Cited by 106Hematopoietic Stem Cell TransplantationPluripotent Stem Cells ResearchMesenchymal stem cell research

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An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state

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Wahlestedt, Martin, Norddahl, Gudmundur L., Sten, Gerd, Ugale, Amol, Frisk, Mary-Ann Micha, Mattsson, Ragnar, Deierborg, Tomas, Sigvardsson, Mikael, Bryder, David·2013·Blood

DOI 10.1182/blood-2012-11-469080

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Abstract

Key Points: Hematopoietic stem cell aging associates with stable transcriptional alterations. Somatic cell reprogramming reverses functional defects associated with hematopoietic aging.

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“For instance, the key epigenetic regulator Ezh2 is down-regulated in aged HSCs.36 Although we previously found little evidence of epigenetic changes at the p16INK4a locus in aged HSCs,36 a wellestablished Ezh2 target loci in other cells,37 the broad and potent roles of Ezh2 might well underlie other epigenetic alterat…”
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Authors: Wahlestedt, M., Norddahl, G. L., Sten, G., Ugale, A., Frisk, M.-A. M., Mattsson, R., Deierborg, T., Sigvardsson, M., & Bryder, D.
Affiliations: Lund University (SE)
Immunology Section,
Transgenic Core Facility, and
Linköping University (SE)
ORCID: Norddahl, Gudmundur L.
Ugale, Amol
Deierborg, Tomas
Sigvardsson, Mikael
Bryder, David
Venue: Blood
Publisher: American Society of Hematology
Published: 2013-05-23
Volume: 121
Issue: 21
Pages: 4257-4264
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2012-11-469080
OpenAlex: W1972698198
Cited by: 106
References: 39
Citations by year: 2026: 1 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 5 · 2016: 20 · 2015: 12 · 2014: 10 · 2013: 1
FWCI: 10.28
Type: journal article
Language: en
Open access: green
lup.lub.lu.se
Licence: other-oa
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Lund University Publications (Lund University) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: hematopoietic stem cell aging, epigenetic aging, induced pluripotent stem cells, hematopoietic progenitor cells, blastocyst complementation, HSC transplantation, chimeras, self-renewal
MeSH terms: Animals, Cell Differentiation, Hematopoietic Stem Cells, Mice, Inbred C57BL, Transcription, Genetic, Telomere, Cellular Senescence, Hematopoietic Stem Cell Transplantation, Gene Expression Regulation, Developmental, Totipotent Stem Cells, Epigenesis, Genetic, Mice, Genome-Wide Association Study

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An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state

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