Cited by 1,012Cytokine Signaling Pathways and InteractionsImmune Response and InflammationT-cell and B-cell Immunology

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

Schindler, R, Mancilla, J, Endres, S, Ghorbani, R, Clark, SC, Dinarello, CA·1990·Blood

Open this paper in CoChat — free account

Abstract

Interleukin-6 (IL-6) shares several biologic properties with IL-1, including hematopoietin-1 activity and stimulation of T cells. Because many of their biologic activities overlap, we developed and used a specific radioimmunoassay (RIA) for IL-6 to compare production of this cytokine on a molar basis with that of IL-1 alpha, IL-1 beta, and tumor necrosis factor (TNF)alpha. The RIA correlated well with the hybridoma bioassay for IL-6 (r = .87, P less than .001). Freshly isolated human peripheral blood mononuclear cells (PBMC) cultured in the absence of stimuli did not produce IL-6 in most cases. Kinetics of secretion and cell-association of IL-6 were studied. In contrast to IL-1 alpha but similar to TNF, IL-6 was almost entirely secreted into the extracellular fluid. Incubation with different stimuli (lipopolysaccharide [LPS], phytohemagglutinin [PHA], Staphylococcus epidermidis, or IL-1 alpha) resulted in production of IL-6. However, on a molar basis PBMC produced approximately two to three times less IL-6 than IL-1 alpha, IL-1 beta, or TNF, regardless of the stimulus. The amount of IL-6 produced from PBMC was consistent when measured in the same subjects six time during a 12-week period. In a cohort of 38 donors, the coefficient of variation for IL-6 production was .32, compared with .92 for IL-1 beta and .96 for TNF. Comparing cytokine production by PBMC, there was a significant correlation between IL-6 and IL-1 beta (r = .72) and between IL-6 and TNF (r = .66). IL-6 did not stimulate IL-1 beta or TNF production, but suppressed IL-1 beta and TNF production induced by LPS or PHA by 30% (P less than .01). This suppression of IL-1 beta and TNF by IL-6 appears to be on the level of transcription.

Integrity signals

Registry

Crossref · 10.1182/blood.v75.1.40.40

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.
Gauldie, J., Richards, C. D., Harnish, D. C., Lansdorp, P. M., & Baumann, H. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.7251 · Cited by 1,635
Production of hybridoma growth factor by human monocytes
Aarden, L. A., de Groot, E. R., Schaap, O. L., & Lansdorp, P. M. (1987) · European Journal of Immunology · doi:10.1002/eji.1830171004 · Cited by 1,091
The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells
Muraguchi, A., Hirano, T., Tang, B., Matsuda, T., Horii, Y., Nakajima, K., & Kishimoto, T. (1988) · The Journal of experimental medicine · doi:10.1084/jem.167.2.332 · Cited by 783
Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.
Damme, J. V., Opdenakker, G., Simpson, R. J., Rubira, M. R., Cayphas, S., Vink, A., Billiau, A., & Snick, J. V. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.165.3.914 · Cited by 669
Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.
Perlmutter, D. H., Dinarello, C. A., Punsal, P. I., & Colten, H. R. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112721 · Cited by 566
Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.
Dinarello, C. A., Ikejima, T., Warner, S. J. C., Orencole, S. F., Lonnemann, G., Cannon, J. G., & Libby, P. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.6.1902 · Cited by 537
Structure and expression of cDNA and genes for human interferon‐beta‐2, a distinct species inducible by growth‐stimulatory cytokines.
