Hox genes in hematopoiesis and leukemogenesis

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

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Identification of human brain tumour initiating cells

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A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

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Hox genes in vertebrate development

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Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

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Isolation and In vitro Propagation of Tumorigenic Breast Cancer Cells with Stem/Progenitor Cell Properties

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MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

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Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.

Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452 · see citing works

Genome Regulation by Polycomb and Trithorax Proteins

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Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity

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HOMEODOMAIN PROTEINS

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Characterization of clonogenic multiple myeloma cells

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Hematopoietic Stem Cells

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HOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo

Antonchuk, J., Sauvageau, G., & Humphries, R. K. (2002) · Cell · doi:10.1016/s0092-8674(02)00697-9 · Cited by 700 · see citing works

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors

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Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation

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Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitorsPreprint

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Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

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Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

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Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.Preprint

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Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia

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Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1

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Hox cofactors in vertebrate development

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Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.

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Divergent homeo box proteins recognize similar DNA sequences in Drosophila

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AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

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Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9Preprint

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JunB Deficiency Leads to a Myeloproliferative Disorder Arising from Hematopoietic Stem Cells

Passegue, E. A., Wagner, E. F., & Weissman, I. L. (2004) · Cell · doi:10.1016/j.cell.2004.10.010 · Cited by 433 · see citing works

The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis

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Expressing the human genome

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HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL)

Soulier, J., Clappier, E., Cayuela, J., Régnault, A., García-Peydró, M., Dombret, H., Baruchel, A., Toribio, M. L., & Sigaux, F. (2005) · Blood · doi:10.1182/blood-2004-10-3900 · Cited by 382 · see citing works

Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia

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Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance

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CREB Binding Protein Interacts with Nucleoporin-Specific FG Repeats That Activate Transcription and Mediate NUP98-HOXA9 Oncogenicity

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Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation

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Overexpression of the myeloid leukemia–associatedHoxa9 gene in bone marrow cells induces stem cell expansion

Þorsteinsdóttir, U., Mamo, A., KROON, E. J., Jerome, L., Bijl, J. J., Lawrence, H. J., Humphries, R. K., & Sauvageau, G. (2002) · Blood · doi:10.1182/blood.v99.1.121 · Cited by 347 · see citing works

Hoxa9 and Meis1 Are Key Targets for MLL-ENL-Mediated Cellular Immortalization

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Meis1, a PBX1-Related Homeobox Gene Involved in Myeloid Leukemia in BXH-2 Mice

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Overexpression of HOXA10 in Murine Hematopoietic Cells Perturbs both Myeloid and Lymphoid Differentiation and Leads to Acute Myeloid Leukemia

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The pathophysiology of HOX genes and their role in cancer

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Hematopoietic, angiogenic and eye defects in Meis1 mutant animals

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Mice Bearing a Targeted Interruption of the Homeobox Gene HOXA9 Have Defects in Myeloid, Erythroid, and Lymphoid Hematopoiesis

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Defining Roles for HOX and MEIS1 Genes in Induction of Acute Myeloid Leukemia

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Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny

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Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein

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AbdB-Like Hox Proteins Stabilize DNA Binding by the Meis1 Homeodomain Proteins

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Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia

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Maintenance of functional equivalence during paralogous Hox gene evolution

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cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes

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The Role of HOX Homeobox Genes in Normal and Leukemic Hematopoiesis

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Most Acute Myeloid Leukemia Progenitor Cells With Long-Term Proliferative Ability In Vitro and In Vivo Have the Phenotype CD34+/CD71−/HLA-DR−

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Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed.Preprint

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NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia

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NUP98–HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice

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Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells

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Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias

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Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells

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HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation

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Regulation of number and size of digits by posterior Hox genes: A dose-dependent mechanism with potential evolutionary implications

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The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.

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Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia

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Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality

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Overexpression of HOXB3 in Hematopoietic Cells Causes Defective Lymphoid Development and Progressive Myeloproliferation

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Leukaemic transformation by CALM–AF10 involves upregulation of Hoxa5 by hDOT1L

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An Mll-Dependent Hox Program Drives Hematopoietic Progenitor Expansion

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Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis

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The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver

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The specificity of homeotic gene function

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c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells

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HOXandNon‐HOXHomeobox Genes in Leukemic Hematopoiesis

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Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9

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Roles for c-Myc in Self-renewal of Hematopoietic Stem Cells

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Enhanced In Vivo Regenerative Potential of HOXB4-Transduced Hematopoietic Stem Cells With Regulation of Their Pool Size

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Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1

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Molecular characterization of acute leukemias by use of microarray technology

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Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis

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Mutations in Paralogous Hox Genes Result in Overlapping Homeotic Transformations of the Axial Skeleton: Evidence for Unique and Redundant Function

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Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells

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