Immunological analysis and differential genes screening of venous thromboembolism
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Abstract
PURPOSE: To explore the pathogenesis of venous thromboembolism (VTE) and provide bioinformatics basis for the prevention and treatment of VTE. METHODS: The R software was used to obtain the gene expression profile data of GSE19151, combining with the CIBERSORT database, obtain immune cells and differentially expressed genes (DEGs) of blood samples of VTE patients and normal control, and analyze DEGs for GO analysis and KEGG pathway enrichment analysis. Then, the protein-protein interaction (PPI) network was constructed by using the STRING database, the key genes (hub genes) and immune differential genes were screened by Cytoscape software, and the transcription factors (TFs) regulating hub genes and immune differential genes were analyzed by the NetworkAnalyst database. RESULTS: Compared with the normal group, monocytes and resting mast cells were significantly expressed in the VTE group, while regulatory T cells were significantly lower. Ribosomes were closely related to the occurrence of VTE. 10 hub genes and immune differential genes were highly expressed in VTE. MYC, SOX2, XRN2, E2F1, SPI1, CREM and CREB1 can regulate the expressions of hub genes and immune differential genes. CONCLUSIONS: Ribosomal protein family genes are most relevant to the occurrence and development of VTE, and the immune differential genes may be the key molecules of VTE, which provides new ideas for further explore the pathogenesis of VTE.
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COVID-19 is associated with thromboembolism and clotting, driven by factors including complement and mast cell activation.
“COVID-19 is also associated with thromboembolism and clotting, which is driven by a number of factors including complement and mast cell activation. 147,148”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [148]
The Discussion (page unavailable) links venous thromboembolism to inflammation and reports increased resting mast cells in VTE. It does not address COVID-19 or complement activation, and increased resting mast cells do not establish that mast cell activation drives clotting. (LLM, conf=0.84)
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Cites
Szklarczyk, D., Morris, J. H., Cook, H., Kuhn, M., Wyder, S., Simonovic, M., Santos, A., Doncheva, N. T., Roth, A., Bork, P., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw937 · Cited by 6,980 · see citing works
Zhou, G., Soufan, O., Ewald, J., Hancock, R. E. W., Basu, N., & Xia, J. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz240 · Cited by 1,894 · see citing works
von Brühl, M.-L., Stark, K., Steinhart, A., Chandraratne, S., Konrad, I., Lorenz, M., Khandoga, A. G., Tirniceriu, A., Coletti, R., Köllnberger, M., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112322 · Cited by 1,827 · see citing works
Epidemiology of venous thromboembolism
Heit, J. A. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.83 · Cited by 1,277 · see citing works
ImmPort: disseminating data to the public for the future of immunology
Bhattacharya, S., Andorf, S., Gomes, L., Dunn, P. J., Schaefer, H., Pontius, J. U., Berger, P., Desborough, V., Smith, T., Campbell, J. P., et al. (2014) · Immunologic Research · doi:10.1007/s12026-014-8516-1 · Cited by 807 · see citing works
Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients
Khorana, A. A., Francis, C. W., Culakova, E., Kuderer, N. M., & Lyman, G. H. (2007) · Cancer · doi:10.1002/cncr.23062 · Cited by 801 · see citing works
Risk of Arterial Thromboembolism in Patients With Cancer
Navi, B. B., Reiner, A. S., Kamel, H., Iadecola, C., Okin, P. M., Elkind, M. S. V., Panageas, K. S., & DeAngelis, L. M. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.06.047 · Cited by 658 · see citing works
Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients
Gómez, M. L., Gómez-Raposo, C., & Samper, F. L. (2008) · Cancer · doi:10.1002/cncr.23524 · Cited by 549 · see citing works
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency
Barna, M., Pusic, A., Zollo, O., Costa, M. J., Kondrashov, N., Rego, E., Rao, P., & Ruggero, D. (2008) · Nature · doi:10.1038/nature07449 · Cited by 434 · see citing works
Farge, D., Bounameaux, H., Brenner, B., Cajfinger, F., Debourdeau, P., Khorana, A. A., Pabinger, I., Solymoss, S., Douketis, J. D., & Kakkar, A. K. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30369-2 · Cited by 347 · see citing works
