BMP4 signaling directs primitive endoderm-derived XEN cells to an extraembryonic visceral endoderm identity

Epithelial-Mesenchymal Transitions in Development and Disease

Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931 · see citing works

Establishment in culture of pluripotential cells from mouse embryos

Evans, M. J., & Kaufman, M. H. (1981) · Nature · doi:10.1038/292154a0 · Cited by 8,623 · see citing works

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

Martin, G. R. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.12.7634 · Cited by 5,756 · see citing works

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,114 · see citing works

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O’Shea, K. S., Powell-Braxton, L., Hillan, K. J., & Moore, M. W. (1996) · Nature · doi:10.1038/380439a0 · Cited by 3,624 · see citing works

BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3

Ying, Q.-L., Nichols, J., Chambers, I., & Smith, A. G. (2003) · Cell · doi:10.1016/s0092-8674(03)00847-x · Cited by 2,114 · see citing works

Manipulating the Mouse Embryo: A Laboratory Manual

Behringer, R. R., Gertsenstein, M., Nagy, K. V., & Nagy, A. (2002) · Cited by 2,046 · see citing works

Parental imprinting of the mouse insulin-like growth factor II gene

DeChiara, T. M., Robertson, E. J., & Efstratiadis, A. (1991) · Cell · doi:10.1016/0092-8674(91)90513-x · Cited by 1,795 · see citing works

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.Preprint

Winnier, G. E., Blessing, M., Labosky, P. A., & Hogan, B. L. M. (1995) · Genes & Development · doi:10.1101/gad.9.17.2105 · Cited by 1,789 · see citing works

Nanog safeguards pluripotency and mediates germline development

Chambers, I., Silva, J. C. R., Colby, D., Nichols, J., Nijmeijer, B., Robertson, M., Vrána, J., Jones, K., Grotewold, L., & Smith, A. G. (2007) · Nature · doi:10.1038/nature06403 · Cited by 1,635 · see citing works

Bmp4 is required for the generation of primordial germ cells in the mouse embryo.Preprint

Lawson, K. A., Dunn, N. R., Roelen, B., Zeinstra, L., Davis, A. M., Wright, C., Korving, J., & Hogan, B. (1999) · Genes & Development · doi:10.1101/gad.13.4.424 · Cited by 1,373 · see citing works

Promotion of Trophoblast Stem Cell Proliferation by FGF4

Tanaka, S., Kunath, T., Hadjantonakis, A., Nagy, A., & Rossant, J. (1998) · Science · doi:10.1126/science.282.5396.2072 · Cited by 1,370 · see citing works

Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming.

Samavarchi-Tehrani, P., Golipour, A., David, L., Sung, H., Beyer, T. A., Datti, A., Woltjen, K., Nagy, A., & Wrana, J. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.04.015 · Cited by 1,035 · see citing works

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

Zhang, H., & Bradley, A. (1996) · Development · doi:10.1242/dev.122.10.2977 · Cited by 988 · see citing works

Early Lineage Segregation between Epiblast and Primitive Endoderm in Mouse Blastocysts through the Grb2-MAPK Pathway

Chazaud, C., Yamanaka, Y., Pawson, T., & Rossant, J. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.02.020 · Cited by 898 · see citing works

Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo

Arnold, S. J., & Robertson, E. J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2618 · Cited by 816 · cited 1× · see citing works

Signaling networks guiding epithelial–mesenchymal transitions during embryogenesis and cancer progression

Moustakas, A., & Heldin, C. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00550.x · Cited by 798 · see citing works

Signalling, cell cycle and pluripotency in embryonic stem cells

Burdon, T., Smith, A. T., & Savatier, P. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02352-8 · Cited by 710 · see citing works

Dynamic Equilibrium and Heterogeneity of Mouse Pluripotent Stem Cells with Distinct Functional and Epigenetic States

Hayashi, K., Lopes, S. M. C. D. S., Tang, F., & Surani, M. A. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.027 · Cited by 649 · see citing works

Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse

Rossant, J., & Tam, P. (2009) · Development · doi:10.1242/dev.017178 · Cited by 629 · see citing works

Signals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo

Coucouvanis, E. C., & Martin, G. R. (1995) · Cell · doi:10.1016/0092-8674(95)90169-8 · Cited by 600 · see citing works

Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst

Plusa, B., Piliszek, A., Frankenberg, S., Artus, J., & Hadjantonakis, A.-K. (2008) · Development · doi:10.1242/dev.021519 · Cited by 556 · see citing works

Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo

Thomas, P. Q., & Beddington, R. S. P. (1996) · Current Biology · doi:10.1016/s0960-9822(96)00753-1 · Cited by 552 · see citing works

Identification and characterization of subpopulations in undifferentiated ES cell culture

Toyooka, Y., Shimosato, D., Murakami, K., Takahashi, K., & Niwa, H. (2008) · Development · doi:10.1242/dev.017400 · Cited by 525 · see citing works

Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts

Kunath, T., Arnaud, D., Uy, G. D., Okamoto, I., Chureau, C., Yamanaka, Y., Heard, É., Gardner, R. L., Avner, P. R., & Rossant, J. (2005) · Development · doi:10.1242/dev.01715 · Cited by 404 · see citing works

Embryonic origin of the adult hematopoietic system: advances and questions

Medvinsky, A., Александрович, Р. С., & Taoudi, S. (2011) · Development · doi:10.1242/dev.040998 · Cited by 403 · see citing works

The Endoderm of the Mouse Embryo Arises by Dynamic Widespread Intercalation of Embryonic and Extraembryonic Lineages

Kwon, G. S., Viotti, M., & Hadjantonakis, A.-K. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.07.017 · Cited by 402 · see citing works

Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo

Dyer, M. A., Farrington, S. M., Mohn, D., Munday, J. R., & Baron, M. H. (2001) · Development · doi:10.1242/dev.128.10.1717 · Cited by 402 · see citing works

Making the blastocyst: lessons from the mouse

Cockburn, K., & Rossant, J. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41229 · Cited by 394 · see citing works

A Heterogeneous Expression Pattern for Nanog in Embryonic Stem Cells

Singh, A. M., Hamazaki, T., Hankowski, K. E., & Terada, N. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0126 · Cited by 353 · see citing works

Defined Conditions for Neural Commitment and Differentiation

Ying, Q., & Smith, A. G. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)65023-8 · Cited by 328 · see citing works

BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo

Coucouvanis, E. C., & Martin, G. R. (1999) · Development · doi:10.1242/dev.126.3.535 · Cited by 326 · see citing works

Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo

Zernicka‐Goetz, M., Morris, S. A., & Bruce, A. W. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2564 · Cited by 322 · see citing works

Locus unlinked to alpha-fetoprotein under the control of the murine raf and Rif genes.

