J., John, J. A., Glesinger, R. J., May, P. E., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.09.012 · Cited by 20
LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-κB/RELT signal pathway
Wang, H., Wang, L., Luan, H., Xiao, J., Zhao, Z., Yu, P., Deng, M., Liu, Y., Ji, S., Ma, J., et al. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03110-y · Cited by 20
Novel tracers to assess myocardial inflammation with radionuclide imaging
Lucinian, Y. A., Martineau, P., Abikhzer, G., Harel, F., & Pelletier‐Galarneau, M. (2024) · Journal of Nuclear Cardiology · doi:10.1016/j.nuclcard.2024.102012 · Cited by 21
Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network
Richard, A. C., Peters, J. E., Lee, J. C., Vahedi, G., Schäffer, A. A., Siegel, R. M., Lyons, P., & Smith, K. G. C. (2016) · Genome Medicine · doi:10.1186/s13073-016-0329-5 · Cited by 20
Harnessing co-stimulatory TNF receptors for cancer immunotherapy: Current approaches and future opportunities
Waight, J. D., Gombos, R. B., & Wilson, N. S. (2017) · Human Antibodies · doi:10.3233/hab-160308 · Cited by 20
The Correlation Between TNF-α Promoter Gene Polymorphism and Genetic Susceptibility to Cervical Cancer
Li, X., Yin, G., Li, J., Wu, A., Yuan, Z., Liang, J., & Sun, Q. (2018) · Technology in Cancer Research & Treatment · doi:10.1177/1533033818782793 · Cited by 20
Ligand-based pharmacophore modeling of TNF-α to design novel inhibitors using virtual screening and molecular dynamics
Jade, D., Pandey, R., Kumar, R., & Gupta, D. K. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1831962 · Cited by 20
The role of immunity in insulin resistance in patients with polycystic ovary syndrome
Zhang, Q., Yang, Z., Ou, X., Zhang, M., Qin, X., & Wu, G. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1464561 · Cited by 19
Role and mechanism of the Dectin‑1‑mediated Syk/NF‑κB signaling pathway in Talaromyces marneffei infection
Peng, Y., Chen, Y., Ma, J., Zhou, W. J., Wang, Y., Wang, Y., Zheng, H., & Shi, W. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.11007 · Cited by 19
Effects of dietary zinc (Zn) levels on growth performance, nutrient composition, muscle development, antioxidant and inflammatory responses in yellow catfish muscle
Xu, X., Song, C.-C., Tan, X.-Y., Zhong, C.-C., & Luo, Z. (2023) · Aquaculture Reports · doi:10.1016/j.aqrep.2023.101640 · Cited by 19
Cytokine-overexpressing dendritic cells for cancer immunotherapy
Han, J., & Wang, H. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01353-5 · Cited by 19
Early embryonic and endometrial regulation of tumor necrosis factor and tumor necrosis factor receptor 2 in the cattle uterus
Correia-Álvarez, E., Gómez, E., Martín, D., Carrocera, S., Pérez-López, S., Peynot, N., Giraud‐Delville, C., Caamaño, J. N., Balseiro, A., Sandra, O., et al. (2014) · Theriogenology · doi:10.1016/j.theriogenology.2014.12.007 · Cited by 19
Tumor Necrosis Factor-α 238 G/A Polymorphism and Risk of Hepatocellular Carcinoma: Evidence from a Meta-analysis
Cheng, K., Zhao, Y., Liu, L., & Wan, J.-J. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.5.3275 · Cited by 19
Network-level effects of kinase inhibitors modulate TNF-α–induced apoptosis in the intestinal epithelium
Gierut, J. J., Wood, L. B., Lau, K. S., Lin, Y.-J., Genetti, C. A., Samatar, A. A., Lauffenburger, D. A., & Haigis, K. M. (2015) · Science Signaling · doi:10.1126/scisignal.aac7235 · Cited by 19
Exploring the interplay between autoimmunity and cancer to find the target therapeutic hotspots
Kumar, N., Chugh, H., Tomar, R., Tomar, V., Singh, V. K., & Chandra, R. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1350188 · Cited by 19
Effect of the proinflammatory cytokine TNF-α on intestinal riboflavin uptake: inhibition mediated via transcriptional mechanism(s)
