Recent discoveries concerning the tumor - mesenchymal stem cell interactions

Lazennec, Gwendal; Lam, Paula Y.

doi:10.1016/j.bbcan.2016.10.004

Cited by 117Mesenchymal stem cell researchCancer Cells and MetastasisTGF-β signaling in diseases

Recent discoveries concerning the tumor - mesenchymal stem cell interactions

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Lazennec, Gwendal, Lam, Paula Y.·2016·Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

DOI 10.1016/j.bbcan.2016.10.004

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Abstract

Tumor microenvironment plays a crucial role in coordination with cancer cells in the establishment, growth and dissemination of the tumor. Among cells of the microenvironment, mesenchymal stem cells (MSCs) and their ability to evolve into cancer associated fibroblasts (CAFs) have recently generated a major interest in the field. Numerous studies have described the potential pro- or anti-tumorigenic action of MSCs. The goal of this review is to synthesize recent and emerging discoveries concerning the mechanisms by which MSCs can be attracted to tumor sites, how they can generate CAFs and by which way MSCs are able to modulate the growth, response to treatments, angiogenesis, invasion and metastasis of tumors. The understanding of the role of MSCs in tumor development has potential and clinical applications in terms of cancer management.

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The pro- or anti-tumorigenic effect of mesenchymal stromal cells on tumour progression depends mainly on the mesenchymal stromal cell source and the tumour model used.
“The pro- or anti-tumorigenic effect of MSCs on tumour progression depends mainly on the MSC source and the tumour model used [31].”
From Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice (2019) · cites this paper as [31]

Human mesenchymal stem cells modulate allogeneic immune cell responses
Aggarwal, S., & Pittenger, M. F. (2005) · Blood · doi:10.1182/blood-2004-04-1559 · Cited by 4,511 · see citing works
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715 · see citing works
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
Karnoub, A. E., Dash, A. B., Vo, A. P., Sullivan, A., Brooks, M. W., Bell, G. W., Richardson, A. L., Polyak, K., Tubo, R., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06188 · Cited by 3,206 · see citing works
Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production
Németh, K., Leelahavanichkul, A., Yuen, P. S. T., Mayer, B., Parmelee, A., Doi, K., Robey, P. G., Leelahavanichkul, K., Koller, B. H., Brown, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1905 · Cited by 2,364 · see citing works
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
Uyttenhove, C., Pilotte, L., Théate, I., Stroobant, V., Colau, D., Parmentier, N., Boon, T., & Van den Eynde, B. J. (2003) · Nature Medicine · doi:10.1038/nm934 · Cited by 2,305 · see citing works
Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase–mediated tryptophan degradation
Meisel, R., Zibert, A., Laryea, M. D., Göbel, U., Däubener, W., & Dilloo, D. (2004) · Blood · doi:10.1182/blood-2003-11-3909 · Cited by 1,638 · see citing works
A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype
Waterman, R. S., Tomchuck, S. L., Henkle, S. L., & Betancourt, A. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010088 · Cited by 1,238 · see citing works
Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals
Djouad, F., Plence, P., Bony, C., Tropel, P., Apparailly, F., Sany, J., Noël, D., & Jorgensen, C. (2003) · Blood · doi:10.1182/blood-2003-04-1193 · Cited by 1,166 · see citing works
Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
Quante, M., Tu, S. P., Tomita, H., Gonda, T. A., Wang, S. S. W., Takashi, S., Baik, G. H., Shibata, W., DiPrete, B. L., Betz, K. S., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.01.020 · Cited by 1,047 · see citing works
Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells
Mishra, P. J., Mishra, P. J., Humeniuk, R., Medina, D. J., Alexe, G., Mesirov, J. P., Ganesan, S., Glod, J. W., & Banerjee, D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0943 · Cited by 912 · see citing works
Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression
Spaeth, E. L., Dembinski, J. L., Sasser, A. K., Watson, K., Klopp, A., Hall, B., Andreeff, M., & Marini, F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004992 · Cited by 807 · see citing works
BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression
Roccaro, A. M., Sacco, A., Maiso, P., Azab, A. K., Tai, Y., Reagan, M. R., Azab, F., Flores, L. M., Campigotto, F., Weller, E. A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66517 · Cited by 794 · see citing works
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
Khakoo, A. Y., Pati, S., Anderson, S. A., Reid, W., Elshal, M. F., Rovira, I. I., Nguyen, A. T., Malide, D., Combs, C. A., Hall, G., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051921 · Cited by 747 · see citing works
Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma
Lou, G., Song, X., Yang, F., Wu, S., Wang, J., Chen, Z., & Liu, Y. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0220-7 · Cited by 700 · see citing works
MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2
Spaggiari, G. M., Abdelrazik, H., Becchetti, F., & Moretta, L. (2009) · Blood · doi:10.1182/blood-2009-02-203943 · Cited by 670 · see citing works
Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells
Ono, M., Kosaka, N., Tominaga, N., Yoshioka, Y., Takeshita, F., Takahashi, R.-U., Yoshida, M., Tsuda, H., Tamura, K., & Ochiya, T. (2014) · Science Signaling · doi:10.1126/scisignal.2005231 · Cited by 663 · see citing works
Chemokines and chemokine receptors: new insights into cancer-related inflammation
Lazennec, G., & Richmond, A. J. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.01.003 · Cited by 651 · see citing works
Self-citation
Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells
Lee, J.-K., Park, S., Jung, B.-K., Jeon, Y., Lee, Y.-S., Kim, M.-K., Kim, Y.-G., Jang, J.-Y., & Kim, C.-W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084256 · Cited by 647 · see citing works
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
Liu, S., Ginestier, C., Ou, S. J., Clouthier, S. G., Patel, S. H., Monville, F., Korkaya, H., Heath, A., Dutcher, J., Kleer, C. G., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-0538 · Cited by 611 · see citing works
Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo
Zhu, W., Huang, L., Li, Y., Zhang, X., Gu, J., Yan, Y., Xu, X., Wang, M., Qian, H., & Xu, W. (2012) · Cancer Letters · doi:10.1016/j.canlet.2011.10.002 · Cited by 488 · see citing works
Toll-Like Receptors on Human Mesenchymal Stem Cells Drive Their Migration and Immunomodulating Responses
Tomchuck, S. L., Zwezdaryk, K. J., Coffelt, S. B., Waterman, R. S., Danka, E. S., & Scandurro, A. B. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0563 · Cited by 449 · see citing works
Monocyte Chemotactic Protein-1 Secreted by Primary Breast Tumors Stimulates Migration of Mesenchymal Stem Cells
Dwyer, R. M., Potter-Beirne, S. M., Harrington, K. A., Lowery, A., Hennessy, E., Murphy, M. J., Barry, F., O’Brien, T., & Kerin, M. J. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0731 · Cited by 431 · see citing works
VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma
Beckermann, B. M., Kallifatidis, G., Groth, A., Frommhold, D., Apel, A., Mattern, J., Salnikov, A. V., Moldenhauer, G., Wagner, W., Diehlmann, A., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604508 · Cited by 406 · see citing works
Mesenchymal Stem Cell–Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow
Bliss, S. A., Sinha, G., Sandiford, O. A., Williams, L. M., Engelberth, D. J., Guiro, K., Isenalumhe, L. L., Greco, S. J., Ayer, S., Bryan, M., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1092 · Cited by 383 · see citing works
Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production