Pachnis, V., Belayew, A., & Tilghman, S. M. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.17.5523 · Cited by 317 · see citing works

Bone Morphogenic Protein-7 Induces Mesenchymal to Epithelial Transition in Adult Renal Fibroblasts and Facilitates Regeneration of Injured Kidney

Zeisberg, M., Shah, A. A., & Kalluri, R. K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413102200 · Cited by 317 · see citing works

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewalPreprint

Niakan, K. K., Ji, H., Maehr, R., Vokes, S. A., Rodolfa, K. T., Sherwood, R. I., Yamaki, M., Dimos, J. T., Chen, A. E., Melton, D. A., et al. (2010) · Genes & Development · doi:10.1101/gad.1833510 · Cited by 309 · see citing works

Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells

Enver, T., Soneji, S., Joshi, C., Brown, J., Iborra, F. J., Orntoft, T. F., Thykjær, T., Maltby, E. L., Smith, K., Dawud, R. A., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi345 · Cited by 292 · see citing works

Multiple Developmental Roles of VEGF Suggested by a LacZ-Tagged Allele

Miquerol, L., Gertsenstein, M., Harpal, K., Rossant, J., & Nagy, A. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9355 · Cited by 281 · see citing works

Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes.Preprint

Tucker, K. L., Beard, C., Dausman, J. A., Jackson‐Grusby, L., Laird, P. W., Lei, H., Li, E., & Jaenisch, R. (1996) · Genes & Development · doi:10.1101/gad.10.8.1008 · Cited by 275 · see citing works

The intrinsic factor–vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein

Kozyraki, R., Fyfe, J. C., Kristiansen, M., Gerdes, C., Jacobsen, C. B., Cui, S., Christensen, E., Aminoff, M., de la Chapelle, A., Krahe, R., et al. (1999) · Nature Medicine · doi:10.1038/9504 · Cited by 273 · see citing works

Tumor Cells Secrete Galectin-1 to Enhance Endothelial Cell Activity

Thijssen, V. L., Barkan, B., Shoji, H., Ariës, I. M., Mathieu, V., Deltour, L., Hackeng, T. M., Robert Kiss, A., Kloog, Y., Poirier, F., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4150 · Cited by 246 · see citing works

Investigation of cell lineage and differentiation in the extraembryonic endoderm of the mouse embryo

Gardner, R. L. (1982) · Development · doi:10.1242/dev.68.1.175 · Cited by 235 · see citing works

The primitive endoderm lineage of the mouse blastocyst: Sequential transcription factor activation and regulation of differentiation by Sox17

Artus, J., Piliszek, A., & Hadjantonakis, A.-K. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2010.12.007 · Cited by 232 · see citing works

Blood island formation: longstanding observations and modern interpretations

Ferkowicz, M. J., & Yöder, M. C. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.06.006 · Cited by 231 · see citing works

Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages

Lim, C. Y., Tam, W.-L., Zhang, J., Ang, H. S., Jia, H., Lipovich, L., Ng, H.-H., Wei, C.-L., Sung, W. K., Robson, P., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.08.004 · Cited by 224 · see citing works

Localization and synthesis of alphafoetoprotein in post-implantation mouse embryos

Dziadek, M. A., & Adamson, E. D. (1978) · Development · doi:10.1242/dev.43.1.289 · Cited by 216 · see citing works

Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins

Bailey, J. M., Singh, P. K., & Hollingsworth, M. A. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21509 · Cited by 209 · see citing works

Epiblast Stem Cell Subpopulations Represent Mouse Embryos of Distinct Pregastrulation Stages

Han, D., Tàpia, N., Joo, J. Y., Greber, B., Araúzo-Bravo, M. J., Bernemann, C., Ko, K., Wu, G., Stehling, M., Tae, J., et al. (2010) · Cell · doi:10.1016/j.cell.2010.10.015 · Cited by 203 · see citing works

Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo

Belaoussoff, M., Farrington, S. M., & Baron, M. H. (1998) · Development · doi:10.1242/dev.125.24.5009 · Cited by 198 · see citing works

Active cell migration drives the unilateral movements of the anterior visceral endoderm

Srinivas, S., Rodríguez, T. A., Clements, M., Smith, J. C., & Beddington, R. S. P. (2004) · Development · doi:10.1242/dev.01005 · Cited by 185 · see citing works

Distinct roles for visceral endoderm during embryonic mouse development

Bielińska, M., Narita, N., & Wilson, D. B. (1999) · The International Journal of Developmental Biology · doi:10.1387/ijdb.10410899 · Cited by 182 · see citing works

Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis

Dunwoodie, S. L., Rodríguez, T. A., & Beddington, R. S. P. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00011-2 · Cited by 174 · see citing works

Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst

Meilhac, S. M., Adams, R. J., Morris, S. A., Danckaert, A., Garrec, J. L., & Zernicka‐Goetz, M. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.04.036 · Cited by 169 · see citing works

Clonal isolation of hESCs reveals heterogeneity within the pluripotent stem cell compartment

Stewart, M. H., Bosse, M. M., Chadwick, K., Menéndez, P. R., Bendall, S. C., & Bhatia, M. (2006) · Nature Methods · doi:10.1038/nmeth939 · Cited by 167 · see citing works

A Continuum of Cell States Spans Pluripotency and Lineage Commitment in Human Embryonic Stem Cells

Hough, S. R., Laslett, A. L., Grimmond, S. M., Kolle, G., & Pera, M. F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007708 · Cited by 159 · see citing works

Cubilin, the endocytic receptor for intrinsic factor-vitamin B 12 complex, mediates high-density lipoprotein holoparticle endocytosis

