Cited by 212Acute Myeloid Leukemia ResearchGlioma Diagnosis and TreatmentChromatin Remodeling and Cancer

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML

Chaturvedi, Anuhar, Araujo Cruz, Michelle Maria, Jyotsana, Nidhi, Sharma, Amit, Yun, Haiyang, Görlich, Kerstin, Wichmann, Martin, Schwarzer, Adrian +16 more·2013·Blood

Abstract

Key Points: IDH1 promotes leukemogenesis in vivo in cooperation with HoxA9. Pharmacologic inhibition of mutant IDH1 efficiently inhibits AML cells of IDH1-mutated patients but not of normal CD34+ bone marrow cells.

Integrity signals

Registry

Crossref · 10.1182/blood-2013-03-491571

Cites

45 of 45 references verified0 citation errors · 0 not checkable

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  • Overexpression of HOXA9 dysregulates MAPK signalling and collaborates with IDH1R132H to induce a short-latency AML in mice.

    “in vivo transplantation experiments have shown that the overexpression of HOXA9 dysregulates MAPK signalling and collaborates with IDH1R132H to induce a short-latency AML in mice.9”
  • HOXA9 is frequently overexpressed in human AMLs, notably in patients harbouring the IDH1R132H mutation.

    “The homeobox protein HOXA9 contributes to haematopoiesis and is frequently overexpressed in human AMLs,8 notably in patients harbouring the IDH1R132H mutation.9”

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Research works printed but not linked: 1

  1. Irwin, ZINC: a free tool to discover chemistry for biology [published online ahead of print June 15, 2012]., J Chem Inf Model

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Authors
Chaturvedi, A., Araujo Cruz, M. M., Jyotsana, N., Sharma, A., Yun, H., Görlich, K., Wichmann, M., Schwarzer, A., Preller, M., Thol, F., Meyer, J., Haemmerle, R., Struys, E. A., Jansen, E. E., Modlich, U., Li, Z., Sly, L. M., Geffers, R., Lindner, R., Manstein, D. J., Lehmann, U., Krauter, J., Ganser, A., & Heuser, M.
Affiliations
  • Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation,
  • Institute of Experimental Hematology, and
  • Medizinische Hochschule Hannover (DE)
  • Vrije Universiteit Amsterdam (NL)
  • University of British Columbia (CA)
  • Helmholtz Centre for Infection Research (DE)
  • Institute of Cell Biology (UA)
Venue
Blood
Published
2013-10-17
Volume
122
Issue
16
Pages
2877-2887
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2071370702
Cited by
210
References
45
Citations by year
2026: 2 · 2025: 14 · 2024: 9 · 2023: 7 · 2022: 8 · 2021: 15 · 2020: 18 · 2019: 14 · 2018: 19 · 2017: 23 · 2016: 18 · 2015: 26 · 2014: 35 · 2013: 2
FWCI
19.37
Type
journal article
Language
en
Open access
closed
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
IDH1 mutation, isocitrate dehydrogenase, acute myeloid leukemia, leukemogenesis, 2-hydroxyglutarate, HOXA9, myeloproliferative neoplasms, CDKN2A, CDKN2B, MAPK signaling, IDH1 inhibitor, therapeutic target
MeSH terms
Adolescent, Adult, Animals, Cell Cycle, Female, Humans, Isocitrate Dehydrogenase, Mice, Inbred C57BL, Middle Aged, Mutation, Leukemia, Myeloid, Acute, Gene Expression Regulation, Leukemic, Bone Marrow Transplantation, Apoptosis, Antigens, CD34, MAP Kinase Signaling System, Mice, Young Adult

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