McLean, K., Gong, Y., Choi, Y., Deng, N., Yang, K., Bai, S., Cabrera, L., Keller, E., McCauley, L., Cho, K. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45273 · Cited by 380 · see citing works
CCR2-Dependent Recruitment of Macrophages by Tumor-Educated Mesenchymal Stromal Cells Promotes Tumor Development and Is Mimicked by TNFα
Ren, G., Zhao, X., Wang, Y., Zhang, X., Chen, X., Xu, C., Yuan, Z.-R., Roberts, A. I., Zhang, L., Zheng, H. B., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.08.013 · Cited by 363 · see citing works
Oestrogen receptor negative breast cancers exhibit high cytokine content
Chavey, C., Bibeau, F., Gourgou-Bourgade, S., Burlinchon, S., Boissière, F., Laune, D., Roques, S., & Lazennec, G. (2007) · Breast Cancer Research · doi:10.1186/bcr1648 · Cited by 357 · see citing works
Self-citation
MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function
Caicedo, A., Fritz, V., Brondello, J., Ayala, M., Dennemont, I., Abdellaoui, N., de Fraipont, F., Moisan, A., Angebault, C., Boukhaddaoui, H., et al. (2015) · Scientific Reports · doi:10.1038/srep09073 · Cited by 345 · see citing works
Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E2 Signaling
Li, H., Reinhardt, F., Herschman, H. R., & Weinberg, R. A. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0101 · Cited by 340 · see citing works
Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling
Qiao, L., Xu, Z.-L., Zhao, T.-J., Ye, L.-H., & Zhang, X.-D. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.04.032 · Cited by 313 · see citing works
Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids
Roodhart, J. M. L., Daenen, L. G. M., Stigter, E. C. A., Prins, H.-J., Gerrits, J., Houthuijzen, J. M., Gerritsen, M. G., Schipper, H. S., Backer, M. J. G., van Amersfoort, M., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.08.010 · Cited by 305 · see citing works
Tumor Irradiation Increases the Recruitment of Circulating Mesenchymal Stem Cells into the Tumor Microenvironment
Klopp, A. H., Spaeth, E. L., Dembinski, J. L., Woodward, W. A., Munshi, A., Meyn, R. E., Cox, J. D., Andreeff, M., & Marini, F. C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1406 · Cited by 304 · see citing works
The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells
Coffelt, S. B., Marini, F. C., Watson, K., Zwezdaryk, K. J., Dembinski, J. L., LaMarca, H. L., Tomchuck, S. L., zu Bentrup, K. H., Danka, E. S., Henkle, S. L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900244106 · Cited by 292 · see citing works
Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT)
Martin, F. T., Dwyer, R. M., Kelly, J., Khan, S., Murphy, J. M., Curran, C., Miller, N., Hennessy, E., Dockery, P., Barry, F. P., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0734-1 · Cited by 290 · see citing works
Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts
Chowdhury, R., Webber, J. P., Gurney, M., Mason, M. D., Tabi, Z., & Clayton, A. (2014) · Oncotarget · doi:10.18632/oncotarget.2711 · Cited by 272 · see citing works
Concise Review: Adult Multipotent Stromal Cells and Cancer: Risk or Benefit?
Lazennec, G., & Jørgensen, C. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1006 · Cited by 256 · see citing works
Self-citation
Concentration of interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) in blood serum of breast cancer patients.
Kozłowski, L., Zakrzewska, I., Tokajuk, P., & Wojtukiewicz, M. Z. (2003) · PubMed · Cited by 248 · see citing works
Differential Gene Expression Associated with Migration of Mesenchymal Stem Cells to Conditioned Medium from Tumor Cells or Bone Marrow Cells
Menon, L. G., Picinich, S. C., Koneru, R., Gao, H., Lin, S. Y., Koneru, M., Mayer‐Kuckuk, P., Glod, J. W., & Banerjee, D. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0257 · Cited by 237 · see citing works
Human Bone Marrow-Derived Mesenchymal Stem Cells Suppress Human Glioma Growth Through Inhibition of Angiogenesis
Ho, I. A. W., Toh, H. C., Ng, W. H., Teo, Y. L., Guo, C. M., Hui, K. M., & Lam, P. Y. P. (2012) · Stem Cells · doi:10.1002/stem.1247 · Cited by 236 · see citing works
Self-citation
Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer
Ji, R., Zhang, B., Zhang, X., Xue, J., Yuan, X., Yan, Y., Wang, M., Zhu, W., Qian, H., & Xu, W. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1005530 · Cited by 235 · see citing works
Mesenchymal Stem Cells are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-β1
Barcellos‐de‐Souza, P., Comito, G., Segura, C. P., Taddei, M. L., Gori, V., Becherucci, V., Bambi, F., Margheri, F., Laurenzana, A., Rosso, M. D., et al. (2016) · Stem Cells · doi:10.1002/stem.2412 · Cited by 231 · see citing works
Mesenchymal stem cells promote growth and angiogenesis of tumors in mice
Huang, W.-H., Chang, M.-C., Tsai, K.-S., Hung, M., Chen, H.-L., & Hung, S.-C. (2012) · Oncogene · doi:10.1038/onc.2012.458 · Cited by 227 · see citing works
Interleukin‐6 is a potent growth factor for ER‐α‐positive human breast cancer
Sasser, A. K., Sullivan, N. J., Studebaker, A. W., Hendey, L. F., Axel, A. E., & Hall, B. M. (2007) · The FASEB Journal · doi:10.1096/fj.07-8832com · Cited by 222 · see citing works
Mesenchymal Stem Cell 1 (MSC1)-Based Therapy Attenuates Tumor Growth Whereas MSC2-Treatment Promotes Tumor Growth and Metastasis
Waterman, R. S., Henkle, S. L., & Betancourt, A. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045590 · Cited by 198 · see citing works
Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines
Birnbaum, T., Roider, J., Schankin, C. J., Padovan, C. S., Schichor, C., Goldbrunner, R., & Straube, A. M. (2007) · Journal of Neuro-Oncology · doi:10.1007/s11060-007-9332-4 · Cited by 188 · see citing works
Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis
Mi, Z., Bhattacharya, S. D., Kim, V. M., Guo, H., Talbot, L. J., & Kuo, P. C. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr009 · Cited by 179 · see citing works
Mesenchymal Stem Cells Promote Formation of Colorectal Tumors in Mice
Tsai, K., Yang, S., Lei, Y., Tsai, C., Chen, H., Hsu, C., Chen, L., Wang, H., Miller, S. A., Chiou, S., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.05.045 · Cited by 175 · see citing works
MSC-Regulated MicroRNAs Converge on the Transcription Factor FOXP2 and Promote Breast Cancer Metastasis
Cuiffo, B., Campagne, A., Bell, G. W., Lembo, A., Orso, F., Lien, E. C., Bhasin, M., Raimo, M., Hanson, S. E., Marusyk, A., et al. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.10.001 · Cited by 173 · see citing works
Mesenchymal stromal cells orchestrate follicular lymphoma cell niche through the CCL2-dependent recruitment and polarization of monocytes
Guilloton, F., Caron, G., Menard, C., Pangault, C., Amé-Thomas, P., Dulong, J., Vos, J. D., Delphine Rossille, A., Henry, C., Lamy, T., et al. (2012) · Blood · doi:10.1182/blood-2011-08-370908 · Cited by 159 · see citing works
Tumour cell–derived extracellular vesicles interact with mesenchymal stem cells to modulate the microenvironment and enhance cholangiocarcinoma growth
Haga, H., Yan, I. K., Takahashi, K., Wood, J. D., Zubair, A. C., & Patel, T. C. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.24900 · Cited by 159 · see citing works
Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion
Pinilla, S., Alt, E., Abdul Khalek, F. J., Jotzu, C., Muehlberg, F., Beckmann, C., & Song, Y.-H. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.04.013 · Cited by 156 · see citing works
Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling
Luo, J., Lee, S., Liang, L., Huang, C.-K., Li, L., Wen, S., & Chang, C. (2013) · Oncogene · doi:10.1038/onc.2013.233 · Cited by 151 · see citing works
Macrophage Migration Inhibitory Factor–CXCR4 Is the Dominant Chemotactic Axis in Human Mesenchymal Stem Cell Recruitment to Tumors
Lourenco, S. D. S., TEIXEIRA, V. H., Kalber, T. L., José, R. J. P., Floto, R. A., & Janes, S. M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402097 · Cited by 151 · see citing works
Concise review: Adult mesenchymal stromal cell therapy for inflammatory diseases: How well are we joining the dots?