Hammad, S. M., Stefansson, S., Twal, W. O., Drake, C. J., Fleming, P., Remaley, A. T., Brewer, H. B., & Argraves, W. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10158 · Cited by 156 · see citing works

In vivo imaging and differential localization of lipid‐modified GFP‐variant fusions in embryonic stem cells and mice

Rhee, J. M., Pirity, M. K., Lackan, C. S., Long, J. Z., Kondoh, G., Takeda, J., & Hadjantonakis, A. (2006) · genesis · doi:10.1002/dvg.20203 · Cited by 154 · see citing works

The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm–specific protein with an extracellular cysteine-rich domain

Kalantry, S., Manning, S., Haub, O., Tomihara-Newberger, C., Lee, H.-G., Fangman, J., Distèche, C. M., Manova, K., & Lacy, E. (2001) · Nature Genetics · doi:10.1038/86912 · Cited by 138 · see citing works

Dynamic morphogenetic events characterize the mouse visceral endoderm

Rivera‐Pérez, J. A., Mager, J., & Magnuson, T. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00302-6 · Cited by 131 · see citing works

A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst

Artus, J., Panthier, J., & Hadjantonakis, A. (2010) · Development · doi:10.1242/dev.050864 · Cited by 130 · see citing works

Origins and plasticity of neural crest cells and their roles in jaw and craniofacial evolution

Trainor, P. A., Melton, K. R., & Manzanares, M. (2003) · The International Journal of Developmental Biology · doi:10.1387/ijdb.14756330 · Cited by 127 · see citing works

Origin and role of distal visceral endoderm, a group of cells that determines anterior–posterior polarity of the mouse embryo

Takaoka, K., Yamamoto, M., & Hamada, H. (2011) · Nature Cell Biology · doi:10.1038/ncb2251 · Cited by 127 · see citing works

Role of suppressors of cytokine signaling (Socs) in leukemia inhibitory factor (LIF) -dependent embryonic stem cell survival

Duval, D., Reinhardt, B., Kédinger, C., & Bœuf, H. (2000) · The FASEB Journal · doi:10.1096/fj.14.11.1577 · Cited by 126 · see citing works

Prospective isolation and global gene expression analysis of definitive and visceral endoderm

Sherwood, R. I., Jitianu, C., Cleaver, O., Shaywitz, D. A., Lamenzo, J. O., Chen, A. E., Golub, T. R., & Melton, D. A. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.01.011 · Cited by 122 · see citing works

Gene expression pattern and progression of embryogenesis in the immediate post-implantation period of mouse development

Pfister, S., Steiner, K. A., & Tam, P. (2007) · Gene Expression Patterns · doi:10.1016/j.modgep.2007.01.005 · Cited by 121 · see citing works

Rac1-Dependent Collective Cell Migration Is Required for Specification of the Anterior-Posterior Body Axis of the Mouse

Migeotte, I., Omelchenko, T., Hall, A., & Anderson, K. V. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000442 · Cited by 114 · see citing works

Cell interactions and endoderm differentiation in cultured mouse embryos

Hogan, B. L. M., & Tilly, R. (1981) · Development · doi:10.1242/dev.62.1.379 · Cited by 112 · see citing works

Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst

Gerbe, F., Cox, B., Rossant, J., & Chazaud, C. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.10.048 · Cited by 109 · see citing works

High Density Lipoprotein Uptake by Scavenger Receptor SR-BII

Eckhardt, E. R. M., Cai, L., Sun, B., Webb, N. R., & van der Westhuyzen, D. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313793200 · Cited by 106 · see citing works

Genetic and spectrally distinct in vivoimaging: embryonic stem cells and mice with widespread expression of a monomeric red fluorescent protein

Long, J. Z., Lackan, C. S., & Hadjantonakis, A. (2005) · BMC Biotechnology · doi:10.1186/1472-6750-5-20 · Cited by 102 · see citing works

Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo

Yamamoto, M., Beppu, H., Takaoka, K., Meno, C., Li, E., Miyazono, K., & Hamada, H. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200808044 · Cited by 101 · see citing works

BMP-2 induces cell migration and periostin expression during atrioventricular valvulogenesis

Inai, K., Norris, R. A., Hoffman, S., Markwald, R. R., & Sugi, Y. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2007.12.028 · Cited by 97 · see citing works

Modulated expression of WFDC1 during carcinogenesis and cellular senescence

Madar, S., Brosh, R., Buganim, Y., Ezra, O., Goldstein, I., Solomon, H., Kogan, I., Goldfinger, N., Klocker, H., & Rotter, V. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn232 · Cited by 87 · see citing works

Endothelial Cells in the Early Murine Yolk Sac Give Rise to CD41-expressing Hematopoietic Cells

Li, W., Ferkowicz, M. J., Johnson, S. A., Shelley, W. C., & Yöder, M. C. (2005) · Stem Cells and Development · doi:10.1089/scd.2005.14.44 · Cited by 87 · see citing works

Temporal and spatial pattern of expression of the HDL receptor SR-BI during murine embryogenesis

Hatzopoulos, A. K., Rigotti, A., ROSENBERG, R. D., & Krieger, M. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33289-2 · Cited by 87 · see citing works

Mouse amnionless, which is required for primitive streak assembly,mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules

Strope, S., Rivi, R., Metzger, T. E., Manova, K., & Lacy, E. (2004) · Development · doi:10.1242/dev.01341 · Cited by 84 · see citing works

The fetal liver is a niche for maturation of primitive erythroid cells

Isern, J., Fraser, S. T., He, Z., & Baron, M. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802032105 · Cited by 83 · see citing works

Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death

Brandt, B., Abou-eladab, E., Tiedge, M., & Walzel, H. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.1 · Cited by 80 · see citing works

<i>Tg</i>(<i>Afp</i>‐<i>GFP</i>) expression marks primitive and definitive endoderm lineages during mouse development

Kwon, G. S., Fraser, S. T., Eakin, G. S., Mangano, M., Isern, J., Sahr, K. E., Hadjantonakis, A., & Baron, M. H. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20843 · Cited by 80 · see citing works

Cellular dynamics in the early mouse embryo: from axis formation to gastrulation

Nowotschin, S., & Hadjantonakis, A.-K. (2010) · Current Opinion in Genetics &amp; Development · doi:10.1016/j.gde.2010.05.008 · Cited by 79 · cited 1× · see citing works

