The liver as a source of extrarenal erythropoietin production
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Abstract Nephrectomized rats exposed to intense hypoxia produce sufficient erythropoietin (Ep) to detectably increase their plasma Ep titers. Extrarenal Ep production is no longer detectable if nephrectomized rats are also subjected to 80% hepatectomy prior to being made hypoxic at 0.465 atmos and is barely detectable but significantly lower than in nephrectomized rats when exposed to 0.435 atmos. These results suggest that the liver plays an important role in the production of extrarenal erythropoietin.
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In adults, the liver retains the ability to produce EPO in response to moderate/severe hypoxia or pharmacologic HIF activation.
“However, in adults, the liver retains its ability to produce EPO in response to moderate/severe hypoxia or to pharmacologic HIF activation. 23–25”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [23]
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- Authors
- Fried, W.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Fried, Walter
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1972-11-01
- Volume
- 40
- Issue
- 5
- Pages
- 671-677
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W200215156
- Cited by
- 235
- References
- 18
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › High Altitude and Hypoxia
- Keywords
- erythropoietin, liver, hepatectomy, hypoxia, nephrectomy, hypobaric hypoxia, plasma erythropoietin levels
- MeSH terms
- Adrenalectomy, Animals, Hypoxia, Castration, Erythropoiesis, Erythropoietin, Hepatectomy, Hydrocortisone, Liver, Nephrectomy, Polycythemia, Rats
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