Proliferation: Driver of HSC aging phenotypes?
Open accessAbstract
The decline of stem cell performance with age is a potential paramount mechanism of aging. Hematopoietic stem cells (HSCs) are perhaps the most studied and best characterized tissue-specific somatic stem cells. As such, HSCs offer an excellent research model of how aging affects stem cell performance, and vice versa. Studies from recent years have elucidated major aging phenotypes of HSCs including a decline in reconstitution potential, altered differentiation predisposition, an increase in number, accumulation of DNA damage/mutations and several others. However, what drives these changes, and exactly how they translate to pathology is poorly understood. Recent studies point to proliferative stress of HSCs as a potential driver of their aging and the resulting pathologies. Here we discuss the recent discoveries and suggest the context in which aging phenotypes could be driven, and the relevant mechanisms by which HSCs could be affected.
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Other stem cell subpopulations lose quiescence and become abnormally activated, particularly in blood and muscle.
“Other stem cell subpopulations lose quiescence and become abnormally activated, particularly in blood and muscle12,35,44.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [44]
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- Authors
- Yanai, H., & Beerman, I.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Yanai, Hagai
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 191
- Pages
- 111331
- ISSN
- 0047-6374 (ISSN-L)
- PMC
- PMC7541746
- OpenAlex
- W3049256100
- Cited by
- 9
- References
- 68
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 4 · 2022: 2
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- hematopoietic stem cells, stem cell aging, HSC proliferation, DNA damage accumulation, somatic aging
- MeSH terms
- Animals, Cell Differentiation, DNA Damage, Hematopoietic Stem Cells, Humans, Cellular Senescence, Cell Proliferation
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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