Griffin, M. D., Elliman, S. J., Cahill, E., English, K., Ceredig, R. H., & Ritter, T. (2013) · Stem Cells · doi:10.1002/stem.1452 · Cited by 148 · see citing works
Matrix Metalloproteinase 1 Is Necessary for the Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells Toward Human Glioma
Ho, I. A. W., Chan, K. Y. W., Ng, W.-H., Guo, C. M., Hui, K. M., Cheang, P., & Lam, P. Y. P. (2009) · Stem Cells · doi:10.1002/stem.50 · Cited by 147 · see citing works
Self-citation
Macrophage-Associated Mesenchymal Stem Cells Assume an Activated, Migratory, Pro-Inflammatory Phenotype with Increased IL-6 and CXCL10 Secretion
Anton, K., Banerjee, D., & Glod, J. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035036 · Cited by 141 · see citing works
Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistanceviaa BMP4/HH signaling loop
Coffman, L. G., Choi, Y., McLean, K., Allen, B. L., di Magliano, M. P., & Buckanovich, R. J. (2016) · Oncotarget · doi:10.18632/oncotarget.6870 · Cited by 129 · see citing works
Mesenchymal Stromal Cells Protect Cancer Cells From ROS-induced Apoptosis and Enhance the Warburg Effect by Secreting STC1
Ohkouchi, S., Block, G. J., Katsha, A. M., Kanehira, M., Ebina, M., Kikuchi, T., Saijo, Y., Nukiwa, T., & Prockop, D. J. (2011) · Molecular Therapy · doi:10.1038/mt.2011.259 · Cited by 121 · see citing works
Adipose derived stem cells (ASCs) isolated from breast cancer tissue express IL-4, IL-10 and TGF-β1 and upregulate expression of regulatory molecules on T cells: Do they protect breast cancer cells from the immune response?
Razmkhah, M., Jaberipour, M., Erfani, N., Habibagahi, M., Talei, A.-R., & Ghaderi, A. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2010.09.005 · Cited by 116 · see citing works
Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice
Ljujić, B., Milovanović, M., Volarević, V., Murray, B. A., Bugarski, D. S., Przyborski, S. A., Arsenijević, N., Lukić, M. L., & Stojković, M. (2013) · Scientific Reports · doi:10.1038/srep02298 · Cited by 115 · see citing works
Human Bone Marrow-Derived Stem Cells Acquire Epithelial Characteristics through Fusion with Gastrointestinal Epithelial Cells
Ferrand, J., Noël, D., Lehours, P., Prochazkova‐Carlotti, M., Chambonnier, L., Ménard, A., Mégraud, F., & Varon, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019569 · Cited by 115 · see citing works
Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor Mediate Human Stem Cell Tropism to Malignant Solid Tumors
Gutova, M., Najbauer, J., Frank, R. T., Kendall, S. E., Gevorgyan, A., Metz, M. Z., Guevorkian, M., Edmiston, M., Zhao, D., Glackin, C. A., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0141 · Cited by 112 · see citing works
Gastric cancer-derived mesenchymal stem cells prompt gastric cancer progression through secretion of interleukin-8
Li, W., Zhou, Y., Yang, J., Zhang, X., Zhang, H., Zhang, T., Zhao, S., Zheng, P., Huo, J., & Wu, H. (2015) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-015-0172-3 · Cited by 112 · see citing works
Treatment of advanced gastrointestinal tumors with genetically modified autologous mesenchymal stromal cells (TREAT-ME1): study protocol of a phase I/II clinical trial
Nieß, H., von Einem, J. C., Thomas, M. N., Michl, M., Angele, M. K., Huss, R., Günther, C., Nelson, P. J., Bruns, C. J., & Heinemann, V. (2015) · BMC Cancer · doi:10.1186/s12885-015-1241-x · Cited by 111 · see citing works
Bone marrow-derived mesenchymal stromal cells are attracted by multiple myeloma cell-produced chemokine CCL25 and favor myeloma cell growth in vitro and in vivo
Xu, S., Menu, E., Becker, A. D., Van Camp, B., Vanderkerken, K., & Van Riet, I. (2012) · Stem Cells · doi:10.1002/stem.787 · Cited by 103 · see citing works
Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor
Halpern, J. L., Kilbarger, A. K., & Lynch, C. C. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.04.018 · Cited by 102 · see citing works
Spontaneous Formation of Tumorigenic Hybrids between Breast Cancer and Multipotent Stromal Cells Is a Source of Tumor Heterogeneity
Rappa, G., Mercapide, J., & Lorico, A. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.02.020 · Cited by 99 · see citing works
Targeted Methylation of Two Tumor Suppressor Genes Is Sufficient to Transform Mesenchymal Stem Cells into Cancer Stem/Initiating Cells
Teng, I.-W., Hou, P., Lee, K., Chu, P., Yeh, K., Jin, V. X., Tseng, M., Tsai, S., Chang, Y., Wu, C., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3418 · Cited by 98 · see citing works
Notch signalling drives bone marrow stromal cell-mediated chemoresistance in acute myeloid leukemia
Kamga, P. T., Bassi, G., Cassaro, A., Midolo, M., Trapani, M. D., Gatti, A., Carusone, R., Resci, F., Perbellini, O., Gottardi, M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7964 · Cited by 98 · see citing works
Characterization of an adaptive immune response in microsatellite-instable colorectal cancer
Boissière‐Michot, F., Lazennec, G., Frugier, H., Jarlier, M., Roca, L., Duffour, J., Paty, E. D., Laune, D., Blanchard, F., Pessot, F. L., et al. (2014) · OncoImmunology · doi:10.4161/onci.29256 · Cited by 96 · see citing works
Self-citation
Mesenchymal stem cell-derived exosomes facilitate nasopharyngeal carcinoma progression.