Bone morphogenetic protein 7 induces mesenchymal‐to‐epithelial transition in melanoma cells, leading to inhibition of metastasis

Na, Y., Seok, S. H., Kim, D., Han, J., Kim, T., Jung, H. J., Lee, B., & Park, J. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01301.x · Cited by 75 · see citing works

Foxa2 Activity Increases Plasma High Density Lipoprotein Levels by Regulating Apolipoprotein M

Wolfrum, C., Howell, J. J., Ndungo, E., & Stoffel, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801930200 · Cited by 74 · see citing works

Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo

Isern, J., He, Z., Fraser, S. T., Nowotschin, S., Ferrer‐Vaquer, A., Moore, R., Hadjantonakis, A., Schulz, V., Tuck, D. P., Gallagher, P. G., et al. (2011) · Blood · doi:10.1182/blood-2010-10-313676 · Cited by 70 · see citing works

Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation

Smith, B. T., Mussell, J. C., Fleming, P. A., Barth, J. L., Spyropoulos, D. D., Cooley, M. A., Drake, C. J., & Argraves, W. S. (2006) · BMC Developmental Biology · doi:10.1186/1471-213x-6-30 · Cited by 66 · see citing works

Genetic targeting of the endoderm with claudin‐6CreER

Anderson, W. J., Zhou, Q., Alcalde, V., Kaneko, O. F., Blank, L. J., Sherwood, R. I., Guseh, J. S., Rajagopal, J., & Melton, D. A. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21437 · Cited by 62 · see citing works

Regulation of extra-embryonic endoderm stem cell differentiation by Nodal and Cripto signaling

Julio, M. K.-D., Alvarez, M. J., Galli, A., Chu, J., Price, S. M., Califano, A., & Shen, M. M. (2011) · Development · doi:10.1242/dev.065656 · Cited by 62 · see citing works

Transitions between epithelial and mesenchymal states and the morphogenesis of the early mouse embryo

Ferrer‐Vaquer, A., Viotti, M., & Hadjantonakis, A. (2010) · Cell Adhesion & Migration · doi:10.4161/cam.4.3.10771 · Cited by 61 · see citing works

Characterization of a binding protein for leukemia inhibitory factor localized in extracellular matrix

Méreau, A., Grey, L., Piquet‐Pellorce, C., & Heath, J. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.3.713 · Cited by 60 · see citing works

A Comparative Analysis of Extra-Embryonic Endoderm Cell Lines

Brown, K., Legros, S., Artus, J., Doss, M. X., Khanin, R., Hadjantonakis, A., & Foley, A. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012016 · Cited by 59 · see citing works

Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi

Soares, M. L., Haraguchi, S., Torres‐Padilla, M., Kalmár, T., Carpenter, L., Bell, G., Morrison, A., Ring, C., Clarke, N. J., Glover, D. M., et al. (2005) · BMC Developmental Biology · doi:10.1186/1471-213x-5-28 · Cited by 57 · see citing works

A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE)

Hou, J., Charters, A. M., Lee, S. C., Zhao, Y., Wu, M. K., Jones, S. J., Marra, M. A., & Hoodless, P. A. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-92 · Cited by 56 · see citing works

Purification of a Novel Protein (ps20) from Urogenital Sinus Mesenchymal Cells with Growth Inhibitory Properties in Vitro

Rowley, D. R., Dang, T. D., Larsen, M., Gerdes, M. J., McBride, L., & Lu, B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.37.22058 · Cited by 52 · see citing works

The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives.

Tomihara-Newberger, C., Haub, O., Lee, H.-G., Soares, V., Manova, K., & Lacy, E. (1998) · Developmental Biology · doi:10.1006/dbio.1998.9034 · Cited by 48 · see citing works

Bone morphogenetic protein 4 signaling regulates development of the anterior visceral endoderm in the mouse embryo

Soares, M. L., Torres‐Padilla, M., & Zernicka‐Goetz, M. (2008) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2008.01059.x · Cited by 43 · see citing works

Early patterning of the mouse embryo: Implications for hematopoietic commitment and differentiation

Baron, M. H. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.06.001 · Cited by 38 · see citing works

Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf

Isern, J., Fraser, S. T., He, Z., Zhang, H., & Baron, M. H. (2010) · Blood · doi:10.1182/blood-2010-04-281196 · Cited by 38 · see citing works

NANOG Reporter Cell Lines Generated by Gene Targeting in Human Embryonic Stem Cells

Fischer, Y., Ganić, E., Ameri, J., Xian, X., Johannesson, M., & Semb, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012533 · Cited by 36 · see citing works

eXtraembryonic ENdoderm (XEN) Stem Cells Produce Factors that Activate Heart Formation

Brown, K., Doss, M. X., Legros, S., Artus, J., Hadjantonakis, A., & Foley, A. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013446 · Cited by 34 · see citing works

Bone morphogenetic protein–2 activity is regulated by secreted phosphoprotein–24 kd, an extracellular pseudoreceptor, the gene for which maps to a region of the human genome important for bone quality

Brochmann, E. J., Behnam, K., & Murray, S. S. (2009) · Metabolism · doi:10.1016/j.metabol.2009.01.001 · Cited by 24 · see citing works

Vegf regulates embryonic erythroid development through Gata1 modulation

Drogat, B., Kalucka, J. M., Gutiérrez, L., Hammad, H., Goossens, S., Ghahremani, M. F., Bartunkova, S., Haigh, K., Deswarte, K., Nyabi, O., et al. (2010) · Blood · doi:10.1182/blood-2010-01-264143 · Cited by 24 · see citing works

Embryonic fates for extraembryonic lineages: New perspectives

Fraser, S. T., & Baron, M. H. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22165 · Cited by 19 · see citing works

Impaired Mitotic Progression and Preimplantation Lethality in Mice Lacking OMCG1, a New Evolutionarily Conserved Nuclear Protein

Artus, J., Vandormael‐Pournin, S., Frödin, M., Nacerddine, K., Babinet, C., & Cohen‐Tannoudji, M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.6289-6302.2005 · Cited by 19 · see citing works

