The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement
Abstract
Graft-versus-host disease is one of the major problems in clinical bone marrow transplantation. Many experiments in animals have shown that it could be greatly reduced if mature T lymphocytes were removed from the donor marrow. Here we describe a new rat monoclonal antibody, CAMPATH 1, which is suitable for depleting lymphocytes from human marrow grafts. CAMPATH 1 is an IgM that fixes human complement. It binds to both T and B lymphocytes and some monocytes but not to other hemopoietic cells. When peripheral blood mononuclear cells were treated with CAMPATH 1 and complement, more than 99% of lymphocytes were killed and viable T cells could no longer be detected. Under these conditions, in vitro multipotential erythroid and myeloid colony-forming cells were unaffected. As well as being used for in vitro treatment of bone marrow to remove T cells, CAMPATH 1 could potentially be applied to other experimental and clinical situations where depletion of lymphoid cells is required, including serotherapy to achieve immunosuppression for organ transplants or to treat lymphocytic leukemias.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens
Kung, P. C., Goldstein, G., Reinherz, E. L., & Schlossman, S. F. (1979) · Science · doi:10.1126/science.314668 · Cited by 1,453
Thomas, E., Buckner, C., Banaji, M., Clift, R., Fefer, A., Flournoy, N., Goodell, B., Hickman, R., Lerner, K., Neiman, P., et al. (1977) · Blood · doi:10.1182/blood.v49.4.511.511 · Cited by 979
Microdroplet Testing for HLA-A, -B, -C, and -D Antigens: The Philip Levine Award Lecture
Terasaki, P. I., Bernoco, D., Park, M. S., Ozturk, G., & Iwaki, Y. (1978) · American Journal of Clinical Pathology · doi:10.1093/ajcp/69.2.103 · Cited by 935
Korngold, R., & Sprent, J. (1978) · The Journal of experimental medicine · doi:10.1084/jem.148.6.1687 · Cited by 513
Beverley, P. C. L., & Callard, R. E. (1981) · European Journal of Immunology · doi:10.1002/eji.1830110412 · Cited by 494
Fluorescence-Activated Cell Sorting
Herzenberg, L. A., Sweet, R. G., & Herzenberg, L. A. (1976) · Scientific American · doi:10.1038/scientificamerican0376-108 · Cited by 460
Rat × rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG
GALFRÈ, G., MILSTEIN, C., & WRIGHT, B. (1979) · Nature · doi:10.1038/277131a0 · Cited by 402
Cobbold, S. P., & Waldmann, H. (1981) · Journal of Immunological Methods · doi:10.1016/0022-1759(81)90340-9 · Cited by 82
Self-citation
Cited by
REMISSION INDUCTION IN NON-HODGKIN LYMPHOMA WITH RESHAPED HUMAN MONOCLONAL ANTIBODY CAMPATH-1H
Hale, G., Clark, M. R., Marcus, R., Winter, G., Dyer, M. J. S., Phillips, J. M., Riechmann, L., & Waldmann, H. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90588-0 · Cited by 688
Self-citationWarner, J. L., & Arnason, J. E. (2012) · Therapeutic Advances in Hematology · doi:10.1177/2040620712458949 · Cited by 31
Anti-CD52 Therapy for Multiple Sclerosis: An Update in the COVID Era
Kasarello, K., & Mirowska-Guzel, D. (2021) · ImmunoTargets and Therapy · doi:10.2147/itt.s240890 · Cited by 11
Metadata
- Authors
- Hale, G., Bright, S., Chumbley, G., Hoang, T., Metcalf, D., Munro, A., & Waldmann, H.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1983-10-01
- Volume
- 62
- Issue
- 4
- Pages
- 873-882
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W85233391
- Cited by
- 360
- References
- 9
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement. https://app.cochat.ai/papers/10.1182/blood.v62.4.873.873
- The paper
- Hale, G., Bright, S., Chumbley, G., Hoang, T., Metcalf, D., Munro, A., & Waldmann, H. (1983). Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement. Blood. https://doi.org/10.1182/blood.v62.4.873.873
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
