Cited by 1,012Cytokine Signaling Pathways and InteractionsImmune Response and InflammationT-cell and B-cell Immunology

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Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

Schindler, R, Mancilla, J, Endres, S, Ghorbani, R, Clark, SC, Dinarello, CA·1990·Blood

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Abstract

Interleukin-6 (IL-6) shares several biologic properties with IL-1, including hematopoietin-1 activity and stimulation of T cells. Because many of their biologic activities overlap, we developed and used a specific radioimmunoassay (RIA) for IL-6 to compare production of this cytokine on a molar basis with that of IL-1 alpha, IL-1 beta, and tumor necrosis factor (TNF)alpha. The RIA correlated well with the hybridoma bioassay for IL-6 (r = .87, P less than .001). Freshly isolated human peripheral blood mononuclear cells (PBMC) cultured in the absence of stimuli did not produce IL-6 in most cases. Kinetics of secretion and cell-association of IL-6 were studied. In contrast to IL-1 alpha but similar to TNF, IL-6 was almost entirely secreted into the extracellular fluid. Incubation with different stimuli (lipopolysaccharide [LPS], phytohemagglutinin [PHA], Staphylococcus epidermidis, or IL-1 alpha) resulted in production of IL-6. However, on a molar basis PBMC produced approximately two to three times less IL-6 than IL-1 alpha, IL-1 beta, or TNF, regardless of the stimulus. The amount of IL-6 produced from PBMC was consistent when measured in the same subjects six time during a 12-week period. In a cohort of 38 donors, the coefficient of variation for IL-6 production was .32, compared with .92 for IL-1 beta and .96 for TNF. Comparing cytokine production by PBMC, there was a significant correlation between IL-6 and IL-1 beta (r = .72) and between IL-6 and TNF (r = .66). IL-6 did not stimulate IL-1 beta or TNF production, but suppressed IL-1 beta and TNF production induced by LPS or PHA by 30% (P less than .01). This suppression of IL-1 beta and TNF by IL-6 appears to be on the level of transcription.

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Crossref · 10.1182/blood.v75.1.40.40

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Gauldie, J., Richards, C. D., Harnish, D. C., Lansdorp, P. M., & Baumann, H. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.7251 · Cited by 1,635
Production of hybridoma growth factor by human monocytes
Aarden, L. A., de Groot, E. R., Schaap, O. L., & Lansdorp, P. M. (1987) · European Journal of Immunology · doi:10.1002/eji.1830171004 · Cited by 1,091
The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells
Muraguchi, A., Hirano, T., Tang, B., Matsuda, T., Horii, Y., Nakajima, K., & Kishimoto, T. (1988) · The Journal of experimental medicine · doi:10.1084/jem.167.2.332 · Cited by 783
Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.
Damme, J. V., Opdenakker, G., Simpson, R. J., Rubira, M. R., Cayphas, S., Vink, A., Billiau, A., & Snick, J. V. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.165.3.914 · Cited by 669
Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.
Perlmutter, D. H., Dinarello, C. A., Punsal, P. I., & Colten, H. R. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112721 · Cited by 566
Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.
Dinarello, C. A., Ikejima, T., Warner, S. J. C., Orencole, S. F., Lonnemann, G., Cannon, J. G., & Libby, P. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.6.1902 · Cited by 537
Structure and expression of cDNA and genes for human interferon‐beta‐2, a distinct species inducible by growth‐stimulatory cytokines.
Zilberstein, A., Ruggieri, R., Korn, J. H., & Revel, M. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04531.x · Cited by 486
SERUM LEVELS OF INTERLEUKIN-6 AND ACUTE PHASE RESPONSES
Nijsten, M. W., de Groot, E. R., ten Duis, H. J., Klasen, H. J., Hack, C. E., & Aarden, L. A. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91413-9 · Cited by 457
Interleukin 6 is involved in interleukin 1‐induced activities
Helle, M., Brakenhoff, J. P. J., de Groot, E. R., & Aarden, L. A. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180619 · Cited by 409
Induction of rat acute‐phase proteins by interleukin 6 in vivo
Geiger, T. M., Andus, T., Klapproth, J., Hirano, T., Kishimoto, T., & Heinrich, P. C. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180510 · Cited by 401