VEGF and IHH rescue definitive hematopoiesis in Gata-4 and Gata-6–deficient murine embryoid bodies

Pierre, M. S., Yoshimoto, M., Huang, L. J., Richardson, M. R., & Yöder, M. C. (2009) · Experimental Hematology · doi:10.1016/j.exphem.2009.05.011 · Cited by 14 · see citing works

A Parallel Association between Differentiation and Induction of Galectin-1, and Inhibition of Galectin-3 by Retinoic Acid in Mouse Embryonal Carcinoma F9 Cells

Lu, Y. W., Amos, B., Cruise, E., Lotan, D., & Lotan, R. (1998) · Biological Chemistry · doi:10.1515/bchm.1998.379.11.1323 · Cited by 13 · see citing works

Expression of nidogens in rat uterus and embryo during decidualization and implantation

Öner, H., Öner, J., & Demir, R. (2006) · Journal of Morphology · doi:10.1002/jmor.10449 · Cited by 10 · see citing works

The emergent landscape of the mouse gut endoderm at single-cell resolution

Nowotschin, S., Setty, M., Kuo, Y.-Y., Liu, V., Garg, V., Sharma, R., Simon, C. S., Saiz, N., Gardner, R., Boutet, S. C., et al. (2019) · Nature · doi:10.1038/s41586-019-1127-1 · Cited by 383 · see citing works

The embryonic origins of erythropoiesis in mammals

Baron, M. H., Isern, J., & Fraser, S. T. (2012) · Blood · doi:10.1182/blood-2012-01-153486 · Cited by 185 · see citing works

Lineage specificity of primary cilia in the mouse embryo

Bangs, F. K., Schrode, N., Hadjantonakis, A.-K., & Anderson, K. V. (2015) · Nature Cell Biology · doi:10.1038/ncb3091 · Cited by 174 · see citing works

Naïve human pluripotent stem cells respond to Wnt, Nodal and LIF signalling to produce expandable naïve extra-embryonic endoderm

Linneberg-Agerholm, M., Wong, Y. F., Herrera, J. A. R., Monteiro, R. S., Anderson, K. G. V., & Brickman, J. M. (2019) · Development · doi:10.1242/dev.180620 · Cited by 168 · see citing works

Derivation of extraembryonic endoderm stem (XEN) cells from mouse embryos and embryonic stem cells

Niakan, K. K., Schrode, N., Cho, L. T. Y., & Hadjantonakis, A. (2013) · Nature Protocols · doi:10.1038/nprot.2013.049 · Cited by 132 · see citing works

Network inference with Granger causality ensembles on single-cell transcriptomics

Deshpande, A., Chu, L.-F., Stewart, R., & Gitter, A. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110333 · Cited by 130 · see citing works

A Rapid and Efficient 2D/3D Nuclear Segmentation Method for Analysis of Early Mouse Embryo and Stem Cell Image Data

Lou, X., Kang, M., Xenopoulos, P., Descalzo, S. M., & Hadjantonakis, A. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.01.010 · Cited by 116 · see citing works

Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states

Cho, L. T. Y., Wamaitha, S. E., Tsai, I. J., Artus, J., Sherwood, R. I., Pedersen, R. A., Hadjantonakis, A., & Niakan, K. K. (2012) · Development · doi:10.1242/dev.078519 · Cited by 106 · see citing works

Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm

Anderson, K. G. V., Hamilton, W. B., Roske, F. V., Azad, A., Knudsen, T. E., Canham, M. A., Forrester, L. M., & Brickman, J. M. (2017) · Nature Cell Biology · doi:10.1038/ncb3617 · Cited by 93 · see citing works

The Developing Chicken Yolk Sac Acquires Nutrient Transport Competence by an Orchestrated Differentiation Process of Its Endodermal Epithelial Cells

Bauer, R., Plieschnig, J. A., Finkes, T., Riegler, B., Hermann, M., & Schneider, W. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.393090 · Cited by 76 · see citing works

LIF supports primitive endoderm expansion during pre-implantation development

Morgani, S. M., & Brickman, J. M. (2015) · Development · doi:10.1242/dev.125021 · Cited by 64 · see citing works

All models are wrong, but some are useful: Establishing standards for stem cell-based embryo models

Pósfai, E., Lanner, F., Mulas, C., & Leitch, H. G. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.03.019 · Cited by 61 · see citing works

A close look at the mammalian blastocyst: epiblast and primitive endoderm formation

Artus, J., & Chazaud, C. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1630-3 · Cited by 60 · see citing works

Sox17-Mediated XEN Cell Conversion Identifies Dynamic Networks Controlling Cell-Fate Decisions in Embryo-Derived Stem Cells

McDonald, A., Biechele, S., Rossant, J., & Stanford, W. L. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.026 · Cited by 54 · see citing works

OSKM Induce Extraembryonic Endoderm Stem Cells in Parallel to Induced Pluripotent Stem Cells

Parenti, A., Halbisen, M. A., Wang, K., Latham, K. E., & Ralston, A. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.02.003 · Cited by 57 · see citing works

Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture

Wei, Y., Zhang, E., Yu, L., Ci, B., Sakurai, M., Guo, L., Zhang, X., Lin, S., Takii, S., Liu, L., et al. (2023) · Cell · doi:10.1016/j.cell.2023.11.008 · Cited by 51 · see citing works

Actl6a Protects Embryonic Stem Cells From Differentiating Into Primitive Endoderm

Lu, W., Fang, L., Ouyang, B., Zhang, X., Zhan, S., Feng, X., Bai, Y., Han, X., Kim, H., He, Q., et al. (2015) · Stem Cells · doi:10.1002/stem.2000 · Cited by 48 · see citing works

Primitive endoderm differentiation: from specification to epithelium formation

Hermitte, S., & Chazaud, C. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0537 · Cited by 47 · see citing works

Development and differentiation of the erythroid lineage in mammals

Barminko, J., Reinholt, B. M., & Baron, M. H. (2015) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2015.12.012 · Cited by 46 · see citing works

Primitive Endoderm Differentiation: From Specification to Epithelialization

Bassalert, C., Estrella, L. V., & Chazaud, C. (2018) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.12.001 · Cited by 38 · see citing works

