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Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages
Abstract
Key Points: Of the 30 000 genes, there are ∼0.1% genes whose expression is linked to the origin of the cell rather than the environment. Marco was most conserved by embryonic origin and not altered by the environment, whereas C1qb and Plbd1 were most conserved by adult origin.
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“Tissue macrophages, such as Kupffer cells (KC) and alveolar macrophages (AM), have been reported to be faithfully replaced by BM-derived cells in irradiation chimeras and other small animal models involving deficiencies of the resident compartment6–9.”
From Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge (2018) · cites this paper as [7]
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Metadata
- Authors
- Gibbings, S. L., Goyal, R., Desch, A. N., Leach, S. M., Prabagar, M., Atif, S. M., Bratton, D. L., Janssen, W., & Jakubzick, C. V.
- Affiliations
- Department of Pediatrics,
- Department of Immunology and Microbiology,
- Integrated Center for Genes, Environment, and Health, and
- Department of Medicine, National Jewish Health and University of Colorado Denver Anschutz Campus, Denver, CO
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2015-09-10
- Volume
- 126
- Issue
- 11
- Pages
- 1357-1366
- ISSN
- 0006-4971
- 1528-0020
- Cited by
- 240
- References
- 50
- Language
- en
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