The ageing haematopoietic stem cell compartment
Abstract
Stem cell ageing underlies the ageing of tissues, especially those with a high cellular turnover. There is growing evidence that the ageing of the immune system is initiated at the very top of the haematopoietic hierarchy and that the ageing of haematopoietic stem cells (HSCs) directly contributes to changes in the immune system, referred to as immunosenescence. In this Review, we summarize the phenotypes of ageing HSCs and discuss how the cell-intrinsic and cell-extrinsic mechanisms of HSC ageing might promote immunosenescence. Stem cell ageing has long been considered to be irreversible. However, recent findings indicate that several molecular pathways could be targeted to rejuvenate HSCs and thus to reverse some aspects of immunosenescence.
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Aged HSCs show no difference in cycling activity.
“Regulation of cell number and cycling activity is different for aging HSCs, which actually show increases in cell number, possibly due to a reduced capacity for asymmetric division123, with no difference in cycling activity124.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [124]
Many molecular and cell-intrinsic mechanisms have been reported to contribute to the age-associated decline in HSC function.
“Multiple molecular and cell-intrinsic mechanisms have been reported to contribute to the age-associated decline of HSC functioning”
From Aging of hematopoietic stem cells (2018) · cites this paper as [45]
Age-associated alterations in adaptive immunity are thought in part to be driven by an ageing haematopoietic stem cell niche and fewer circulating stem cells, which are characterised by intrinsic damage and a phenotype skewed towards the myeloid lineage.
“Age-associated alterations in adaptive immunity are thought in part, to be driven by an ageing haematopoietic stem cell niche and fewer circulating stem cells, which in turn, are characterised by intrinsic damage and a phenotype skewed towards the myeloid lineage (Geiger et al. 2013).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Geiger et al. 2013
Ageing results in alterations to almost all aspects of innate and adaptive immune function.
“Ageing results in alterations to almost all aspects of innate and adaptive immune function, and these changes are typically assumed to reflect deregulation.”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Geiger et al. 2013
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Aged murine hematopoietic stem cells drive aging-associated immune remodeling
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- Authors
- Geiger, H., de Haan, G., & Florian, M. C.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Universität Ulm (DE)
- Corresponding author
- Geiger, Hartmut
- Venue
- Nature Reviews Immunology
- Published
- 2013-04-15
- Volume
- 13
- Issue
- 5
- Pages
- 376-389
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2114514472
- Cited by
- 604
- References
- 156
- Citations by year
- 2026: 30 · 2025: 43 · 2024: 37 · 2023: 44 · 2022: 46 · 2021: 59 · 2020: 59 · 2019: 48 · 2018: 53 · 2017: 55 · 2016: 42 · 2015: 39 · 2014: 30 · 2013: 19
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Baden-Württemberg Stiftung
- Edward P. Evans Foundation
- Evans Medical Foundation
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- National Institute on Aging (AG040118, R01AG040118)
- National Heart, Lung, and Blood Institute (R01HL076604, HL076604)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK077762, R21DK077762)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- hematopoietic stem cells, stem cell aging, immunosenescence, autoimmunity, leukemia, tissue aging
- MeSH terms
- Animals, Hematopoietic Stem Cells, Humans, Immune System, Phenotype, Cellular Senescence
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