Mauracher, L., Posch, F., Martinod, K., Grilz, E., Däullary, T., Hell, L., Brostjan, C., Zielinski, C. C., Ay, C., Wagner, D. D., et al. (2018) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13951 · Cited by 307 · see citing works
Klarin, D. M., Program, V. A. M. V., Busenkell, E., Judy, R., Lynch, J. A., Levin, M. G., Haessler, J., Aragam, K. G., Chaffin, M. D., Haas, M., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0519-3 · Cited by 236 · see citing works
Lindström, S., Wang, L., Smith, E. N., Gordon, W., van Hylckama Vlieg, A., de Andrade, M., Brody, J. A., Pattee, J. W., Haessler, J., Brumpton, B. M., et al. (2019) · Blood · doi:10.1182/blood.2019000435 · Cited by 223 · see citing works
Balla, J., Vercellotti, G. M., Jeney, V., Yachie, A., Varga, Z., Jacob, H. S., Eaton, J. W., & Balla, G. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1787 · Cited by 212 · see citing works
Molecular networks in Network Medicine: Development and applications
Silverman, E. K., Schmidt, H. H. H. W., Anastasiadou, E., Altucci, L., Angelini, M., Badimón, L., Balligand, J., Benincasa, G., Capasso, G., Conte, F., et al. (2020) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1489 · Cited by 211 · see citing works
Venous thromboembolism: thrombosis, inflammation, and immunothrombosis for clinicians
Vázquez‐Garza, E., Carlos Jerjes-Sánchez, D., Navarrete-López, C. A., Joya-Harrison, J., & Rodríguez, D. (2017) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-017-1528-7 · Cited by 177 · see citing works
Increased lipoprotein (a) levels as an independent risk factor for venous thromboembolism
von Depka, M., Nowak‐Göttl, U., Eisert, R. M., Dieterich, C., Barthels, M., Scharrer, I., Ganser, A., & Ehrenforth, S. (2000) · Blood · doi:10.1182/blood.v96.10.3364 · Cited by 174 · see citing works
The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism
Duez, H., & Staels, B. (2008) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2008.0014 · Cited by 132 · see citing works
Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion
Wu, Y. C., Tao, B., Zhang, T., Fan, Y., & Mao, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02451 · Cited by 126 · see citing works
Inflammation as a cause of venous thromboembolism
Saghazadeh, A., & Rezaei, N. (2016) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2016.01.007 · Cited by 120 · see citing works
Erythrocyte Hemolysis and Hemoglobin Oxidation Promote Ferric Chloride-induced Vascular Injury
Woollard, K. J., Sturgeon, S. A., Chin-Dusting, J. P. F., Salem, H. H., & Jackson, S. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809095200 · Cited by 112 · see citing works
Patients with CD3G mutations reveal a role for human CD3γ in Treg diversity and suppressive function
Rowe, J. H., Delmonte, O. M., Keles, S., Stadinski, B. D., Dobbs, K., Henderson, L. A., Yamazaki, Y., Allende, L. M., Bonilla, F. A., González‐Granado, L. I., et al. (2018) · Blood · doi:10.1182/blood-2018-02-835561 · Cited by 73 · see citing works
Plasma S100A12 Level Is Associated with Cardiovascular Disease in Hemodialysis Patients
Shiotsu, Y., Mori, Y., Nishimura, M., et al. (2011) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.08310910 · Cited by 60 · see citing works
Strengths and Opportunities of Network Medicine in Cardiovascular Diseases
Benincasa, G., Marfella, R., Mura, N. D., Schiano, C., & Claudio Napoli, A. (2019) · Circulation Journal · doi:10.1253/circj.cj-19-0879 · Cited by 60 · see citing works
How I treat cancer-associated venous thromboembolism
Kraaijpoel, N., & Carrier, M. (2018) · Blood · doi:10.1182/blood-2018-08-835595 · Cited by 58 · see citing works
Ribosomal Protein L15 is involved in Colon Carcinogenesis
Dong, Z., Jiang, H., Liang, S., et al. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.34386 · Cited by 50 · see citing works
Benincasa, G., Costa, D., Infante, T., Lucchese, R., Donatelli, F., & Claudio Napoli, A. (2019) · Thrombosis Research · doi:10.1016/j.thromres.2019.03.008 · Cited by 45 · see citing works
Shih, L., Kaplan, D., Kraiss, L. W., et al. (2016) · Scientific Reports · doi:10.1038/srep27478 · Cited by 30 · see citing works
Rare genetic variants in SMAP1, B3GAT2, and RIMS1 contribute to pediatric venous thromboembolism
Rühle, F., Witten, A., Barysenka, A., et al. (2016) · Blood · doi:10.1182/blood-2016-07-728840 · Cited by 26 · see citing works