In vitro generation of mouse polarized embryo-like structures from embryonic and trophoblast stem cells

Harrison, S., Sözen, B., & Zernicka‐Goetz, M. (2018) · Nature Protocols · doi:10.1038/s41596-018-0005-x · Cited by 37 · see citing works

Stem-cell-based human and mouse embryo models

Bao, M., Cornwall-Scoones, J., & Zernicka‐Goetz, M. (2022) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2022.101970 · Cited by 36 · see citing works

The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency

Athanasouli, P., Balli, M., De Jaime-Soguero, A., Boel, A., Papanikolaou, S., van der Veer, B. K., Janiszewski, A., Vanhessche, T., Francis, A., El Laithy, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36914-1 · Cited by 31 · see citing works

Troika of the Mouse Blastocyst: Lineage Segregation and Stem Cells

Artus, J., & Hadjantonakis, A. (2012) · Current Stem Cell Research & Therapy · doi:10.2174/157488812798483403 · Cited by 30 · see citing works

Roles of MicroRNAs in Establishing and Modulating Stem Cell Potential

Zhang, Z., Zhuang, L., & Lin, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153643 · Cited by 28 · see citing works

Isolation of primitive mouse extraembryonic endoderm (pXEN) stem cell lines

Zhong, Y., Choi, T., Kim, M., Jung, K. H., Chai, Y. G., & Binas, B. (2018) · Stem Cell Research · doi:10.1016/j.scr.2018.05.008 · Cited by 27 · see citing works

Efficient derivation of extraembryonic endoderm stem cell lines from mouse postimplantation embryos

Lin, J., Khan, M., Zapiec, B., & Mombaerts, P. (2016) · Scientific Reports · doi:10.1038/srep39457 · Cited by 26 · see citing works

Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation

Tomaz, R. A., Harman, J. J., Karimlou, D., Weavers, L., Fritsch, L., Bou-Kheir, T., Bell, E., del Valle, I., Niakan, K. K., Fisher, C. L., et al. (2017) · Development · doi:10.1242/dev.142489 · Cited by 24 · see citing works

Making Blood: The Haematopoietic Niche throughout Ontogeny

Al-Drees, M. A., Yeo, J. H., Boumelhem, B. B., Antas, V. I., Brigden, K. W. L., Colonne, C. K., & Fraser, S. T. (2015) · Stem Cells International · doi:10.1155/2015/571893 · Cited by 23 · see citing works

Extraembryonic Endoderm cells as a model of endoderm development

Moerkamp, A. T., Paca, A., Goumans, M., Kunath, T., Kruithof, B. P. T., & Julio, M. K. (2013) · Development Growth & Differentiation · doi:10.1111/dgd.12036 · Cited by 22 · see citing works

Journey of the mouse primitive endoderm: from specification to maturation

Chowdhary, S., & Hadjantonakis, A. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0252 · Cited by 21 · see citing works

Regulation of the embryonic erythropoietic niche: a future perspective

Yumine, A., Fraser, S. T., & Sugiyama, D. (2017) · Blood Research · doi:10.5045/br.2017.52.1.10 · Cited by 20 · see citing works

Lineage-specific regulation of imprinted X inactivation in extraembryonic endoderm stem cells

Merzouk, S., Deuve, J. L., Dubois, A., Navarro, P., Avner, P. R., & Morey, C. (2014) · Epigenetics & Chromatin · doi:10.1186/1756-8935-7-11 · Cited by 17 · see citing works

Activation of the PTHRP/adenylate cyclase pathway promotes differentiation of rat XEN cells into parietal endoderm, whereas Wnt/β-catenin signaling promotes differentiation into visceral endoderm

Chuykin, I. A., Schulz, H., Guan, K., & Bäder, M. (2012) · Journal of Cell Science · doi:10.1242/jcs.110239 · Cited by 17 · see citing works

The mouse allantois: new insights at the embryonic–extraembryonic interface

Downs, K. M. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0251 · Cited by 16 · see citing works

In vitro modeling of early mammalian embryogenesis

Hadjantonakis, A., Siggia, E. D., & Simunovic, M. (2020) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2020.02.003 · Cited by 16 · see citing works

Cell specification and functional interactions in the pig blastocyst inferred from single-cell transcriptomics and uterine fluids proteomics

Dufour, A., Kurylo, C., Stöckl, J. B., Laloë, D., Bailly, Y., Manceau, P., Martins, F., Turhan, A. G., Ferchaud, S., Pain, B., et al. (2024) · Genomics · doi:10.1016/j.ygeno.2023.110780 · Cited by 14 · see citing works

N‐glycoprotein surfaceomes of four developmentally distinct mouse cell types

Kropp, E. M., Bhattacharya, S., Waas, M., Chuppa, S. L., Hadjantonakis, A., Boheler, K. R., & Gundry, R. L. (2014) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400021 · Cited by 13 · see citing works

Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic

Aykul, S., Parenti, A., Chu, K. Y., Reske, J. J., Floer, M., Ralston, A., & Martı́nez-Hackert, E. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.747501 · Cited by 13 · see citing works

Transcriptional network governing extraembryonic endoderm cell fate choice

Pham, P. D., Lu, H., Han, H., Zhou, J. J., Madan, A., Wang, W., Murre, C., & Cho, K. W. Y. (2023) · Developmental Biology · doi:10.1016/j.ydbio.2023.07.002 · Cited by 11 · see citing works

Capturing Identity and Fate Ex Vivo

Garg, V., Morgani, S. M., & Hadjantonakis, A. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.04.007 · Cited by 10 · see citing works

Nodal mutant eXtraembryonic ENdoderm (XEN) stem cells upregulate markers for the anterior visceral endoderm and impact the timing of cardiac differentiation in mouse embryoid bodies

Liu, W., Brown, K., Legros, S., & Foley, A. C. (2012) · Biology Open · doi:10.1242/bio.2012038 · Cited by 11 · see citing works

Derivation of Porcine Extra-Embryonic Endoderm Cell Lines Reveals Distinct Signaling Pathway and Multipotency States

Zhang, M., Jin, Y., Zhao, L., Zhang, J., Zhou, M. Q., Li, M., Yin, Z., Wang, Z., Zhao, L., Li, X., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312918 · Cited by 10 · see citing works