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Wu, B., Huang, C., García‐García, L., Ponce‐de‐León, A., Sifuentes‐Osornio, J., Bobadilla-del-Valle, M., Ferreira, L., Canizales‐Quintero, S., Small, P. M., Kato‐Maeda, M., et al. (2007) · Infection and Immunity · doi:10.1128/iai.00244-07 · Cited by 56
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Hernández, M. E., Becerril‐Villanueva, E., Pérez, M., Leff, P., Antón, B., Estrada-Parra, S. A., Estrada, I., Sarasa, M., Serrano, E., & Pavón, L. (2010) · BMC Research Notes · doi:10.1186/1756-0500-3-156 · Cited by 56
The systemic inflammatory response syndrome (SIRS): Immunology and potential immunotherapy
Darville, T. L., Jacobs, R. F., & Giroir, B. P. (1993) · Infection · doi:10.1007/bf01712446 · Cited by 55
Agglomerates of ultrafine particles of elemental carbon and TiO2 induce generation of lipid mediators in alveolar macrophages.
Beck‐Speier, I., Dayal, N., Karg, E. W., Maier, K., Roth, C., Ziesenis, A., & Heyder, J. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109s4613 · Cited by 56
n-3 PUFA supplementation, monocyte PCA expression and interleukin-6 production
Abbate, R., Gori, A. M., Martini, F., Brunelli, T., Filippini, M., Francalanci, I., Paniccia, R., Prisco, D., Gensini, G. F., & Serneri, G. G. N. (1996) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(96)90028-9 · Cited by 56
Inflammatory mediators in perinatal asphyxia and infection
Xanthou, M., Fotopoulos, S., Mouchtouri, A., Lipsou, N., Zika, I., & Sarafidou, J. (2002) · Acta Paediatrica · doi:10.1111/j.1651-2227.2002.tb02911.x · Cited by 55
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Rosen, H. R., Winkle, P. J., Kendall, B. J., & Diehl, D. L. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018822628096 · Cited by 55
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Buccellato, F. R., Miloso, M., Braga, M., Nicolini, G., Morabito, A., PRAVETTONI, G., Tredici, G., & Scalabrino, G. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.2.297 · Cited by 54
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Strużyna, J., Pojda, Z., Braun, B., Chomicka, M., Sobiczewska, E., & Wrembel, J. (1995) · Burns · doi:10.1016/0305-4179(95)00018-7 · Cited by 52
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Interleukin-1
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Earp, J. C., DuBois, D. C., Molano, D. S., Pyszczynski, N. A., Almon, R. R., & Jusko, W. J. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.137414 · Cited by 51
Resistance exercise attenuates skeletal muscle oxidative stress, systemic pro-inflammatory state, and cachexia in Walker-256 tumor-bearing rats
Padilha, C. S., Borges, F. H., da Silva, L. E. C. M., Frajácomo, F. T. T., Jordão, A. A., Duarte, J. A., Cecchini, R., Guarnier, F. A., & Deminice, R. (2017) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2016-0436 · Cited by 51
Effects of exercise on inflammation in patients receiving chemotherapy: a nationwide NCORP randomized clinical trial
Kleckner, I. R., Kamen, C. S., Cole, C. L., Fung, C., Heckler, C. E., Guido, J. J., Culakova, E., Onitilo, A. A., Conlin, A. K., Kuebler, J. P., et al. (2019) · Supportive Care in Cancer · doi:10.1007/s00520-019-04772-7 · Cited by 51
Extrathymic Pathways of T‐Cell Differentiation: A Primitive and Fundamental Immune System
Abo, T. (1993) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1993.tb03207.x · Cited by 51
Type I interferons (IFN-α and -β) suppress cytotoxin (tumor necrosis factor-α and lymphotoxin) production by mitogen-stimulated human peripheral blood mononuclear cells
Khabar, K. S. A., Armstrong, J. A., & Ho, M. (1992) · Journal of Leukocyte Biology · doi:10.1002/jlb.52.2.165 · Cited by 51
Loss of IL-6 Receptor Expression in Cervical Carcinoma Cells Inhibits Autocrine IL-6 Stimulation: Abrogation of Constitutive Monocyte Chemoattractant Protein-1 Production
Hess, S., Smola, H., de Silva, U. S., Hadaschik, D., Kube, D., Baldus, S. E., Flucke, U., & Pfister, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.1939 · Cited by 50
β- cell dynamics in type 2 diabetes and in dietary and exercise interventions