Zilberstein, A., Ruggieri, R., Korn, J. H., & Revel, M. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04531.x · Cited by 486
SERUM LEVELS OF INTERLEUKIN-6 AND ACUTE PHASE RESPONSES
Nijsten, M. W., de Groot, E. R., ten Duis, H. J., Klasen, H. J., Hack, C. E., & Aarden, L. A. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91413-9 · Cited by 457
Interleukin 6 is involved in interleukin 1‐induced activities
Helle, M., Brakenhoff, J. P. J., de Groot, E. R., & Aarden, L. A. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180619 · Cited by 409
Induction of rat acute‐phase proteins by interleukin 6 in vivo
Geiger, T. M., Andus, T., Klapproth, J., Hirano, T., Kishimoto, T., & Heinrich, P. C. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180510 · Cited by 401

Show all 34 references

Sorted by citations

Items 501–600 of 998

Porphyromonas gingivalis lipopolysaccharide induces tumor necrosis factor‐α and interleukin‐6 secretion, and CCL25 gene expression, in mouse primary gingival cell lines: interleukin‐6‐driven activation of CCL2
Ekhlassi, S., Scruggs, L. Y., Garza, T., Montufar‐Solis, D., Moretti, A. J., & Klein, J. R. (2008) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2008.01090.x · Cited by 30
The Effect of Iron on the Expression of Cytokines in Macrophages Infected with Mycobacterium tuberculosis
Serafín-López, J., Chacón-Salinas, R., Muñoz-Cruz, S., Enciso-Moreno, J. A., Estrada-Parra, S., & Estrada-García, I. (2004) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2004.01482.x · Cited by 30
Proinflammatory or Regulatory Cytokines Released from BALF Macrophages of Healthy Smokers
Mikuniya, T., Nagai, S., Tsutsumi, T., Morita, K., Mio, T., Satake, N., & Izumi, T. (1999) · Respiration · doi:10.1159/000029425 · Cited by 30
Inflammatory cytokines in major surgery: a functional perspective
Lin, E., & Lowry, S. F. (1999) · Intensive Care Medicine · doi:10.1007/s001340050832 · Cited by 30
The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness
Kato, C. D., Matovu, E., Mugasa, C. M., Nanteza, A., & Alibu, V. P. (2016) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-016-0113-5 · Cited by 28
Interleukin‐6 Infusion During Human Endotoxaemia Inhibits In Vitro Release of the Urokinase Receptor from Peripheral Blood Mononuclear Cells
Ostrowski, S. R., Plomgaard, P., Fischer, C. P., Steensberg, A., Møller, K., Høyer‐Hansen, G., Pedersen, B. K., & Ullum, H. (2005) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2005.01547.x · Cited by 29
Viral characteristics of human papillomavirus infection and antioxidant levels as risk factors for cervical dysplasia
Ho, G., Palan, P. R., Basu, J., Romney, S. L., Kadish, A. S., Mikhail, M. S., Wassertheil‐Smoller, S., Runowicz, C. D., & Burk, R. D. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19981123)78:5 · Cited by 84
Isolation of a Puumala-like Virus from Mus musculus Captured in Yugoslavia and Its Association with Severe Hemorrhagic Fever with Renal Syndrome
Diglisic, G., Xiao, S., Gligić, A., Obradović, M., Stojanovic, R., Velimirovic, D., LUKAC, V., Rossi, C. A., & LeDuc, J. W. (1994) · The Journal of Infectious Diseases · doi:10.1093/infdis/169.1.204 · Cited by 29
Effect of growth hormone or chromium picolinate on swine metabolism and inflammatory cytokine production after endotoxin challenge exposure
Myers, M. J., Farrell, D. E., Evock-Clover, C. M., McDonald, M. W., & Steele, N. C. (1997) · American Journal of Veterinary Research · doi:10.2460/ajvr.1997.58.06.594 · Cited by 29
Chapter 26 Neurotransmitters and cytokines in CNS pathology
Mitrovic, B., Martin, F. C., Charles, A. C., Ignarro, L. J., Anton, P. A., Shanahan, F., & Merrill, J. E. (1994) · Progress in brain research · doi:10.1016/s0079-6123(08)61146-2 · Cited by 29
Cardiotrophin-1 therapy prevents gentamicin-induced nephrotoxicity in rats
Quirós, Y., Blanco-Gozalo, V., Sánchez-Gallego, J. I., López-Hernández, F. J., Ruiz, J. C., de Obanos, M. P. P., & López-Novoa, J. M. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.02.025 · Cited by 28
Late brain alterations in sepsis‐survivor rats
Steckert, A. V., Comim, C. M., Mina, F., Mendonça, B. P., Dominguini, D., Ferreira, G. K., Carvalho‐Silva, M., Vieira, J. S., STRECK, E. L., Quevedo, J., et al. (2013) · Synapse · doi:10.1002/syn.21686 · Cited by 28
