The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages
Abstract
Key Points: Of the 30 000 genes, there are ∼0.1% genes whose expression is linked to the origin of the cell rather than the environment. Marco was most conserved by embryonic origin and not altered by the environment, whereas C1qb and Plbd1 were most conserved by adult origin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Tissue macrophages, such as Kupffer cells (KC) and alveolar macrophages (AM), have been reported to be faithfully replaced by BM-derived cells in irradiation chimeras and other small animal models involving deficiencies of the resident compartment6–9.”
From Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge (2018) · cites this paper as [7]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome Biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 12,172
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311 · cited 1×
“The self-renewal and maintenance of host-derived AMs has also been illustrated in parabiotic mouse studies, which demonstrated that AMs are minimally replenished by postnatal circulating monocytes.(10,11) Overall these studies demonstrate that in both perturbed and unperturbed lungs, there is minimal replacement of se…”
BackgroundTissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
Lavin, Y., Winter, D., Blecher-Gonen, R., David, E., Keren-Shaul, H., Merad, M., Jung, S., & Amit, I. (2014) · Cell · doi:10.1016/j.cell.2014.11.018 · Cited by 2,167
the Immunological Genome Consortium, Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K. G., et al. (2012) · Nature Immunology · doi:10.1038/ni.2419 · Cited by 1,972
Self-citationDendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
Guilliams, M., Ginhoux, F., Jakubzick, C., Naik, S. H., Onai, N., Schraml, B. U., Segura, É., Tussiwand, R., & Yona, S. (2014) · Nature reviews. Immunology · doi:10.1038/nri3712 · Cited by 1,944
Self-citationOrigin and functions of tissue macrophages
Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.013 · Cited by 1,585
The Isolation and Characterization of Murine Macrophages
Zhang, X., Goncalves, R., & Mosser, D. M. (2008) · Current Protocols in Immunology · doi:10.1002/0471142735.im1401s83 · Cited by 1,536
Gosselin, D., Link, V. M., Romanoski, C. E., Fonseca, G. J., Eichenfield, D. Z., Spann, N. J., Stender, J. D., Chun, H. B., Garner, H., Geissmann, F., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.023 · Cited by 1,307
Guilliams, M., De Kleer, I., Henri, S., Post, S., Vanhoutte, L., De Prijck, S., Deswarte, K., Malissen, B., Hammad, H., & Lambrecht, B. N. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20131199 · Cited by 1,276
Plantinga, M., Guilliams, M., Vanheerswynghels, M., Deswarte, K., Branco-Madeira, F., Toussaint, W., Vanhoutte, L., Neyt, K., Killeen, N., Malissen, B., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.016 · Cited by 893
Flow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung
Misharin, A. V., Morales-Nebreda, L., Mutlu, G. M., Budinger, G. R. S., & Perlman, H. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0086ma · Cited by 838
Jakubzick, C., Gautier, E. L., Gibbings, S. L., Sojka, D. K., Schlitzer, A., Johnson, T. E., Ivanov, S., Duan, Q., Bala, S., Condon, T., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.007 · Cited by 783
Self-citationLangerhans cells arise from monocytes in vivo
Ginhoux, F., Tacke, F., Angeli, V., Bogunovic, M., Loubeau, M., Dai, X.-M., Stanley, E. R., Randolph, G. J., & Merad, M. (2006) · Nature Immunology · doi:10.1038/ni1307 · Cited by 738
Blériot, C., Dupuis, T., Jouvion, G., Eberl, G., Disson, O., & Lecuit, M. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.020 · Cited by 471
Thepen, T., Van Rooijen, N., & Kraal, G. (1989) · The Journal of experimental medicine · doi:10.1084/jem.170.2.499 · Cited by 422
Arredouani, M., Yang, Z., Ning, Y., Qin, G., Soininen, R., Tryggvason, K., & Kobzik, L. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040731 · Cited by 361
Janssen, W. J., Barthel, L., Muldrow, A., Oberley-Deegan, R. E., Kearns, M. T., Jakubzick, C., & Henson, P. M. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201011-1891oc · Cited by 345
Self-citationDistinct Differentiation Potential of Blood Monocyte Subsets in the Lung
Landsman, L., Varol, C., & Jung, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2000 · Cited by 322
Guilliams, M., Lambrecht, B. N., & Hammad, H. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.14 · Cited by 280
Modulation of Dendritic Cell Trafficking to and from the Airways
Jakubzick, C., Tacke, F., Llodrá, J., van Rooijen, N., & Randolph, G. J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.6.3578 · Cited by 253
Self-citationXML, bioinformatics and data integration
Achard, F., Vaysseix, G., & Barillot, E. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.2.115 · Cited by 237
Jakubzick, C., Tacke, F., Ginhoux, F., Wagers, A. J., van Rooijen, N., Mack, M., Mérad, M., & Randolph, G. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3019 · Cited by 235
Self-citationThe PYHIN protein family as mediators of host defenses
Schattgen, S., & Fitzgerald, K. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01053.x · Cited by 224
The Membrane-type Collectin CL-P1 Is a Scavenger Receptor on Vascular Endothelial Cells
Ohtani, K., Suzuki, Y., Eda, S., Kawai, T., Kase, T., Keshi, H., Sakai, Y., Fukuoh, A., Sakamoto, T., Itabe, H., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103942200 · Cited by 217