Shi, S., Zhang, Q., Xia, Y., You, B., Shan, Y., Bao, L., Li, L., You, Y., & Gu, Z. (2016) · PubMed Central · Cited by 96 · see citing works
Paracrine Factors of Human Fetal MSCs Inhibit Liver Cancer Growth Through Reduced Activation of IGF-1R/PI3K/Akt Signaling
Yulyana, Y., Ho, I. A. W., Sia, K. C., Newman, J. P. A., Toh, X. Y., Endaya, B., Chan, J. K. Y., Gnecchi, M., Huynh, H. T., Chung, A. Y. F., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.13 · Cited by 93 · see citing works
Self-citation
Bone marrow-derived mesenchymal stem cell-secreted IL-8 promotes the angiogenesis and growth of colorectal cancer
Wang, J., Wang, Y., Wang, S., Cai, J., Shi, J., Sui, X. Y., Cao, Y., Huang, W., Chen, X., Cai, Z., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5739 · Cited by 92 · see citing works
Involvement of Wnt/β-catenin signaling in the mesenchymal stem cells promote metastatic growth and chemoresistance of cholangiocarcinoma
Wang, W., Zhong, W., Yuan, J., Yan, C., Hu, S., Tong, Y., Mao, Y., Hu, T., Zhang, B., & Song, G. (2015) · Oncotarget · doi:10.18632/oncotarget.5514 · Cited by 92 · see citing works
Mesenchymal Stem Cells Induce Directional Migration of Invasive Breast Cancer Cells through TGF-β
McAndrews, K. M., McGrail, D. J., Ravikumar, N., & Dawson, M. (2015) · Scientific Reports · doi:10.1038/srep16941 · Cited by 89 · see citing works
Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase
Hajjami, H. M.-E., Amé-Thomas, P., Pangault, C., Tribut, O., Vos, J. D., Jean, R., Bescher, N., Monvoisin, C., Dulong, J., Lamy, T., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3000 · Cited by 85 · see citing works
Overexpression of CXC Chemokine Receptors Is Required for the Superior Glioma-Tracking Property of Umbilical Cord Blood-Derived Mesenchymal Stem Cells
Kim, D., Kim, J. H., Lee, J. K., Choi, S. J., Kim, J.-S., Jeun, S., Oh, W., Yang, Y. S., & Chang, J. W. (2008) · Stem Cells and Development · doi:10.1089/scd.2008.0050 · Cited by 85 · see citing works
Mesenchymal stem cells generate pericytes to promote tumor recurrence via vasculogenesis after stereotactic body radiation therapy
Wang, H.-H., Cui, Y.-L., Zaorsky, N. G., Lan, J., Deng, L., Zeng, X.-L., Wu, Z.-Q., Tao, Z., Guo, W.-H., Wang, Q.-X., et al. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.02.033 · Cited by 83 · see citing works
Human Mesenchymal Stroma/Stem Cells Exchange Membrane Proteins and Alter Functionality During Interaction with Different Tumor Cell Lines
Yang, Y., Otte, A., & Hass, R. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0413 · Cited by 82 · see citing works
Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells
Miklikova, S., Matúšková, M., Boháč, M., Toro, L., Durinikova, E., Tyčiaková, S., Demková, L., Gurský, J., & Kučerová, L. (2016) · Cell Communication and Signaling · doi:10.1186/s12964-016-0127-0 · Cited by 82 · see citing works
Mesenchymal stem cells promote colorectal cancer progression through AMPK/mTOR-mediated NF-κB activation
Wu, X., Liu, Y., Wang, G., Xu, X., Cai, Y., Wang, H., Li, Y., Meng, H., Dai, F., & Jin, J.-D. (2016) · Scientific Reports · doi:10.1038/srep21420 · Cited by 78 · see citing works
Immunosuppressive effect of bone marrow-derived mesenchymal stem cells in inflammatory microenvironment favours the growth of B16 melanoma cells
Han, Z., Tian, Z., Lv, G., Zhang, L., Jiang, G., Sun, K., Wang, C., Bu, X., Li, R., Shi, Y., et al. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01215.x · Cited by 76 · see citing works
IL-1β produced by aggressive breast cancer cells is one of the factors that dictate their interactions with mesenchymal stem cells through chemokine production
Escobar, P., Bouclier, C., Serret, J., Bièche, I., Brigitte, M., Caicedo, A., Sanchez, E., Vacher, S., Vignais, M., Bourin, P., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4732 · Cited by 76 · see citing works
Self-citation
Conditioned Medium from Adipose-Derived Stem Cells (ADSCs) Promotes Epithelial-to-Mesenchymal-Like Transition (EMT-Like) in Glioma Cells In vitro
Iser, I. C., Ceschini, S. M., Onzi, G. R., Bertoni, A. P. S., Lenz, G., & Wink, M. R. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9585-4 · Cited by 69 · see citing works
Role of mesenchymal stem cell-derived fibrinolytic factor in tissue regeneration and cancer progression
Heissig, B., Dhahri, D., Eiamboonsert, S., Salama, Y., Shimazu, H., Munakata, S., & Hattori, K. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2035-7 · Cited by 67 · see citing works
Multiple Facets of the DNA Damage Response Contribute to the Radioresistance of Mouse Mesenchymal Stromal Cell Lines
Sugrue, T., Brown, J. A. L., Lowndes, N. F., & Ceredig, R. (2012) · Stem Cells · doi:10.1002/stem.1222 · Cited by 66 · see citing works
Tumor Specific Recruitment and Reprogramming of Mesenchymal Stem Cells in Tumorigenesis
Berger, L., Shamai, Y., Skorecki, K. L., & Tzukerman, M. (2015) · Stem Cells · doi:10.1002/stem.2269 · Cited by 63 · see citing works
In Vitro Evidence of the Presence of Mesenchymal Stromal Cells in Cervical Cancer and Their Role in Protecting Cancer Cells from Cytotoxic T Cell Activity
Montesinos, J. J., Mora‐García, M. D. L., Mayani, H., Figueroa, E. F., García‐Rocha, R., Fajardo-Orduña, G. R., Castro-Manrreza, M. E., Weiss‐Steider, B., & Monroy, A. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0084 · Cited by 58 · see citing works
The isolation of novel mesenchymal stromal cell chemotactic factors from the conditioned medium of tumor cells
Lin, S., Yang, J. T., Everett, A. D., Clevenger, C. V., Koneru, M., Mishra, P. K., Kamen, B. A., BANERJEE, D., & Glod, J. W. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.07.028 · Cited by 54 · see citing works
Physical Intimacy of Breast Cancer Cells with Mesenchymal Stem Cells Elicits Trastuzumab Resistance through Src Activation
Daverey, A., Drain, A. P., & Kidambi, S. (2015) · Scientific Reports · doi:10.1038/srep13744 · Cited by 49 · see citing works
Secretome of human bone marrow mesenchymal stem cells: an emerging player in lung cancer progression and mechanisms of translation initiation
Attar‐Schneider, O., Zismanov, V., Drucker, L., & Gottfried, M. (2015) · Tumor Biology · doi:10.1007/s13277-015-4304-3 · Cited by 48 · see citing works
Treg/Th17 polarization by distinct subsets of breast cancer cells is dictated by the interaction with mesenchymal stem cells.