Modulating Effects of Intravenous Immunoglobulins on Serum Cytokine Levels in Patients with Primary Hypogammaglobulinemia
ez, C. I., Su, P., Fierro, A. C. B., guez, S. R., pez, M. L., lvarez, A. N. C.-A., de Gracia, J., & Ronsano, J. B. M. (2005) · BioDrugs · doi:10.2165/00063030-200519010-00007 · Cited by 28
Immune transcriptome reveals the mincle C-type lectin receptor acts as a partial replacement for TLR4 in lipopolysaccharide-mediated inflammatory response in barramundi ( Lates calcarifer )
Zoccola, E., Kellie, S., & Barnes, A. C. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.01.010 · Cited by 28
The effect of dental bleaching on pulpal tissue response in a diabetic animal model: a study of immunoregulatory cytokines
Ferreira, L. L., Gomes‐Filho, J. E., Benetti, F., Carminatti, M., Ervolino, E., Briso, A. L. F., & Cintra, L. T. Â. (2017) · International Endodontic Journal · doi:10.1111/iej.12852 · Cited by 28
Human Cytomegalovirus Enhances Chemokine Production by Lipopolysaccharide‐Stimulated Lamina Propria Macrophages
Redman, T. K., Britt, W. J., Wilcox, C. M., Graham, M. F., & Smith, P. D. (2002) · The Journal of Infectious Diseases · doi:10.1086/339007 · Cited by 28
The Pivotal Role of Interleukin 6 in Formation and Function of Hematopoietically Active Murine Long‐Term Bone Marrow Cultures
Hauser, S. P., Kajkenova, O., & Lipschitz, D. A. (1997) · Stem Cells · doi:10.1002/stem.150125 · Cited by 28
Pneumocystis carinii induces interleukin 6 production by an alveolar epithelial cell line
Pottratz, Reese, & Sheldon (1998) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1998.00299.x · Cited by 28
Somatostatin (SRIF) stimulates the release of interleukin-6 (IL-6) from human peripheral blood monocytes (PBM) in vitro
Komorowski, J., & Stepien, H. (1995) · Neuropeptides · doi:10.1016/0143-4179(95)90087-x · Cited by 28
Wound Healing of Intestinal Anastomosis after Digestive Surgery under Septic Conditions: Participation of Local Interleukin‐6 Expression
Ishimura, K., TSUBOUCHI, T., Okano, K., Maeba, T., & Maeta, H. (1998) · World Journal of Surgery · doi:10.1007/s002689900519 · Cited by 28
Role of Dialysis Modality in Responses of Blood Monocytes and Peritoneal Macrophages to Endotoxin Stimulation
Friedlander, M. A., Hilbert, C., Wu, Y. C., & Rich, E. A. (1993) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)70161-0 · Cited by 28
Regulation of tumor necrosis factor production by monocyte-macrophages and lymphocytes
Trinchieri, G. (1991) · Immunologic Research · doi:10.1007/bf02918157 · Cited by 28
Depression caused by long-term stress regulates premature aging and is possibly associated with disruption of circadian rhythms in mice
Xie, X., Shen, Q., Cao, L., Chen, Y., Ma, L., Xiao, Q., Yu, C., & Fu, Z. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.11.011 · Cited by 27
Influence of inflammatory mechanisms on the redox balance in interstitial lung diseases
Lenz, A., Hinze-Heyn, H., Schneider, A., Behr, J., Häussinger, K., Heindl, S., Stanzel, F., & Maier, K. (2004) · Respiratory Medicine · doi:10.1016/j.rmed.2004.02.007 · Cited by 27
IL-6-soluble IL-6 receptor complex inhibits the proliferation of dermal fibroblasts
Mihara, M., Moriya, Y., & Ohsugi, Y. (1996) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(95)00106-9 · Cited by 27
Production of modified crosslinked cell‐free hemoglobin for human use: the role of quantitative determination of endotoxin contamination
Roth, R. I., Levin, J., Chapman, K. W., Schmeizl, M., & Rickles, F. R. (1993) · Transfusion · doi:10.1046/j.1537-2995.1993.331194082383.x · Cited by 27
Association between serum cytokine concentrations and the presence of hypertriglyceridemia
Mirhafez, S. R., Tajfard, M., Avan, A., Pasdar, A., Nedaeinia, R., Aghasizadeh, M., Davari, H., Manian, M., Mahdizadeh, A., Meshkat, Z., et al. (2016) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2016.03.009 · Cited by 26
Effect of physical activity promotion on adiponectin, leptin and other inflammatory markers in prediabetes: a systematic review and meta-analysis of randomized controlled trials
Jadhav, R., Maiya, A. G., Hombali, A. S., Umakanth, S., & Shivashankar, K. N. (2020) · Acta Diabetologica · doi:10.1007/s00592-020-01626-1 · Cited by 31
