PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

Cibulskis, K., Lawrence, M. S., Carter, S. L., Sivachenko, A., Jaffe, D. B., Sougnez, C. L., Gabriel, S., Meyerson, M. M., Lander, E. S., & Getz, G. A. (2013) · Nature Biotechnology · doi:10.1038/nbt.2514 · Cited by 4,965

Age-related clonal hematopoiesis associated with adverse outcomes

Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

Doench, J. G., Fusi, N., Sullender, M., Hegde, M., Vaimberg, E. W., Donovan, K. F., Smith, I., Tothova, Z., Wilen, C., Orchard, R., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3437 · Cited by 4,637

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

Platt, R. J., Chen, S., Zhou, Y., Yim, M. J., Swiech, L., Kempton, H. R., Dahlman, J. E., Parnas, O., Eisenhaure, T. M., Jovanovic, M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.014 · Cited by 2,001

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

Steensma, D. P., Bejar, R., Jaiswal, S., Lindsley, R. C., Sekeres, M. A., Hasserjian, R. P., & Ebert, B. L. (2015) · Blood · doi:10.1182/blood-2015-03-631747 · Cited by 1,971

Age-related mutations associated with clonal hematopoietic expansion and malignancies

Xie, M., Lu, C., Wang, J., McLellan, M. D., Johnson, K. J., Wendl, M. C., McMichael, J. F., Schmidt, H. K., Yellapantula, V., Miller, C. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3733 · Cited by 1,874

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

Certo, M. V., Moore, V. D. G., Nishino, M., Wei, G., Korsmeyer, S. J., Armstrong, S. A., & Letai, A. G. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.03.027 · Cited by 1,278

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia

Wong, T. N., Ramsingh, G., Young, A. L., Miller, C. A., Touma, W., Welch, J. S., Lamprecht, T. L., Shen, D., Hundal, J., Fulton, R. S., et al. (2015) · Nature · doi:10.1038/nature13968 · Cited by 892

Therapy-related clonal hematopoiesis in patients with non-hematologic cancers is common and associated with adverse clinical outcomes

Coombs, C. C., Zehir, A., Devlin, S. M., Kishtagari, A., Syed, A., Jonsson, P., Hyman, D. M., Solit, D. B., Robson, M. E., Baselga, J., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.07.010 · Cited by 866

The Origin of Clonal Hematopoiesis and Its Implication in Human Diseases

Zhang, Z., & Sun, J. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-99-7471-9_5

SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cellsPreprint

Zhang, L., Hsu, J. I., Braekeleer, E. D., Chen, C.-W., Patel, T. D., Martell, A. G., Guzman, A. G., Wohlan, K., Waldvogel, S. M., Urya, H., et al. (2024) · eLife · doi:10.7554/elife.91611.2

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery PlatformPreprint

Jiang, W., Shaw, S., Rush, J. S., Dumont, N., Kim, J., Singh, R., Skepner, A. P., Khodier, C., Raffier, C., Yan, N., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.20.595001

The Clonal Hematopoiesis-associated Gene Srcap Plays an Essential Role in HematopoiesisPreprint

Wong, T., Mychalowych, A., Feldpausch, E. R., Carson, A., Karpova, D., & Link, D. C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.16.607812

PPM1D truncation-associated overexpression of the stress-related protein NQO1 confers sensitivity to the bioactivatable drug IB-DNQ in diffuse intrinsic pontine gliomaPreprint

Janin, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.05.611476

PPM1D/Wip1 is amplified, overexpressed, and mutated in human non-Hodgkin's lymphomas

Pi̇levneli̇, H., Döger, F. K., Karagenç, L., Kozacı, L. D., & Eren, M. K. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-10029-2

Low-Frequency PPM1D Gene Mutations Associated with Inferior Treatment Response to CD19 Targeted CAR-T Cell Therapy in Mantle Cell Lymphoma

Seipel, K., Benninger, L., Bacher, U., & Pabst, T. (2024) · Therapeutics · doi:10.3390/therapeutics1020009

PPM1D Truncation-associated Overexpression of the Stress-related Protein NQO1 Confers Sensitivity to the Bioactivatable Drug IB-DNQ in Diffuse Intrinsic Pontine Glioma

Janin, M. (2024) · ASEAN Journal of Psychiatry · doi:10.54615/2231-7805.440

Subclonal emergence of polycythemia vera, chronic myelomonocytic leukemia, and chronic myeloid leukemia

Quang, V. T., Cretin, J., Loyaux, R., Jedidia, B. B., Tarfi, S., Gricourt, G., Barathon, Q., Joy, C., Etancelin, P., Wagner‐Ballon, O., et al. (2025) · Annals of Hematology · doi:10.1007/s00277-025-06417-8