Patel, S. A., Dave, M. A., Bliss, S. A., Giec-Ujda, A. B., Bryan, M., Pliner, L. F., & Rameshwar, P. (2014) · Journal of Cancer Stem Cell Research · doi:10.14343/jcscr.2014.2e1003 · Cited by 46 · see citing works
H3K9me-Enhanced DNA Hypermethylation of the p16 INK4a Gene: An Epigenetic Signature for Spontaneous Transformation of Rat Mesenchymal Stem Cells
Zheng, Y., He, L., Wan, Y., & Song, J. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0172 · Cited by 43 · see citing works
Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasionviaaltering the CCL5/HIF2α/androgen receptor signals
Luo, J., Lee, S. O., Cui, Y., Yang, R., Li, L., & Chang, C. (2015) · Oncotarget · doi:10.18632/oncotarget.4515 · Cited by 39 · see citing works
Matrix metalloproteinase‐1‐mediated mesenchymal stem cell tumor tropism is dependent on crosstalk with stromal derived growth factor 1/C‐X‐C chemokine receptor 4 axis
Ho, I. A. W., Yulyana, Y., Sia, K. C., Newman, J. P. A., Guo, C. M., Hui, K. M., & Lam, P. Y. P. (2014) · The FASEB Journal · doi:10.1096/fj.14-252551 · Cited by 38 · see citing works
Self-citation
Inflammatory Chemokines MIP-1δ and MIP-3α Are Involved in the Migration of Multipotent Mesenchymal Stromal Cells Induced by Hepatoma Cells
Lejmi, E., Perriraz, N., Clément, S., Morel, P., Baertschiger, R. M., Christofilopoulos, P., Meier, R. P. H., Bosco, D., Bühler, L. H., & Gonelle‐Gispert, C. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0176 · Cited by 36 · see citing works
Pancreatic cancer cells activate CCL5 expression in mesenchymal stromal cells through the insulin‐like growth factor‐I pathway
Makinoshima, H., & Dezawa, M. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.061 · Cited by 34 · see citing works
CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells
Al-Toub, M., Vishnubalaji, R., Hamam, R., Kassem, M. S., Aldahmash, A. M., & Alajez, N. M. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0123-0 · Cited by 29 · see citing works
Loss of interactions between p53 and survivin gene in mesenchymal stem cells after spontaneous transformation in vitro
He, L., Zhao, F., Zheng, Y., Wan, Y., & Song, J. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.03.018 · Cited by 21 · see citing works
Mesenchymal Stem Cells Shed Amphiregulin at the Surface of Lung Carcinoma Cells in a Juxtacrine Manner
Carnet, O., Lecomte, J., Masset, A., Primac, I., Durré, T., Maertens, L., Detry, B., Blacher, S., Gilles, C., Péqueux, C., et al. (2015) · Neoplasia · doi:10.1016/j.neo.2015.07.002 · Cited by 16 · see citing works

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Nanomedicine in cancer therapy
Fan, D., Cao, Y., Cao, M., Wang, Y., Cao, Y., & Gong, T. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01536-y · Cited by 944 · see citing works
Obesity and adverse breast cancer risk and outcome: mechanistic insights and strategies for intervention
Picon-Ruiz, M., Morata-Tarifa, C., Valle-Goffin, J. J., Friedman, E., & Slingerland, J. (2017) · Ca · doi:10.3322/caac.21405 · Cited by 816 · see citing works
Tumor-associated neutrophils and neutrophil-targeted cancer therapies
Que, H., Fu, Q., Lan, T., Tian, X., & Wei, X. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188762 · Cited by 320 · see citing works
Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment
Whiteside, T. L. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.12.003 · Cited by 310 · see citing works
Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development
Papaccio, F., Paino, F., Regad, T., Papaccio, G., Desiderio, V., & Tirino, V. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0138 · Cited by 293 · see citing works
Challenges and Strategies for Improving the Regenerative Effects of Mesenchymal Stromal Cell-Based Therapies
Baldari, S., Rocco, G. D., Piccoli, M., Pozzobon, M., Muraca, M., & Toietta, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102087 · Cited by 281 · see citing works
Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer
Biswas, S., Mandal, G., Chowdhury, S. R., Purohit, S., Payne, K. K., Anadon, C. M., Gupta, A., Swanson, P., Yu, X., Conejo-Garcia, J. R., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900692 · Cited by 195 · see citing works
Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy
Vignais, M., Caicedo, A., Brondello, J., & Jørgensen, C. (2017) · Stem Cells International · doi:10.1155/2017/6917941 · Cited by 190 · see citing works
Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature
Pannunzio, A., & Coluccia, M. (2018) · Pharmaceuticals · doi:10.3390/ph11040101 · Cited by 171 · see citing works
Mesenchymal stromal cells in cancer: A review of their immunomodulatory functions and dual effects on tumor progression
Galland, S., & Stamenkovic, I. (2020) · The Journal of Pathology · doi:10.1002/path.5357 · Cited by 165 · see citing works
Bioengineered cellular and cell membrane-derived vehicles for actively targeted drug delivery: So near and yet so far
Thanuja, M. Y., Anupama, C., & Ranganath, S. H. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.06.012 · Cited by 156 · see citing works
Recruitment of stromal cells into tumour microenvironment promote the metastatic spread of breast cancer
Hill, B. S., Sarnella, A., D’Avino, G., & Zannetti, A. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.07.028 · Cited by 138 · see citing works
Tumor-educated mesenchymal stem cells promote pro-metastatic phenotype
Hill, B. S., Pelagalli, A., Passaro, N., & Zannetti, A. (2017) · Oncotarget · doi:10.18632/oncotarget.20265 · Cited by 110 · see citing works
Breast Cancer Tumor Stroma: Cellular Components, Phenotypic Heterogeneity, Intercellular Communication, Prognostic Implications and Therapeutic Opportunities