Tumor necrosis factor alpha serum levels and inflammatory response in acute ischemic stroke
Domaç, F. M., Somay, G., Mısırlı, H., & Erenoğlu, N. Y. (2007) · Neurosciences · doi:10.17712/1658-3183.1463 · Cited by 26
Energy Balance and Cancer
Hursting, S. D., Rogers, C. J., Mahabir, S., Núñez, N. P., Barrett, J. C., Perkins, S. N., & Forman, M. R. (2006) · Elsevier eBooks · doi:10.1016/b978-012088393-6/50061-0 · Cited by 26
The role of alpha7 nicotinic acetylcholine receptors in inflammatory bowel disease: involvement of different cellular pathways
Seyedabadi, M., Rahimian, R., & Ghia, J. (2018) · Expert opinion on therapeutic targets · doi:10.1080/14728222.2018.1420166 · Cited by 26
Real-Time Monitoring and Detection of Single-Cell Level Cytokine Secretion Using LSPR Technology
Zhu, C., Luo, X. B., Espulgar, W. V., Koyama, S., Kumanogoh, A., Saito, M., Takamatsu, H., & Tamiya, E. (2020) · Micromachines · doi:10.3390/mi11010107 · Cited by 26
Interleukin-1 beta and interleukin-6 release by peripheral blood monocytes in head and neck cancer
Gallo, O., Gori, A. M., Attanasio, M., Martini, F., Giusti, B., Boddi, M., Gallina, E., Fini, O., & Abbate, R. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.371 · Cited by 26
Role of neutrophils in release of some cytokines and their soluble receptors
Jabłońska, E., Jablonski, J., & Hołownia, A. (2000) · Immunology Letters · doi:10.1016/s0165-2478(99)00148-0 · Cited by 26
Soluble CD23 potentiates interleukin‐1‐induced secretion of interleukin‐6 and interleukin‐1 receptor antagonist by human monocytes
Herbelin, A., Elhadadu, S., Ouaazu, F., de Grooteu, D., & Descamps‐Latscha, B. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240823 · Cited by 26
The role of IL-1ß in the regulation of IL-8 and IL-6 in human corneal epithelial cells during Pseudomonas aeruginosa colonization
Xue, M. L., Zhu, H., Willcox, M. D. P., Wakefield, D., Lloyd, A. R., & Thakur, A. B. (2001) · Current Eye Research · doi:10.1076/ceyr.23.6.406.6969 · Cited by 26
Paraneoplastic Syndrome in Haemophagocytic Histiocytic Sarcoma in a Dog
Soare, T., Noble, P. J. W., Hetzel, U., Fonfara, S., & Kipar, A. (2011) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2011.05.006 · Cited by 25
Is interleukin-6 the necessary pyrogenic cytokine?
Roth, J., Rummel, C. D., Harré, E. ‐., Voß, T., Mütze, J., Gerstberger, R., & Hübschle, T. (2004) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2004.08.002 · Cited by 25
Are circulating cytokine responses to exercise in the heat augmented in older men?
Wright, H. E., McLellan, T. M., Larose, J., Hardcastle, S. G., Boulay, P., & Kenny, G. P. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0223 · Cited by 24
Regulation of Il-10 gene expression by Il-6 via Stat3 in grass carp head kidney leucocytes
Wen, C., Gan, N., Zeng., T., Lv, M., Zhang, N., Zhou, H. Y., Zhang, A., & Wang, X. (2020) · Gene · doi:10.1016/j.gene.2020.144579 · Cited by 25
Chronic Deep Brain Stimulation of the Hypothalamic Nucleus in Wistar Rats Alters Circulatory Levels of Corticosterone and Proinflammatory Cytokines
Calleja-Castillo, J. M., de la Cruz-Aguilera, D. L., Manjarrez-Marmolejo, J., Velasco-Velázquez, M. A., Espinoza, G. M., Moreno-Aguilar, J., Hernández, M. E., Aguirre‐Cruz, L., & Pavón, L. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/698634 · Cited by 25
Direct Activation of Human Peritoneal Mesothelial Cells by Heat-killed Microorganisms
Kinnaert, P., Wilde, J.-P. D., Bournonville, B., Husson, C. P., & Salmon, I. J. (1996) · Annals of Surgery · doi:10.1097/00000658-199612000-00010 · Cited by 25
FcγRIII activation is different in CD16+ cytotoxic T lymphocytes and natural killer cells
Uciechowski, P., Gessner, J. E., Schindler, R., & Schmidt, R. E. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220643 · Cited by 25
Cytokine gene expression and synthesis by human megakaryocytic cells
Avraham, H. K., Vannier, E. G., Chi, S. Y., Dinarello, C. A., & Groopman, J. E. (1992) · The International Journal Of Cell Cloning · doi:10.1002/stem.5530100203 · Cited by 25
Effects of mineral fibers on the expression of genes whose product may play a role in fiber pathogenesis.
