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Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal
Abstract
Key Points: Single-cell approaches identify regulators of malignant HSC self-renewal. Identification of novel roles for Bmi1, Pbx1, and Meis1 in myeloproliferative neoplasms.
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“in line with the previously described self-renewal advantage of TET2 -/-HSCs”
From A scalable in vitro cell competition model identifies preleukemic super competitor clones (2026) · cites this paper as Shepherd et al, 2018
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Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2
Nangalia, J., Massie, C. E., Baxter, E. J., Nice, F. L., Gundem, G., Wedge, D. C., Avezov, E., Li, J., Kollmann, K., Kent, D. G., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1312542 · Cited by 1,756
Self-citationTet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
Moran-Crusio, K., Reavie, L., Shih, A., Abdel-Wahab, O., Ndiaye-Lobry, D., Lobry, C., Figueroa, M. E., Vasanthakumar, A., Patel, J., Zhao, X., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.001 · Cited by 1,339
Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis
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Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells
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Cited by
A scalable in vitro cell competition model identifies preleukemic super competitor clones
Cabrera-Cosme, L., Rubio-Lara, J. A., Bennett, E., Miłek, J., Baldreki, C., Dowle, A., Vijayabaskar, M. S., Davies, S. J., Taylor-Smith, E., Bain, F. M., et al. (2026) · doi:10.64898/2026.10.21.760611
Self-citation
Metadata
- Authors
- Shepherd, M. S., Li, J., Wilson, N. K., Oedekoven, C. A., Li, J., Belmonte, M., Fink, J., Prick, J. C. M., Pask, D. C., Hamilton, T. L., Loeffler, D., Rao, A., Schröder, T., Göttgens, B., Green, A. R., & Kent, D. G.
- Affiliations
- Wellcome MRC Cambridge Stem Cell Institute and
- Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; and
- La Jolla Institute and Department of Pharmacology, University of California, San Diego, La Jolla, CA;
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2018-08-23
- Volume
- 132
- Issue
- 8
- Pages
- 791-803
- ISSN
- 0006-4971
- 1528-0020
- Cited by
- 33
- References
- 7
- Language
- en
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