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Effect of Mutation Order on Myeloproliferative Neoplasms
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“Among the mutated genes driving competitive advantage and enhanced self-renewal is TET2, an epigenetic regulator commonly mutated in both CH and a wide range of myeloid malignancies”
From A scalable in vitro cell competition model identifies preleukemic super competitor clones (2026) · cites this paper as Ortmann et al, 2015
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Citations
Cites
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A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
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Mutation in TET2 in Myeloid Cancers
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Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2
Nangalia, J., Massie, C. E., Baxter, E. J., Nice, F. L., Gundem, G., Wedge, D. C., Avezov, E., Li, J., Kollmann, K., Kent, D. G., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1312542 · Cited by 1,756
Self-citationTet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
Moran-Crusio, K., Reavie, L., Shih, A., Abdel-Wahab, O., Ndiaye-Lobry, D., Lobry, C., Figueroa, M. E., Vasanthakumar, A., Patel, J., Zhao, X., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.001 · Cited by 1,339
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Skoulidis, F., & Heymach, J. V. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0179-8 · Cited by 1,019
Blakely, C. M., Watkins, T. B. K., Wu, W., Gini, B., Chabon, J. J., McCoach, C. E., McGranahan, N., Wilson, G. A., Birkbak, N. J., Olivas, V. R., et al. (2017) · Nature Genetics · doi:10.1038/ng.3990 · Cited by 571
Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies
Bowman, R. L., Busque, L., & Levine, R. L. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.01.011 · Cited by 448
Somatic mutations and cell identity linked by Genotyping of Transcriptomes
Nam, A. S., Kim, K.-T., Chaligne, R., Izzo, F., Ang, C., Taylor, J., Myers, R. M., Abu-Zeinah, G., Brand, R., Omans, N. D., et al. (2019) · Nature · doi:10.1038/s41586-019-1367-0 · Cited by 333
Metadata
- Authors
- Ortmann, C. A., Kent, D. G., Nangalia, J., Silber, Y., Wedge, D. C., Grinfeld, J., Baxter, E. J., Massie, C. E., Papaemmanuil, E., Menon, S., Godfrey, A. L., Dimitropoulou, D., Guglielmelli, P., Bellosillo, B., Besses, C., Döhner, K., Harrison, C. N., Vassiliou, G. S., Vannucchi, A., Campbell, P. J., & Green, A. R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2015-02-12
- Volume
- 372
- Issue
- 7
- Pages
- 601-612
- ISSN
- 0028-4793
- 1533-4406
- PMC
- PMC4660033
- Cited by
- 562
- References
- 7
- Language
- en
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- CoChat. (2026). Citation check: Effect of Mutation Order on Myeloproliferative Neoplasms. https://app.cochat.ai/papers/10.1056/nejmoa1412098
- The paper
- Ortmann, C. A., Kent, D. G., Nangalia, J., Silber, Y., Wedge, D. C., Grinfeld, J., Baxter, E. J., Massie, C. E., Papaemmanuil, E., Menon, S., Godfrey, A. L., Dimitropoulou, D., Guglielmelli, P., Bellosillo, B., Besses, C., Döhner, K., Harrison, C. N., Vassiliou, G. S., Vannucchi, A., . . . Green, A. R. (2015). Effect of Mutation Order on Myeloproliferative Neoplasms. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1412098