Eiró, N., González, L. O., Fraile, M., Cid, S., Schneider, J., & Vizoso, F. J. (2019) · Cancers · doi:10.3390/cancers11050664 · Cited by 104 · see citing works
Role of miRNAs in human cancer metastasis: Implications for therapeutic intervention
Jafri, M., Al-Qahtani, M. H., & Shay, J. W. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.02.004 · Cited by 100 · see citing works
Bone marrow‐derived mesenchymal stem cells promote invasiveness and transendothelial migration of osteosarcoma cells via a mesenchymal to amoeboid transition
Pietrovito, L., Leo, A., Gori, V., Lulli, M., Parri, M., Becherucci, V., Piccini, L., Bambi, F., Taddei, M. L., & Chiarugi, P. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12189 · Cited by 91 · see citing works
Bioinstructive microparticles for self-assembly of mesenchymal stem Cell-3D tumor spheroids
Ferreira, L. P., Gaspar, V. M., & Mano, J. F. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.007 · Cited by 73 · see citing works
Heterotypic clustering of circulating tumor cells and circulating cancer-associated fibroblasts facilitates breast cancer metastasis
Sharma, U., Medina-Saenz, K., Miller, P. C., Troness, B., Spartz, A. K., Sandoval-Leon, A. C., Parke, D. N., Seagroves, T. N., Lippman, M. E., & El‐Ashry, D. (2021) · Breast Cancer Research and Treatment · doi:10.1007/s10549-021-06299-0 · Cited by 72 · see citing works
Growth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling
Peake, B. F., Eze, S. M., Yang, L. P. H., Castellino, R. C., & Nahta, R. (2017) · Oncotarget · doi:10.18632/oncotarget.21765 · Cited by 68 · see citing works
Principal Criteria for Evaluating the Quality, Safety and Efficacy of hMSC-Based Products in Clinical Practice: Current Approaches and Challenges
Guadix, J. A., López‐Beas, J., Clares, B., Soriano-Ruiz, J. L., Zugaza, J. L., & Gálvez‐Martín, P. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11110552 · Cited by 67 · see citing works
A Role of Tumor-Released Exosomes in Paracrine Dissemination and Metastasis
Spugnini, E., Logozzi, M., Raimo, R. D., Mizzoni, D., & Fais, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123968 · Cited by 61 · see citing works
Immunomodulatory Effect of MSCs and MSCs-Derived Extracellular Vesicles in Systemic Lupus Erythematosus
Yang, C., Sun, J.-M., Tian, Y., Li, H., Zhang, L., Yang, J., Wang, J., Zhang, J., Yan, S., & Xu, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.714832 · Cited by 60 · see citing works
Improved therapeutic potential of MSCs by genetic modification
Wei, W., Huang, Y., Li, D.-D., Gou, H., & Wang, W. (2018) · Gene Therapy · doi:10.1038/s41434-018-0041-8 · Cited by 50 · see citing works
Methylation-Based Therapies for Colorectal Cancer
Cervena, K., Siskova, A., Buchler, T., Vodicka, P., & Vymetalkova, V. (2020) · Cells · doi:10.3390/cells9061540 · Cited by 57 · see citing works
Bioengineering a humanized 3D tri-culture osteosarcoma model to assess tumor invasiveness and therapy response
Monteiro, C. F., Custódio, C. A., & Mano, J. F. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.07.034 · Cited by 57 · see citing works
The Dual Role of Mesenchymal Stem Cells in Cancer Pathophysiology: Pro-Tumorigenic Effects versus Therapeutic Potential
Slama, Y., Ah-Pine, F., Khettab, M., Arcambal, A., Begue, M., Dutheil, F., & Gasque, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713511 · Cited by 57 · see citing works
Human Bone Marrow-Derived Mesenchymal Stem Cells Promote the Growth and Drug-Resistance of Diffuse Large B-Cell Lymphoma by Secreting IL-6 and Elevating IL-17A Levels
Zhong, W., Zhu, Z., Xu, X., Zhang, H., Xiong, H., Li, Q., & Wei, Y. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1081-7 · Cited by 55 · see citing works
Dual Role of MSC-Derived Exosomes in Tumor Development
Zhao, R., Chen, X., Song, H., Bie, Q., & Zhang, B. (2020) · Stem Cells International · doi:10.1155/2020/8844730 · Cited by 54 · see citing works
Persistent Inflammatory Stimulation Drives the Conversion of MSCs to Inflammatory CAFs That Promote Pro-Metastatic Characteristics in Breast Cancer Cells
Rubinstein-Achiasaf, L., Morein, D., Ben-Yaakov, H., Liubomirski, Y., Meshel, T., Elbaz, E., Dorot, O., Pichinuk, E., Gershovits, M., Weil, M., et al. (2021) · Cancers · doi:10.3390/cancers13061472 · Cited by 53 · see citing works
Effects of pericytes and colon cancer stem cells in the tumor microenvironment
Garza-Treviño, E. N., González, P. D., Salgado, C. I. V., & Garza, A. M. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0888-9 · Cited by 52 · see citing works
Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective
Gentric, G., & Mechta‐Grigoriou, F. (2021) · Cancers · doi:10.3390/cancers13030399 · Cited by 50 · see citing works
Adipose-derived mesenchymal stem cells promote the malignant phenotype of cervical cancer
Castro‐Oropeza, R., Vázquez-Santillán, K., Díaz-Gastelum, C., Meléndez-Zajgla, J., Zampedri, C., Ferat-Osorio, E. A., Rodríguez-González, A., Arriaga‐Pizano, L., & Maldonado, V. (2020) · Scientific Reports · doi:10.1038/s41598-020-69907-x · Cited by 49 · see citing works
Pathogenetic significance and possibility as a therapeutic target of platelet derived growth factor
Ishii, Y., Hamashima, T., Yamamoto, S., & Sasahara, M. (2017) · Pathology International · doi:10.1111/pin.12530 · Cited by 43 · see citing works
Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer
Kang, J., Zhang, L., Luo, X., Ma, X., Wang, G., Yang, Y., Yan, Y., Qian, H., Zhang, X., Xu, W., et al. (2018) · BioMed Research International · doi:10.1155/2018/9652817 · Cited by 43 · see citing works
Hypoxia-inducible factor 1 α protects mesenchymal stem cells against oxygen-glucose deprivation-induced injury via autophagy induction and PI3K/AKT/mTOR signaling pathway.