Anandam, K. Y., Alwan, O. A., Subramanian, V. S., Srinivasan, P., Kapadia, R., & Said, H. M. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00295.2018 · Cited by 19
New missense variants in RELT causing hypomineralised amelogenesis imperfecta
Nikolopoulos, G., Smith, C. E. L., Brookes, S. J., El‐Asrag, M. E., Brown, C. J., Patel, A., Knudsen, G. M., O’Connell, M. J., Inglehearn, C. F., & Mighell, A. J. (2020) · Clinical Genetics · doi:10.1111/cge.13721 · Cited by 19
The immunocytokine L19-TNF eradicates sarcomas in combination with chemotherapy agents or with immune check-point inhibitors
Corbellari, R., Nadal, L., Villa, A., Neri, D., & Luca, R. D. (2020) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000938 · Cited by 19
Enhancing responsiveness of human jejunal enteroids to host and microbial stimuli
Ruan, W. H., Engevik, M. A., Chang‐Graham, A. L., Danhof, H. A., Goodwin, A., Engevik, K. A., Shi, Z., Hall, A., Rienzi, S. C. D., Venable, S. F., et al. (2020) · The Journal of Physiology · doi:10.1113/jp279423 · Cited by 19
An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice
Javaid, N., Patra, M. C., Cho, D., Batool, M., Kim, Y., Choi, G. M., Kim, M. S., Hahm, D., & Choi, S. (2022) · Science Signaling · doi:10.1126/scisignal.abi8713 · Cited by 19
Production of porcine TNFα by ADAM17-mediated cleavage negatively regulates porcine reproductive and respiratory syndrome virus infection
Ren, L., Guo, L., Gu, W., Luo, X., Zhang, J., Xu, Y., Tian, Z., Feng, L., & Wang, Y. (2016) · Immunologic Research · doi:10.1007/s12026-015-8772-8 · Cited by 19
Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-α through up-regulation of TNF receptor 1 in lung cancer cells
You, B. R., Han, B. R., & Park, W. H. (2017) · Oncotarget · doi:10.18632/oncotarget.14628 · Cited by 19
TNF-alpha inhibitors for the six treatment targets of psoriatic arthritis
Lubrano, E., Scriffignano, S., & Perrotta, F. M. (2019) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2020.1685382 · Cited by 19
Synthesis and Application of Selenium Nanoparticles for the Modulation of Inflammatory Diseases
Bai, X., Zhou, T., Wu, X., Chang, J. K., & Wu, X. (2025) · Nano Biomedicine and Engineering · doi:10.26599/nbe.2025.9290111 · Cited by 21
Applications of mRNA Delivery in Cancer Immunotherapy
Pan, X., Zhang, Y.-W.-Q., Dai, C., Zhang, J., Zhang, M., & Chen, X. X. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s500520 · Cited by 19
Tumor necrosis factor suppresses interleukin 10 in peripheral B cells via upregulating Bcl2‐like protein 12 in patients with inflammatory bowel disease
Guo, X., Li, M., Li, S., Liu, F., Liu, Z., & Yang, P. (2017) · Cell Biochemistry and Function · doi:10.1002/cbf.3250 · Cited by 18
Review and prospect of immune checkpoint blockade therapy represented by PD-1/PD-L1 in the treatment of clear cell renal cell carcinoma
Ge, W., Song, S., Qi, X., Chen, F., Che, X., Sun, Y., Wang, J., Li, X., Liu, N., Wang, Q., et al. (2023) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2023.027942 · Cited by 18
Kindlin-2 controls angiogenesis through modulating Notch1 signaling
Dong, Y., Ma, G., Hou, X., Han, Y., Ding, Z., Tang, W., Chen, L., Chen, Y., Zhou, B., Rao, F., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04866-w · Cited by 18
Cell death classification: A new insight based on molecular mechanisms
Dehghan, S., Kheshtchin, N., Hassannezhad, S., & Soleimani, M. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113860 · Cited by 21
Inter-cell type interactions that control JNK signaling in the Drosophila intestine
Zhang, P., Pronovost, S. M., Marchetti, M., Zhang, C., Kang, X., Kandelouei, T., Li, C., & Edgar, B. A. (2024) · Nature Communications · doi:10.1038/s41467-024-49786-w · Cited by 18
Uterine epithelial expression of the tumor necrosis factor superfamily: a strategy for immune privilege during pregnancy in a true epitheliochorial placentation species
