The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells
Open accessAbstract
Human mucosal associated invariant T (MAIT) CD8+ and Tc17 cells are important tissue-homing cell populations, characterized by high expression of CD161 (++) and type-17 differentiation, but their origins and relationships remain poorly defined. By transcriptional and functional analyses, we demonstrate that a pool of polyclonal, precommitted type-17 CD161++CD8αβ+ T cells exist in cord blood, from which a prominent MAIT cell (TCR Vα7.2+) population emerges post-natally. During this expansion, CD8αα T cells appear exclusively within a CD161++CD8+/MAIT subset, sharing cytokine production, chemokine-receptor expression, TCR-usage, and transcriptional profiles with their CD161++CD8αβ+ counterparts. Our data demonstrate the origin and differentiation pathway of MAIT-cells from a naive type-17 precommitted CD161++CD8+ T-cell pool and the distinct phenotype and function of CD8αα cells in man.
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Ussher, J. E., Bilton, M., Attwod, E., Shadwell, J., Richardson, R., de Lara, C., Mettke, E., Kurioka, A., Hansen, T. H., Klenerman, P., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201343509 · Cited by 543
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MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets
Kurioka, A., Ussher, J. E., Cosgrove, C., Clough, C., Fergusson, J. R., Smith, K., Kang, Y.-H., Walker, L. J., Hansen, T. H., Willberg, C. B., et al. (2015) · Mucosal Immunology · doi:10.1038/mi.2014.81 · Cited by 398
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Metadata
- Authors
- Walker, L. J., Kang, Y.-H., Smith, M. O., Tharmalingham, H., Ramamurthy, N., Fleming, V. M., Sahgal, N., Leslie, A., Oo, Y., Geremia, A., Scriba, T. J., Hanekom, W. A., Lauer, G. M., Lantz, O., Adams, D. H., Powrie, F., Barnes, E., & Klenerman, P.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-01-12
- Volume
- 119
- Issue
- 2
- Pages
- 422-433
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2049739427
- Cited by
- 255
- References
- 37
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Walker, L. J., Kang, Y.-H., Smith, M. O., Tharmalingham, H., Ramamurthy, N., Fleming, V. M., Sahgal, N., Leslie, A., Oo, Y., Geremia, A., Scriba, T. J., Hanekom, W. A., Lauer, G. M., Lantz, O., Adams, D. H., Powrie, F., Barnes, E., & Klenerman, P. (2012). Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells. Blood. https://doi.org/10.1182/blood-2011-05-353789
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
