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The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis
Abstract
Key Points: After induced HSPC depletion, HSC numbers remain at low levels whereas progenitors show robust recovery. Despite low HSC numbers, hematopoiesis proceeds normally without increased proliferation of the few residual HSCs.
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“While this is compatible with rare output of adult HSC compared to embryonic HSC14, the quantitative output of adult HSC is controversial 19–21.”
From Polylox barcoding reveals haematopoietic stem cell fates realized in vivo (2017) · cites this paper as [20]
Citations
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Cited by
Polylox barcoding reveals haematopoietic stem cell fates realized in vivo
Pei, W., Feyerabend, T. B., Rössler, J., Wang, X., Postrach, D., Busch, K., Rode, I., Klapproth, K., Dietlein, N., Quedenau, C., et al. (2017) · Nature · doi:10.1038/nature23653 · Cited by 443
Clonal hematopoiesis: Mutation-specific adaptation to environmental change
Florez, M. A., Tran, B. T., Wathan, T. K., DeGregori, J., Pietras, E. M., & King, K. Y. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.05.006 · Cited by 129
Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny
Ganuza, M., Hall, T., Finkelstein, D., Chabot, A., Kang, G., & McKinney-Freeman, S. (2017) · Nature Cell Biology · doi:10.1038/ncb3607 · Cited by 94
Chapple, R. H., Tseng, Y.-J., Hu, T., Kitano, A., Takeichi, M., Hoegenauer, K. A., & Nakada, D. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018016295 · Cited by 90
The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing
Pucella, J. N., Upadhaya, S., & Reizis, B. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-020520-114601 · Cited by 53
Metadata
- Authors
- Schoedel, K. B., Morcos, M. N. F., Zerjatke, T., Roeder, I., Grinenko, T., Voehringer, D., Göthert, J. R., Waskow, C., Roers, A., & Gerbaulet, A.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2016-11-10
- Volume
- 128
- Issue
- 19
- Pages
- 2285-2296
- ISSN
- 0006-4971
- 1528-0020
- Cited by
- 120
- References
- 7
- Language
- en
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