Yoo, I., Kye, Y.-C., Han, J., Kim, M., Lee, S., Jung, W., Hong, M., Park, T. S., Yun, C., & Ka, H. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioz233 · Cited by 18
Positive lymph‐node breast cancer patients – activation of NF ‐κB in tumor‐associated leukocytes stimulates cytokine secretion that promotes metastasis via C‐C chemokine receptor CCR 7
Elghonaimy, E. A., El‐Shinawi, M., Ibrahim, S., Elghazaly, H. A., Abdeltawab, R. E., Nouh, M. A., El‐Mamlouk, T., & Mohamed, M. M. (2014) · FEBS Journal · doi:10.1111/febs.13124 · Cited by 18
Identification and analysis of divergent immune gene families within the Tasmanian devil genome
Morris, K., Cheng, Y., Warren, W. C., Papenfuss, A. T., & Belov, K. (2015) · BMC Genomics · doi:10.1186/s12864-015-2206-9 · Cited by 18
Animal models of infection-induced acute lung injury
Tan, W., Qi, L., & Tan, Z. (2024) · Experimental Lung Research · doi:10.1080/01902148.2024.2428939 · Cited by 19
A fascinating story of the discovery & development of biologicals for use in clinical medicine
MALAVIYA, A. N., & Mehra, N. K. (2018) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_1471_18 · Cited by 18
CSF1R Inhibition Combined with GM-CSF Reprograms Macrophages and Disrupts Protumoral Interplays with AML Cells
Смирнова, Т. А., Spertini, C., & Spertini, O. (2021) · Cancers · doi:10.3390/cancers13215289 · Cited by 17
Enantioselective Effect of Chiral Small Molecules in SARS‐CoV‐2 Vaccine‐Induced Immune Response
Zhou, Z., Zhang, Y., Ji, H., Jin, Y., Chen, S., Duan, P., & Liu, Y. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202301085 · Cited by 17
Pituitary Tumor Transforming Gene 1 Induces Tumor Necrosis Factor-α Production from Keratinocytes: Implication for Involvement in the Pathophysiology of Psoriasis
Ishitsuka, Y., Kawachi, Y., Maruyama, H., Taguchi, S., Fujisawa, Y., Furuta, J., Nakamura, Y., Ishii, Y., & Otsuka, F. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.189 · Cited by 17
Nef, the shuttling molecular adaptor of HIV, influences the cytokine network
Percario, Z. A., Ali, M., Mangino, G., & Affabris, E. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.11.010 · Cited by 17
Manipulation of Innate Immunity for Cancer Therapy in Dogs
Regan, D. P., & DOW, S. W. (2015) · Veterinary Sciences · doi:10.3390/vetsci2040423 · Cited by 17
Sphingomyelinase D inhibits store-operated Ca2+ entry in T lymphocytes by suppressing ORAI current
Combs, D. J., & Lü, Z. (2015) · The Journal of General Physiology · doi:10.1085/jgp.201511359 · Cited by 17
Developmental HSC Microenvironments: Lessons from Zebrafish
Nik, S., Weinreb, J. T., & Bowman, T. V. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-69194-7_4 · Cited by 17
Immunotherapy in Psoriasis
Landeck, L., Sabat, R., Ghoreschi, K., Man, X., Fuhrmeister, K., Gonzalez-Martinez, E., & Asadullah, K. (2021) · Immunotherapy · doi:10.2217/imt-2020-0292 · Cited by 17
Plasma proteomics reveals early, broad release of chemokine, cytokine, TNF, and interferon mediators following trauma with delayed increases in a subset of chemokines and cytokines in patients that remain critically ill
Bonaroti, J. W., Billiar, I. M., Moheimani, H., Wu, J., Namas, R. A., Li, S. R., Kar, U. K., Yoram Vodovotz, B., Neal, M. D., Sperry, J. L., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1038086 · Cited by 18
Chemoprevention in gastrointestinal physiology and disease. Targeting the progression of cancer with natural products: a focus on gastrointestinal cancer
Khoogar, R., Kim, B.-C., Morris, J., & Wargovich, M. J. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00201.2015 · Cited by 17
Immune System Disorders: Hypersensitivity and Autoimmunity