Lv, B., Hua, T., Li, F., Han, J., Fang, J., Xu, L., Sun, C., Zhang, Z., Feng, Z., & Jiang, X. (2017) · Europe PMC (PubMed Central) · Cited by 43 · see citing works
PGC-1α induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma
Kumar, P. R., Saad, M., Hellmich, C., Mistry, J. J., Moore, J. A., Conway, S., Morris, C. J., Bowles, K. M., Moncrieff, M. D., & Rushworth, S. A. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01783-w · Cited by 43 · see citing works
Pivotal Role for Cxcr2 in Regulating Tumor-Associated Neutrophil in Breast Cancer
Timaxian, C., Vogel, C. F. A., Orcel, C., Vetter, D., Durochat, C., Chinal, C., NGuyen, P., Aknin, M.-L. R., Mercier‐Nomé, F., Davy, M., et al. (2021) · Cancers · doi:10.3390/cancers13112584 · Cited by 40 · see citing works
Self-citation
Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies
Mancini, S. J. C., Balabanian, K., Corre, I., Gavard, J., Lazennec, G., Bousse‐Kerdilès, M. L., Louache, F., Maguer‐Satta, V., Mazure, N. M., Mechta‐Grigoriou, F., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.766275 · Cited by 41 · see citing works
Self-citation
Environmental exposure and the role of AhR in the tumor microenvironment of breast cancer
Sweeney, C. A., Lazennec, G., & Vogel, C. F. A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1095289 · Cited by 39 · see citing works
Self-citation
Prognostic Value of CXCR2 in Breast Cancer
Boissière‐Michot, F., Jacot, W., Fraisse, J., Gourgou, S., Timaxian, C., & Lazennec, G. (2020) · Cancers · doi:10.3390/cancers12082076 · Cited by 38 · see citing works
Self-citation
CXCR2 Levels Correlate with Immune Infiltration and a Better Prognosis of Triple-Negative Breast Cancers
Boissière‐Michot, F., Jacot, W., Massol, O., Mollévi, C., & Lazennec, G. (2021) · Cancers · doi:10.3390/cancers13102328 · Cited by 38 · see citing works
Self-citation
Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice
Stamatopoulos, A., Stamatopoulos, T., Gamie, Z., Kenanidis, E., Ribeiro, R. D. C., Rankin, K. S., Gerrand, C., Dalgarno, K., & Tsiridis, E. (2019) · Journal of Bone Oncology · doi:10.1016/j.jbo.2019.100231 · Cited by 37 · see citing works
“The pro- or anti-tumorigenic effect of MSCs on tumour progression depends mainly on the MSC source and the tumour model used [31].”
Background
Role of Tumor Specific niche in Colon Cancer Progression and Emerging Therapies by Targeting Tumor Microenvironment
Banerjee, A., Chabria, Y., R., R. K. N., Gopi, J., Rowlo, P., Sun, X., & Pathak, S. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2019_355 · Cited by 37 · see citing works
A Spheroid Model of Early and Late‐Stage Osteosarcoma Mimicking the Divergent Relationship between Tumor Elimination and Bone Regeneration
Freeman, F. E., Burdis, R., Mahon, O. R., Kelly, D. J., & Artzi, N. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101296 · Cited by 36 · see citing works
First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells
Minev, B., Lander, E. B., Feller, J. F., Berman, M. H., Greenwood, B. M., Minev, I., Santidrián, A. F., Nguyen, D. H., Draganov, D., Kilinc, M. O., et al. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-2011-3 · Cited by 36 · see citing works
Mesenchymal stem cells promote cell invasion and migration and autophagy‐induced epithelial‐mesenchymal transition in A549 lung adenocarcinoma cells
Luo, D., Hu, S., Tang, C., & Liu, G. (2018) · Cell Biochemistry and Function · doi:10.1002/cbf.3320 · Cited by 35 · see citing works
Cancer cell-soluble factors reprogram mesenchymal stromal cells to slow cycling, chemoresistant cells with a more stem-like state
El-Badawy, A., Ghoneim, M., Gabr, M., Salah, R., Mohamed, I. K., Amer, M., & El-Badri, N. (2017) · Stem cell research & therapeutics · doi:10.1186/s13287-017-0709-9 · Cited by 33 · see citing works
Hematological Malignancy-Derived Small Extracellular Vesicles and Tumor Microenvironment: The Art of Turning Foes into Friends
Gargiulo, E., Paggetti, J., & Moussay, E. (2019) · Cells · doi:10.3390/cells8050511 · Cited by 33 · see citing works
Mitochondrial characteristics contribute to proliferation and migration potency of MDA-MB-231 cancer cells and their response to cisplatin treatment
Rostami, M. K., Roudkenar, M. H., Jahanian‐Najafabadi, A., Tomita, K., Kuwahara, Y., Sato, T., & Roushandeh, A. M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117339 · Cited by 34 · see citing works
Adipogenic progenitors in different organs: Pathophysiological implications
Favaretto, F., Bettini, S., Busetto, L., Milan, G., & Vettor, R. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09686-6 · Cited by 33 · see citing works
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Moloudizargari, M., Govahi, A., Fallah, M., Rezvanfar, M. A., Asghari, M. H., & Abdollahi, M. R. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30038 · Cited by 32 · see citing works
The role of microRNA-30c in targeting interleukin 6, as an inflammatory cytokine, in the mesenchymal stem cell: a therapeutic approach in colorectal cancer
Mahjoor, M., Afkhami, H., Najafi, M., Nasr, A., & Khorrami, S. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04123-w · Cited by 32 · see citing works
The Carbonic Anhydrase IX inhibitor SLC-0111 as emerging agent against the mesenchymal stem cell-derived pro-survival effects on melanoma cells
Peppicelli, S., Andreucci, E., Ruzzolini, J., Bianchini, F., Nediani, C., Supuran, C. T., & Calorini, L. (2020) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2020.1764549 · Cited by 31 · see citing works
Tumor Mesenchymal Stromal Cells Regulate Cell Migration of Atypical Teratoid Rhabdoid Tumor through Exosome-Mediated miR155/SMARCA4 Pathway
Yang, Y.-P., Nguyen, P. N. N., Ma, H.-I., Ho, W.-J., Chen, Y., Chien, Y., Yarmishyn, A. A., Huang, P., Lo, W., Wang, C., et al. (2019) · Cancers · doi:10.3390/cancers11050720 · Cited by 28 · see citing works
Mesenchymal stromal cells as carriers of IL-12 reduce primary and metastatic tumors of murine melanoma
Kułach, N., Pilny, E., Cichoń, T., Czapla, J., Jarosz–Biej, M., Rusin, M., Drzyzga, A., Matuszczak, S., Szala, S., & Smolarczyk, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-97435-9 · Cited by 27 · see citing works
A review of adipose-derived mesenchymal stem cells‘ impacts and challenges: metabolic regulation, tumor modulation, immunomodulation, regenerative medicine and genetic engineering therapies
Wang, L., Jiang, X., Zhao, F., Duan, P., Li, Z., & Luo, Y. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1606847 · Cited by 31 · see citing works
The interplay between adipose-derived stem cells and bladder cancer cells
Maj, M., Kokocha, A., Bajek, A., & Drewa, T. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-33397-9 · Cited by 26 · see citing works
Mesenchymal stromal cells induce inhibitory effects on hepatocellular carcinoma through various signaling pathways
Ai, J., Ketabchi, N., Verdi, J., Gheibi, N., Haghighian, H. K., & Kavianpour, M. (2019) · Cancer Cell International · doi:10.1186/s12935-019-1038-0 · Cited by 26 · see citing works
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Jia, L., Li, B., Fang, C., Liang, X., Xie, Y., Sun, X., Wang, W., Zheng, L., & Wang, D. (2022) · Stem Cells International · doi:10.1155/2022/3577015 · Cited by 26 · see citing works
