The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state
Open accessAbstract
Key Points: Hematopoietic stem cell aging associates with stable transcriptional alterations. Somatic cell reprogramming reverses functional defects associated with hematopoietic aging.
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“This possibility has been supported in part by studies in which aged hematopoietic progenitors were reprogrammed to produce iPSCs. These iPSCs were then used to create new HSCs in a chimeric embryo system and yielded complete rejuvenation of hematopoietic activity183.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [183]
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Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,550
Epigenetic memory in induced pluripotent stem cells
Kim, K., Doi, A., Wen, B., Ng, K., Zhao, R. C., Cahan, P., Kim, J., Aryee, M. J., Ji, H., Ehrlich, L. I. R., et al. (2010) · Nature · doi:10.1038/nature09342 · Cited by 2,415
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Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
Lister, R., Pelizzola, M., Kida, Y. S., Hawkins, R. D., Nery, J. R., Hon, G. C., Antosiewicz‐Bourget, J., O’Malley, R. C., Castanon, R., Klugman, S. A., et al. (2011) · Nature · doi:10.1038/nature09798 · Cited by 1,595
The origin and evolution of mutations in acute myeloid leukemia
Welch, J. S., Ley, T. J., Link, D. C., Miller, C. A., Larson, D. E., Koboldt, D. C., Wartman, L. D., Lamprecht, T. L., Liu, F., Xia, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.023 · Cited by 1,575
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Cell intrinsic alterations underlie hematopoietic stem cell aging
Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152 · cited 10×
“For instance, the key epigenetic regulator Ezh2 is down-regulated in aged HSCs.36 Although we previously found little evidence of epigenetic changes at the p16INK4a locus in aged HSCs,36 a wellestablished Ezh2 target loci in other cells,37 the broad and potent roles of Ezh2 might well underlie other epigenetic alterat…”
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Faculty Opinions recommendation of Understanding intrinsic hematopoietic stem cell aging.
Méndez‐Ferrer, S. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737043526.793575345
Skinder, N., Fernández, I. S., Dethmers-Ausema, A., Weersing, E., & de Haan, G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.14.553203
Epidermal Growth Factor Rejuvenates Aged Hematopoietic Stem CellsPreprint
Chang, V. Y., He, Y., Grohe, S., Brady, M. J., Chan, A., Kadam, R., Fang, T., Pang, A., Pohl, K. A., Tran, E., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4685388
Cellular Reprogramming to Stimulate Retina Regeneration
Urrutia-Cabrera, D., Wang, L., & Wong, R. C. B. (2025) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-031-94101-6_12
Hematopoietic (stem) cells—The elixir of life?
Cerezo, E. L., Anderson, J., Vedrenne, E. D., Martín, N. Y., & Lengefeld, J. (2025) · FEBS Letters · doi:10.1002/1873-3468.70215
Hematopoietic stem cell senescence and opportunities for intervention
Barve, A., Dabas, P., Cain, T. L., & McKinney‐Freeman, S. (2026) · Experimental Hematology · doi:10.1016/j.exphem.2026.105425 · Cited by 1
Metadata
- Authors
- Wahlestedt, M., Norddahl, G. L., Sten, G., Ugale, A., Frisk, M.-A. M., Mattsson, R., Deierborg, T., Sigvardsson, M., & Bryder, D.
- Affiliations
- Lund University (SE)
- Immunology Section,
- Transgenic Core Facility, and
- Linköping University (SE)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2013-05-23
- Volume
- 121
- Issue
- 21
- Pages
- 4257-4264
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1972698198
- Cited by
- 106
- References
- 39
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 5 · 2016: 20 · 2015: 12 · 2014: 10 · 2013: 1
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- green
- lup.lub.lu.se
- Licence
- other-oa
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- hematopoietic stem cell aging, epigenetic aging, induced pluripotent stem cells, hematopoietic progenitor cells, blastocyst complementation, HSC transplantation, chimeras, self-renewal
- MeSH terms
- Animals, Cell Differentiation, Hematopoietic Stem Cells, Mice, Inbred C57BL, Transcription, Genetic, Telomere, Cellular Senescence, Hematopoietic Stem Cell Transplantation, Gene Expression Regulation, Developmental, Totipotent Stem Cells, Epigenesis, Genetic, Mice, Genome-Wide Association Study
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