Muñoz‐Carrillo, J. L., Castro-García, F. P., Chávez-Ruvalcaba, F., Chávez-Rubalcaba, I., Martínez-Rodríguez, J. L., & Hernández-Ruíz, M. (2018) · InTech eBooks · doi:10.5772/intechopen.75794 · Cited by 17
Strategic internal covalent cross-linking of TNF produces a stable TNF trimer with improved TNFR2 signaling
Ban, L., Kühtreiber, W. M., Butterworth, J., Okubo, Y., Vanamee, É. S., & Faustman, D. L. (2015) · Molecular and Cellular Therapies · doi:10.1186/s40591-015-0044-4 · Cited by 17
Discovery of highly potent TNFα inhibitors using virtual screen
Shen, Q., Chen, J., Wang, Q., Deng, X., Liu, Y., & Lai, L. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.07.091 · Cited by 17
At The Interface: Small-Molecule Inhibitors of Soluble Cytokines
Raavi, Koehler, A. N., & Vegas, A. J. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00469 · Cited by 18
Transitioning from native to synthetic receptors: broadening T-cell engineering and beyond
Li, Y., Liu, Y., & Lin, X. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01304-8 · Cited by 17
RKIP regulates bone marrow macrophage differentiation to mediate osteoclastogenesis and H-type vessel formation
Zheng, Z., Tao, S., Jin, J., Li, Y., Dai, L., Huang, Z., Zhao, Y., Huang, B. H., Saijilafu, Lin, W., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62972-8 · Cited by 17
CgTNF-2 promotes the proliferation of haemocytes by regulating the expressions of CgRunx and cell cycle related genes in the Pacific oyster Crassostrea gigas
Wu, W., Sun, J., Dong, M., Yang, Q., Yang, W., Zhang, T., Wang, L., & Song, L. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.108478 · Cited by 16
TNF Superfamily and ILC2 Activation in Asthma
Matsuyama, T., Salter, B., Fard, N. E., Machida, K., & Sehmi, R. (2024) · Biomolecules · doi:10.3390/biom14030294 · Cited by 16
Iridium complexes inhibit tumor necrosis factor-α by utilizing light and mixed ligands
Sauvageot, E., Lafite, P., Duverger, E., Marion, R., Hamel, M., Gaillard, S., Renaud, J., & Daniellou, R. (2016) · Journal of Organometallic Chemistry · doi:10.1016/j.jorganchem.2016.02.001 · Cited by 16
An explorative study on deep profiling of peripheral leukocytes to identify predictors for responsiveness to anti-tumour necrosis factor alpha therapies in ankylosing spondylitis: natural killer cells in focus
Schulte‐Wrede, U., Sörensen, T., Grün, J. R., Häupl, T., Hirseland, H., Steinbrich‐Zöllner, M., Wu, P., Radbruch, A., Poddubnyy, D., Sieper, J., et al. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1692-y · Cited by 16
Host-defense peptides AC12, DK16 and RC11 with immunomodulatory activity isolated from Hypsiboas raniceps skin secretion
Popov, C., Magalhães, B. S., Goodfellow, B. J., Bocca, A. L., Pereira, D. M., Andrade, P. B., Valentão, P., Pereira, P. J. B., Rodrigues, J. A., Júnior, P. H. D. H. V., et al. (2019) · Peptides · doi:10.1016/j.peptides.2018.12.007 · Cited by 16
Relative risk of tuberculosis in patients with rheumatic diseases managed with anti-tumour necrosis factor-alpha therapy: A nationwide cohort study
Aydın, V., Akıcı, A., İşli, F., Aksoy, M., Aydın, M., & Gürsöz, H. (2019) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12814 · Cited by 16
TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis
Ahmed, A. A., Rasheed, Z., Salem, T., Al‐Dhubaibi, M. S., Robaee, A. A. A., & Alzolibani, A. A. (2020) · BMC Medical Genetics · doi:10.1186/s12881-020-01043-9 · Cited by 16
C-tag TNF: a reporter system to study TNF shedding
Pinci, F., Gaidt, M. M., Jung, C., Kuut, G., Jackson, M. A., Bauernfried, S., & Hornung, V. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015248 · Cited by 16
Anti-tumor Necrosis Factor-Alpha Therapy and Hypoglycemia: A Real-World Pharmacovigilance Analysis
Zhou, Y., Xie, W., Wang, L., Zhu, X., Liu, L., Liu, L., Zhu, S., & Wang, L. (2022) · Drug Safety · doi:10.1007/s40264-022-01210-2 · Cited by 16
Role of PTEN in TNFα induced insulin resistance
