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Requirement for CDK6 in MLL-rearranged acute myeloid leukemia
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Key Points: CDK6 is a critical effector of MLL fusions in myeloid leukemogenesis. Genetic and pharmacologic inhibition of CDK6 overcome the differentiation block associated with MLL-rearranged AML.
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“Multiple types of leukemia cells are dependent on CDK6 for survival, including mixed-lineage leukemia (MLL) [123] and Philadelphia chromosome-positive ALL (Ph+ ALL) [9].”
From Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies (2020) · cites this paper as [123]
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Metadata
- Authors
- Placke, T., Faber, K., Nonami, A., Putwain, S. L., Salih, H. R., Heidel, F. H., Krämer, A., Root, D. E., Barbie, D. A., Krivtsov, A. V., Armstrong, S. A., Hahn, W. C., Huntly, B. J., Sykes, S. M., Milsom, M. D., Scholl, C., & Fröhling, S.
- Affiliations
- German Cancer Research Center (DE)
- Universität Ulm (DE)
- Dana-Farber Cancer Institute (US)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Broad Institute (US)
- Memorial Sloan Kettering Cancer Center (US)
- Fox Chase Cancer Center (US)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-07-03
- Volume
- 124
- Issue
- 1
- Pages
- 13-23
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4190617
- OpenAlex
- W1990966504
- Cited by
- 170
- References
- 60
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 6 · 2023: 11 · 2022: 16 · 2021: 19 · 2020: 24 · 2019: 10 · 2018: 14 · 2017: 9 · 2016: 17 · 2015: 23 · 2014: 6
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R00CA158461, U01CA176058, K08CA138918, P30CA008748)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- CDK6, MLL rearrangement, acute myeloid leukemia, MLL-AF9, CDK4, cell cycle regulators, myeloid differentiation, leukemogenesis, MLL fusion proteins, CDK6 inhibitors, leukemia mouse model
- MeSH terms
- Animals, Flow Cytometry, Humans, Mice, Inbred C57BL, Transduction, Genetic, Immunoblotting, Leukemia, Myeloid, Acute, Oncogene Proteins, Fusion, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, RNA, Small Interfering, Cell Line, Tumor, Cyclin-Dependent Kinase 6, Mice, Myeloid-Lymphoid Leukemia Protein
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