Wypasek, E., Padjas, A., Szymańska, M., et al. (2018) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/76262 · Cited by 25 · see citing works
Symptomatic Venous Thromboembolism Is a Disease Related to Infection and Immune Dysfunction
Duan, Q., Gong, Z., Song, H., et al. (2012) · International Journal of Medical Sciences · doi:10.7150/ijms.4453 · Cited by 24 · see citing works
Cardiovascular Diseases and the Risk of Venous Thromboembolism: A Hospital-based Case-control Study
Yang, C., & Kao, C. (2007) · Journal of the Chinese Medical Association · doi:10.1016/s1726-4901(09)70339-9 · Cited by 23 · see citing works
Venous thromboembolism and cancer: pathophysiology and incidence
Stricker, H. J. (2014) · VASA · doi:10.1024/0301-1526/a000358 · Cited by 21 · see citing works
Secular trends and etiologies of venous thromboembolism in Chinese from 2004 to 2016
Huang, D., Chan, P., She, H.-L., et al. (2018) · Thrombosis Research · doi:10.1016/j.thromres.2018.04.021 · Cited by 21 · see citing works
Ribosomes in platelets protect the messenger
Rowley, J. W., & Weyrich, A. S. (2017) · Blood · doi:10.1182/blood-2017-03-770180 · Cited by 14 · see citing works
Reperfusion in acute pulmonary thromboembolism
Fernandes, C. J. C. D. S., Jardim, C., Alves, J. L., Gavilanes, F., Morinaga, L. T. K., & Souza, R. (2018) · Jornal Brasileiro de Pneumologia · doi:10.1590/s1806-37562017000000204 · Cited by 14 · see citing works
Rattazzi, M., Villalta, S., Galliazzo, S., et al. (2013) · Clinical Science · doi:10.1042/cs20120698 · Cited by 11 · see citing works
Calgranulin C (S100A12) Is Differentially Expressed in Subtypes of Chronic Rhinosinusitis
Pulsipher, A., Davis, B. M., Smith, K. A., Ashby, S., Qin, X., Firpo, M. A., Orlandi, R. R., & Alt, J. A. (2018) · American Journal of Rhinology and Allergy · doi:10.1177/1945892418782238 · Cited by 11 · see citing works
Immune‐ and Ribosome‐Related Genes were Associated with Systemic Vasculitis
Gan, S., Ye, B., Qian, S., et al. (2014) · Scandinavian Journal of Immunology · doi:10.1111/sji.12252 · Cited by 10 · see citing works
Jiang, L., Xu, J., Ni, J., Gao, X., Zhu, Z., Dong, D., Wang, X., Shi, C., Tao, X., Dong, W., et al. (2012) · DNA and Cell Biology · doi:10.1089/dna.2012.1706 · Cited by 8 · see citing works
Eukaryotic Ribosome as a Target for Cardiovascular Disease
Pellegrino, S., & Yusupova, G. Z. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2016.11.004 · Cited by 7 · see citing works
The importance of the World Symposium on Pulmonary Hypertension
Jardim, C., & Waetge, D. (2018) · Jornal Brasileiro de Pneumologia · doi:10.1590/s1806-37562018000030001 · Cited by 7 · see citing works
Characterization of immune cells and perforin mutations in familiar venous thromboembolism.
Duan, Q., Lv, W., Yang, M., et al. (2015) · PubMed · Cited by 1 · see citing works
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COVID-19, Myocarditis and Pericarditis
Fairweather, D., Beetler, D. J., Di Florio, D. N., Musigk, N., Heidecker, B., & Cooper, L. T. (2023) · Circulation Research · doi:10.1161/circresaha.123.321878 · Cited by 181 · see citing works
- Authors
- Gao, L.-N., Li, Q., Xie, J.-Q., Yang, W.-X., & You, C.-G.
- Affiliations
- First Hospital of Lanzhou University (CN)
- ORCID
- Li, Qiang
- Venue
- Hereditas
- Published
- 2021-01-02
- Volume
- 158
- Issue
- 1
- Pages
- 2-2
- ISSN
- 0018-0661 (ISSN-L)
- 1601-5223
- PMC
- PMC7778808
- OpenAlex
- W3119543631
- Cited by
- 12
- References
- 43
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 1
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Hereditas (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Gansu Science and Technology Department (18YF1FA108)
- Key Science and Technology Foundation of Gansu Province (1506RJZA230)
- Topics
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- venous thromboembolism, immune cell infiltration, differentially expressed genes, hub genes, ribosomal protein genes, monocytes, regulatory T cells, mast cells, transcription factors, c-Myc, SOX2, XRN2, E2F1, PU.1, CREM, CREB1, gene expression profiling, pathogenesis
- MeSH terms
- Humans, Mast Cells, Monocytes, Transcription Factors, Computational Biology, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, T-Lymphocytes, Regulatory, Gene Regulatory Networks, Venous Thromboembolism, Protein Interaction Maps
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