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Clonality in context: hematopoietic clones in their marrow environment

Cooper, James N., Young, Neal S.·2017·Blood
DOI 10.1182/blood-2017-07-794362
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Abstract

Clonal hematopoiesis occurs normally, especially with aging, and in the setting of disease, not only in myeloid cancers but in bone marrow failure as well. In cancer, malignant clones are characterized by recurrent somatic mutations in specific sets of genes, but the direct relationship of such mutations to leukemogenesis, when they occur in cells of an apparently healthy older individual or after recovery from immune aplastic anemia, is uncertain. Here we emphasize a view of clonal evolution that stresses natural selection over deterministic ontogeny, and we stress the selective role of the environment of the marrow and organism. Clonal hematopoieses after chemotherapy, in marrow failure, and with aging serve as models. We caution against the overinterpretation of clinical results of genomic testing in the absence of a better understanding of clonal selection and evolution.

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Cited by

Metadata

Authors
Cooper, J. N., & Young, N. S.
Affiliations
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
Venue
Blood
Publisher
American Society of Hematology
Published
2017-11-30
Volume
130
Issue
22
Pages
2363-2372
ISSN
  • 0006-4971
  • 1528-0020
DOI
10.1182/blood-2017-07-794362
Cited by
87
References
26
Language
en

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