Role of Iron Metabolism-Related Genes in Prenatal Development: Insights from Mouse Transgenic Models

Kopeć, Z., Starzyński, R. R., Jończy, A., Mazgaj, R., & Lipiński, P. (2021) · Genes · doi:10.3390/genes12091382 · Cited by 10 · see citing works

A rapid passage through a two-active-X-chromosome state accompanies the switch of imprinted X-inactivation patterns in mouse trophoblast stem cells

Prudhomme, J., Dubois, A., Navarro, P., Arnaud, D., Avner, P. R., & Morey, C. (2015) · Epigenetics & Chromatin · doi:10.1186/s13072-015-0044-2 · Cited by 10 · see citing works

Stress Decreases Host Viral Resistance and Increases Covid Susceptibility in Embryonic Stem Cells

Abdulhasan, M. A., Ruden, X. L., Rappolee, B., Dutta, S., Gurdziel, K., Ruden, D. M., Awonuga, A. O., Korzeniewski, S. J., Puscheck, E. E., & Rappolee, D. A. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10188-w · Cited by 10 · see citing works

Cellular sociology regulates the hierarchical spatial patterning and organization of cells in organisms

Ganesh, S., Utebay, B., Heit, J. J., & Coskun, A. F. (2020) · Open Biology · doi:10.1098/rsob.200300 · Cited by 9 · see citing works

Defined Stem Cell Culture Conditions to Model Mouse Blastocyst Development

Żylicz, J. J. (2020) · Current Protocols in Stem Cell Biology · doi:10.1002/cpsc.105 · Cited by 9 · see citing works

Specification and role of extraembryonic endoderm lineages in the periimplantation mouse embryo

Filimonow, K., & de la Fuente, R. (2021) · Theriogenology · doi:10.1016/j.theriogenology.2021.12.021 · Cited by 9 · see citing works

Automated, High‐Throughput Phenotypic Screening and Analysis Platform to Study Pre‐ and Post‐Implantation Morphogenesis in Stem Cell‐Derived Embryo‐Like Structures

Shankar, V., van Blitterswijk, C., Vrij, E., & Giselbrecht, S. (2023) · Advanced Science · doi:10.1002/advs.202304987 · Cited by 7 · see citing works

Capturing and Interconverting Embryonic Cell Fates in a Dish

Watts, J. L., Lokken, A. A., Moauro, A., & Ralston, A. (2018) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.11.008 · Cited by 8 · see citing works

In vitro models of human hypoblast and mouse primitive endoderm

Perera, M., & Brickman, J. M. (2023) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2023.102115 · Cited by 7 · see citing works

Characterisation of extraembryonic endoderm-like cells from mouse embryonic fibroblasts induced using chemicals alone

He, X., Chi, G., Li, M., Xu, J., Zhang, L., Song, Y., Wang, L., & Li, Y. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01664-0 · Cited by 7 · see citing works

Is extra-embryonic endoderm a source of placental blood cells?

Downs, K. M. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.07.008 · Cited by 7 · see citing works

Charting the emergent organotypic landscape of the mammalian gut endoderm at single-cell resolutionPreprint

Nowotschin, S., Setty, M. N., Kuo, Y.-Y., Lui, V. C. H., Garg, V., Sharma, R., Simon, C. S., Saiz, N., Gardner, R., Boutet, S. C., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/471078 · Cited by 7 · see citing works

Formation of the Anterior-Posterior Axis in Mammals

Perea-Gómez, A., & Meilhac, S. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405945-0.00010-7 · Cited by 6 · see citing works

Both BMP4 and serum have significant roles in differentiation of embryonic stem cells to primitive and definitive endoderm

Taha, M. F., Javeri, A., Majidizadeh, T., & Valojerdi, M. R. (2015) · Cytotechnology · doi:10.1007/s10616-015-9891-8 · Cited by 6 · see citing works

Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern

Kuliński, T. M., Casari, M. R. T., Guenzl, P. M., Wenzel, D., Andergassen, D., Hladik, A., Datlinger, P., Farlik, M., Theussl, H., Penninger, J. M., et al. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.04.010 · Cited by 6 · see citing works

Single-cell analysis of bidirectional reprogramming between early embryonic states reveals mechanisms of differential lineage plasticitiesPreprint

Garg, V., Yang, Y., Nowotschin, S., Setty, M. N., Kuo, Y.-Y., Sharma, R., Polyzos, A., Salataj, E., Murphy, D., Jang, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.28.534648 · Cited by 6 · see citing works

Divergent destinies: insights into the molecular mechanisms underlying EPI and PE fate determination

Athanasouli, P., Vanhessche, T., & Lluı́s, F. (2025) · Life Science Alliance · doi:10.26508/lsa.202403091 · Cited by 5 · see citing works

Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential before implantation

Kruger, R. E., Frum, T., Brumm, A. S., Hickey, S. L., Niakan, K. K., Aziz, F., Shammami, M. A., Roberts, J., & Ralston, A. (2024) · Development · doi:10.1242/dev.202377 · Cited by 5 · see citing works

Single-cell analysis of bidirectional reprogramming between early embryonic states identify mechanisms of differential lineage plasticities in mice

Garg, V., Yang, Y., Nowotschin, S., Setty, M. N., Salataj, E., Kuo, Y.-Y., Murphy, D., Sharma, R., Jang, A., Polyzos, A., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.11.022 · Cited by 9 · see citing works

XEN and the Art of Stem Cell Maintenance: Molecular Mechanisms Maintaining Cell Fate and Self-Renewal in Extraembryonic Endoderm Stem (XEN) Cell Lines

Ralston, A. (2017) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-319-63187-5_6 · Cited by 4 · see citing works

Mitotic bookmarking by transcription factors and the preservation of pluripotency

Owens, N. D. L., González, I., Artus, J., & Navarro, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814085-7.00006-4 · Cited by 3 · see citing works

Culture of Mouse Amniotic Fluid-Derived Cells on Irradiated STO Feeders Results in the Generation of Primitive Endoderm Cell Lines Capable of Self-Renewal in vitro

Babic, A. M., Jang, S., Nicolov, E., Voicu, H., & Luckey, C. J. (2013) · Cells Tissues Organs · doi:10.1159/000353942 · Cited by 2 · see citing works

