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From Clonal Hematopoiesis to Therapy-Related Myeloid Neoplasms: The Silent Way of Cancer Progression

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Contributions of Noncardiac Organ–Heart Immune Crosstalk and Somatic Mosaicism to Heart Failure: Current Knowledge and Perspectives

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Pharmacological Inhibition of WIP1 Sensitizes Acute Myeloid Leukemia Cells to the MDM2 Inhibitor Nutlin-3a

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A novel assay for screening WIP1 phosphatase substrates in nuclear extracts

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Low-Frequency PPM1D Gene Mutations Affect Treatment Response to CD19-Targeted CAR T-Cell Therapy in Large B-Cell Lymphoma

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PPM1D mutations appear in complete remission after exposure to chemotherapy without predicting emerging AML relapse

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CLONAL HEMATOPOIESIS: ROLE IN HEMATOLOGIC NON-HEMATOLOGIC

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Clonal Hematopoiesis of Indeterminate Potential Influences Breast Cancer Outcomes in a Genotype-Specific Manner

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CHEK2 loss endows chemotherapy resistance to hematopoietic stem cells

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Potential Pre‐Leukemic Mutations in PPM1D Confer Chemotherapy Resistance to Aged HSC Clones

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SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells

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An ATM-PPM1D Circuit Controls the Processing and Restart of DNA Replication ForksPreprint

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Rare Gene Rearrangement t(11;22)(q23;q13)/KMT2A-EP300 in Therapy-related Acute Myeloid Leukemia: A Case Report

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Aging, Causes, and Rejuvenation of Hematopoietic Stem Cells

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Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform

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PPM1D Mutation as a Distinct Feature of Myeloid Neoplasms in B-Cell Non-Hodgkin Lymphoma Patients: A Retrospective Analysis

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Ph-chromosome-negative myeloproliferative neoplasms: clonal dynamics are the name of the game

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Ppm1d Clonal Hematopoiesis Does Not Promote Atherosclerosis in Murine Models

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Combined inhibition of PLK4 and PPM1D promotes cell death in cancer cells with 17q amplification

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Under pressure: clonal hematopoiesis in patients receiving cancer therapy

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Cancer treatment alters mutant selection in normal esophagus

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CHIPing out PPM1D-mutant hematopoiesis

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Klonale Hämatopoese und solide Neoplasien

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PPM1D inhibition may allow us to WIP leukemia

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MDS Mimics Including CHIP, ICUS, and CCUS

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Molecular Landscape of MDS

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Meta-análise de dados de sequenciamento completo de exoma em pacientes com neoplasias mieloproliferativas e mielodisplásicas/mieloproliferativas Filadélfia-negativo

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A view from the hospital window.

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Proteomics and phosphoproteomics profiling in glutamatergic neurons and microglia in an iPSC model of Jansen de Vries SyndromePreprint

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SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cellsPreprint

Zhang, L., Hsu, J. I., Braekeleer, E. D., Chen, C.-W., Patel, T. D., Urya, H., Guzman, A. G., Martell, A. G., Waldvogel, S. M., Tovy, A., et al. (2023) · eLife · doi:10.7554/elife.91611.1

Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation MutagenesisPreprint

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PPM1D Truncating Mutations Confer Chemotherapy Resistance in Hematopoietic Stem Cells, Which Is Reversible By PPM1D Inhibition

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Somatic mosaic truncating mutations of PPM1D in blood can result from expansion of a mutant clone under selective pressure of chemotherapy

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High Prevalence of PPM1D Mutations in Therapy-Related AML/MDS Is Due to Context-Specific Clonal Hematopoiesis

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CHIPing out PPM1D-mutant hematopoiesis

Kindler, T. (2018) · Blood · doi:10.1182/blood-2018-07-861716 · Cited by 1

Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients

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