The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
TGF-β signaling in the control of hematopoietic stem cells
Abstract
Blood is a tissue with high cellular turnover, and its production is a tightly orchestrated process that requires constant replenishment. All mature blood cells are generated from hematopoietic stem cells (HSCs), which are the self-renewing units that sustain lifelong hematopoiesis. HSC behavior, such as self-renewal and quiescence, is regulated by a wide array of factors, including external signaling cues present in the bone marrow. The transforming growth factor-β (TGF-β) family of cytokines constitutes a multifunctional signaling circuitry, which regulates pivotal functions related to cell fate and behavior in virtually all tissues of the body. In the hematopoietic system, TGF-β signaling controls a wide spectrum of biological processes, from homeostasis of the immune system to quiescence and self-renewal of HSCs. Here, we review key features and emerging concepts pertaining to TGF-β and downstream signaling pathways in normal HSC biology, featuring aspects of aging, hematologic disease, and how this circuitry may be exploited for clinical purposes in the future.
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Cites
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Cited by
TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
Morikawa, M., Derynck, R., & Miyazono, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021873 · Cited by 1,321
TGF-β Signaling in Cellular Senescence and Aging-Related Pathology
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Bandyopadhyay, S., Duffy, M. P., Ahn, K. J., Sussman, J. H., Pang, M., Smith, D., Duncan, G., Zhang, I., Huang, J., Lin, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.04.013 · Cited by 300
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A comprehensive transcriptome signature of murine hematopoietic stem cell aging
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Metadata
- Authors
- Blank, U., & Karlsson, S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2015-06-04
- Volume
- 125
- Issue
- 23
- Pages
- 3542-3550
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1969280128
- Cited by
- 278
- References
- 118
- FWCI
- 15.60
- Type
- journal article
- Language
- en
- Open access
- closed
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