A differentiation program induced by bone morphogenetic proteins 4 and 7 in endodermal epithelial cells provides the molecular basis for efficient nutrient transport by the chicken yolk sac

Bauer, R., Tondl, P., & Schneider, W. J. (2019) · Developmental Dynamics · doi:10.1002/dvdy.129 · Cited by 2 · see citing works

Chemically induced cell plasticity enables the generation of high-fidelity embryo modelPreprint

Li, H., Huang, J., Guan, W., Wu, J., Luo, H., Chang, L., Zhao, H., Chen, C., Gao, Y., Zhang, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.20.598030 · Cited by 2 · see citing works

Primitive means first, not worst: Critical roles for primitive endoderm in embryos and embryo models

Shammami, M. A., Virola‐Iarussi, A., McCrary, I., & Ralston, A. (2025) · Developmental Biology · doi:10.1016/j.ydbio.2025.09.008 · Cited by 1 · see citing works

Synthetic embryos: current progress, application and challenges

Wang, L., Guo, F., Chen, Y., & Dai, X. (2026) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-026-01550-z · Cited by 1 · see citing works

First Cell Fate Decisions in Early Development

Hemberger, M., & Dean, W. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394445-0.00008-4 · Cited by 1 · see citing works

Stem Cells from Early Mammalian Embryos

Hadjantonakis, A., Gavrilov, S., Xenopoulos, P., & Papaioannou, V. E. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7696-2_3

In vitro models of human blastocysts and early embryogenesis

Tan, J. P., Liu, X., & Polo, J. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91380-5.00001-0

Defined Conditions Control the Morphological Dualism of Rat Primitive Extraembryonic Endoderm Stem Cells

Wang, X., Kim, M., Jung, K. H., Chai, Y. G., & Binas, B. (2023) · Stem Cells and Development · doi:10.1089/scd.2023.0187

OCT4 is expressed in extraembryonic endoderm stem (XEN) cell progenitors during somatic cell reprogrammingPreprint

Moauro, A., Hickey, S. L., Halbisen, M. A., Parenti, A., & Ralston, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.22.576724

Additional file 2 of Characterisation of extraembryonic endoderm-like cells from mouse embryonic fibroblasts induced using chemicals alone

He, X., Chi, G., Li, M., Xu, J., Zhang, L., Song, Y., Wang, L., & Li, Y. (2020) · Figshare · doi:10.6084/m9.figshare.12143877

Additional file 1 of Characterisation of extraembryonic endoderm-like cells from mouse embryonic fibroblasts induced using chemicals alone

He, X., Chi, G., Li, M., Xu, J., Zhang, L., Song, Y., Wang, L., & Li, Y. (2020) · Figshare · doi:10.6084/m9.figshare.12143874

Modular engineering of embryonic-extraembryonic interactions generates advanced gastruloid morphotypesPreprint

Smirnova, N. P., Ponomartsev, S. V., Ali, T. M. L., Lycke, M., Chung, B. K., Øgaard, J., Melum, E., Combriat, T. M. D., Veenvliet, J. V., & Krauss, S. J. K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.09.687163

Caractérisation de la différenciation de l'endoderme primitif : Coopération entre la voie de signalisation RTK-FGF et le facteur de transcription Gata 6

Hermitte, S. (2017) · doi:10.70675/6b207faaze6c2z44d8za445z1d7b4d5bf750

Influence des voies de signalisation IGF et MAPK sur la spécification des lignages de l'embryon de souris préimplantatoire

Bassalert, C. (2018) · doi:10.70675/9dc72f37ze258z453eza783z6e0feb58d9d7

The PI3K/AKT pathway regulates cell fate identities during early mouse development

Geiselmann, A. (2022) · doi:10.70675/b659b413z8c04z4865z994aza128ef343a8c

Déchiffrer le réseau moléculaire contrôlant la pluripotence du porc

Dufour, A. (2024) · doi:10.70675/6694a20az0df0z414bz9bbez1b753d188739

Développement et morphogenèse de l'endoderme pariétal extra-embryonnaire de la souris : implication du facteur de transcription GATA6

Quenec’Hdu, R. (2024) · doi:10.70675/c94aefebzbec5z4eecz9d14z353b696d5196

The vertebrate yolk sac: evolutionary origins and current advances in in vitro models

Blagrove, J. R., Orsi, A. E. R., Cindrová‐Davies, T., & Niakan, K. K. (2026) · Development · doi:10.1242/dev.205384

Systematic Methods to Resolve Lineage-Specific Stress States in Early Mammalian Embryos and That May Enable Miscarriage Prediction

Ruden, X. L., Coddington, C., Asplund, L., Dinakin, A., Awonuga, A. O., Ruden, D. M., Korzeniewski, S. J., Zhang, L., Puscheck, E., & Rappolee, D. A. (2026) · Cells · doi:10.3390/cells15110996

A primitive endoderm-centric view of mammalian development

Kim, R., Faerberg, D. F., & Pósfai, E. (2026) · Development · doi:10.1242/dev.205485

BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm

Paca, A., Séguin, C. A., Clements, M., Ryczko, M., Rossant, J., Rodriguez, T. A., & Kunath, T. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2011.10.013 · Cited by 87 · see citing works

Differentiation of extraembryonic endoderm stem cell lines and parietal endoderm into visceral endoderm: the art of XEN cells

Paca, A. (2012) · OpenGrey (Institut de l'Information Scientifique et Technique)

XEN cells: An in vitro model of extraembryonic endoderm

Ryczko, M. C. (2007) · TSpace (University of Toronto)

Activation of the PTHRP/adenylate cyclase pathway promotes differentiation of rat XEN cells into parietal endoderm, whereas Wnt/β-catenin signaling promotes differentiation into visceral endoderm

Chuykin, I. A., Schulz, H., Guan, K., & Bäder, M. (2013) · Development · doi:10.1242/dev.096396

17-P001 Bmp4 promotes differentiation of the first vertebrate epithelium

Wei, J., Sanchez-Ripoll, Y., Welham, M. J., & Chalmers, A. D. (2009) · Mechanisms of Development · doi:10.1016/j.mod.2009.06.722