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Rahmatizadeh, F., Aziz, S. G., Khodadadi, K., Ataei, M. L., Ebrahimie, E., Rad, J. S., & Pashaiasl, M. (2019) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2019.063 · Cited by 25 · see citing works
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Borzone, F. R., Giorello, M. B., Sanmartin, M. C., Yannarelli, G., Martinez, L. M., & Chasseing, N. A. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15861 · Cited by 24 · see citing works
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Boesch, M., Baty, F., Rumpold, H. F., Sopper, S., Wolf, D. G. F., & Brutsche, M. H. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.06.003 · Cited by 20 · see citing works
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Cui, G., Li, Z., Florholmen, J., & Goll, R. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111761 · Cited by 20 · see citing works
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Zaman, W. S. W. K., Nurul, A., & Nordin, F. (2021) · Biomedicines · doi:10.3390/biomedicines9091245 · Cited by 17 · see citing works
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Gil-Chinchilla, J. I., Zapata, A. G., Moraleda, J. M., & García‐Bernal, D. (2024) · Biomolecules · doi:10.3390/biom14070734 · Cited by 16 · see citing works
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Ferreira, L. P., Gaspar, V. M., Henrique, R., Jerónimo, C., & Mano, J. F. (2017) · Biotechnology Journal · doi:10.1002/biot.201700079 · Cited by 15 · see citing works
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Mehdipour, F., Razmkhah, M., Rezaeifard, S., Bagheri, M., Talei, A., Khalatbari, B., & Ghaderi, A. A. (2018) · Cell Biology International · doi:10.1002/cbin.11062 · Cited by 15 · see citing works
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Nikoo, A., Roudkenar, M. H., Sato, T., Kuwahara, Y., Tomita, K., Pourmohammadi-Bejarpasi, Z., Najafi-Ghalehlou, N., & Roushandeh, A. M. (2023) · Human Cell · doi:10.1007/s13577-023-00896-5 · Cited by 14 · see citing works
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Moradi-Gharibvand, N., Setayeshmehr, M., Kazemi, M., Safaee, A., Khorsandi, L. S., Nejad, D. B., Hasheminia, S. J., & Hashemibeni, B. (2022) · Research in Pharmaceutical Sciences · doi:10.4103/1735-5362.350238 · Cited by 14 · see citing works
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Teufelsbauer, M., Rath, B., Moser, D., Haslik, W., Huk, I., & Hamilton, G. (2019) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000005839 · Cited by 13 · see citing works
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Liu, Z., Li, S., Ma, T., Zeng, J., Zhou, X., Li, H., Tang, M., Liu, X., Li, F., Jiang, B., et al. (2020) · Immunity Inflammation and Disease · doi:10.1002/iid3.372 · Cited by 12 · see citing works
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Bogusławska, J., Grzanka, M., Popławski, P., Zarychta‐Wiśniewska, W., Burdzińska, A., Hanusek, K., Kossowska, H., Iwanicka‐Nowicka, R., Białas, A., Rybicka, B., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-024-02001-1 · Cited by 11 · see citing works
Mesenchymal stromal cell engagement in cancer cell epithelial to mesenchymal transition
Trivanović, D. I., Krstić, J., Jauković, A., Bugarski, D. S., & Santibanez, J. F. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24583 · Cited by 11 · see citing works
Mesenchymal stem cells in cancer therapy; the art of harnessing a foe to a friend.
Karimi‐Shahri, M., Javid, H., Mashhad, A. S., Yazdani, S., & Hashemy, S. I. (2021) · PubMed Central · doi:10.22038/ijbms.2021.58227.12934 · Cited by 11 · see citing works
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Zhao, X., Xu, M., Hu, X., Ding, X., Zhang, X., Xu, L., Li, L., Sun, X., & Song, J. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03373-w · Cited by 9 · see citing works
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la Fuente-Hernández, M. A. D., Alanis-Manriquez, E. C., Ferat-Osorio, E. A., Rodríguez-González, A., Arriaga‐Pizano, L., Vázquez-Santillán, K., Meléndez-Zajgla, J., Fragoso‐Ontiveros, V., Álvarez-Gómez, R. M., & Lagunas, V. M. (2022) · Cellular Oncology · doi:10.1007/s13402-021-00653-6 · Cited by 7 · see citing works
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Li, X., Li, J., Li, J., Liu, N., & Zhuang, L. (2024) · BMC Genomics · doi:10.1186/s12864-023-09815-2 · Cited by 6 · see citing works
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Panda, S. K., Robinson, N., & Desiderio, V. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189205 · Cited by 6 · see citing works
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Mamchur, A., Leman, E., Salah, S., Avivi, A., Shams, I., & Manov, I. (2018) · Stem Cells · doi:10.1002/stem.2884 · Cited by 6 · see citing works
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Babadag, S., Altundag‐Erdogan, Ö., Akkaya‐Ulum, Y. Z., & Çelebi‐Saltik, B. (2024) · DNA and Cell Biology · doi:10.1089/dna.2024.0031 · Cited by 4 · see citing works
Mesenchymal multipotent stromal cells and cancer safety: two sides of the same coin or a double-edged sword (review of foreign literature)
Александрович, И. Д., & Kudlay, D. A. (2021) · Russian Journal of Pediatric Hematology and Oncology · doi:10.21682/2311-1267-2021-8-1-64-84 · Cited by 3 · see citing works
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Bone marrow-derived mesenchymal stem cells and the tumor microenvironment
Bergfeld, S. A., & DeClerck, Y. A. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9222-7 · Cited by 345 · see citing works
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Li-ju, F. (2014) · Basic & Clinical Medicine
Cancer-associated mesenchymal stem/stromal cells: role in progression and potential targets for therapeutic approaches
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Mesenchymal stem cells in tumor development
Cuiffo, B., & Karnoub, A. E. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.20875 · Cited by 204 · see citing works

Authors: Lazennec, G., & Lam, P. Y.
Affiliations: Centre National de la Recherche Scientifique (FR)
National University of Singapore (SG)
Corresponding author: Lazennec, Gwendal
ORCID: Lazennec, Gwendal
Venue: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Publisher: Elsevier BV
Published: 2016-12
Volume: 1866
Issue: 2
Pages: 290-299
ISSN: 0304-419X (ISSN-L)
DOI: 10.1016/j.bbcan.2016.10.004
OpenAlex: W2533248522
Cited by: 117
References: 100
Citations by year: 2025: 3 · 2024: 8 · 2023: 9 · 2022: 12 · 2021: 17 · 2020: 13 · 2019: 20 · 2018: 17 · 2017: 18
FWCI: 2.14
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Funders: ARC Fundation
la Ligue contre le Cancer
National Medical Research Council
Singapore Stem Cell Consortium
Topics: Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords: mesenchymal stem cells, tumor microenvironment, cancer-associated fibroblasts, tumor angiogenesis, tumor invasion, metastasis, tumor response
MeSH terms: Cancer-Associated Fibroblasts, Animals, Cell Communication, Humans, Neoplasms, Apoptosis, Neovascularization, Physiologic, Cell Proliferation, Tumor Microenvironment, Mesenchymal Stem Cells

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