The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas
Open accessAbstract
Germinal centers (GCs) are sites of B-cell clonal expansion, hypermutation, and selection. GCs are polarized into dark (DZ) and light zones (LZ), a distinction that is of key importance to GC selection. However, the difference between the B cells in each of these zones in humans remains unclear. We show that, as in mice, CXCR4 and CD83 can be used to distinguish human LZ and DZ cells. Using these markers, we show that LZ and DZ cells in mice and humans differ only in the expression of characteristic “activation” and “proliferation” programs, suggesting that these populations represent alternating states of a single-cell type rather than distinct differentiation stages. In addition, LZ/DZ transcriptional profiling shows that, with the exception of “molecular” Burkitt lymphomas, nearly all human B-cell malignancies closely resemble LZ cells, which has important implications for our understanding of the molecular programs of lymphomagenesis.
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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
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TM4: a free, open-source system for microarray data management and analysis
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Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878
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Self-citationSequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding
Scheid, J. F., Mouquet, H., Ueberheide, B., Diskin, R., Klein, F., Oliveira, T. Y. K., Pietzsch, J., Fenyo, D., Abadir, A., Velinzon, K., et al. (2011) · Science · doi:10.1126/science.1207227 · Cited by 1,139
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Crotty, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.004 · Cited by 1,847
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De Silva, N. S., & Klein, U. (2015) · Nature Reviews Immunology · doi:10.1038/nri3804 · Cited by 1,084
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Scott, D. W., & Gascoyne, R. D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3774 · Cited by 552
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Basso, K., & Dalla-Favera, R. (2015) · Nature Reviews Immunology · doi:10.1038/nri3814 · Cited by 510
Self-citationThe proto-oncogene MYC is required for selection in the germinal center and cyclic reentry
Dominguez-Sola, D., Victora, G. D., Ying, C. Y., Phan, R. T., Saito, M., Nussenzweig, M. C., & Dalla-Favera, R. (2012) · Nature Immunology · doi:10.1038/ni.2428 · Cited by 490
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Metadata
- Authors
- Victora, G. D., Dominguez-Sola, D., Holmes, A. B., Deroubaix, S., Dalla-Favera, R., & Nussenzweig, M. C.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-09-13
- Volume
- 120
- Issue
- 11
- Pages
- 2240-2248
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2016175731
- Cited by
- 411
- References
- 47
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Victora, G. D., Dominguez-Sola, D., Holmes, A. B., Deroubaix, S., Dalla-Favera, R., & Nussenzweig, M. C. (2012). Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. Blood. https://doi.org/10.1182/blood-2012-03-415380
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