The DOI matches its Crossref record; 176 of the 176 references it cites were found in a registry or an index.
The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia
Open accessAbstract
T-cell acute lymphoblastic leukemia (T-ALL) is a highly proliferative hematologic malignancy that results from the transformation of immature T-cell progenitors. Aberrant cell growth and proliferation in T-ALL lymphoblasts are sustained by activation of strong oncogenic drivers promoting cell anabolism and cell cycle progression. Oncogenic NOTCH signaling, which is activated in more than 65% of T-ALL patients by activating mutations in the NOTCH1 gene, has emerged as a major regulator of leukemia cell growth and metabolism. T-ALL NOTCH1 mutations result in ligand-independent and sustained NOTCH1-receptor signaling, which translates into activation of a broad transcriptional program dominated by upregulation of genes involved in anabolic pathways. Among these, the MYC oncogene plays a major role in NOTCH1-induced transformation. As result, the oncogenic activity of NOTCH1 in T-ALL is strictly dependent on MYC upregulation, which makes the NOTCH1-MYC regulatory circuit an attractive therapeutic target for the treatment of T-ALL.
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Cites
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Cited by
The genetics and molecular biology of T-ALL
Girardi, T., Vicente, C., Cools, J., & De Keersmaecker, K. (2017) · Blood · doi:10.1182/blood-2016-10-706465 · Cited by 355
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Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping
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Metadata
- Authors
- Sanchez-Martin, M., & Ferrando, A.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2017-03-02
- Volume
- 129
- Issue
- 9
- Pages
- 1124-1133
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2580215615
- Cited by
- 256
- References
- 176
- FWCI
- 21.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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