Tsuda, T., Morimoto, Y., Yamato, H., Nakamura, H., Hori, H., Nagata, N., Kido, M., Higashi, T., & Tanaka, I. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s51173 · Cited by 25
Cytokine (Interleukin-1 alpha, Interleukin-1 beta, Tumor Necrosis Factor alpha, and Interleukin-6)-Possessing Cells in Lymph Nodes of Malignant Lymphoma
Takeshita, M., Sumiyoshi, Y., Masuda, Y., Ohshima, K., Yoshida, T., Kikuchi, M., & Müller, H. (1993) · Pathology - Research and Practice · doi:10.1016/s0344-0338(11)80112-3 · Cited by 25
Dilemmas of low dosage glucocorticoid treatment in rheumatoid arthritis: considerations of timing
Masi, A. T., & Chrousos, G. P. (1997) · Annals of the Rheumatic Diseases · doi:10.1136/ard.56.1.1 · Cited by 25
Perspektiven in der Schockforschung
Menger, M. D., & Vollmar, B. (2006) · Notfall + Rettungsmedizin · doi:10.1007/s10049-006-0855-6 · Cited by 25
Therapeutic efficacy of Nano-formulation of lactoperoxidase and lactoferrin via promoting immunomodulatory and apoptotic effects
El‐Fakharany, E. M., Ashry, M., Abd-Elaleem, A.-E. H., Romeih, M. H., Morsy, F. A., Shaban, R. A., & Abdel-Wahhab, K. G. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.08.067 · Cited by 24
La inflamación como agente terapéutico en el infarto cerebral: respuesta inflamatoria celular y mediadores inflamatorios
Cuenca-López, M. D., Brea, D., Segura, T., Galindo, M. F., Martinez, D., Freire, J. A., Castillo, J., & Bueso, J. J. (2010) · Revista de Neurología · doi:10.33588/rn.5006.2009666 · Cited by 24
Beneficial Effects of Anti-Interleukin-6 Antibodies on Impaired Gastrointestinal Motility, Inflammation and Increased Colonic Permeability in a Murine Model of Sepsis Are Most Pronounced When Administered in a Preventive Setup
Nullens, S., Staessens, M., Peleman, C., Plaeke, P., Malhotra‐Kumar, S., Francque, S., Man, J. G. D., & Winter, B. Y. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152914 · Cited by 26
IL-1β and IL-6 in mouse parotid acinar cells: characterization of synthesis, storage, and release
Tanda, N., Ohyama, H., Yamakawa, M., Ericsson, M., Tsuji, T., McBride, J., Elovic, A., Wong, D. T., & Login, G. R. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.274.1.g147 · Cited by 25
Partnered sexual activity moderates menstrual cycle–related changes in inflammation markers in healthy women: an exploratory observational study
Lorenz, T. K., Demas, G. E., & Heiman, J. R. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.11.010 · Cited by 24
Electric Foot-Shock Stress Drives TNF-α Production in the Liver of IL-6-Deficient Mice
Chida, Y., Sudo, N., Motomura, Y., & Kubo, C. (2004) · NeuroImmunoModulation · doi:10.1159/000080153 · Cited by 24
POTENTIAL BIOLOGIC AGENTS FOR TREATING RHEUMATOID ARTHRITIS
Moreland, L. W. (2001) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70212-x · Cited by 23
Expression of the Interleukin-6 Gene Is Constitutive and Not Regulated by Estrogen in Rat Vascular Smooth Muscle Cells in Culture
Maret, A., Clamens, S., Delrieu, I., Elhage, R., Arnal, J., & Bayard, F. (1999) · Endocrinology · doi:10.1210/endo.140.6.6763 · Cited by 24
Muscle as an Endocrine Organ
Legaard, G. E., & Pedersen, B. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814593-7.00013-x · Cited by 24
The effect of resistance exercise upon age-related systemic and local skeletal muscle inflammation
Ziegler, A. K., Jensen, S. M., Schjerling, P., Mackey, A. L., Andersen, J. L., & Kjær, M. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.03.007 · Cited by 23
HDL and LDL have distinct, opposing effects on LPS-induced brain inflammation
Radford‐Smith, D. E., Yates, A. G., Rizvi, L., Anthony, D. C., & Probert, F. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01817-z · Cited by 24
Effects of an acute bout of moderate-intensity exercise on postprandial lipemia and airway inflammation
Johnson, A. M., Kurti, S. P., Smith, J. R., Rosenkranz, S. K., & Harms, C. A. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0314 · Cited by 24
Autocrine Effects of Interleukin-6 Mediate Acute-Phase Proinflammatory and Tissue-Reparative Transcriptional Responses of Canine Bladder Mucosa
Wood, M. W., Breitschwerdt, E. B., & Gookin, J. L. (2010) · Infection and Immunity · doi:10.1128/iai.01102-10 · Cited by 23
Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity
Metsios, G. S., Stavropoulos‐Kalinoglou, A., Sandoo, A., Zanten, J. V., Toms, T. E., John, H., & Kitas, G. D. (2010) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192401004010089 · Cited by 26
Interleukin-6 Polymorphism: A Genetic Risk Factor for Cardiac Transplant Related Coronary Vasculopathy?
