The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Mesenchymal stromal cells orchestrate follicular lymphoma cell niche through the CCL2-dependent recruitment and polarization of monocytes
Open accessAbstract
Accumulating evidence indicates that infiltrating stromal cells contribute directly and indirectly to tumor growth in a wide range of cancers. In follicular lymphoma (FL), malignant B cells are found admixed with heterogeneous lymphoid-like stromal cells within invaded lymph nodes and BM. In addition, mesenchymal stromal cells (MSCs) support in vitro FL B-cell survival, in particular after their engagement toward lymphoid differentiation. We show here that BM-MSCs obtained from patients with FL (FL-MSCs) display a specific gene expression profile compared with MSCs obtained from healthy age-matched donors (HD-MSCs). This FL-MSC signature is significantly enriched for genes associated with a lymphoid-like commitment. Interestingly, CCL2 could be detected at a high level within the FL-cell niche, is up-regulated in HD-MSCs by coculture with malignant B cells, and is overexpressed by FL-MSCs, in agreement with their capacity to recruit monocytes more efficiently than HD-MSCs. Moreover, FL-MSCs and macrophages cooperate to sustain malignant B-cell growth, whereas FL-MSCs drive monocyte differentiation toward a proangiogenic and lipopolysaccharide-unresponsive phenotype close to that of tumor-associated macrophages. Altogether, these results highlight the complex role of FL stromal cells that promote direct tumor B-cell growth and orchestrate FL-cell niche, thus emerging as a potential therapeutic target in this disease.
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Cites
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
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Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
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Self-citationBone marrow mesenchymal stem cells are abnormal in multiple myeloma
Corre, J., Mahtouk, K., Attal, M., Gadelorge, M., Huynh, A., Fleury-Cappellesso, S., Danho, C., Laharrague, P., Klein, B., Rème, T., et al. (2007) · Leukemia · doi:10.1038/sj.leu.2404621 · Cited by 328
Cited by
Macrophage plasticity and polarization in tissue repair and remodelling
Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384
Targeting B cell receptor signalling in cancer: preclinical and clinical advances
Burger, J. A., & Wiestner, A. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.121 · Cited by 431
Pathogenesis of follicular lymphoma
Kridel, R., Sehn, L. H., & Gascoyne, R. D. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63186 · Cited by 310
Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells
Boice, M., Salloum, D., Mourcin, F., Sanghvi, V., Amin, R., Oricchio, E., Jiang, M., Mottok, A., Denis-Lagache, N., Ciriello, G., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.032 · Cited by 257
Self-citationRecent discoveries concerning the tumor - mesenchymal stem cell interactions
Lazennec, G., & Lam, P. Y. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.10.004 · Cited by 117
Metadata
- Authors
- Guilloton, F., Caron, G., Ménard, C., Pangault, C., Amé-Thomas, P., Dulong, J., De Vos, J., Rossille, D., Henry, C., Lamy, T., Fouquet, O., Fest, T., & Tarte, K.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-03-15
- Volume
- 119
- Issue
- 11
- Pages
- 2556-2567
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2017223956
- Cited by
- 159
- References
- 7
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Guilloton, F., Caron, G., Ménard, C., Pangault, C., Amé-Thomas, P., Dulong, J., De Vos, J., Rossille, D., Henry, C., Lamy, T., Fouquet, O., Fest, T., & Tarte, K. (2012). Mesenchymal stromal cells orchestrate follicular lymphoma cell niche through the CCL2-dependent recruitment and polarization of monocytes. Blood. https://doi.org/10.1182/blood-2011-08-370908
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