Multifaceted roles of CRISPR technology in blood cancer research

Solayappan, M., Azlan, A., Khor, K. Z., Yik, M. Y., Jaishanker, A., Thevendran, R., Saleem, M. T. S., Yusoff, N. M., & Moses, E. J. (2025) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000855

Diffusely Increased Bone Marrow Uptake on DOTATATE PET/CT Due to PRRT-related Myelodysplasia Syndrome

Wu, C., Menshikova, E., & Takalkar, A. M. (2025) · Clinical Nuclear Medicine · doi:10.1097/rlu.0000000000006095

Oral mucosal manifestations with identical mutations to the bone marrow in a patient with VEXAS syndrome

Vasaitis, L., Blomstrand, L., Pandzic, T., Gulyás, M., Baliakas, P., & Ljungström, V. (2025) · Rheumatology & autoimmunity · doi:10.1002/rai2.70025

Impaired IL-10 Receptor Signaling Leads to Inflammation Induced Exhaustion in Hematopoietic Stem CellsPreprint

Wadley, W. L. P., Huang, H. Q., Lai, H. Y., Heidmann, J. C., Chen, J., Soyfer, E. M., Guillermo, K., Arora, E., Chen, L., Hoover, B., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.30.679613

Calcium signature in the pancreatic cancer : role in the activation of the pancreatic stellate cells and in the progression of the pancreatic cancer

Radoslavova, S. (2021) · theses.fr (ABES) · doi:10.70675/caff0fc7z69abz4a91z9ffez4ae67a4969ae

Second primary cancers following hematologic malignancies: Epidemiology, pathobiology and clinical management

Pan, Y., Yang, H., Shao, J., Qiang, X., & Wang, Q. (2026) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2026.2654318

VEXAS syndrome with atypical presentation: A case report and review of eosinophils in cutaneous biopsies

Tang, M., Oliva, R., Nisar, N., & Menge, T. D. (2026) · JAAD Case Reports · doi:10.1016/j.jdcr.2026.04.070

No Effect of Ppm1d -Mutant Clonal Hematopoiesis on Atherosclerosis Development in Mice

Amorós-Pérez, M., Zuriaga, M. A., Zorita, V., Ramos-Neble, B. L., Matesanz, N., Plötner, C., Carli, M. D., Mol, E. L. C., Moro, R., Cuevas, D., et al. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.323734

Distinct Proteasomal Pathways Drive Oncogenic PPM1D ActivationPreprint

Yan, N., Shrestha, D., Schluter, C., Jin, C., Wang, E., Silva, C. D., Gritti, I., Tsopoulidis, N., Yang, R., Sperling, A. S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.01.729344

The role of the PPM1D gene in the carcinogenesis of myeloid neoplasms: molecular mechanisms and prospects for targeted therapy

Kolosova, E. D., Bogdanova, D. A., & Demidov, O. N. (2026) · Siberian Journal of Oncology · doi:10.21294/1814-4861-2026-25-3-96-109

Proteo-genomics-guided interpretation of somatic mutations in cancer genomes

Hyeon, D. Y., Zhou, Y., Chung, W. K., & Dietlein, F. (2026) · Cancer Cell · doi:10.1016/j.ccell.2026.07.017

Targeting BIRC6 rejuvenates hematopoietic stem cell aging and immunosenescence

Liao, W., Shao, F., Wang, S., Wang, Y., Chen, X., Zhang, Y., Zhang, Z., Zai, X., Yang, Y., Yin, Y., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02787-1

Silent, but not innocent: the emerging role of clonal hematopoiesis in predicting therapy-related myeloid neoplasms

Ünsal, Ş. E. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1943135

PPM1D Truncating Mutations Confer Chemotherapy Resistance in Hematopoietic Stem Cells, Which Is Reversible By PPM1D Inhibition

Kahn, J. D., Silver, A. J., Mertins, P., Carr, S. A., Jaiswal, S., & Ebert, B. L. (2016) · Blood · doi:10.1182/blood.v128.22.740.740

Somatic mosaic truncating mutations of PPM1D in blood can result from expansion of a mutant clone under selective pressure of chemotherapy

Kim, B., Won, D., Lee, S., & Choi, J. R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217521 · Cited by 10

High Prevalence of PPM1D Mutations in Therapy-Related AML/MDS Is Due to Context-Specific Clonal Hematopoiesis

Hsu, J. I., Dayaram, T., Tovy, A., Braekeleer, E. D., Jeong, M., Rogers, J. H., Wang, F., Zhang, J., Garcia‐Manero, G., Kantarjian, H. M., et al. (2018) · Blood · doi:10.1182/blood-2018-99-115007

CHIPing out PPM1D-mutant hematopoiesis

Kindler, T. (2018) · Blood · doi:10.1182/blood-2018-07-861716 · Cited by 1

Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients

Zajkowicz, A., Butkiewicz, D., Drosik, A., Giglok, M., Suwiński, R., & Rusin, M. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.79 · Cited by 54