Lv, C.-A., Sun, Y., Zhang, Z. Y., Aboelela, Z., Qiu, X., & Meng, Z. (2022) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac046 · Cited by 57
Spontaneous Ocular Surface Inflammation and Goblet Cell Disappearance in IκBζ Gene-Disrupted Mice
Ueta, M., Hamuro, J., Yamamoto, M., Kaseda, K., Akira, S., & Kinoshita, S. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1055 · Cited by 50
Size dependent induction of proinflammatory cytokines and cytotoxicity of particulate beta-tricalciumphosphate in vitro
Lange, T., Schilling, A. F., Peters, F., Mujas, J., Wicklein, D., & Amling, M. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.02.039 · Cited by 50
Longitudinal study of antimyelin T-cell reactivity in relapsing–remitting multiple sclerosis: association with clinical and MRI activity
Hellings, N., Gelin, G., Medaer, R., Bruckers, L. M., Palmers, Y., Raus, J., & Stinissen, P. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00052-8 · Cited by 50
The role of lipocortin‐1 in dexamethasone‐induced suppression of PGE2 and TNFα release from human peripheral blood mononuclear cells
Sudlow, A. W., Carey, F., Forder, R. A., & Rothwell, N. J. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15305.x · Cited by 50
Precision medicine in sepsis and septic shock: From omics to clinical tools
Ruiz‐Rodríguez, J. C., Plata-Menchaca, E. P., Chiscano‐Camón, L., Ruiz-Sanmartín, A., Pérez-Carrasco, M., Palmada, C., Ribas, V. J., Martínez‐Gallo, M., Hernández-González, M., González‐López, J. J., et al. (2022) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v11.i1.1 · Cited by 49
The role of chronic low-grade inflammation in the development of sarcopenia: Advances in molecular mechanisms
Cheng, Y., Lin, S., Cao, Z., Yu, R., Fan, Y., & Chen, J. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114056 · Cited by 55
Acute reactive oxygen species (ROS)-dependent effects of IL-1β, TNF-α, and IL-6 on the glomerular filtration barrier (GFB) in vivo
Sverrisson, K., Axelsson, J., Rippe, A., Asgeirsson, D., & Rippe, B. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00111.2015 · Cited by 49
Role of cytokines and other factors involved in theMycobacterium tuberculosisinfection
Romero-Adrián, T. B. (2015) · World Journal of Immunology · doi:10.5411/wji.v5.i1.16 · Cited by 51
Nicotine modulates molecules of the innate immune response in epithelial cells and macrophages during infection withM. tuberculosis
Valdez-Miramontes, C., Martínez, L. A. T., Torres-Juárez, F., Rodríguez-Carlos, A., Marín-Luevano, S. P., de Haro‐Acosta, J., Enciso‐Moreno, J. A., & Rivas-Santiago, B. T. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13388 · Cited by 49
Clinical and inflammatory effects of dietary l-arginine in patients with intractable angina pectoris
Blum, A., Porat, R., Rosenschein, U., Keren, G., Roth, A., Laniado, S., & Miller, H. I. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00129-0 · Cited by 49
Why haematomas cause flap failure: An evidence-based paradigm
Glass, G. E., & Nanchahal, J. (2012) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2011.12.014 · Cited by 48
Cytokine Production by Human Milk Cells and Peripheral Blood Mononuclear Cells from the Same Mothers
Hawkes, J. S., Bryan, D., & Gibson, R. A. (2002) · Journal of Clinical Immunology · doi:10.1023/a:1020652215048 · Cited by 48
Serum Amyloid A, Procalcitonin, Tumor Necrosis Factor‐α, and Interleukin‐1β Levels in Neonatal Late‐Onset Sepsis
Uçar, B., Yıldız, B., Akşit, M. A., Yarar, Ç., Çolak, Ö., Akbay, Y., & Çolak, E. (2008) · Mediators of Inflammation · doi:10.1155/2008/737141 · Cited by 48
Defects in Host Defense Mechanisms
van der Meer, J. W. M., & Kullberg, B. J. (2002) · Springer eBooks · doi:10.1007/0-306-47527-8_2 · Cited by 48
Global gene expression profile progression in Gaucher disease mouse models
Xu, Y.-H., Li, J., Quinn, B., Zamzow, M., Stringer, K. F., Aronow, B. J., Sun, Y., Zhang, W., Setchell, K. D. R., & Grabowski, G. A. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-20 · Cited by 47
Involvement of plasma miRNAs, muscle miRNAs and mitochondrial miRNAs in the pathophysiology of frailty