Densem, C. G., Ray, M., Hutchinson, I. V., Yonan, N. A., & Brooks, N. H. (2005) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2004.03.016 · Cited by 23
Blocking interleukin-1 receptors
Dinarello, C. A. (1994) · International Journal of Clinical & Laboratory Research · doi:10.1007/bf02593903 · Cited by 24
Early induction of IL-6 in infants undergoing major abdominal surgery
Sweed, Y., Puri, P., & Reen, D. J. (1992) · Journal of Pediatric Surgery · doi:10.1016/0022-3468(92)90553-j · Cited by 23
Interleukin-6 enhances the expression of tumor necrosis factor receptors on hepatoma cells and hepatocytes
Bladel, S. V., Libert, C., & Fiers, W. (1991) · Cytokine · doi:10.1016/1043-4666(91)90036-d · Cited by 23
Differences in serum IL-6 response after 1 °C rise in core body temperature in individuals with spinal cord injury and cervical spinal cord injury during local heat stress
Hashizaki, T., Nishimura, Y., 寺村, 健., Umemoto, Y., Shibasaki, M., Leicht, C. A., Kouda, K., & Tajima, F. (2018) · International Journal of Hyperthermia · doi:10.1080/02656736.2018.1511838 · Cited by 22
Local delivery of soluble interleukin-6 receptors to improve the outcome of alpha-toxin producing Staphylococcus aureus infection in mice
Onogawa, T. (2005) · Immunobiology · doi:10.1016/j.imbio.2004.09.006 · Cited by 22
Kinetics of Intracellular, Extracellular and Production of Pro-Inflammatory Cytokines in Lipopolysaccharide- Stimulated Human Peripheral Blood Mononuclear Cells
Kumolosasi, E., Salim, E., Jantan, I., & Ahmad, W. (2014) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v13i4.8 · Cited by 22
Oral cadmium exposure affects skin immune reactivity in rats
Tucović, D., Aleksandrov, A. P., Mirkov, I. I., Ninkov, M., Kulaš, J. B., Zolotarevski, L. D., Vukojević, V., Mutić, J. J., Tatalović, N., & Kataranovski, M. V. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.07.117 · Cited by 22
Effects of acute aerobic exercise on cytokines, klotho, irisin, and vascular endothelial growth factor responses in rheumatoid arthritis patients
Ercan, Z., Deniz, G., Yentür, S. B., Arıkan, F. B., Karataş, A., Alkan, G., & Koca, S. S. (2022) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-022-02970-7 · Cited by 26
Interaction between cytokines, nutrition and infection
Muñoz, C., Liana Schlesinger, F., & Cavaillon, J. (1995) · Nutrition Research · doi:10.1016/0271-5317(95)02050-0 · Cited by 22
Sleep and body temperature responses in an acute viral infection model are altered in interferon type I receptor-deficient mice
Traynor, T. R., Majde, J. A., Bohnet, S. G., & Krueger, J. M. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.08.008 · Cited by 21
Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits
Okura, T., Marutsuka, K., Hamada, H., Sekimoto, T., Fukushima, T., Asada, Y., Kitamura, K., & Chosa, E. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2550 · Cited by 21
Thymulin evokes IL-6-C/EBPβ regenerative repair and TNF-α silencing during endotoxin exposure in fetal lung explants
Land, S. C., & Darakhshan, F. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00401.2002 · Cited by 21
Combined treatment with antioxidants and immunosuppressants on cytokine release by human peripheral blood mononuclear cells - chemically injured keratocyte reaction.
