So You Know How to Treat Iron Deficiency Anemia

Schrier, Stanley L.

doi:10.1182/blood-2015-09-666511

Cited by 57Iron Metabolism and DisordersErythropoietin and Anemia TreatmentFerroptosis and cancer prognosis

So You Know How to Treat Iron Deficiency Anemia

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Schrier, Stanley L.·2015·Blood

DOI 10.1182/blood-2015-09-666511

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Abstract

In this issue of Blood, Moretti et al provide data that challenge the entrenched oral treatment of iron deficiency anemia. The paper shows how the newer understanding of hepcidin and iron metabolism in general can lead to very practical improvements in the management of iron deficiency anemia, a disorder that may affect as many as 1 billion people.

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A maximum of 25 mg elemental iron per day can be absorbed, but only under extreme iron deficiency conditions.
“However, a maximum of 25 mg elemental iron per day can be absorbed, but this amount is only under extreme iron deficiency conditions [23].”
From Oral Iron Supplementation—Gastrointestinal Side Effects and the Impact on the Gut Microbiota (2021) · cites this paper as [23]
In the main text (p. 1971), Schrier estimates that about 25 mg per day is absorbed when 200 mg of elemental iron is taken under the conventional treatment regimen. He does not identify 25 mg as a maximum or say that this amount is absorbed only under extreme iron deficiency. (LLM, conf=0.89)
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Moretti D, Goede JS, Zeder C, et al. Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women. Blood. 2015;126(17):1981-1989.
Brittenham GM. Disorders of iron homeostasis: iron deficiency and overload. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop S, Weitz J, Anastasi J, eds. Hematology: Basic Principles and Practice. 6th ed. New York: Saunders/Elsevier; 2013:437-449.
Schrier SL, Auerbach M. UpToDate: Treatment of the Adult with Iron Deficiency Anemia. Philadelphia, PA: Wolters Kluwer; 2015.
Ganz T. Hepcidin and iron regulation, 10 years later. Blood. 2011;117(17):4425-4433.

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Authors: Schrier, S. L.
Affiliations: Stanford Medicine (US)
Corresponding author: Schrier, Stanley L.
Venue: Blood
Publisher: American Society of Hematology
Published: 2015-10-22
Volume: 126
Issue: 17
Pages: 1971-1971
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2015-09-666511
OpenAlex: W1781008050
Cited by: 57
References: 0
Citations by year: 2026: 3 · 2025: 4 · 2024: 10 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 9 · 2019: 3 · 2018: 7 · 2017: 7 · 2016: 3
FWCI: 4.45
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
Keywords: iron deficiency anemia, oral iron supplementation, hepcidin, iron metabolism, iron supplementation, anemia management
MeSH terms: Female, Ferritins, Humans, Iron, Male, Iron, Dietary, Dietary Supplements, Hepcidins

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So You Know How to Treat Iron Deficiency Anemia

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