Rusanova, I., Fernández‐Martínez, J., Fernández‐Ortiz, M., Aranda‐Martínez, P., Escames, G., García‐García, F. J., Rodríguez‐Mañas, L., & Acuña-Castroviejo, D. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110637 · Cited by 45
A rapid ‘one-plate’ in vitro test for pyrogens
Poole, S., Mistry, Y., Ball, C., Das, R. G., Opie, L. P., Tucker, G., & Patel, M. (2003) · Journal of Immunological Methods · doi:10.1016/s0022-1759(02)00519-7 · Cited by 47
Phototherapy for neonatal hyperbilirubinemia affects cytokine production by peripheral blood mononuclear cells
Sirota, L., Straussberg, R., Gurary, N., Aloni, D., & Bessler, H. (1999) · European Journal of Pediatrics · doi:10.1007/s004310051240 · Cited by 47
EFFECTS OF AN INTRAVENOUS CATHETER ON THE LOCAL PRODUCTION OF CYTOKINES AND SOLUBLE CYTOKINE RECEPTORS IN HEALTHY MEN
Haack, M., Reichenberg, A., Kraus, T., Schuld, A., Yirmiya, R., & Pollmächer, T. (2000) · Cytokine · doi:10.1006/cyto.1999.0665 · Cited by 47
Expression and Regulation of Human Alveolar Macrophage-derived Interleukin-1 Receptor Antagonist
Moore, S. A., Strieter, R. M., Rolfe, M. W., Standiford, T. J., Burdick, M. D., & Kunkel, S. L. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/6.6.569 · Cited by 48
Detection of abnormal peripheral blood mononuclear cell cytokine networks in human IgA nephropathy
de Caestecker, M. P., Bottomley, M., Telfer, B. A., Hutchinson, I. V., Vose, B. M., & BALLARDIE, F. W. (1993) · Kidney International · doi:10.1038/ki.1993.382 · Cited by 47
Cytochrome P450 and Antioxidant Activity in Interleukin-6 Knockout Mice After Induction of the Acute-Phase Response
Warren, G. W., Ess, P. J. V., Watson, A. M., Mattson, M. P., & Blouin, R. A. (2001) · Journal of Interferon & Cytokine Research · doi:10.1089/107999001753238060 · Cited by 46
Spontaneous bacterial peritonitis is associated with high levels of interleukin‐6 and its secondary mediators in ascitic fluid
Propst, T., Propst, A., Herold, M., SCHAUER, G., Judmaier, G., Braunsteiner, H., Stöffler, G., & Vogel, W. (1993) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1993.tb00738.x · Cited by 46
Docosahexaenoic acid regulates serum amyloid A protein to promote lipolysis through down regulation of perilipin
Wang, Y. C., Kuo, W., Chen, C., Lin, H., Wu, H. T., Liu, B. H., Chen, C. H., Mersmann, H. J., Chang, K., & Ding, S. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.01.004 · Cited by 48
Relation between cytokines and routine laboratory data in children with septic shock and purpura
Hazelzet, J. A., van der Voort, E., Lindemans, J. W., ter Heerdt, P. G. J., & Neijens, H. J. (1994) · Intensive Care Medicine · doi:10.1007/bf01720912 · Cited by 46
Anti-TNF monoclonal antibodies prevent haemorrhage-induced suppression of Kupffer cell antigen presentation and MHC class II antigen expression.
Ertel, W., Morrison, M., Ayala, A., Perrin, M. M., & Chaudry, I. H. (1991) · PubMed Central · Cited by 46
Source and Kinetics of Interleukin-6 in Humans during Exercise Demonstrated by a Minimally Invasive Model
Toft, A. D., Falahati, A., & Steensberg, A. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1755-5 · Cited by 45
A Novel Distal Enhancer Mediates Cytokine Induction of Mouse Rankl Gene Expression
Bishop, K. A., Meyer, M. B., & Pike, J. W. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0209 · Cited by 46
Evaluation of photodynamic therapy on fibroblast viability and cytokine production
Gomes‐Filho, J. E., Sivieri‐Araújo, G., Sipert, C. R., Santos, L. M. D. S., Queiroz, Í. O. D. A., Martins, C. M., Maia, N. K. D. C., Cintra, L. T. Â., Dezan, E., Bagnato, V. S., et al. (2016) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2016.01.007 · Cited by 45
Regiospecific synthesis, anti-inflammatory and anticancer evaluation of novel 3,5-disubstituted isoxazoles from the natural maslinic and oleanolic acids
Chouaïb, K., Romdhane, A., Delemasure, S., Dutartre, P., Elie, N., Touboul, D., Jannet, H. B., & Hamza, M. A. (2016) · Industrial Crops and Products · doi:10.1016/j.indcrop.2016.03.024 · Cited by 45