Yi, K., Chung, T. Y., Hyon, J. Y., Koh, J. W., Wee, W. R., & Shin, Y. J. (2011) · Europe PMC (PubMed Central) · Cited by 21
Leishmania major: low infection dose causes short-lived hyperalgesia and cytokines upregulation in mice
Karam, M. C., Hamdan, H. G., Abi Chedid, N. A., Bodman-Smith, K. B., Eales-Reynolds, L.-J. E., & Baroody, G. M. (2006) · Experimental Parasitology · doi:10.1016/j.exppara.2006.01.003 · Cited by 21
Gene Therapy for Rheumatoid Arthritis
Chernajovsky, Y., Annenkov, A. E., Herman, C., Triantaphyllopoulos, K. A., Gould, D., Dreja, H. S., Moyes, S. P., Croxford, J. L., Mageed, R. A., Podhajcer, O. L., et al. (1998) · Drugs & Aging · doi:10.2165/00002512-199812010-00004 · Cited by 21
Protein kinase A-dependent IL-6 production induced by calcitonin in human glioblastoma A172 cells
Kiriyama, Y., Murayama, T., Tokumitsu, Y., & Nomura, Y. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00044-1 · Cited by 21
Peritoneal mononuclear cell differentiation and cytokine production in intermittent and continuous automated peritoneal dialysis
Wrenger, E., Baumann, C., Behrend, M., Zamore, E., Schindler, R., & Brunkhorst, R. R. (1998) · American Journal of Kidney Diseases · doi:10.1053/ajkd.1998.v31.pm9469493 · Cited by 21
Age-related Alterations in IL-1β, TNF-α, and IL-6 Concentrations in Parotid Acinar Cells from BALB/c and Non-obese Diabetic Mice
Yamakawa, M., Weinstein, R. S., Tsuji, T., McBride, J., Wong, D. T., & Login, G. R. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004800802 · Cited by 21
A two-part phase I trial of high-dose interleukin 2 in combination with soluble (Chinese hamster ovary) interleukin 1 receptor.
McDermott, D. F., Trehu, E., Mier, J. W., Sorce, D., Rand, W., Ronayne, L., Kappler, K., Clancy, M., Klempner, M. S., & Atkins, M. B. (1998) · PubMed · Cited by 21
Local vs. systemic immune and haemostatic response to hip arthroplasty
Kristiansson, M., Soop, Sundqvist, Soop, Suontakas, & Blomback (1998) · European Journal of Anaesthesiology · doi:10.1046/j.1365-2346.1998.00254.x · Cited by 21
Modification of cytokine production by piroxicam.
Rosenstein, E. D., Kunická, J., Kramer, N., & Goldstein, G. (1994) · PubMed · Cited by 21
Cytokine abnormalities in inflammatory arthritis
Miossec, P. (1992) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(05)80180-3 · Cited by 21
The Effects of 21-Day General Rehabilitation after Hip or Knee Surgical Implantation on Plasma Levels of Selected Interleukins, VEGF, TNF-α, PDGF-BB, and Eotaxin-1
Idzik, M., Poloczek, J., Skrzep-Poloczek, B., Dróżdż, E., Chełmecka, E., Czuba, Z. P., Jochem, J., & Stygar, D. M. (2022) · Biomolecules · doi:10.3390/biom12050605 · Cited by 21
IL-6 Signaling Attenuates TNF-α Production by Plasmacytoid Dendritic Cells in Rheumatoid Arthritis
Papadaki, G., Goutakoli, P., Tiniakou, I., Grün, J. R., Grützkau, A., Pavlopoulos, G. A., Iliopoulos, I., Bertsias, G. K., Boumpas, D. T., Ospelt, C., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100882 · Cited by 20
Blunted IL-6 and IL-10 response to maximal aerobic exercise in patients with traumatic brain injury
Timmerman, K. L., Amonette, W. E., Markofski, M. M., Ansinelli, H. A., Gleason, E. A., Rasmussen, B. B., & Mossberg, K. A. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2997-4 · Cited by 20
Interleukin-6 Blood Levels in Sensitive and Multiresistant Tuberculosis
Correia, J. W., Freitas, M. V. C., Queiroz, J. Á. N., PereiraPerrin, M., & Cavadas, B. (2008) · Infection · doi:10.1007/s15010-008-7398-3 · Cited by 20
Induction of interleukin 6 and interleukin 8 expression by Broncho-Vaxom (OM-85 BV) via C-Fos/serum responsive element.