Bulger, D. A., Conley, J., Conner, S., Majumdar, G., & Solomon, S. S. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.04.063 · Cited by 16
2′-Hydroxy flavanone derivatives as an inhibitors of pro-inflammatory mediators: Experimental and molecular docking studies
Patel, N. K., Bairwa, K., Gangwal, R. P., Jaiswal, G., Jachak, S. M., Sangamwar, A. T., & Bhutani, K. K. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.03.025 · Cited by 16
Comparison of cytokine expressions in acute myocardial infarction and stable angina stages of coronary artery disease.
Yan, W., Wen, S., Wang, L., Duan, Q., & Ding, L. (2015) · PubMed Central · Cited by 16
TNF-alpha: Roles in pathogenesis and therapeutics in cancer
Valenzuela-Cardenas, M., & Nowicki, T. S. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111251 · Cited by 18
A meta-analysis of tumor necrosis factor-α and FAS/FASL polymorphisms with risk of pre-eclampsia
Lin, Y., Wang, L., Yan, Y., Zhou, W., & Chen, Z. (2019) · Hypertension in Pregnancy · doi:10.1080/10641955.2018.1543432 · Cited by 15
Langerhans cells orchestrate apoptosis of DNA‐damaged keratinocytes upon high‐dose UVB skin exposure
Ortner, D., Strandt, H., Tripp, C. H., Spoeck, S., Seretis, A., Hornsteiner, F., Dieckmann, S. M., Schmuth, M., & Stoitzner, P. (2024) · European Journal of Immunology · doi:10.1002/eji.202451020 · Cited by 15
Anti-inflammatory and antibacterial hydrogel based on a polymerizable ionic liquid
Romero-Antolìn, J. A., Gómez‐Cerezo, N., Manzano, M., Pablos, J. L., & Vallet‐Regí, M. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.03.015 · Cited by 15
Tumor necrosis factor superfamily member 13 is a novel biomarker for diagnosis and prognosis and promotes cancer cell proliferation in laryngeal squamous cell carcinoma
Wang, R., Guo, Y., Ma, H., Feng, L., Wang, Q., Chen, X., Lian, M., Wang, H., & Fang, J. (2015) · Tumor Biology · doi:10.1007/s13277-015-4016-8 · Cited by 15
Molecular pathways driving disease-specific alterations of intestinal epithelial cells
López-Posadas, R., Neurath, M. F., & Atreya, I. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2363-2 · Cited by 16
Association of TNFRSF1B Promoter Polymorphisms with Human Disease: Further Studies Examining T-Regulatory Cells Are Required
Li, H., & Anderson, S. K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00443 · Cited by 15
Analysis of therapeutic potential of preclinical models based on DR3/TL1A pathway modulation (Review)
Yu, Y., Jiang, P., Sun, P., Su, N., & Lin, F. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10125 · Cited by 15
In silico database screening of potential targets and pathways of compounds contained in plants used for psoriasis vulgaris
May, B. H., Deng, S., Zhang, A. L., Lu, C., & Xue, C. C. (2015) · Archives of Dermatological Research · doi:10.1007/s00403-015-1577-8 · Cited by 15
Sixteen kiwi (Apteryx spp) transcriptomes provide a wealth of genetic markers and insight into sex chromosome evolution in birds
Ramstad, K. M., Miller, H. C., & Kolle, G. (2016) · BMC Genomics · doi:10.1186/s12864-016-2714-2 · Cited by 15
Quantitative analysis of cell surface antigen-antibody interaction using Gaussia princeps luciferase antibody fusion proteins
Kums, J., Nelke, J., Rüth, B., Schäfer, V., Siegmund, D., & Wajant, H. (2017) · mAbs · doi:10.1080/19420862.2016.1274844 · Cited by 15
Increased cytokines production and oxidative stress are related with purinergic signaling and cell survival in post-thyroidectomy hypothyroidism
Baldissarelli, J., Mânica, A., Pillat, M. M., Bagatini, M. D., Leal, D. B. R., Abdalla, F. H., Morsch, V. M., Ulrich, H., Bornemann, C. P., & Schetinger, M. R. C. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110594 · Cited by 15
Is the callus shape an optimal response to a mechanobiological stimulus?
