Cited by 174Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressBioactive Compounds and Antitumor Agents

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Superoxide-forming enzyme from human neutrophils: evidence for a flavin requirement

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Babior, BM, Kipnes, RS·1977·Blood

DOI 10.1182/blood.v50.3.517.517

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Abstract

The superoxide-forming activity of 27,000-g particles prepared from homogenates of zymosan-treated human neutrophils is lost if the assay is conducted in the presence of 0.045% Triton X-100. This loss in activity in the presence of detergent is prevented by 40 micron flavin adenine dinucleotide (FAD), but not by flavin mononucleotide, riboflavin, adenosine 5′-diphosphate, or adenosine 5′-monophosphate. With resting particles or particles from zymosan-treated chronic granulomatous disease neutrophils, no superoxide-forming activity is detectable even in the presence of FAD; this is true whether or not detergent is present in the assay. Particles extracted with detergent prior to assay are fully active if assayed in the presence of FAD, but show little activity if FAD is omitted from the assay mixture. These results suggest that the superoxide-forming enzyme from human neutrophils is a FAD-requiring enzyme.

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Self-citation
Expression of functional mammal flavocytochrome b558 in yeast: Comparison with improved insect cell system
Ostuni, M. A., Lamanuzzi, L. B., Bizouarn, T., Dagher, M., & Baciou, L. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.02.016 · Cited by 21

Authors: Babior, B., & Kipnes, R.
Venue: Blood
Publisher: American Society of Hematology
Published: 1977-09-01
Volume: 50
Issue: 3
Pages: 517-524
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood.v50.3.517.517
OpenAlex: W2475048516
Cited by: 174
References: 23
Citations by year: 2023: 4 · 2022: 2 · 2021: 2 · 2019: 3 · 2018: 1 · 2016: 1 · 2014: 2 · 2013: 1
FWCI: 2.86
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords: neutrophils, flavin adenine dinucleotide, NADPH oxidase, zymosan, chronic granulomatous disease, detergent extraction, Triton X-100, flavin mononucleotide, riboflavin
MeSH terms: Adenine Nucleotides, Detergents, Flavins, Granulomatous Disease, Chronic, Humans, Neutrophils, Peroxides, Zymosan

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Superoxide-forming enzyme from human neutrophils: evidence for a flavin requirement

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