Tateno, H., Crocker, P. R., & Paulson, J. C. (2005) · Glycobiology · doi:10.1093/glycob/cwi097 · Cited by 167
Robays, L. J., Maes, T., Lebecque, S., Lira, S. A., Kuziel, W. A., Brusselle, G., Joos, G., & Vermaelen, K. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5305 · Cited by 120
Mononuclear phagocytes of the intestine, the skin, and the lung
Scott, C. L., Henri, S., & Guilliams, M. (2014) · Immunological Reviews · doi:10.1111/imr.12220 · Cited by 113
Adoptive Transfer of Alveolar Macrophages Abrogates Bronchial Hyperresponsiveness
Careau, É., & Bissonnette, É. Y. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0229oc · Cited by 107
The Role of Alveolar Macrophages in Regulation of Lung Inflammation
Thepen, T., Kraal, G., & Holt, P. G. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39802.x · Cited by 101
Jakubzick, C., Helft, J., Kaplan, T. J., & Randolph, G. J. (2008) · Journal of Immunological Methods · doi:10.1016/j.jim.2008.07.005 · Cited by 98
Self-citationDepletion of alveolar macrophages by liposome-encapsulated dichloromethylene diphosphonate
Berg, J. T., Lee, S. T., Thepen, T., Lee, C. Y., & Tsan, M. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.74.6.2812 · Cited by 89
MacLean, J. A., Xia, W., Pinto, C. E., Zhao, L.-H., Liu, H., & Kradin, R. L. (1996) · Europe PMC (PubMed Central) · Cited by 83
Matute‐Bello, G., Lee, J. S., Frevert, C. W., Liles, W. C., Sutlief, S. G., Ballman, K. K., Wong, V., Selk, A., & Martin, T. R. (2004) · Journal of Immunological Methods · doi:10.1016/j.jim.2004.05.010 · Cited by 71
The Significance of Local Resident Pulmonary Alveolar Macrophage Proliferation to Population Renewal
Sawyer, R. T. (1986) · Journal of Leukocyte Biology · doi:10.1002/jlb.39.1.77 · Cited by 70
The Proliferation Kinetics of Pulmonary Alveolar Macrophages
Coggle, J. E., & Tarling, J. D. (1984) · Journal of Leukocyte Biology · doi:10.1002/jlb.35.3.317 · Cited by 67
Jang, S., Ohtani, K., Fukuoh, A., Yoshizaki, T., Fukuda, M., Motomura, W., Mori, K., Fukuzawa, J., Kitamoto, N., Yoshida, I., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807477200 · Cited by 67
Augmented Proliferation of Human Alveolar Macrophages After Allogeneic Bone Marrow Transplantation
Nakata, K., Gotoh, H., Watanabe, J., Uetake, T., Komuro, I., Yuasa, K., Watanabe, S., Ieki, R., Sakamaki, H., Akiyama, H., et al. (1999) · Blood · doi:10.1182/blood.v93.2.667 · Cited by 66
GEST: a gene expression search tool based on a novel Bayesian similarity metric
Hunter, L., Taylor, R. C., Leach, S. M., & Simon, R. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.suppl_1.s115 · Cited by 65
Self-citationCS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes
Kim, J., Horton, N., Mathew, S. O., & Mathew, P. A. (2013) · Inflammation Research · doi:10.1007/s00011-013-0632-1 · Cited by 56
Benard, E. L., Roobol, S. J., Spaink, H. P., & Meijer, A. H. (2014) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2014.07.022 · Cited by 51
Requirements for and consequences of Rac-dependent protrusion
Steffen, A., Koestler, S. A., & Rottner, K. (2014) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2014.01.008 · Cited by 33
Wickenhauser, C., Thiele, J., Pérez, F., Varus, E., Stoffel, M. S., Kvasnicka, H. M., Beelen, D. W., & Schaefer, U. W. (2002) · Transplantation · doi:10.1097/00007890-200201150-00020 · Cited by 18
Janssen, W. J., Muldrow, A., Kearns, M. T., Barthel, L., & Henson, P. M. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2010.03.013 · Cited by 18
Self-citationLu, X. (2012) · Oncology Reports · doi:10.3892/or.2012.1751 · Cited by 14
Haque, A., Koide, N., Odkhuu, E., Tsolmongyn, B., Naiki, Y., Komatsu, T., Yoshida, T., & Yokochi, T. (2013) · Innate Immunity · doi:10.1177/1753425913481636 · Cited by 14
Cited by
Tissue-Resident Macrophage Ontogeny and Homeostasis
Ginhoux, F., & Guilliams, M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.024 · Cited by 1,884
Macrophage Polarization States in the Tumor Microenvironment
Boutilier, A. J., & Elsawa, S. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136995 · Cited by 1,631
Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations
MacParland, S. A., Liu, J. C., Ma, X.-Z., Innes, B. T., Bartczak, A. M., Gage, B. K., Manuel, J., Khuu, N., Echeverri, J., Linares, I., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06318-7 · Cited by 1,552
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C.-I., Anekalla, K. R., Joshi, N., Williams, K. J. N., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162152 · Cited by 1,133
Shemer, A., Grozovski, J., Tay, T. L., Tao, J., Volaski, A., Süß, P., Ardura-Fabregat, A., Gross-Vered, M., Kim, J.-S., David, E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07548-5 · Cited by 1,052
Metadata
- Authors
- Gibbings, S. L., Goyal, R., Desch, A. N., Leach, S. M., Prabagar, M., Atif, S. M., Bratton, D. L., Janssen, W., & Jakubzick, C. V.
- Affiliations
- Department of Pediatrics,
- Department of Immunology and Microbiology,
- Integrated Center for Genes, Environment, and Health, and
- Department of Medicine, National Jewish Health and University of Colorado Denver Anschutz Campus, Denver, CO
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2015-09-10
- Volume
- 126
- Issue
- 11
- Pages
- 1357-1366
- ISSN
- 0006-4971
- 1528-0020
- Cited by
- 240
- References
- 50
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
