ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes

Parrilla Castellar, Edgardo R.; Jaffe, Elaine S.; Said, Jonathan W.; Swerdlow, Steven H.; Ketterling, Rhett P.; Knudson, Ryan A.; Sidhu, Jagmohan S.; Hsi, Eric D.; Karikehalli, Shridevi; Jiang, Liuyan; Vasmatzis, George; Gibson, Sarah E.; Ondrejka, Sarah; Nicolae, Alina; Grogg, Karen L.; Allmer, Cristine; Ristow, Kay M.; Wilson, Wyndham H.; Macon, William R.; Law, Mark E.; Cerhan, James R.; Habermann, Thomas M.; Ansell, Stephen M.; Dogan, Ahmet; Maurer, Matthew J.; Feldman, Andrew L.

doi:10.1182/blood-2014-04-571091

Cited by 472

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes

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Parrilla Castellar, Edgardo R., Jaffe, Elaine S., Said, Jonathan W., Swerdlow, Steven H., Ketterling, Rhett P., Knudson, Ryan A., Sidhu, Jagmohan S., Hsi, Eric D., Karikehalli, Shridevi, Jiang, Liuyan, Vasmatzis, George, Gibson, Sarah E., Ondrejka, Sarah, Nicolae, Alina, Grogg, Karen L., Allmer, Cristine, Ristow, Kay M., Wilson, Wyndham H., Macon, William R., Law, Mark E., Cerhan, James R., Habermann, Thomas M., Ansell, Stephen M., Dogan, Ahmet, Maurer, Matthew J., Feldman, Andrew L.·2014·Blood

DOI 10.1182/blood-2014-04-571091

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Abstract

Key Points: ALK-negative ALCLs have chromosomal rearrangements of DUSP22 or TP63 in 30% and 8% of cases, respectively. DUSP22-rearranged cases have favorable outcomes similar to ALK-positive ALCLs, whereas other genetic subtypes have inferior outcomes.

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Show all 22 references

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See all 472

Authors: Parrilla Castellar, E. R., Jaffe, E. S., Said, J. W., Swerdlow, S. H., Ketterling, R. P., Knudson, R. A., Sidhu, J. S., Hsi, E. D., Karikehalli, S., Jiang, L., Vasmatzis, G., Gibson, S. E., Ondrejka, S., Nicolae, A., Grogg, K. L., Allmer, C., Ristow, K. M., Wilson, W. H., Macon, W. R., Law, M. E., Cerhan, J. R., Habermann, T. M., Ansell, S. M., Dogan, A., Maurer, M. J., & Feldman, A. L.
Venue: Blood
Publisher: American Society of Hematology
Published: 2014-08-28
Volume: 124
Issue: 9
Pages: 1473-1480
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2014-04-571091
OpenAlex: W1992099424
Cited by: 472
References: 22
FWCI: 24.43
Type: journal article
Language: en
Open access: green

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This page: CoChat. (2026). Citation check: ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. https://app.cochat.ai/papers/10.1182/blood-2014-04-571091
The paper: Parrilla Castellar, E. R., Jaffe, E. S., Said, J. W., Swerdlow, S. H., Ketterling, R. P., Knudson, R. A., Sidhu, J. S., Hsi, E. D., Karikehalli, S., Jiang, L., Vasmatzis, G., Gibson, S. E., Ondrejka, S., Nicolae, A., Grogg, K. L., Allmer, C., Ristow, K. M., Wilson, W. H., Macon, W. R., . . . Feldman, A. L. (2014). ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. Blood. https://doi.org/10.1182/blood-2014-04-571091

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ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes

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