Huntly, Brian J. P.

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

Levine, R. L., Wadleigh, M., Cools, J., Ebert, B. L., Wernig, G., Huntly, B. J. P., Boggon, T. J., Wlodarska, I., Clark, J. J., Moore, S., et al. (2005) · Cancer Cell

Myeloproliferative Neoplasms: Diagnosis and TreatmentAcute Myeloid Leukemia Research

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Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

Nangalia, J., Massie, C. E., Baxter, E. J., Nice, F. L., Gundem, G., Wedge, D. C., Avezov, E., Li, J., Kollmann, K., Kent, D. G., et al. (2013) · New England Journal of Medicine

Myeloproliferative Neoplasms: Diagnosis and TreatmentAcute Myeloid Leukemia Research

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FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

Tothova, Z., Kollipara, R., Huntly, B. J., Lee, B. H., Castrillon, D. H., Cullen, D. E., McDowell, E. P., Lazo-Kallanian, S., Williams, I. R., Sears, C., et al. (2007) · Cell

FOXO transcription factor regulationHematopoietic Stem Cell Transplantation

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A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

Tzelepis, K., Koike-Yusa, H., De Braekeleer, E., Li, Y., Metzakopian, E., Dovey, O. M., Mupo, A., Grinkevich, V., Li, M., Mazan, M., et al. (2016) · Cell Reports

Acute Myeloid Leukemia ResearchChromatin Remodeling and Cancer

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MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors

Huntly, B. J. P., Shigematsu, H., Deguchi, K., Lee, B. H., Mizuno, S., Duclos, N., Rowan, R., Amaral, S., Curley, D., Williams, I. R., et al. (2004) · Cancer Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

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Population dynamics of normal human blood inferred from somatic mutations

Lee-Six, H., Øbro, N. F., Shepherd, M. S., Grossmann, S., Dawson, K., Belmonte, M., Osborne, R. J., Huntly, B. J. P., Martincorena, I., Anderson, E., et al. (2018) · Nature

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

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Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

Sciacovelli, M., Gonçalves, E., Johnson, T. I., Zecchini, V. R., da Costa, A. S. H., Gaude, E., Drubbel, A. V., Theobald, S. J., Abbo, S. R., Tran, M. G. B., et al. (2016) · Nature

Cancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation

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BET inhibitor resistance emerges from leukaemia stem cells

Fong, C. Y., Gilan, O., Lam, E. Y. N., Rubin, A. F., Ftouni, S., Tyler, D., Stanley, K., Sinha, D., Yeh, P., Morison, J., et al. (2015) · Nature

Protein Degradation and InhibitorsChromatin Remodeling and Cancer

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Reprogramming of T Cells to Natural Killer–Like Cells upon Bcl11b Deletion

Li, P., Burke, S., Wang, J., Chen, X., Ortiz, M., Lee, S.-C., Lu, D., Campos, L., Goulding, D., Ng, B. L., et al. (2010) · Science

T-cell and B-cell ImmunologyImmune Cell Function and Interaction

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Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

Placke, T., Faber, K., Nonami, A., Putwain, S. L., Salih, H. R., Heidel, F. H., Krämer, A., Root, D. E., Barbie, D. A., Krivtsov, A. V., et al. (2014) · Blood

Acute Myeloid Leukemia ResearchChromatin Remodeling and Cancer

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Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors

Booth, C. A. G., Barkas, N., Neo, W. H., Boukarabila, H., Soilleux, E. J., Giotopoulos, G., Farnoud, N., Giustacchini, A., Ashley, N., Carrelha, J., et al. (2018) · Cancer Cell

Acute Myeloid Leukemia ResearchAcute Lymphoblastic Leukemia research

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Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells

Domingues, A. F., Kulkarni, R., Giotopoulos, G., Gupta, S., Vinnenberg, L., Arede, L., Foerner, E., Khalili, M., Adao, R. R., Johns, A., et al. (2020) · eLife

Acute Myeloid Leukemia ResearchGenomics and Chromatin Dynamics

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KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia

Arede, L., Foerner, E., Wind, S., Kulkarni, R., Domingues, A. F., Giotopoulos, G., Kleinwaechter, S., Mollenhauer-Starkl, M., Davison, H., Chandru, A., et al. (2022) · Blood Advances

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Impact of BCR::ABL1 single nucleotide variants on asciminib efficacy

Innes, A. J., Hayden, C., Orovboni, V., Claudiani, S., Fernando, F., Khan, A., Rees, D., Byrne, J., Gallipoli, P., Francis, S., et al. (2024) · Leukemia

Chronic Myeloid Leukemia TreatmentsChronic Lymphocytic Leukemia Research

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