Authors: Schindler, R., Mancilla, J., Endres, S., Ghorbani, R., Clark, S., & Dinarello, C.
Affiliations: Tufts University (US)
Department of Medicine, Tufts University School of Medicine, Boston, MA.
ORCID: Endres, S
Venue: Blood
Publisher: American Society of Hematology
Published: 1990-01-01
Volume: 75
Issue: 1
Pages: 40-47
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood.v75.1.40.40
OpenAlex: W204546040
Cited by: 1,012
References: 34
Citations by year: 2026: 7 · 2025: 17 · 2024: 16 · 2023: 11 · 2022: 29 · 2021: 19 · 2020: 22 · 2019: 31 · 2018: 33 · 2017: 18 · 2016: 35 · 2015: 17 · 2014: 32 · 2013: 26 · 2012: 38
FWCI: 24.10
Type: journal article
Language: en
Open access: closed
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI‑15614)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: interleukin-6, IL-1β, TNF-α, cytokine production, peripheral blood mononuclear cells, cytokine inhibition, lipopolysaccharide, phytohemagglutinin, Staphylococcus epidermidis, radioimmunoassay, transcriptional regulation, hematopoietic function
MeSH terms: Biological Assay, Gene Expression Regulation, Humans, Interleukin-1, Leukocytes, Mononuclear, Radioimmunoassay, RNA, Messenger, Tumor Necrosis Factor-alpha, Interleukin-6, In Vitro Techniques

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Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

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