Keul, R., Roth, M., Papakonstantinou, E., Nauck, M., Perruchoud, A. P., & Block, L. H. (1996) · Thorax · doi:10.1136/thx.51.2.150 · Cited by 20
Activation of the Hypothalamic- Pituitary-Adrenal Axis in IL-1β-Converting Enzyme-Deficient Mice
Liège, S., Moze, E., Kelley, K. W., Parnet, P., & Neveu, P. J. (2000) · NeuroImmunoModulation · doi:10.1159/000026438 · Cited by 20
Impact of cancer cachexia on respiratory muscle function and the therapeutic potential of exercise
Murphy, B. T., Mackrill, J. J., & O’Halloran, K. D. (2022) · The Journal of Physiology · doi:10.1113/jp283569 · Cited by 20
IL-1 Transcriptional Responses to Lipopolysaccharides Are Regulated by a Complex of RNA Binding Proteins
Shi, L., Song, L., Maurer, K., Dou, Y., Patel, V. R., Su, C., Leonard, M. E., Lu, S., Hodge, K. M., Torres, A., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900650 · Cited by 18
Prevalence of mucosotropic human papillomaviruses in squamous-cell carcinomas of the head and neck
Snijders, P. J. F., Scholes, A. G. M., Hart, C. A., Jones, A. S., Vaughan, E. D., Woolgar, J. A., Meijer, C. J. L. M., Walboomers, J. M. M., & Field, J. K. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19960516)66:4 · Cited by 122
Interactions Involving Cyclosporine A., Interleukin-6, and Epstein-Barr Virus Lead to the Promotion of B-Cell Lymphoproliferative Disease
Tanner, J. E., & Alfierp, C. (1996) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199609093435 · Cited by 19
Reduced adrenal response to bacterial lipopolysaccharide in interleukin-6-deficient mice
van Enckevort, F. H. J., Sweep, F. C. G. J., Span, P. N., Demacker, P. N. M., Hermsen, C. C., & Hermus, A. R. M. M. (2001) · Journal of Endocrinological Investigation · doi:10.1007/bf03343928 · Cited by 19
Initial responses of osteoblasts derived from human alveolar bone to various compressive forces
Tripuwabhrut, K., Mustafa, K., Brudvik, P., & Mustafa, M. (2012) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2012.00980.x · Cited by 18
Effect of acute moderate exercise on induced inflammation and arterial function in older adults
Ranadive, S. M., Kappus, R. M., Cook, M. D., Yan, H., Lane, A. D., Woods, J. A., Wilund, K. R., Iwamoto, G. A., Vanar, V., Tandon, R., et al. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2013.077636 · Cited by 17
Growth Regulation of Hematopoietic Cells :An overview
Olofsson, T. (1991) · Acta Oncologica · doi:10.3109/02841869109088241 · Cited by 18
TLR2 Expression in Relation to IL‐6 and IL‐1β and theirNatural Regulators Production by PMN and PBMC in Patients withLyme Disease
Jabłońska, E., & Marcińczyk, M. (2006) · Mediators of Inflammation · doi:10.1155/mi/2006/32071 · Cited by 18

Authors: Schindler, R., Mancilla, J., Endres, S., Ghorbani, R., Clark, S., & Dinarello, C.
Affiliations: Tufts University (US)
Department of Medicine, Tufts University School of Medicine, Boston, MA.
ORCID: Endres, S
Venue: Blood
Publisher: American Society of Hematology
Published: 1990-01-01
Volume: 75
Issue: 1
Pages: 40-47
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood.v75.1.40.40
OpenAlex: W204546040
Cited by: 1,012
References: 34
Citations by year: 2026: 7 · 2025: 17 · 2024: 16 · 2023: 11 · 2022: 29 · 2021: 19 · 2020: 22 · 2019: 31 · 2018: 33 · 2017: 18 · 2016: 35 · 2015: 17 · 2014: 32 · 2013: 26 · 2012: 38
FWCI: 24.10
Type: journal article
Language: en
Open access: closed
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI‑15614)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: interleukin-6, IL-1β, TNF-α, cytokine production, peripheral blood mononuclear cells, cytokine inhibition, lipopolysaccharide, phytohemagglutinin, Staphylococcus epidermidis, radioimmunoassay, transcriptional regulation, hematopoietic function
MeSH terms: Biological Assay, Gene Expression Regulation, Humans, Interleukin-1, Leukocytes, Mononuclear, Radioimmunoassay, RNA, Messenger, Tumor Necrosis Factor-alpha, Interleukin-6, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks