Cited by 174Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressBioactive Compounds and Antitumor Agents

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Superoxide-forming enzyme from human neutrophils: evidence for a flavin requirement

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Babior, BM, Kipnes, RS·1977·Blood

DOI 10.1182/blood.v50.3.517.517

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Abstract

The superoxide-forming activity of 27,000-g particles prepared from homogenates of zymosan-treated human neutrophils is lost if the assay is conducted in the presence of 0.045% Triton X-100. This loss in activity in the presence of detergent is prevented by 40 micron flavin adenine dinucleotide (FAD), but not by flavin mononucleotide, riboflavin, adenosine 5′-diphosphate, or adenosine 5′-monophosphate. With resting particles or particles from zymosan-treated chronic granulomatous disease neutrophils, no superoxide-forming activity is detectable even in the presence of FAD; this is true whether or not detergent is present in the assay. Particles extracted with detergent prior to assay are fully active if assayed in the presence of FAD, but show little activity if FAD is omitted from the assay mixture. These results suggest that the superoxide-forming enzyme from human neutrophils is a FAD-requiring enzyme.

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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent
Babior, B. M., Kipnes, R. S., & Curnutte, J. T. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107236 · Cited by 2,931
Self-citation
The Biochemical Basis of Phagocytosis
Sbarra, A. J., & Karnovsky, M. L. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70011-2 · Cited by 1,256
The Reduction of Cytochrome c by Milk Xanthine Oxidase
McCord, J. M., & Fridovich, I. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)91929-0 · Cited by 1,196
Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.
Goldstein, I. M., Roos, D., Kaplan, H. B., & Weissmann, G. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108191 · Cited by 746
The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.
Johnston, R. B., Keele, B. B., Misra, H. P., Lehmeyer, J. E., Webb, L., Baehner, R. L., & Rajagopalan, K. V. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108055 · Cited by 704
Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function*
Holmes, B. M., Page, A. R., & Good, R. A. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105634 · Cited by 684
Biochemical Aspects of Phagocytosis
Iyer, G. Y. N., Islam, M. F., & Quastel, J. H. (1961) · Nature · doi:10.1038/192535a0 · Cited by 658
H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors.
Root, R. K., Metcalf, J. A., Oshino, N., & Chance, B. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108024 · Cited by 646
Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes.
Sj, K. (1975) · PubMed · Cited by 573

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Bibliography Articles Cited in Commentaries
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Cytochrome B558 Component of O‐2M Generating Oxidase in the Neutrophils From Patients With Chronic Granulomatous Disease
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Superoxide generation system as a target for evaluation of antiallergic drugs
Fukuishi, N., SAKAGUTI, M., Fukuyama, Y., & Akagi, M. (1996) · Folia Pharmacologica Japonica · doi:10.1254/fpj.108.supplement_161
Effect of guanosine nucleotides on the respiratory burst oxidase from human neutrophils
Kaufman, M. R., & BABIOR, B. M. (1983) · Inflammation · doi:10.1007/bf00917260
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Nathan, C., & Cohn, Z. A. (1981)
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Authors: Babior, B., & Kipnes, R.
Venue: Blood
Publisher: American Society of Hematology
Published: 1977-09-01
Volume: 50
Issue: 3
Pages: 517-524
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood.v50.3.517.517
OpenAlex: W2475048516
Cited by: 174
References: 23
Citations by year: 2023: 4 · 2022: 2 · 2021: 2 · 2019: 3 · 2018: 1 · 2016: 1 · 2014: 2 · 2013: 1
FWCI: 2.86
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords: neutrophils, flavin adenine dinucleotide, NADPH oxidase, zymosan, chronic granulomatous disease, detergent extraction, Triton X-100, flavin mononucleotide, riboflavin
MeSH terms: Adenine Nucleotides, Detergents, Flavins, Granulomatous Disease, Chronic, Humans, Neutrophils, Peroxides, Zymosan

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Superoxide-forming enzyme from human neutrophils: evidence for a flavin requirement

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