Ribeiro, F. O., Folgado, J., García‐Aznar, J. M., Gómez‐Benito, M. J., & Fernandes, P. R. (2014) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2014.07.015 · Cited by 15
Inflammatory Biomarker Responses to Whole-Body Vibration in Subjects with Different Clinical Status: A Systematic Review
Moreira-Marconi, E., Teixeira-Silva, Y., de Meirelles, A. G., Melo-Oliveira, M. E. D. S., Santos, A. C. G., Reis-Silva, A., Paineiras-Domingos, L. L., Seixas, A., Dionello, C. D. F., de Sá-Caputo, D. D. C., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192214853 · Cited by 14
The double roles of T cell-mediated immune response in the progression of MASLD
Li, Z., Wang, S., Xu, Q., Su, X., Wang, Y., Wang, L., & Zhang, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116333 · Cited by 15
Saikosaponin A alleviates depressive-like behavior induced by reserpine in mice by regulating gut microflora and inflammatory responses
Wang, M., Li, H., Zhang, W., Zhang, L., Wang, S., Miao, J., Jia, L., Zhang, Y., Gao, H., Zhang, X., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0311207 · Cited by 14
Deletion of tumour necrosis factor α receptor 1 elicits an increased TH17 immune response in the chronically inflamed liver
Berkhout, L. K., Barikbin, R., Schiller, B., Ravichandran, G., Krech, T., Neumann, K., Sass, G., & Tiegs, G. (2019) · Scientific Reports · doi:10.1038/s41598-019-40324-z · Cited by 14
CTRP-1 levels are related to insulin resistance in pregnancy and gestational diabetes mellitus
Deischinger, C., Leitner, K., Baumgartner-Parzer, S. M., Bancher‐Todesca, D., Kautzky‐Willer, A., & Harreiter, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-74413-1 · Cited by 14
The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-α-Induced Cell Death Triggered by RIPK1
Shimada, T., Kudoh, Y., Noguchi, T., Kagi, T., Suzuki, M., Tsuchida, M., Komatsu, H., Takahashi, M., Hirata, Y., & Matsuzawa, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115796 · Cited by 14
Progress in the efficacy and mechanism of spinal cord stimulation in neuropathological pain
Li, S., Li, J., Xu, H., Liu, Y., Yang, T., & Yuan, H. (2022) · Ibrain · doi:10.1002/ibra.12020 · Cited by 14
Nanotechnology to the Rescue: Therapeutic Strategies Based on Brown Algae for Neurodegenerative Diseases
Gonçalves, A., Fernandes, M. S., Lima, M., Gomes, J. P., Silva, F., Castro, S., Sampaio, F., & Gomes, A. C. (2023) · Applied Sciences · doi:10.3390/app13031883 · Cited by 14
Status Quo and Future Perspectives of Molecular and Genomic Studies on the Genus Biomphalaria—The Intermediate Snail Host of Schistosoma mansoni
Au, M. F. F., Williams, G. A., & Hui, J. H. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054895 · Cited by 14
Computational identification and analysis of signaling subnetworks with distinct functional roles in the regulation of TNF production
Tomaiuolo, M., Kottke, M. A., Matheny, R. W., Jaques Reifman, A., & Mitrophanov, A. Y. (2016) · Molecular BioSystems · doi:10.1039/c5mb00456j · Cited by 14
Current position of TNF-α in melanomagenesis
Nenu, I., Tudor, D. V., Filip, G. A., & Bâldea, I. (2015) · Tumor Biology · doi:10.1007/s13277-015-3639-0 · Cited by 16
Contribution of Mass Spectrometry-Based Proteomics to the Understanding of TNF-α Signaling
Ciuffa, R., Caron, É., Leitner, A., Uliana, F., Gstaiger, M., & Aebersold, R. H. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00728 · Cited by 14
Does progranulin account for the opposite effects of etanercept and infliximab/adalimumab in osteoarthritis?
Wei, J., Buza, J. A., & Liu, C.-J. (2015) · Journal of Orthopaedic Research® · doi:10.1002/jor.23091 · Cited by 14
The immune‐enhancing effect and in vitro antioxidant ability of different fractions separated from Colla corii asini
Zhang, G., Guo, F., Zeng, M., Wang, Z., Qin, F., Chen, J., Zheng, Z., & He, Z. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14174 · Cited by 13
The potential mechanism of Guizhi Fuling Wan effect in the treatment of cervical squamous cell carcinoma: A bioinformatics analysis investigation
Wang, X., Wang, T., Jiang, X., Ruan, Y., Wang, J., & Qi, C. (2024) · Medicine · doi:10.1097/md.0000000000037153 · Cited by 13
Research on the role and mechanism of IL-17 in intervertebral disc degeneration
Peng, B., Qian, L., Chen, J., & Wang, Z. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111992 · Cited by 13
Paradoxical and bimodal immune‐mediated dermatological side effects of TNF‐α inhibitors: A comprehensive review
Behrangi, E., Moodi, F., Jafarzadeh, A., & Goodarzi, A. (2024) · Skin Research and Technology · doi:10.1111/srt.13718 · Cited by 13
Vaccine induced mucosal and systemic memory NK/ILCs elicit decreased risk of SIV/SHIV acquisition
Rahman, M. A., de Castro, I. S., Schifanella, L., Bissa, M., & Franchini, G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1441793 · Cited by 13
Biomarkers Involved in the Pathogenesis of Hemophilic Arthropathy
Bădulescu, O. V., Scripcariu, D. V., Bădescu, M. C., Ciocoiu, M., Vladeanu, M. C., Pleșoianu, C. E., Bojan, A., Iliescu-Halițchi, D., Tudor, R., Huzum, B., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189897 · Cited by 13

Authors: Aggarwal, B. B., Gupta, S. C., & Kim, J. H.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
ORCID: Aggarwal, Bharat B.
Gupta, Subash C.
Venue: Blood
Publisher: American Society of Hematology
Published: 2012-01-19
Volume: 119
Issue: 3
Pages: 651-665
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2011-04-325225
PMC: PMC3265196
OpenAlex: W1989219560
Cited by: 877
References: 144
Citations by year: 2026: 35 · 2025: 76 · 2024: 72 · 2023: 82 · 2022: 57 · 2021: 74 · 2020: 76 · 2019: 62 · 2018: 45 · 2017: 59 · 2016: 62 · 2015: 70 · 2014: 49 · 2013: 41 · 2012: 13
FWCI: 3.08
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (CA-16 672, 16672, CA-124787-01A2)
Genentech
University of California, San Francisco
National Cancer Institute (CA-16672, P01CA124787, CA-124787-01A2, P30CA016672)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: TNF-α, TNF superfamily, lymphotoxin, TNF receptor, TNF-alpha inhibitors, apoptosis, inflammation, angiogenesis, metastasis, drug development, rheumatoid arthritis, psoriasis, Crohn's disease, osteoporosis
MeSH terms: Humans, Neoplasms, Tumor Necrosis Factor-alpha, History, 20th Century, History, 21st Century

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks