The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia
Open accessAbstract
Key Points: AZD1208 is a selective pan-Pim kinase inhibitor with efficacy in AML cells, xenografts, and Flt3-internal tandem duplication or Flt3 wild-type patient samples. AML cell growth inhibition is associated with suppression of p70S6K, 4EBP1 phosphorylation, and messenger RNA translation.
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Citations
Cites
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
Fingar, D. C., Salama, S., Tsou, C., Harlow, E., & Blenis, J. (2002) · Genes & Development · doi:10.1101/gad.995802 · Cited by 1,093
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
Gingras, A.-C., Raught, B., Gygi, S. P., Niedzwiecka, A., Miron, M., Burley, S. K., Polakiewicz, R. D., Wyslouch-Cieszynska, A., Aebersold, R., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.912401 · Cited by 883
mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs
Dowling, R. J. O., Topisirovic, I., Alain, T., Bidinosti, M., Fonseca, B. D., Petroulakis, E., Wang, X., Larsson, O., Selvaraj, A., Liu, Y., et al. (2010) · Science · doi:10.1126/science.1187532 · Cited by 726
Theo Cuypers, H., Selten, G., Quint, W., Zijlstra, M., Maandag, E. R., Boelens, W., van Wezenbeek, P., Melief, C., & Berns, A. (1984) · Cell · doi:10.1016/0092-8674(84)90309-x · Cited by 639
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
Ruvinsky, I., Sharon, N., Lerer, T., Cohen, H., Stolovich-Rain, M., Nir, T., Dor, Y., Zisman, P., & Meyuhas, O. (2005) · Genes & Development · doi:10.1101/gad.351605 · Cited by 638
For better or for worse: the role of Pim oncogenes in tumorigenesis
Nawijn, M. C., Alendar, A., & Berns, A. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2986 · Cited by 481
Ohanna, M., Sobering, A. K., Lapointe, T., Lorenzo, L., Praud, C., Petroulakis, E., Sonenberg, N., Kelly, P. A., Sotiropoulos, A., & Pende, M. (2005) · Nature Cell Biology · doi:10.1038/ncb1231 · Cited by 392
The serine/threonine kinase Pim-1
Bachmann, M., & Möröy, T. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.11.005 · Cited by 372
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
Fox, C. J., Hammerman, P. S., Cinalli, R. M., Master, S. R., Chodosh, L. A., & Thompson, C. B. (2003) · Genes & Development · doi:10.1101/gad.1105003 · Cited by 336
Aho, T. L. T., Sandholm, J., Peltola, K. J., Mankonen, H. P., Lilly, M., & Koskinen, P. J. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.050 · Cited by 325
Cited by
Khwaja, A., Bjorkholm, M., Gale, R. E., Levine, R. L., Jordan, C. T., Ehninger, G., Bloomfield, C. D., Estey, E., Burnett, A., Cornelissen, J. J., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.10 · Cited by 592
Cortes, J., Tamura, K., DeAngelo, D. J., de Bono, J., Lorente, D., Minden, M., Uy, G. L., Kantarjian, H., Chen, L. S., Gandhi, V., et al. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0082-1 · Cited by 120
Self-citationPIM kinases: From survival factors to regulators of cell motility
Santio, N. M., & Koskinen, P. J. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.10.016 · Cited by 69
Hendriks, D. F. G., Vorrink, S. U., Smutny, T., Sim, S. C., Nordling, Å., Ullah, S., Kumondai, M., Jones, B. C., Johansson, I., Andersson, T. B., et al. (2020) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1860 · Cited by 57
Xu, J., Xiong, G., Cao, Z., Huang, H., Wang, T., You, L., Zhou, L., Zheng, L., Hu, Y., Zhang, T., et al. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0406-z · Cited by 53
Metadata
- Authors
- Keeton, E. K., McEachern, K., Dillman, K. S., Palakurthi, S., Cao, Y., Grondine, M. R., Kaur, S., Wang, S., Chen, Y., Wu, A., Shen, M., Gibbons, F. D., Lamb, M. L., Zheng, X., Stone, R. M., DeAngelo, D. J., Platanias, L. C., Dakin, L. A., Chen, H., Lyne, P. D., & Huszar, D.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-02-06
- Volume
- 123
- Issue
- 6
- Pages
- 905-913
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2033341978
- Cited by
- 254
- References
- 38
- FWCI
- 14.50
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. https://app.cochat.ai/papers/10.1182/blood-2013-04-495366
- The paper
- Keeton, E. K., McEachern, K., Dillman, K. S., Palakurthi, S., Cao, Y., Grondine, M. R., Kaur, S., Wang, S., Chen, Y., Wu, A., Shen, M., Gibbons, F. D., Lamb, M. L., Zheng, X., Stone, R. M., DeAngelo, D. J., Platanias, L. C., Dakin, L. A., Chen, H., . . . Huszar, D. (2014). AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood. https://doi.org/10.1182/blood-2013-04-495366
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
